Landscape of Dysregulated Placental RNA Editing Associated With Preeclampsia

Dysregulated RNA editing is well documented in several diseases, such as cancer and neurodegenerative diseases. The extent to which RNA editing might be involved in diseases originated in the placenta remains unknown. Here, we have systematically profiled RNA editome on the placentae, 9 from patient...

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Published in	Hypertension (Dallas, Tex. 1979) Vol. 75; no. 6; pp. 1532 - 1541
Main Authors	Yang, Xiaoxue, Yang, Jing, Liang, Xiaozhen, Chen, Qian, Jiang, Sijia, Liu, Haihua, Gao, Yue, Ren, Zhonglu, Shi, Yi-Wu, Li, Sheng, Yu, Yanhong, Zhong, Mei, Yang, Xinping
Format	Journal Article
Language	English
Published	United States American Heart Association, Inc 01.06.2020
Subjects	Adult Binding Sites Cell Line Female Gene Expression Profiling - methods Gene Expression Regulation Gestational Age Humans Leptin - genetics Leptin - metabolism MicroRNAs - genetics Placenta - metabolism Pre-Eclampsia - genetics Pre-Eclampsia - metabolism Pre-Eclampsia - physiopathology Pregnancy Pregnancy Trimesters RNA Editing - physiology Severity of Illness Index Up-Regulation placenta RNA editing preeclampsia hypertension untranslated regions
Online Access	Get full text
ISSN	0194-911X 1524-4563 1524-4563
DOI	10.1161/HYPERTENSIONAHA.120.14756

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Abstract	Dysregulated RNA editing is well documented in several diseases, such as cancer and neurodegenerative diseases. The extent to which RNA editing might be involved in diseases originated in the placenta remains unknown. Here, we have systematically profiled RNA editome on the placentae, 9 from patients with early-onset severe preeclampsia (EOSPE) and 32 from normal subjects, and a widespread RNA editing dysregulation in EOSPE has been identified. The mis-edited gene set is enriched with known preeclampsia-associated genes and differentially expressed genes in EOSPE. The RNA editing events at 2 microRNA binding sites in 3′-untranslated region of the LEP mRNA were generated, which could inhibit the microRNA-induced mRNA downregulation of LEP in placenta-derived cell line, consistent with the observation in the placentae of preeclampsia patients. These results demonstrate the association of dysregulated placental RNA editing with preeclampsia, and providing a resource for further study on the role of RNA editing in the pathogenesis of this disease.
AbstractList	Dysregulated RNA editing is well documented in several diseases, such as cancer and neurodegenerative diseases. The extent to which RNA editing might be involved in diseases originated in the placenta remains unknown. Here, we have systematically profiled RNA editome on the placentae, 9 from patients with early-onset severe preeclampsia (EOSPE) and 32 from normal subjects, and a widespread RNA editing dysregulation in EOSPE has been identified. The mis-edited gene set is enriched with known preeclampsia-associated genes and differentially expressed genes in EOSPE. The RNA editing events at 2 microRNA binding sites in 3'-untranslated region of the mRNA were generated, which could inhibit the microRNA-induced mRNA downregulation of in placenta-derived cell line, consistent with the observation in the placentae of preeclampsia patients. These results demonstrate the association of dysregulated placental RNA editing with preeclampsia, and providing a resource for further study on the role of RNA editing in the pathogenesis of this disease. Dysregulated RNA editing is well documented in several diseases, such as cancer and neurodegenerative diseases. The extent to which RNA editing might be involved in diseases originated in the placenta remains unknown. Here, we have systematically profiled RNA editome on the placentae, 9 from patients with early-onset severe preeclampsia (EOSPE) and 32 from normal subjects, and a widespread RNA editing dysregulation in EOSPE has been identified. The mis-edited gene set is enriched with known preeclampsia-associated genes and differentially expressed genes in EOSPE. The RNA editing events at 2 microRNA binding sites in 3′-untranslated region of the LEP mRNA were generated, which could inhibit the microRNA-induced mRNA downregulation of LEP in placenta-derived cell line, consistent with the observation in the placentae of preeclampsia patients. These results demonstrate the association of dysregulated placental RNA editing with preeclampsia, and providing a resource for further study on the role of RNA editing in the pathogenesis of this disease. Dysregulated RNA editing is well documented in several diseases, such as cancer and neurodegenerative diseases. The extent to which RNA editing might be involved in diseases originated in the placenta remains unknown. Here, we have systematically profiled RNA editome on the placentae, 9 from patients with early-onset severe preeclampsia (EOSPE) and 32 from normal subjects, and a widespread RNA editing dysregulation in EOSPE has been identified. The mis-edited gene set is enriched with known preeclampsia-associated genes and differentially expressed genes in EOSPE. The RNA editing events at 2 microRNA binding sites in 3'-untranslated region of the LEP mRNA were generated, which could inhibit the microRNA-induced mRNA downregulation of LEP in placenta-derived cell line, consistent with the observation in the placentae of preeclampsia patients. These results demonstrate the association of dysregulated placental RNA editing with preeclampsia, and providing a resource for further study on the role of RNA editing in the pathogenesis of this disease.Dysregulated RNA editing is well documented in several diseases, such as cancer and neurodegenerative diseases. The extent to which RNA editing might be involved in diseases originated in the placenta remains unknown. Here, we have systematically profiled RNA editome on the placentae, 9 from patients with early-onset severe preeclampsia (EOSPE) and 32 from normal subjects, and a widespread RNA editing dysregulation in EOSPE has been identified. The mis-edited gene set is enriched with known preeclampsia-associated genes and differentially expressed genes in EOSPE. The RNA editing events at 2 microRNA binding sites in 3'-untranslated region of the LEP mRNA were generated, which could inhibit the microRNA-induced mRNA downregulation of LEP in placenta-derived cell line, consistent with the observation in the placentae of preeclampsia patients. These results demonstrate the association of dysregulated placental RNA editing with preeclampsia, and providing a resource for further study on the role of RNA editing in the pathogenesis of this disease. Dysregulated RNA editing is well documented in several diseases, such as cancer and neurodegenerative diseases. The extent to which RNA editing might be involved in diseases originated in the placenta remains unknown. Here, we have systematically profiled RNA editome on the placentae, 9 from patients with early-onset severe preeclampsia (EOSPE) and 32 from normal subjects, and a widespread RNA editing dysregulation in EOSPE has been identified. The mis-edited gene set is enriched with known preeclampsia-associated genes and differentially expressed genes in EOSPE. The RNA editing events at 2 microRNA binding sites in 3′-untranslated region of the LEP mRNA were generated, which could inhibit the microRNA-induced mRNA downregulation of LEP in placenta-derived cell line, consistent with the observation in the placentae of preeclampsia patients. These results demonstrate the association of dysregulated placental RNA editing with preeclampsia, and providing a resource for further study on the role of RNA editing in the pathogenesis of this disease.
Author	Li, Sheng Ren, Zhonglu Yang, Xiaoxue Zhong, Mei Chen, Qian Shi, Yi-Wu Yang, Xinping Gao, Yue Jiang, Sijia Yang, Jing Liu, Haihua Yu, Yanhong Liang, Xiaozhen
AuthorAffiliation	From the Center for Genetics and Developmental Systems Biology, Department of Obstetrics and Gynecology, Nanfang Hospital (Xiaoxue Yang, J.Y., X.L., Q.C., S.J., H.L., Y.G., Z.R., Y.Y., M.Z., Xinping Yang), Southern Medical University, Guangzhou, Guangdong, China Key Laboratory of Mental Health of the Ministry of Education (J.Y., Y.G., Xinping Yang), Southern Medical University, Guangzhou, Guangdong, China Department of Bioinformatics, School of Basic Medical Sciences (J.Y., Y.G., Xinping Yang), Southern Medical University, Guangzhou, Guangdong, China Institute of Neuroscience and Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, China (Y.-W.S.) Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, China (S.L.)
AuthorAffiliation_xml	– name: From the Center for Genetics and Developmental Systems Biology, Department of Obstetrics and Gynecology, Nanfang Hospital (Xiaoxue Yang, J.Y., X.L., Q.C., S.J., H.L., Y.G., Z.R., Y.Y., M.Z., Xinping Yang), Southern Medical University, Guangzhou, Guangdong, China Key Laboratory of Mental Health of the Ministry of Education (J.Y., Y.G., Xinping Yang), Southern Medical University, Guangzhou, Guangdong, China Department of Bioinformatics, School of Basic Medical Sciences (J.Y., Y.G., Xinping Yang), Southern Medical University, Guangzhou, Guangdong, China Institute of Neuroscience and Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, China (Y.-W.S.) Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, China (S.L.)
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Cites_doi	10.1038/19992 10.1186/s12864-015-2291-9 10.1038/nn.4337 10.1016/j.gde.2017.10.009 10.1007/s11596-006-0633-1 10.1101/gr.164749.113 10.1016/j.cell.2004.11.050 10.12659/msm.901191 10.1101/gr.107524.110 10.1016/0303-7207(89)90209-8 10.1093/nar/gkw835 10.1101/584672 10.1186/s13059-014-0550-8 10.1038/ng.3895 10.1093/bioinformatics/btp616 10.1053/meta.2000.7707 10.1074/jbc.M115.699363 10.1038/nrneph.2014.102 10.1016/S0025-6196(11)60669-1 10.1097/00041433-200104000-00009 10.1093/nar/gkh103 10.1038/nmeth.1923 10.1016/j.ajog.2008.04.020 10.1038/nbt.1621 10.1186/s40659-018-0185-4 10.1126/science.1138050 10.1038/cddis.2017.12 10.1055/s-2007-993890 10.1093/nar/gkt996 10.1086/337952 10.1161/HYPERTENSIONAHA.110.164079 10.1101/gr.231209.117 10.1089/omi.2011.0118 10.1038/nbt.3122 10.1101/gr.2951204 10.1074/jbc.M117.775684 10.1093/nar/gkw767 10.1016/j.ccell.2015.08.013 10.1093/nar/24.3.478 10.1038/sj.embor.7400621 10.1261/rna.041533.113 10.1038/srep14941 10.1093/bioinformatics/btu638 10.1371/journal.pbio.0020391 10.1038/s42003-018-0271-8 10.1016/0092-8674(86)90063-2 10.1146/annurev-biochem-060208-105251 10.1126/science.1111726 10.1093/nar/gkx1081 10.1093/bioinformatics/btq285 10.1002/0471142905.hg1116s87 10.1038/nmeth.4083 10.1016/0092-8674(87)90239-x 10.1038/nrm.2015.4 10.1186/gb-2013-14-4-r36 10.1093/bioinformatics/bts635 10.1016/0092-8674(87)90510-1 10.1101/gr.134957.111 10.1093/nar/gkq603 10.1016/j.celrep.2014.12.019 10.1101/gr.1239303
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References	e_1_3_4_3_2 e_1_3_4_61_2 e_1_3_4_9_2 e_1_3_4_7_2 e_1_3_4_40_2 e_1_3_4_5_2 e_1_3_4_23_2 e_1_3_4_44_2 e_1_3_4_21_2 e_1_3_4_42_2 e_1_3_4_27_2 e_1_3_4_48_2 e_1_3_4_25_2 e_1_3_4_46_2 e_1_3_4_29_2 e_1_3_4_30_2 e_1_3_4_51_2 e_1_3_4_11_2 e_1_3_4_34_2 e_1_3_4_57_2 e_1_3_4_55_2 e_1_3_4_32_2 e_1_3_4_59_2 e_1_3_4_53_2 e_1_3_4_15_2 e_1_3_4_38_2 e_1_3_4_13_2 e_1_3_4_36_2 e_1_3_4_19_2 e_1_3_4_17_2 e_1_3_4_2_2 e_1_3_4_60_2 e_1_3_4_62_2 e_1_3_4_8_2 e_1_3_4_41_2 e_1_3_4_6_2 e_1_3_4_4_2 e_1_3_4_22_2 e_1_3_4_45_2 e_1_3_4_20_2 e_1_3_4_43_2 e_1_3_4_26_2 e_1_3_4_49_2 e_1_3_4_24_2 e_1_3_4_47_2 e_1_3_4_28_2 e_1_3_4_52_2 e_1_3_4_50_2 e_1_3_4_12_2 e_1_3_4_33_2 e_1_3_4_58_2 e_1_3_4_54_2 e_1_3_4_10_2 e_1_3_4_31_2 e_1_3_4_16_2 e_1_3_4_37_2 e_1_3_4_14_2 e_1_3_4_35_2 e_1_3_4_56_2 e_1_3_4_18_2 e_1_3_4_39_2
References_xml	– ident: e_1_3_4_6_2 doi: 10.1038/19992 – ident: e_1_3_4_13_2 doi: 10.1186/s12864-015-2291-9 – ident: e_1_3_4_15_2 doi: 10.1038/nn.4337 – ident: e_1_3_4_55_2 doi: 10.1016/j.gde.2017.10.009 – ident: e_1_3_4_43_2 doi: 10.1007/s11596-006-0633-1 – ident: e_1_3_4_40_2 doi: 10.1101/gr.164749.113 – ident: e_1_3_4_10_2 doi: 10.1016/j.cell.2004.11.050 – ident: e_1_3_4_39_2 doi: 10.12659/msm.901191 – ident: e_1_3_4_23_2 doi: 10.1101/gr.107524.110 – ident: e_1_3_4_44_2 doi: 10.1016/0303-7207(89)90209-8 – ident: e_1_3_4_8_2 doi: 10.1093/nar/gkw835 – ident: e_1_3_4_18_2 doi: 10.1101/584672 – ident: e_1_3_4_30_2 doi: 10.1186/s13059-014-0550-8 – ident: e_1_3_4_42_2 doi: 10.1038/ng.3895 – ident: e_1_3_4_31_2 doi: 10.1093/bioinformatics/btp616 – ident: e_1_3_4_52_2 doi: 10.1053/meta.2000.7707 – ident: e_1_3_4_12_2 doi: 10.1074/jbc.M115.699363 – ident: e_1_3_4_19_2 doi: 10.1038/nrneph.2014.102 – ident: e_1_3_4_17_2 doi: 10.1016/S0025-6196(11)60669-1 – ident: e_1_3_4_57_2 doi: 10.1097/00041433-200104000-00009 – ident: e_1_3_4_38_2 doi: 10.1093/nar/gkh103 – ident: e_1_3_4_21_2 doi: 10.1038/nmeth.1923 – ident: e_1_3_4_51_2 doi: 10.1016/j.ajog.2008.04.020 – ident: e_1_3_4_34_2 doi: 10.1038/nbt.1621 – ident: e_1_3_4_60_2 doi: 10.1186/s40659-018-0185-4 – ident: e_1_3_4_7_2 doi: 10.1126/science.1138050 – ident: e_1_3_4_61_2 doi: 10.1038/cddis.2017.12 – ident: e_1_3_4_45_2 doi: 10.1055/s-2007-993890 – ident: e_1_3_4_25_2 doi: 10.1093/nar/gkt996 – ident: e_1_3_4_59_2 doi: 10.1086/337952 – ident: e_1_3_4_41_2 doi: 10.1161/HYPERTENSIONAHA.110.164079 – ident: e_1_3_4_48_2 doi: 10.1101/gr.231209.117 – ident: e_1_3_4_35_2 doi: 10.1089/omi.2011.0118 – ident: e_1_3_4_33_2 doi: 10.1038/nbt.3122 – ident: e_1_3_4_53_2 doi: 10.1101/gr.2951204 – ident: e_1_3_4_14_2 doi: 10.1074/jbc.M117.775684 – ident: e_1_3_4_27_2 doi: 10.1093/nar/gkw767 – ident: e_1_3_4_16_2 doi: 10.1016/j.ccell.2015.08.013 – ident: e_1_3_4_58_2 doi: 10.1093/nar/24.3.478 – ident: e_1_3_4_47_2 doi: 10.1038/sj.embor.7400621 – ident: e_1_3_4_11_2 doi: 10.1261/rna.041533.113 – ident: e_1_3_4_54_2 doi: 10.1038/srep14941 – ident: e_1_3_4_29_2 doi: 10.1093/bioinformatics/btu638 – ident: e_1_3_4_46_2 doi: 10.1371/journal.pbio.0020391 – ident: e_1_3_4_62_2 doi: 10.1038/s42003-018-0271-8 – ident: e_1_3_4_2_2 doi: 10.1016/0092-8674(86)90063-2 – ident: e_1_3_4_9_2 doi: 10.1146/annurev-biochem-060208-105251 – ident: e_1_3_4_20_2 doi: 10.1126/science.1111726 – ident: e_1_3_4_36_2 doi: 10.1093/nar/gkx1081 – ident: e_1_3_4_26_2 doi: 10.1093/bioinformatics/btq285 – ident: e_1_3_4_50_2 doi: 10.1002/0471142905.hg1116s87 – ident: e_1_3_4_37_2 doi: 10.1038/nmeth.4083 – ident: e_1_3_4_4_2 doi: 10.1016/0092-8674(87)90239-x – ident: e_1_3_4_5_2 doi: 10.1038/nrm.2015.4 – ident: e_1_3_4_22_2 doi: 10.1186/gb-2013-14-4-r36 – ident: e_1_3_4_28_2 doi: 10.1093/bioinformatics/bts635 – ident: e_1_3_4_3_2 doi: 10.1016/0092-8674(87)90510-1 – ident: e_1_3_4_56_2 doi: 10.1101/gr.134957.111 – ident: e_1_3_4_24_2 doi: 10.1093/nar/gkq603 – ident: e_1_3_4_49_2 doi: 10.1016/j.celrep.2014.12.019 – ident: e_1_3_4_32_2 doi: 10.1101/gr.1239303
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Snippet	Dysregulated RNA editing is well documented in several diseases, such as cancer and neurodegenerative diseases. The extent to which RNA editing might be...
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SubjectTerms	Adult Binding Sites Cell Line Female Gene Expression Profiling - methods Gene Expression Regulation Gestational Age Humans Leptin - genetics Leptin - metabolism MicroRNAs - genetics Placenta - metabolism Pre-Eclampsia - genetics Pre-Eclampsia - metabolism Pre-Eclampsia - physiopathology Pregnancy Pregnancy Trimesters RNA Editing - physiology Severity of Illness Index Up-Regulation
Title	Landscape of Dysregulated Placental RNA Editing Associated With Preeclampsia
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