Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study

Progress in medical science has allowed the discovery of many factors affecting the pathogenesis of bipolar disorder, and among the most recent research directions are found regenerative and inflammatory processes. The role of regenerative processes remains particularly poorly explored, but availabl...

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Published inBrain sciences Vol. 10; no. 7; p. 408
Main Authors Reginia, Artur, Samochowiec, Jerzy, Jabłoński, Marcin, Ferensztajn-Rochowiak, Ewa, Rybakowski, Janusz K., Telesiński, Arkadiusz, Tarnowski, Maciej, Misiak, Błażej, Ratajczak, Mariusz Z., Kucharska-Mazur, Jolanta
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 30.06.2020
MDPI
Subjects
Age
Antibodies
Antigens
Bipolar disorder
Body mass index
CD34 antigen
Cloning
Communication
Embryos
Emotional disorders
Inflammation
Lithium
Mental disorders
Mood disorders
Nicotine
Patients
Peripheral blood
Psychotropic drugs
Salts
Stem cells
Studies
VSEL
Online AccessGet full text
ISSN2076-3425
2076-3425
DOI10.3390/brainsci10070408

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Abstract Progress in medical science has allowed the discovery of many factors affecting the pathogenesis of bipolar disorder, and among the most recent research directions are found regenerative and inflammatory processes. The role of regenerative processes remains particularly poorly explored, but available data encourage further research, which may explain the pathogenesis of bipolar disorder (BD). The aim of this study was to evaluate the mobilization of stem cells into peripheral blood, in patients with bipolar disorder during stable phase, not treated with lithium salts. The study included 30 unrelated individuals with the diagnosis of bipolar disorder, with disease duration of at least 10 years, not treated with lithium salts for at least five years prior to the study. The control group consisted of 30 healthy subjects, matched for age, sex, body mass index (BMI), origin, socio-demographic factors and nicotine use. Blood samples underwent cytometric analyses to assess concentrations of: Very Small Embryonic Like (VSEL) CD34+, VSEL AC133+, HSC CD34+, HSC AC133+. There were no significant differences in stem cell levels between patients with BD and healthy controls. However, the level of VSEL cells AC133 + was significantly higher in type I BD patients compared to healthy controls. Our results indicate a disturbance in regenerative processes in patients with bipolar disorder.
AbstractList Progress in medical science has allowed the discovery of many factors affecting the pathogenesis of bipolar disorder, and among the most recent research directions are found regenerative and inflammatory processes. The role of regenerative processes remains particularly poorly explored, but available data encourage further research, which may explain the pathogenesis of bipolar disorder (BD). The aim of this study was to evaluate the mobilization of stem cells into peripheral blood, in patients with bipolar disorder during stable phase, not treated with lithium salts. The study included 30 unrelated individuals with the diagnosis of bipolar disorder, with disease duration of at least 10 years, not treated with lithium salts for at least five years prior to the study. The control group consisted of 30 healthy subjects, matched for age, sex, body mass index (BMI), origin, socio-demographic factors and nicotine use. Blood samples underwent cytometric analyses to assess concentrations of: Very Small Embryonic Like (VSEL) CD34+, VSEL AC133+, HSC CD34+, HSC AC133+. There were no significant differences in stem cell levels between patients with BD and healthy controls. However, the level of VSEL cells AC133 + was significantly higher in type I BD patients compared to healthy controls. Our results indicate a disturbance in regenerative processes in patients with bipolar disorder.
Progress in medical science has allowed the discovery of many factors affecting the pathogenesis of bipolar disorder, and among the most recent research directions are found regenerative and inflammatory processes. The role of regenerative processes remains particularly poorly explored, but available data encourage further research, which may explain the pathogenesis of bipolar disorder (BD). The aim of this study was to evaluate the mobilization of stem cells into peripheral blood, in patients with bipolar disorder during stable phase, not treated with lithium salts. The study included 30 unrelated individuals with the diagnosis of bipolar disorder, with disease duration of at least 10 years, not treated with lithium salts for at least five years prior to the study. The control group consisted of 30 healthy subjects, matched for age, sex, body mass index (BMI), origin, socio-demographic factors and nicotine use. Blood samples underwent cytometric analyses to assess concentrations of: Very Small Embryonic Like (VSEL) CD34+, VSEL AC133+, HSC CD34+, HSC AC133+. There were no significant differences in stem cell levels between patients with BD and healthy controls. However, the level of VSEL cells AC133 + was significantly higher in type I BD patients compared to healthy controls. Our results indicate a disturbance in regenerative processes in patients with bipolar disorder.Progress in medical science has allowed the discovery of many factors affecting the pathogenesis of bipolar disorder, and among the most recent research directions are found regenerative and inflammatory processes. The role of regenerative processes remains particularly poorly explored, but available data encourage further research, which may explain the pathogenesis of bipolar disorder (BD). The aim of this study was to evaluate the mobilization of stem cells into peripheral blood, in patients with bipolar disorder during stable phase, not treated with lithium salts. The study included 30 unrelated individuals with the diagnosis of bipolar disorder, with disease duration of at least 10 years, not treated with lithium salts for at least five years prior to the study. The control group consisted of 30 healthy subjects, matched for age, sex, body mass index (BMI), origin, socio-demographic factors and nicotine use. Blood samples underwent cytometric analyses to assess concentrations of: Very Small Embryonic Like (VSEL) CD34+, VSEL AC133+, HSC CD34+, HSC AC133+. There were no significant differences in stem cell levels between patients with BD and healthy controls. However, the level of VSEL cells AC133 + was significantly higher in type I BD patients compared to healthy controls. Our results indicate a disturbance in regenerative processes in patients with bipolar disorder.
Author Reginia, Artur
Rybakowski, Janusz K.
Misiak, Błażej
Jabłoński, Marcin
Ratajczak, Mariusz Z.
Kucharska-Mazur, Jolanta
Samochowiec, Jerzy
Telesiński, Arkadiusz
Ferensztajn-Rochowiak, Ewa
Tarnowski, Maciej
AuthorAffiliation 6 Department of Genetics, Wroclaw Medical University, 50-368 Wrocław, Poland; mblazej@interia.eu
1 Department of Psychiatry, Pomeranian University of Medicine, 71-460 Szczecin, Poland; jerzysamochowiec@gmail.com (J.S.); marcinjablonski2@wp.pl (M.J.); jola_kucharska@tlen.pl (J.K.-M.)
4 Department of Bioengineering, Faculty of Environmental Management and Agriculture, West Pomeranian University of Technology, 71-434 Szczecin, Poland; atelesinski@zut.edu.pl
3 Department of Psychiatric Nursing, Poznan University of Medical Sciences, 60-179 Poznań, Poland
5 Chair and Department of Physiology, 70-111 Szczecin, Poland; maciej.tarnowski@pum.edu.pl
2 Department of Adult Psychiatry, Poznan University of Medical Sciences, 60-572 Poznań, Poland; ferensztajnewa@gmail.com (E.F.-R.); janusz.rybakowski@gmail.com (J.K.R.)
8 Department of Regenerative Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland
7 Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY
AuthorAffiliation_xml – name: 1 Department of Psychiatry, Pomeranian University of Medicine, 71-460 Szczecin, Poland; jerzysamochowiec@gmail.com (J.S.); marcinjablonski2@wp.pl (M.J.); jola_kucharska@tlen.pl (J.K.-M.)
– name: 6 Department of Genetics, Wroclaw Medical University, 50-368 Wrocław, Poland; mblazej@interia.eu
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– name: 2 Department of Adult Psychiatry, Poznan University of Medical Sciences, 60-572 Poznań, Poland; ferensztajnewa@gmail.com (E.F.-R.); janusz.rybakowski@gmail.com (J.K.R.)
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CitedBy_id crossref_primary_10_3390_ijerph19106001
crossref_primary_10_3390_brainsci12060756
crossref_primary_10_1186_s13287_024_03752_x
Cites_doi 10.1038/leu.2011.242
10.4103/0019-5545.111475
10.1155/2015/251204
10.1016/j.jacc.2008.09.029
10.1016/j.jad.2011.12.049
10.12740/PP/76863
10.1111/j.2044-8341.1959.tb00467.x
10.12740/PP/31939
10.1016/j.yexmp.2018.08.002
10.1182/blood-2009-05-219923
10.1111/pcn.12275
10.1016/j.jpsychires.2017.03.018
10.1176/appi.ajp.2009.09060802
10.1016/j.pharep.2015.09.005
10.3389/fpsyt.2018.00614
10.1016/j.jpsychires.2013.10.016
10.4088/JCP.08r04505
10.1186/s13287-019-1165-5
10.1111/pcn.12089
10.1038/tp.2016.242
10.1016/j.tcb.2013.08.004
10.1038/sj.leu.2404171
10.1016/j.mcn.2012.10.002
10.3109/15622975.2016.1174301
10.1016/S0010-440X(03)00089-0
10.1007/s12015-016-9700-6
10.1016/j.comppsych.2016.12.008
10.1192/bjp.2018.144
10.1007/s10059-010-0081-4
10.1192/bjp.133.5.429
10.1038/leu.2009.158
10.1016/j.lpm.2019.04.017
10.1007/978-1-59745-387-5
10.1007/s12265-012-9371-x
10.1176/appi.ajp.2011.10111704
10.1016/j.bbi.2017.05.002
10.1192/bjp.134.4.382
10.1016/j.biopsych.2017.11.014
10.1038/leu.2010.53
10.3389/fpsyt.2018.00060
10.1016/j.pnpbp.2017.04.023
10.1161/STROKEAHA.108.535062
10.4068/cmj.2016.52.1.18
10.1016/j.psyneuen.2016.02.011
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References Mietto (ref_7) 2015; 2015
Zakrzewski (ref_8) 2019; 10
Shear (ref_27) 2001; 13
Montgomery (ref_23) 1979; 134
Sheehan (ref_22) 1998; 59
Young (ref_24) 1978; 133
Samochowiec (ref_41) 2017; 18
(ref_9) 2012; 5
Ratajczak (ref_10) 2014; 48
Ferreri (ref_2) 2019; 48
Gardner (ref_32) 2010; 167
Sayana (ref_48) 2017; 92
Reginia (ref_21) 2018; 9
Leboyer (ref_46) 2012; 141
Rowland (ref_34) 2018; 213
Rybakowski (ref_36) 2008; 5
Goldstein (ref_43) 2009; 70
Ratajczak (ref_47) 2018; 9
Isgren (ref_44) 2017; 65
Kyritsis (ref_6) 2014; 24
ref_29
Ratajczak (ref_19) 2012; 26
ref_28
Hamilton (ref_26) 1959; 32
Dieset (ref_40) 2016; 67
Jones (ref_45) 2013; 53
Brown (ref_5) 2018; 80
Tarnowski (ref_16) 2014; 49
Tsai (ref_50) 2017; 74
Engelmann (ref_17) 2006; 8
Chistyakov (ref_3) 2018; 105
ref_30
Shin (ref_12) 2010; 29
Talarowska (ref_4) 2018; 52
Han (ref_18) 2010; 115
Song (ref_37) 2018; 84
Keck (ref_49) 2003; 44
Rybakowski (ref_35) 2016; 68
Danivas (ref_31) 2013; 55
Paczkowska (ref_13) 2009; 40
Tarnowski (ref_42) 2017; 13
Kucia (ref_11) 2006; 20
Inada (ref_33) 2015; 69
Posner (ref_25) 2011; 168
Wojakowski (ref_15) 2009; 53
Charney (ref_39) 2017; 7
Ratajczak (ref_14) 2010; 24
Altamura (ref_38) 2014; 68
Lee (ref_20) 2009; 23
Muneer (ref_1) 2016; 52
References_xml – volume: 26
  start-page: 63
  year: 2012
  ident: ref_19
  article-title: A novel perspective on stem cell homing and mobilization: Review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients
  publication-title: Leukemia
  doi: 10.1038/leu.2011.242
– volume: 55
  start-page: 207
  year: 2013
  ident: ref_31
  article-title: Current perspectives on chlorpromazine equivalents: Comparing apples and oranges!
  publication-title: Indian J. Psychiatry
  doi: 10.4103/0019-5545.111475
– volume: 2015
  start-page: 251204
  year: 2015
  ident: ref_7
  article-title: Neurotrauma and inflammation: CNS and PNS responses
  publication-title: Mediat. Inflamm.
  doi: 10.1155/2015/251204
– volume: 53
  start-page: 1
  year: 2009
  ident: ref_15
  article-title: Mobilization of Bone Marrow-Derived Oct-4+SSEA-4+ Very Small Embryonic-Like Stem Cells in Patients with Acute Myocardial Infarction
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2008.09.029
– volume: 8
  start-page: 396
  year: 2006
  ident: ref_17
  article-title: Stem cell therapy after myocardial infarction: Ready for clinical application?
  publication-title: Curr. Opin. Mol. Ther.
– volume: 141
  start-page: 1
  year: 2012
  ident: ref_46
  article-title: Can bipolar disorder be viewed as a multi-system inflammatory disease?
  publication-title: J. Affect. Disord.
  doi: 10.1016/j.jad.2011.12.049
– volume: 52
  start-page: 437
  year: 2018
  ident: ref_4
  article-title: Inflammatory theory of depression
  publication-title: Psychiatr. Pol.
  doi: 10.12740/PP/76863
– volume: 32
  start-page: 50
  year: 1959
  ident: ref_26
  article-title: The assessment of anxiety states by rating
  publication-title: Br. J. Med. Psychol.
  doi: 10.1111/j.2044-8341.1959.tb00467.x
– volume: 48
  start-page: 1073
  year: 2014
  ident: ref_10
  article-title: Stem cell research and its growing impact on contemporary psychiatry
  publication-title: Psychiatr. Pol.
  doi: 10.12740/PP/31939
– volume: 105
  start-page: 190
  year: 2018
  ident: ref_3
  article-title: Resolution of inflammation and mood disorders
  publication-title: Exp. Mol. Pathol.
  doi: 10.1016/j.yexmp.2018.08.002
– volume: 115
  start-page: 957
  year: 2010
  ident: ref_18
  article-title: Adipose tissue is an extramedullary reservoir for functional hematopoietic stem and progenitor cells
  publication-title: Blood
  doi: 10.1182/blood-2009-05-219923
– volume: 69
  start-page: 440
  year: 2015
  ident: ref_33
  article-title: Psychotropic dose equivalence in Japan
  publication-title: Psychiatry Clin. Neurosci.
  doi: 10.1111/pcn.12275
– volume: 92
  start-page: 160
  year: 2017
  ident: ref_48
  article-title: A systematic review of evidence for the role of inflammatory biomarkers in bipolar patients
  publication-title: J. Psychiatr. Res.
  doi: 10.1016/j.jpsychires.2017.03.018
– volume: 167
  start-page: 686
  year: 2010
  ident: ref_32
  article-title: International consensus study of antipsychotic dosing
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.2009.09060802
– volume: 68
  start-page: 224
  year: 2016
  ident: ref_35
  article-title: The effect of lithium on hematopoietic, mesenchymal and neural stem cells
  publication-title: Pharmacol. Rep.
  doi: 10.1016/j.pharep.2015.09.005
– volume: 9
  start-page: 614
  year: 2018
  ident: ref_21
  article-title: Assessment of Complement Cascade Components in Patients with Bipolar Disorder
  publication-title: Front. Psychiatry
  doi: 10.3389/fpsyt.2018.00614
– volume: 49
  start-page: 18
  year: 2014
  ident: ref_16
  article-title: Novel evidence for enhanced stem cell trafficking in antipsychotic-naïve subjects during their first psychotic episode
  publication-title: J. Psychiatr. Res.
  doi: 10.1016/j.jpsychires.2013.10.016
– volume: 70
  start-page: 1078
  year: 2009
  ident: ref_43
  article-title: Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: A systematic review of the literature
  publication-title: J. Clin. Psychiatry
  doi: 10.4088/JCP.08r04505
– volume: 10
  start-page: 1
  year: 2019
  ident: ref_8
  article-title: Stem cells: Past, present, and future
  publication-title: Stem Cell Res. Ther.
  doi: 10.1186/s13287-019-1165-5
– volume: 68
  start-page: 21
  year: 2014
  ident: ref_38
  article-title: Role of immunological factors in the pathophysiology and diagnosis of bipolar disorder: Comparison with schizophrenia
  publication-title: Psychiatry Clin. Neurosci.
  doi: 10.1111/pcn.12089
– ident: ref_30
– volume: 7
  start-page: e993
  year: 2017
  ident: ref_39
  article-title: Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder
  publication-title: Transl. Psychiatry
  doi: 10.1038/tp.2016.242
– volume: 24
  start-page: 128
  year: 2014
  ident: ref_6
  article-title: Neuroinflammation and central nervous system regeneration in vertebrates
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2013.08.004
– volume: 20
  start-page: 857
  year: 2006
  ident: ref_11
  article-title: A population of very small embryonic-like (VSEL) CXCR4(+)SSEA-1(+)Oct-4+ stem cells identified in adult bone marrow
  publication-title: Leukemia
  doi: 10.1038/sj.leu.2404171
– volume: 59
  start-page: 22
  year: 1998
  ident: ref_22
  article-title: The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10
  publication-title: J. Clin. Psychiatry
– volume: 13
  start-page: 166
  year: 2001
  ident: ref_27
  article-title: Reliability and validity of a structured interview guide for the Hamilton Anxiety Rating Scale (SIGH-A). Depress
  publication-title: Anxiety
– volume: 53
  start-page: 52
  year: 2013
  ident: ref_45
  article-title: The role of the innate immune system in psychiatric disorders
  publication-title: Mol. Cell. Neurosci.
  doi: 10.1016/j.mcn.2012.10.002
– volume: 18
  start-page: 54
  year: 2017
  ident: ref_41
  article-title: The effect of long-term lithium treatment of bipolar disorder on stem cells circulating in peripheral blood
  publication-title: World J. Biol. Psychiatry
  doi: 10.3109/15622975.2016.1174301
– volume: 44
  start-page: 263
  year: 2003
  ident: ref_49
  article-title: Psychosis in bipolar disorder: Phenomenology and impact on morbidity and course of illness
  publication-title: Compr. Psychiatry
  doi: 10.1016/S0010-440X(03)00089-0
– volume: 13
  start-page: 217
  year: 2017
  ident: ref_42
  article-title: Mobilization of Peripheral Blood Stem Cells and Changes in the Concentration of Plasma Factors Influencing their Movement in Patients with Panic Disorder
  publication-title: Stem Cell Rev. Rep.
  doi: 10.1007/s12015-016-9700-6
– volume: 74
  start-page: 27
  year: 2017
  ident: ref_50
  article-title: Decreased S100B serum levels after treatment in bipolar patients in a manic phase
  publication-title: Compr. Psychiatry
  doi: 10.1016/j.comppsych.2016.12.008
– volume: 213
  start-page: 514
  year: 2018
  ident: ref_34
  article-title: Neurotrophins, cytokines, oxidative stress mediators and mood state in bipolar disorder: Systematic review and meta-analyses
  publication-title: Br. J. Psychiatry
  doi: 10.1192/bjp.2018.144
– volume: 29
  start-page: 533
  year: 2010
  ident: ref_12
  article-title: Molecular characterization of isolated from murine adult tissues very small embryonic/epiblast like stem cells (VSELs)
  publication-title: Mol. Cells
  doi: 10.1007/s10059-010-0081-4
– volume: 133
  start-page: 429
  year: 1978
  ident: ref_24
  article-title: A rating scale for mania: Reliability, validity and sensitivity
  publication-title: Br. J. Psychiatry J. Ment. Sci.
  doi: 10.1192/bjp.133.5.429
– volume: 23
  start-page: 2052
  year: 2009
  ident: ref_20
  article-title: Impaired mobilization of hematopoietic stem/progenitor cells in C5-deficient mice supports the pivotal involvement of innate immunity in this process and reveals novel promobilization effects of granulocytes
  publication-title: Leukemia
  doi: 10.1038/leu.2009.158
– ident: ref_29
– volume: 5
  start-page: 75
  year: 2008
  ident: ref_36
  article-title: Koncepcja spektrum choroby afektywnej dwubiegunowej
  publication-title: Psychiatria
– volume: 48
  start-page: 609
  year: 2019
  ident: ref_2
  article-title: Intrications organo-psychiatriques: Le concept de troubles psychiatriques complexes, quels examens complémentaires?
  publication-title: Press. Méd.
  doi: 10.1016/j.lpm.2019.04.017
– ident: ref_28
  doi: 10.1007/978-1-59745-387-5
– volume: 5
  start-page: 618
  year: 2012
  ident: ref_9
  article-title: The vascular stem cell niche
  publication-title: J. Cardiovasc. Transl. Res.
  doi: 10.1007/s12265-012-9371-x
– volume: 168
  start-page: 1266
  year: 2011
  ident: ref_25
  article-title: The Columbia-Suicide Severity Rating Scale: Initial validity and internal consistency findings from three multisite studies with adolescents and adults
  publication-title: Am. J. Psychiatry
  doi: 10.1176/appi.ajp.2011.10111704
– volume: 65
  start-page: 195
  year: 2017
  ident: ref_44
  article-title: Markers of neuroinflammation and neuronal injury in bipolar disorder: Relation to prospective clinical outcomes
  publication-title: Brain Behav. Immun.
  doi: 10.1016/j.bbi.2017.05.002
– volume: 134
  start-page: 382
  year: 1979
  ident: ref_23
  article-title: A new depression scale designed to be sensitive to change
  publication-title: Br. J. Psychiatry J. Ment. Sci.
  doi: 10.1192/bjp.134.4.382
– volume: 84
  start-page: 810
  year: 2018
  ident: ref_37
  article-title: Specificity in Etiology of Subtypes of Bipolar Disorder: Evidence from a Swedish Population-Based Family Study
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2017.11.014
– volume: 24
  start-page: 976
  year: 2010
  ident: ref_14
  article-title: Novel insight into stem cell mobilization-Plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex
  publication-title: Leukemia
  doi: 10.1038/leu.2010.53
– volume: 9
  start-page: 60
  year: 2018
  ident: ref_47
  article-title: Sterile Inflammation of Brain, due to Activation of Innate Immunity, as a Culprit in Psychiatric Disorders
  publication-title: Front. Psychiatry
  doi: 10.3389/fpsyt.2018.00060
– volume: 80
  start-page: 189
  year: 2018
  ident: ref_5
  article-title: Depressive disorders: Processes leading to neurogeneration and potential novel treatments
  publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatry
  doi: 10.1016/j.pnpbp.2017.04.023
– volume: 40
  start-page: 1237
  year: 2009
  ident: ref_13
  article-title: Clinical evidence that very small embryonic-like stem cells are mobilized into peripheral blood in patients after stroke
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.108.535062
– volume: 52
  start-page: 18
  year: 2016
  ident: ref_1
  article-title: The Neurobiology of Bipolar Disorder: An Integrated Approach
  publication-title: Chonnam Med. J.
  doi: 10.4068/cmj.2016.52.1.18
– volume: 67
  start-page: 189
  year: 2016
  ident: ref_40
  article-title: Inflammatory evidence for the psychosis continuum model
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/j.psyneuen.2016.02.011
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Snippet Progress in medical science has allowed the discovery of many factors affecting the pathogenesis of bipolar disorder, and among the most recent research...
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SubjectTerms Age
Antibodies
Antigens
Bipolar disorder
Body mass index
CD34 antigen
Cloning
Communication
Embryos
Emotional disorders
Inflammation
Lithium
Mental disorders
Mood disorders
Nicotine
Patients
Peripheral blood
Psychotropic drugs
Salts
Stem cells
Studies
VSEL
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Title Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study
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