Comparative analysis of intrinsic skin aging between Caucasian and Asian subjects by slide‐free in vivo harmonic generation microscopy

• Published in: Journal of biophotonics Vol. 13; no. 4; pp. e201960063 - n/a
• Main Authors: Lin, Kuan‐Hung, Liao, Yi‐Hua, Wei, Ming‐Liang, Sun, Chi‐Kuang
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY‐VCH Verlag GmbH & Co. KGaA 01.04.2020; Wiley Subscription Services, Inc
• Subjects: Aging; Asian; Asian People; Basal cells; Caucasian; Comparative analysis; dermal papillae; Dermatology; Epidermis; Full; harmonic generation microscopy; Harmonic generations; Humans; in vivo imaging; intrinsic aging; Microscopy; race; Skin; Skin Aging; Stratum corneum; viable epidermis; White People; in vivo imaging; harmonic generation microscopy; viable epidermis; race; intrinsic aging; Caucasian; dermal papillae; Asian
• ISSN: 1864-063X; 1864-0648; 1864-0648
• DOI: 10.1002/jbio.201960063

Phenotypical and functional differences in the intrinsic skin aging process of individuals between Caucasians and Asians have generated considerable interest in dermatology and cosmetic industry. Most of the studies focused on the stratum corneum, and in some other studies inter‐individual differences overwhelms the racial difference. None of the studies comparatively analyzes the difference from the histopathological point of view. Here we report our harmonic generation microscopy study to analyze the difference of intrinsic aging between Caucasian and Asian skin from a histopathological point of view. As a result, the cellular and nuclear areas of basal cells in Caucasian subjects were found to increase at the same rate as the Asian subjects, ideal for scoring age. The maximum thickness of the viable epidermis, the dermal papilla (DP) volume per unit area and the depth of the DP zone in Caucasians were found to decrease at faster rates than those in Asians. Phenotypical and functional differences in the intrinsic skin aging process of individuals between Caucasians and Asians have generated considerable interest in dermatology and cosmetic industry. Most of the studies focused on the stratum corneum, and in some other studies inter‐individual differences overwhelms the racial difference. Here we report our harmonic generation microscopy study to analyse the difference of intrinsic aging between Caucasian and Asian skin from a histopathological point of view.