Circumventing the Crabtree effect in cell culture: A systematic review
Metabolic reprogramming and mitochondrial dysfunction are central elements in a broad variety of physiological and pathological processes. While cell culture established itself as a versatile technique for the elaboration of physiology and disease, studying metabolism using standard cell culture pro...
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| Published in | Mitochondrion Vol. 59; pp. 83 - 95 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.07.2021
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1567-7249 1872-8278 1872-8278 |
| DOI | 10.1016/j.mito.2021.03.014 |
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| Abstract | Metabolic reprogramming and mitochondrial dysfunction are central elements in a broad variety of physiological and pathological processes. While cell culture established itself as a versatile technique for the elaboration of physiology and disease, studying metabolism using standard cell culture protocols is profoundly interfered by the Crabtree effect. This phenomenon refers to the adaptation of cultured cells to a glycolytic phenotype, away from oxidative phosphorylation in glucose-containing medium, and questions the applicability of cell culture in certain fields of research. In this systematic review we aim to provide a comprehensive overview and critical appraisal of strategies reported to circumvent the Crabtree effect. |
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| AbstractList | Metabolic reprogramming and mitochondrial dysfunction are central elements in a broad variety of physiological and pathological processes. While cell culture established itself as a versatile technique for the elaboration of physiology and disease, studying metabolism using standard cell culture protocols is profoundly interfered by the Crabtree effect. This phenomenon refers to the adaptation of cultured cells to a glycolytic phenotype, away from oxidative phosphorylation in glucose-containing medium, and questions the applicability of cell culture in certain fields of research. In this systematic review we aim to provide a comprehensive overview and critical appraisal of strategies reported to circumvent the Crabtree effect.Metabolic reprogramming and mitochondrial dysfunction are central elements in a broad variety of physiological and pathological processes. While cell culture established itself as a versatile technique for the elaboration of physiology and disease, studying metabolism using standard cell culture protocols is profoundly interfered by the Crabtree effect. This phenomenon refers to the adaptation of cultured cells to a glycolytic phenotype, away from oxidative phosphorylation in glucose-containing medium, and questions the applicability of cell culture in certain fields of research. In this systematic review we aim to provide a comprehensive overview and critical appraisal of strategies reported to circumvent the Crabtree effect. Metabolic reprogramming and mitochondrial dysfunction are central elements in a broad variety of physiological and pathological processes. While cell culture established itself as a versatile technique for the elaboration of physiology and disease, studying metabolism using standard cell culture protocols is profoundly interfered by the Crabtree effect. This phenomenon refers to the adaptation of cultured cells to a glycolytic phenotype, away from oxidative phosphorylation in glucose-containing medium, and questions the applicability of cell culture in certain fields of research. In this systematic review we aim to provide a comprehensive overview and critical appraisal of strategies reported to circumvent the Crabtree effect. |
| Author | Wüst, Rob C.I. Schaapherder, Alexander F. Bakker, Jaap A. Le Dévédec, Sylvia E. Lindeman, Jan H.N. Zuiderwijk, Melissa de Kok, Michèle J.C. |
| Author_xml | – sequence: 1 givenname: Michèle J.C. surname: de Kok fullname: de Kok, Michèle J.C. organization: Department of Surgery and Leiden Transplant Center, Leiden University Medical Center, Leiden, The Netherlands – sequence: 2 givenname: Alexander F. surname: Schaapherder fullname: Schaapherder, Alexander F. organization: Department of Surgery and Leiden Transplant Center, Leiden University Medical Center, Leiden, The Netherlands – sequence: 3 givenname: Rob C.I. surname: Wüst fullname: Wüst, Rob C.I. organization: Laboratory for Myology, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands – sequence: 4 givenname: Melissa surname: Zuiderwijk fullname: Zuiderwijk, Melissa organization: Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands – sequence: 5 givenname: Jaap A. orcidid: 0000-0002-2918-7361 surname: Bakker fullname: Bakker, Jaap A. organization: Department of Clinical Chemistry & Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands – sequence: 6 givenname: Jan H.N. surname: Lindeman fullname: Lindeman, Jan H.N. organization: Department of Surgery and Leiden Transplant Center, Leiden University Medical Center, Leiden, The Netherlands – sequence: 7 givenname: Sylvia E. surname: Le Dévédec fullname: Le Dévédec, Sylvia E. email: s.e.ledevedec@lacdr.leidenuniv.nl organization: Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands |
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| Cites_doi | 10.1152/ajpcell.1989.256.3.C532 10.1016/S0300-9084(77)80317-9 10.1016/0006-2944(81)90011-9 10.1016/j.cmet.2019.06.005 10.1038/nm.3140 10.1007/BF00135633 10.1016/j.bbabio.2017.12.002 10.1080/15384101.2018.1442622 10.1111/dom.12268 10.1158/0008-5472.CAN-03-1101 10.1159/000504344 10.1007/s10495-020-01637-x 10.1016/j.toxlet.2020.01.015 10.1007/s10495-014-1049-1 10.1016/j.ebiom.2015.07.035 10.1016/j.redox.2013.12.028 10.1007/BF02631415 10.1093/toxsci/kfm052 10.1152/ajpcell.1990.259.3.C455 10.1016/0304-4165(94)00190-9 10.1016/j.cmet.2017.04.015 10.1007/s11064-019-02752-1 10.1073/pnas.1105121108 10.1002/jcp.22061 10.1152/ajpcell.1996.271.6.C2072 10.1074/jbc.M117.786582 10.1096/fj.09-151803 10.1007/BF00769635 10.1007/s00424-020-02411-3 10.1016/0022-2828(90)90984-A 10.1016/j.freeradbiomed.2017.10.003 10.1016/0003-9861(77)90143-6 10.1161/CIRCRESAHA.118.313249 10.1042/bj2500383 10.1159/000063792 10.1371/journal.pone.0070772 10.1038/s42255-019-0105-0 10.1089/biores.2013.0051 10.1038/nbt.1606 10.1039/c3mt00227f 10.1152/ajplegacy.1973.225.5.1153 10.1111/j.1365-2184.2005.00345.x 10.1210/er.2017-00211 10.1126/science.1160809 10.1136/bmj.g7647 10.1002/stem.2047 10.1126/science.123.3191.309 10.1007/978-1-59745-019-5_2 10.1016/S0300-9084(78)80030-3 10.1080/009841096160808 10.1079/PNS2004349 10.1042/bj0230536 10.1152/ajpcell.1995.269.5.C1317 10.1146/annurev-cellbio-092910-154237 10.1152/physrev.00041.2017 10.1016/j.biocel.2016.08.029 10.1007/BF02634554 |
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| Keywords | Glycolysis Cell culture Crabtree effect Mitochondria Oxidative phosphorylation Metabolism |
| Language | English |
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| References | Salabei, Lorkiewicz, Holden, Li, Hong, Bolli, Bhatnagar, Hill (b0260) 2015; 33 Arend, Ehrke, Dringen (b0010) 2019; 44 Place, Domann, Case (b0240) 2017; 113 Heywood, Knight, Lee (b0130) 2010; 223 Nowak, Griffin, Schnellmann (b0205) 1996; 49 Griner, Aleo, Schnellmann (b0110) 1993; 29 Warburg (b0310) 1956; 123 Kishi, Campanholle, Gohil, Perocchi, Brooks, Morizane, Sabbisetti, Ichimura, Mootha, Bonventre (b0155) 2015; 2 Nowak, Schnellmann (b0210) 1996; 271 Hammad, Rosas-Lemus, Uribe-Carvajal, Rigoulet, Devin (b0120) 1857; 1139–1146 Nowak, Schnellmann (b0215) 1995; 269 Storlien, Oakes, Kelley (b0275) 2004; 63 Michaeloudes, Bhavsar, Mumby, Xu, Hui, Chung, Adcock (b0185) 2020; 12 Curi, Newsholme, Newsholme (b0055) 1988; 250 Nagy, A.M., Fekete, R., Horvath, G., Koncsos, G., Kriston, C., Sebestyen, A., Giricz, Z., Kornyei, Z., Madarasz, E., Tretter, L., 2018. Versatility of microglial bioenergetic machinery under starving conditions. Biochim Biophys Acta Bioenerg 1859: 201-214. Tang, Tannen (b0290) 1990; 259 Priolo, Henske (b0245) 2013; 19 Chi, Berezesky, Smith, Trump (b0045) 1995; 1243 Mailloux, Harper (b0175) 2010; 24 Griner, Schnellmann (b0115) 1994; 30 Gohil, Sheth, Nilsson, Wojtovich, Lee, Perocchi, Chen, Clish, Ayata, Brookes, Mootha (b0100) 2010; 28 Hare, Grubman, Ryan, Lothian, Liddell, Grimm, Matsuda, Doble, Cherny, Bush, White, Masters, Roberts (b0125) 2013; 5 Aleo, Schnellmann (b0005) 1992; 262 Glycolysis (b0315) 1972; 32 Felder, Jennings, Seppi, Pfaller (b0090) 2002; 12 Goodpaster, Sparks (b0105) 2017; 25 Robinson (b0250) 1988; 20 Vaughan, Gannon, Barberena, Garcia-Smith, Bisoffi, Mermier, Conn, Trujillo (b0300) 2014; 16 Rossignol, Gilkerson, Aggeler, Yamagata, Remington, Capaldi (b0255) 2004; 64 Nowak, Schnellmann (b0220) 1996; 271 de Alteriis, Cartenì, Parascandola, Serpa, Mazzoleni (b0060) 2018; 17 Crabtree (b0050) 1929; 23 Vander Heiden, Cantley, Thompson (b0295) 2009; 324 Bobba, Amadoro, La Piana, Calissano, Atlante (b0040) 2015; 20 Ast, Mootha (b0015) 2019; 1 Keeley, Mann (b0150) 2019; 99 Garfield (b0095) 2010; 633 Hu, Linders, Yamak, Correia, Kijlstra, Garakani, Xiao, Milan, van der Meer, Serra, Alves, Domian (b0145) 2018; 123 Krützfeldt, Spahr, Mertens, Siegmund, Piper (b0160) 1990; 22 Pérez-Diaz, Carballo, Ayuso-Parrilla, Parrilla (b0230) 1977; 59 Murray, R.K., Granner, D.K., Mayes, P.A., Rodwell, V.W., 2000. Harper’s Biochemistry (25th edition). Appleton & Lange. Wagner, Marc, Engasser, Einsele (b0305) 1991; 7 Farmer, Harris, Jolly, Hathaway, Katzberg, Watanabe, Whitlow, Besch (b0085) 1977; 179 Pettersen, Larsen, Ramsing, Ebbesen (b0235) 2005; 38 Tang, Suresh, Tannen (b0285) 1989; 256 Marroquin, Hynes, Dykens, Jamieson, Will (b0180) 2007; 97 Suzuki, Olah, Modis, Coletta, Kulp, Gerö, Szoleczky, Chang, Zhou, Wu, Wang, Papapetropoulos, Szabo (b0280) 2011; 108 Lunt, Vander Heiden (b0170) 2011; 27 Mot, Liddell, White, Crouch (b0190) 2016; 79 Orlicka-Płocka, Gurda-Wozna, Fedoruk-Wyszomirska, Wyszko (b0225) 2020; 25 Dott, Mistry, Wright, Cain, Herbert (b0075) 2014; 2 Smith, Soeters, Wüst, Houtkooper (b0270) 2018; 39 Kuchka, Markus, Mellman (b0165) 1981; 26 Diaz-Ruiz, Rigoulet, Devin (b0070) 1807; 568–576 Zeidler, Fernandes-Siqueira, Carvalho, Cararo-Lopes, Dias, Ketzer, Galina, Da Poian (b0320) 2017; 292 Balaban, Mandel (b0035) 1988; 254 Holman (b0140) 2020; 472 Baik, Kang, Lee, Choi, Chung, Kim, Mook-Jung (b0030) 2019; 30 Ayuso-Parrilla, Perez-Diaz, Martin, Parrilla (b0025) 1978; 60 Heywood, Nalesso, Lee, Dell'accio (b0135) 2014; 3 Shamseer, L., Moher, D., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., Stewart, L.A., 2015. PRISMA-P Group. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ 350: g7647. Denoon, Sunilkumar, Ford (b0065) 2020; 323 Ayuso, Fisher, Parilla, Williamson (b0020) 1973; 225 Elkalaf, Anděl, Trnka (b0080) 2013; 8 Elkalaf (10.1016/j.mito.2021.03.014_b0080) 2013; 8 Heywood (10.1016/j.mito.2021.03.014_b0130) 2010; 223 10.1016/j.mito.2021.03.014_b0195 Vander Heiden (10.1016/j.mito.2021.03.014_b0295) 2009; 324 Hare (10.1016/j.mito.2021.03.014_b0125) 2013; 5 Heywood (10.1016/j.mito.2021.03.014_b0135) 2014; 3 Crabtree (10.1016/j.mito.2021.03.014_b0050) 1929; 23 Bobba (10.1016/j.mito.2021.03.014_b0040) 2015; 20 Aleo (10.1016/j.mito.2021.03.014_b0005) 1992; 262 Balaban (10.1016/j.mito.2021.03.014_b0035) 1988; 254 Baik (10.1016/j.mito.2021.03.014_b0030) 2019; 30 Tang (10.1016/j.mito.2021.03.014_b0285) 1989; 256 Hammad (10.1016/j.mito.2021.03.014_b0120) 1857; 1139–1146 Arend (10.1016/j.mito.2021.03.014_b0010) 2019; 44 10.1016/j.mito.2021.03.014_b0200 Ast (10.1016/j.mito.2021.03.014_b0015) 2019; 1 de Alteriis (10.1016/j.mito.2021.03.014_b0060) 2018; 17 Holman (10.1016/j.mito.2021.03.014_b0140) 2020; 472 Salabei (10.1016/j.mito.2021.03.014_b0260) 2015; 33 Orlicka-Płocka (10.1016/j.mito.2021.03.014_b0225) 2020; 25 Warburg (10.1016/j.mito.2021.03.014_b0310) 1956; 123 Pettersen (10.1016/j.mito.2021.03.014_b0235) 2005; 38 Ayuso-Parrilla (10.1016/j.mito.2021.03.014_b0025) 1978; 60 Tang (10.1016/j.mito.2021.03.014_b0290) 1990; 259 Griner (10.1016/j.mito.2021.03.014_b0115) 1994; 30 Dott (10.1016/j.mito.2021.03.014_b0075) 2014; 2 Kuchka (10.1016/j.mito.2021.03.014_b0165) 1981; 26 Curi (10.1016/j.mito.2021.03.014_b0055) 1988; 250 Goodpaster (10.1016/j.mito.2021.03.014_b0105) 2017; 25 Farmer (10.1016/j.mito.2021.03.014_b0085) 1977; 179 Griner (10.1016/j.mito.2021.03.014_b0110) 1993; 29 Michaeloudes (10.1016/j.mito.2021.03.014_b0185) 2020; 12 Garfield (10.1016/j.mito.2021.03.014_b0095) 2010; 633 Chi (10.1016/j.mito.2021.03.014_b0045) 1995; 1243 Suzuki (10.1016/j.mito.2021.03.014_b0280) 2011; 108 Marroquin (10.1016/j.mito.2021.03.014_b0180) 2007; 97 Priolo (10.1016/j.mito.2021.03.014_b0245) 2013; 19 Kishi (10.1016/j.mito.2021.03.014_b0155) 2015; 2 Ayuso (10.1016/j.mito.2021.03.014_b0020) 1973; 225 Wagner (10.1016/j.mito.2021.03.014_b0305) 1991; 7 Zeidler (10.1016/j.mito.2021.03.014_b0320) 2017; 292 Gohil (10.1016/j.mito.2021.03.014_b0100) 2010; 28 Nowak (10.1016/j.mito.2021.03.014_b0205) 1996; 49 Diaz-Ruiz (10.1016/j.mito.2021.03.014_b0070) 1807; 568–576 Rossignol (10.1016/j.mito.2021.03.014_b0255) 2004; 64 Storlien (10.1016/j.mito.2021.03.014_b0275) 2004; 63 10.1016/j.mito.2021.03.014_b0265 Denoon (10.1016/j.mito.2021.03.014_b0065) 2020; 323 Nowak (10.1016/j.mito.2021.03.014_b0215) 1995; 269 Mailloux (10.1016/j.mito.2021.03.014_b0175) 2010; 24 Felder (10.1016/j.mito.2021.03.014_b0090) 2002; 12 Nowak (10.1016/j.mito.2021.03.014_b0220) 1996; 271 Krützfeldt (10.1016/j.mito.2021.03.014_b0160) 1990; 22 Lunt (10.1016/j.mito.2021.03.014_b0170) 2011; 27 Nowak (10.1016/j.mito.2021.03.014_b0210) 1996; 271 Vaughan (10.1016/j.mito.2021.03.014_b0300) 2014; 16 Hu (10.1016/j.mito.2021.03.014_b0145) 2018; 123 Glycolysis (10.1016/j.mito.2021.03.014_b0315) 1972; 32 Keeley (10.1016/j.mito.2021.03.014_b0150) 2019; 99 Smith (10.1016/j.mito.2021.03.014_b0270) 2018; 39 Mot (10.1016/j.mito.2021.03.014_b0190) 2016; 79 Robinson (10.1016/j.mito.2021.03.014_b0250) 1988; 20 Pérez-Diaz (10.1016/j.mito.2021.03.014_b0230) 1977; 59 Place (10.1016/j.mito.2021.03.014_b0240) 2017; 113 |
| References_xml | – reference: Nagy, A.M., Fekete, R., Horvath, G., Koncsos, G., Kriston, C., Sebestyen, A., Giricz, Z., Kornyei, Z., Madarasz, E., Tretter, L., 2018. Versatility of microglial bioenergetic machinery under starving conditions. Biochim Biophys Acta Bioenerg 1859: 201-214. – volume: 7 start-page: 7 year: 1991 end-page: 13 ident: b0305 article-title: Growth and metabolism of human tumor kidney cells on galactose and glucose publication-title: Cytotechnology – volume: 16 start-page: 711 year: 2014 end-page: 718 ident: b0300 article-title: Characterization of the metabolic effects of irisin on skeletal muscle in vitro publication-title: Diabetes Obes. Metab. – volume: 20 start-page: 10 year: 2015 end-page: 28 ident: b0040 article-title: Glycolytic enzyme upregulation and numbness of mitochondrial activity characterize the early phase of apoptosis in cerebellar granule cells publication-title: Apoptosis – volume: 2 start-page: 1090 year: 2015 end-page: 1101 ident: b0155 article-title: Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury publication-title: EBioMedicine – volume: 30 start-page: 493 year: 2019 end-page: 507 ident: b0030 article-title: A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease publication-title: Cell Metab. – volume: 30 start-page: 30 year: 1994 end-page: 34 ident: b0115 article-title: Decreasing glycolysis increases sensitivity to mitochondrial inhibition in primary cultures of renal proximal tubule cells publication-title: Vitro Cell Dev. Biol. Anim. – volume: 59 start-page: 411 year: 1977 end-page: 416 ident: b0230 article-title: Preparation and metabolic characterization of isolated rat lung cells publication-title: Biochimie – volume: 123 start-page: 1066 year: 2018 end-page: 1079 ident: b0145 article-title: Metabolic Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes by Inhibition of HIF1α and LDHA publication-title: Circ. Res. – volume: 1 start-page: 858 year: 2019 end-page: 860 ident: b0015 article-title: Oxygen and mammalian cell culture: are we repeating the experiment of Dr. Ox? publication-title: Nat. Metab. – volume: 19 start-page: 407 year: 2013 end-page: 409 ident: b0245 article-title: Metabolic reprogramming in polycystic kidney disease publication-title: Nat. Med. – volume: 323 start-page: 19 year: 2020 end-page: 24 ident: b0065 article-title: Acetoacetate enhances oxidative metabolism and response to toxicants of cultured kidney cells publication-title: Toxicol. Lett. – volume: 2 start-page: 224 year: 2014 end-page: 233 ident: b0075 article-title: Modulation of mitochondrial bioenergetics in a skeletal muscle cell line model of mitochondrial toxicity publication-title: Redox Biol. – volume: 24 start-page: 2495 year: 2010 end-page: 2506 ident: b0175 article-title: Glucose regulates enzymatic sources of mitochondrial NADPH in skeletal muscle cells; a novel role for glucose-6-phosphate dehydrogenase publication-title: FASEB J. – volume: 27 start-page: 441 year: 2011 end-page: 464 ident: b0170 article-title: Aerobic glycolysis: meeting the metabolic requirements of cell proliferation publication-title: Annu. Rev. Cell Dev. Biol. – volume: 29 start-page: 649 year: 1993 end-page: 655 ident: b0110 article-title: The role of short chain fatty acid substrates in aerobic and glycolytic metabolism in primary cultures of renal proximal tubule cells publication-title: In Vitro Cell Dev. Biol. Anim – volume: 225 start-page: 1153 year: 1973 end-page: 1160 ident: b0020 article-title: Glucose metabolism by isolated rat lung cells publication-title: Am. J. Physiol. – volume: 23 start-page: 536 year: 1929 end-page: 545 ident: b0050 article-title: Observations on the carbohydrate metabolism of tumours publication-title: Biochem. J. – volume: 472 start-page: 1155 year: 2020 end-page: 1175 ident: b0140 article-title: Structure, function and regulation of mammalian glucose transporters of the SLC2 family publication-title: Pflugers. Arch. – volume: 3 start-page: 9 year: 2014 end-page: 18 ident: b0135 article-title: Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture publication-title: Biores. Open Access – volume: 49 start-page: 439 year: 1996 end-page: 452 ident: b0205 article-title: Hypoxia and proliferation are primarily responsible for induction of lactate dehydrogenase activity in cultured cells publication-title: J. Toxicol. Environ. Health – volume: 5 start-page: 1656 year: 2013 end-page: 1662 ident: b0125 article-title: Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry publication-title: Metallomics – volume: 259 start-page: C455 year: 1990 end-page: C461 ident: b0290 article-title: Relationship between proliferation and glucose metabolism in primary cultures of rabbit proximal tubules publication-title: Am. J. Physiol. – volume: 633 start-page: 19 year: 2010 end-page: 27 ident: b0095 article-title: Derivation of primary mouse embryonic fibroblast (PMEF) cultures publication-title: Methods Mol. Biol. – volume: 97 start-page: 539 year: 2007 end-page: 547 ident: b0180 article-title: Circumventing the Crabtree effect: replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants publication-title: Toxicol. Sci. – volume: 292 start-page: 14176 year: 2017 end-page: 14187 ident: b0320 article-title: Short-term starvation is a strategy to unravel the cellular capacity of oxidizing specific exogenous/endogenous substrates in mitochondria publication-title: J. Biol. Chem. – volume: 223 start-page: 630 year: 2010 end-page: 639 ident: b0130 article-title: Both superficial and deep zone articular chondrocyte subpopulations exhibit the Crabtree effect but have different basal oxygen consumption rates publication-title: J. Cell Physiol. – volume: 79 start-page: 128 year: 2016 end-page: 138 ident: b0190 article-title: Circumventing the Crabtree Effect: A method to induce lactate consumption and increase oxidative phosphorylation in cell culture publication-title: Int. J. Biochem. Cell Biol. – volume: 38 start-page: 257 year: 2005 end-page: 267 ident: b0235 article-title: Pericellular oxygen depletion during ordinary tissue culturing, measured with oxygen microsensors publication-title: Cell Prolif. – volume: 60 start-page: 823 year: 1978 end-page: 826 ident: b0025 article-title: Glucose inhibition of oxygen utilization by isolated rat lung cells publication-title: Biochimie – volume: 250 start-page: 383 year: 1988 end-page: 388 ident: b0055 article-title: Metabolism of pyruvate by isolated rat mesenteric lymphocytes, lymphocyte mitochondria and isolated mouse macrophages publication-title: Biochem. J. – volume: 99 start-page: 161 year: 2019 end-page: 234 ident: b0150 article-title: Defining Physiological Normoxia for Improved Translation of Cell Physiology to Animal Models and Humans publication-title: Physiol. Rev. – volume: 108 start-page: 13829 year: 2011 end-page: 13834 ident: b0280 article-title: Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function publication-title: Proc. Natl. Acad. Sci. U S A – reference: Shamseer, L., Moher, D., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., Stewart, L.A., 2015. PRISMA-P Group. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ 350: g7647. – volume: 568–576 start-page: 2011 year: 1807 ident: b0070 article-title: The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression publication-title: Biochim. Biophys. Acta – volume: 271 start-page: C2072 year: 1996 end-page: C2080 ident: b0220 article-title: L-ascorbic acid regulates growth and metabolism of renal cells: improvements in cell culture publication-title: Am. J. Physiol. – volume: 12 start-page: 31 year: 2020 end-page: 46 ident: b0185 article-title: Role of Metabolic Reprogramming in Pulmonary Innate Immunity and Its Impact on Lung Diseases publication-title: J. Innate Immun. – volume: 33 start-page: 2613 year: 2015 end-page: 2627 ident: b0260 article-title: Glutamine Regulates Cardiac Progenitor Cell Metabolism and Proliferation publication-title: Stem Cells – volume: 256 start-page: C532 year: 1989 end-page: C539 ident: b0285 article-title: Carbohydrate metabolism by primary cultures of rabbit proximal tubules publication-title: Am. J. Physiol. – volume: 25 start-page: 835 year: 2020 end-page: 852 ident: b0225 article-title: Circumventing the Crabtree effect: forcing oxidative phosphorylation (OXPHOS) via galactose medium increases sensitivity of HepG2 cells to the purine derivative kinetin riboside publication-title: Apoptosis – volume: 269 start-page: C1317 year: 1995 end-page: C1325 ident: b0215 article-title: Integrative effects of EGF on metabolism and proliferation in renal proximal tubular cells publication-title: Am. J. Physiol. – volume: 8 year: 2013 ident: b0080 article-title: Low glucose but not galactose enhances oxidative mitochondrial metabolism in C2C12 myoblasts and myotubes publication-title: PLoS ONE – volume: 39 start-page: 489 year: 2018 end-page: 517 ident: b0270 article-title: Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease publication-title: Endocr. Rev. – volume: 324 start-page: 1029 year: 2009 end-page: 1033 ident: b0295 article-title: Understanding the Warburg effect: the metabolic requirements of cell proliferation publication-title: Science – reference: Murray, R.K., Granner, D.K., Mayes, P.A., Rodwell, V.W., 2000. Harper’s Biochemistry (25th edition). Appleton & Lange. – volume: 1139–1146 start-page: 2016 year: 1857 ident: b0120 article-title: The Crabtree and Warburg effects: Do metabolite-induced regulations participate in their induction? publication-title: Biochim. Biophys. Acta – volume: 179 start-page: 545 year: 1977 end-page: 558 ident: b0085 article-title: Isolation and characterization of adult rat hearts cells publication-title: Arch. Biochem. Biophys. – volume: 12 start-page: 153 year: 2002 end-page: 162 ident: b0090 article-title: LLC-PK(1) cells maintained in a new perfusion cell culture system exhibit an improved oxidative metabolism publication-title: Cell Physiol. Biochem. – volume: 63 start-page: 363 year: 2004 end-page: 368 ident: b0275 article-title: Metabolic flexibility publication-title: Proc. Nutr. Soc. – volume: 25 start-page: 1027 year: 2017 end-page: 1036 ident: b0105 article-title: Metabolic Flexibility in Health and Disease publication-title: Cell Metab. – volume: 1243 start-page: 513 year: 1995 end-page: 520 ident: b0045 article-title: Changes in [Ca2+]i in cultured rat proximal tubular epithelium: an in vitro model for renal ischemia publication-title: Biochim. Biophys. Acta – volume: 123 start-page: 309 year: 1956 end-page: 314 ident: b0310 article-title: On the origin of cancer cells publication-title: Science – volume: 28 start-page: 249 year: 2010 end-page: 255 ident: b0100 article-title: Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis publication-title: Nat. Biotechnol. – volume: 26 start-page: 356 year: 1981 end-page: 364 ident: b0165 article-title: Influence of hexose conditions on glutamine oxidation of SV-40-transformed and diploid fibroblast human cell lines publication-title: Biochem. Med. – volume: 22 start-page: 1393 year: 1990 end-page: 1404 ident: b0160 article-title: Metabolism of exogenous substrates by coronary endothelial cells in culture publication-title: J. Mol. Cell Cardiol. – volume: 64 start-page: 985 year: 2004 end-page: 993 ident: b0255 article-title: Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells publication-title: Cancer Res. – volume: 32 start-page: 2007 year: 1972 end-page: 2016 ident: b0315 article-title: respiration, and anomalous gene expression in experimental hepatomas: G.H.A. Clowes memorial lecture publication-title: Cancer Res. – volume: 254 start-page: F407 year: 1988 end-page: F416 ident: b0035 article-title: Metabolic substrate utilization by rabbit proximal tubule. An NADH fluorescence study publication-title: Am. J. Physiol. – volume: 113 start-page: 311 year: 2017 end-page: 322 ident: b0240 article-title: Limitations of oxygen delivery to cells in culture: An underappreciated problem in basic and translational research publication-title: Free Radic. Biol. Med. – volume: 44 start-page: 2288 year: 2019 end-page: 2300 ident: b0010 article-title: Consequences of a Metabolic Glucose-Depletion on the Survival and the Metabolism of Cultured Rat Astrocytes publication-title: Neurochem. Res. – volume: 20 start-page: 313 year: 1988 end-page: 323 ident: b0250 article-title: Cell culture studies on patients with mitochondrial diseases: molecular defects in pyruvate dehydrogenase publication-title: J. Bioenerg. Biomembr. – volume: 17 start-page: 688 year: 2018 end-page: 701 ident: b0060 article-title: Revisiting the Crabtree/Warburg effect in a dynamic perspective: a fitness advantage against sugar-induced cell death publication-title: Cell Cycle – volume: 271 start-page: F689 year: 1996 end-page: F697 ident: b0210 article-title: Autocrine production and TGF-beta 1-mediated effects on metabolism and viability in renal cells publication-title: Am. J. Physiol. – volume: 262 start-page: F77 year: 1992 end-page: F85 ident: b0005 article-title: Regulation of glycolytic metabolism during long-term primary culture of renal proximal tubule cells publication-title: Am. J. Physiol. – volume: 256 start-page: C532 year: 1989 ident: 10.1016/j.mito.2021.03.014_b0285 article-title: Carbohydrate metabolism by primary cultures of rabbit proximal tubules publication-title: Am. J. Physiol. doi: 10.1152/ajpcell.1989.256.3.C532 – ident: 10.1016/j.mito.2021.03.014_b0195 – volume: 59 start-page: 411 year: 1977 ident: 10.1016/j.mito.2021.03.014_b0230 article-title: Preparation and metabolic characterization of isolated rat lung cells publication-title: Biochimie doi: 10.1016/S0300-9084(77)80317-9 – volume: 26 start-page: 356 year: 1981 ident: 10.1016/j.mito.2021.03.014_b0165 article-title: Influence of hexose conditions on glutamine oxidation of SV-40-transformed and diploid fibroblast human cell lines publication-title: Biochem. Med. doi: 10.1016/0006-2944(81)90011-9 – volume: 30 start-page: 493 year: 2019 ident: 10.1016/j.mito.2021.03.014_b0030 article-title: A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease publication-title: Cell Metab. doi: 10.1016/j.cmet.2019.06.005 – volume: 262 start-page: F77 year: 1992 ident: 10.1016/j.mito.2021.03.014_b0005 article-title: Regulation of glycolytic metabolism during long-term primary culture of renal proximal tubule cells publication-title: Am. J. Physiol. – volume: 19 start-page: 407 year: 2013 ident: 10.1016/j.mito.2021.03.014_b0245 article-title: Metabolic reprogramming in polycystic kidney disease publication-title: Nat. Med. doi: 10.1038/nm.3140 – volume: 7 start-page: 7 year: 1991 ident: 10.1016/j.mito.2021.03.014_b0305 article-title: Growth and metabolism of human tumor kidney cells on galactose and glucose publication-title: Cytotechnology doi: 10.1007/BF00135633 – ident: 10.1016/j.mito.2021.03.014_b0200 doi: 10.1016/j.bbabio.2017.12.002 – volume: 17 start-page: 688 year: 2018 ident: 10.1016/j.mito.2021.03.014_b0060 article-title: Revisiting the Crabtree/Warburg effect in a dynamic perspective: a fitness advantage against sugar-induced cell death publication-title: Cell Cycle doi: 10.1080/15384101.2018.1442622 – volume: 16 start-page: 711 year: 2014 ident: 10.1016/j.mito.2021.03.014_b0300 article-title: Characterization of the metabolic effects of irisin on skeletal muscle in vitro publication-title: Diabetes Obes. Metab. doi: 10.1111/dom.12268 – volume: 64 start-page: 985 year: 2004 ident: 10.1016/j.mito.2021.03.014_b0255 article-title: Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-03-1101 – volume: 12 start-page: 31 year: 2020 ident: 10.1016/j.mito.2021.03.014_b0185 article-title: Role of Metabolic Reprogramming in Pulmonary Innate Immunity and Its Impact on Lung Diseases publication-title: J. Innate Immun. doi: 10.1159/000504344 – volume: 25 start-page: 835 year: 2020 ident: 10.1016/j.mito.2021.03.014_b0225 article-title: Circumventing the Crabtree effect: forcing oxidative phosphorylation (OXPHOS) via galactose medium increases sensitivity of HepG2 cells to the purine derivative kinetin riboside publication-title: Apoptosis doi: 10.1007/s10495-020-01637-x – volume: 323 start-page: 19 year: 2020 ident: 10.1016/j.mito.2021.03.014_b0065 article-title: Acetoacetate enhances oxidative metabolism and response to toxicants of cultured kidney cells publication-title: Toxicol. Lett. doi: 10.1016/j.toxlet.2020.01.015 – volume: 20 start-page: 10 year: 2015 ident: 10.1016/j.mito.2021.03.014_b0040 article-title: Glycolytic enzyme upregulation and numbness of mitochondrial activity characterize the early phase of apoptosis in cerebellar granule cells publication-title: Apoptosis doi: 10.1007/s10495-014-1049-1 – volume: 2 start-page: 1090 year: 2015 ident: 10.1016/j.mito.2021.03.014_b0155 article-title: Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury publication-title: EBioMedicine doi: 10.1016/j.ebiom.2015.07.035 – volume: 2 start-page: 224 year: 2014 ident: 10.1016/j.mito.2021.03.014_b0075 article-title: Modulation of mitochondrial bioenergetics in a skeletal muscle cell line model of mitochondrial toxicity publication-title: Redox Biol. doi: 10.1016/j.redox.2013.12.028 – volume: 568–576 start-page: 2011 year: 1807 ident: 10.1016/j.mito.2021.03.014_b0070 article-title: The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression publication-title: Biochim. Biophys. Acta – volume: 30 start-page: 30 year: 1994 ident: 10.1016/j.mito.2021.03.014_b0115 article-title: Decreasing glycolysis increases sensitivity to mitochondrial inhibition in primary cultures of renal proximal tubule cells publication-title: Vitro Cell Dev. Biol. Anim. doi: 10.1007/BF02631415 – volume: 97 start-page: 539 year: 2007 ident: 10.1016/j.mito.2021.03.014_b0180 article-title: Circumventing the Crabtree effect: replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfm052 – volume: 259 start-page: C455 year: 1990 ident: 10.1016/j.mito.2021.03.014_b0290 article-title: Relationship between proliferation and glucose metabolism in primary cultures of rabbit proximal tubules publication-title: Am. J. Physiol. doi: 10.1152/ajpcell.1990.259.3.C455 – volume: 1243 start-page: 513 year: 1995 ident: 10.1016/j.mito.2021.03.014_b0045 article-title: Changes in [Ca2+]i in cultured rat proximal tubular epithelium: an in vitro model for renal ischemia publication-title: Biochim. Biophys. Acta doi: 10.1016/0304-4165(94)00190-9 – volume: 25 start-page: 1027 year: 2017 ident: 10.1016/j.mito.2021.03.014_b0105 article-title: Metabolic Flexibility in Health and Disease publication-title: Cell Metab. doi: 10.1016/j.cmet.2017.04.015 – volume: 44 start-page: 2288 year: 2019 ident: 10.1016/j.mito.2021.03.014_b0010 article-title: Consequences of a Metabolic Glucose-Depletion on the Survival and the Metabolism of Cultured Rat Astrocytes publication-title: Neurochem. Res. doi: 10.1007/s11064-019-02752-1 – volume: 108 start-page: 13829 year: 2011 ident: 10.1016/j.mito.2021.03.014_b0280 article-title: Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.1105121108 – volume: 223 start-page: 630 year: 2010 ident: 10.1016/j.mito.2021.03.014_b0130 article-title: Both superficial and deep zone articular chondrocyte subpopulations exhibit the Crabtree effect but have different basal oxygen consumption rates publication-title: J. Cell Physiol. doi: 10.1002/jcp.22061 – volume: 271 start-page: C2072 year: 1996 ident: 10.1016/j.mito.2021.03.014_b0220 article-title: L-ascorbic acid regulates growth and metabolism of renal cells: improvements in cell culture publication-title: Am. J. Physiol. doi: 10.1152/ajpcell.1996.271.6.C2072 – volume: 292 start-page: 14176 year: 2017 ident: 10.1016/j.mito.2021.03.014_b0320 article-title: Short-term starvation is a strategy to unravel the cellular capacity of oxidizing specific exogenous/endogenous substrates in mitochondria publication-title: J. Biol. Chem. doi: 10.1074/jbc.M117.786582 – volume: 24 start-page: 2495 year: 2010 ident: 10.1016/j.mito.2021.03.014_b0175 article-title: Glucose regulates enzymatic sources of mitochondrial NADPH in skeletal muscle cells; a novel role for glucose-6-phosphate dehydrogenase publication-title: FASEB J. doi: 10.1096/fj.09-151803 – volume: 20 start-page: 313 year: 1988 ident: 10.1016/j.mito.2021.03.014_b0250 article-title: Cell culture studies on patients with mitochondrial diseases: molecular defects in pyruvate dehydrogenase publication-title: J. Bioenerg. Biomembr. doi: 10.1007/BF00769635 – volume: 472 start-page: 1155 year: 2020 ident: 10.1016/j.mito.2021.03.014_b0140 article-title: Structure, function and regulation of mammalian glucose transporters of the SLC2 family publication-title: Pflugers. Arch. doi: 10.1007/s00424-020-02411-3 – volume: 22 start-page: 1393 year: 1990 ident: 10.1016/j.mito.2021.03.014_b0160 article-title: Metabolism of exogenous substrates by coronary endothelial cells in culture publication-title: J. Mol. Cell Cardiol. doi: 10.1016/0022-2828(90)90984-A – volume: 113 start-page: 311 year: 2017 ident: 10.1016/j.mito.2021.03.014_b0240 article-title: Limitations of oxygen delivery to cells in culture: An underappreciated problem in basic and translational research publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2017.10.003 – volume: 179 start-page: 545 year: 1977 ident: 10.1016/j.mito.2021.03.014_b0085 article-title: Isolation and characterization of adult rat hearts cells publication-title: Arch. Biochem. Biophys. doi: 10.1016/0003-9861(77)90143-6 – volume: 32 start-page: 2007 year: 1972 ident: 10.1016/j.mito.2021.03.014_b0315 article-title: respiration, and anomalous gene expression in experimental hepatomas: G.H.A. Clowes memorial lecture publication-title: Cancer Res. – volume: 123 start-page: 1066 year: 2018 ident: 10.1016/j.mito.2021.03.014_b0145 article-title: Metabolic Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes by Inhibition of HIF1α and LDHA publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.118.313249 – volume: 250 start-page: 383 year: 1988 ident: 10.1016/j.mito.2021.03.014_b0055 article-title: Metabolism of pyruvate by isolated rat mesenteric lymphocytes, lymphocyte mitochondria and isolated mouse macrophages publication-title: Biochem. J. doi: 10.1042/bj2500383 – volume: 12 start-page: 153 year: 2002 ident: 10.1016/j.mito.2021.03.014_b0090 article-title: LLC-PK(1) cells maintained in a new perfusion cell culture system exhibit an improved oxidative metabolism publication-title: Cell Physiol. Biochem. doi: 10.1159/000063792 – volume: 8 year: 2013 ident: 10.1016/j.mito.2021.03.014_b0080 article-title: Low glucose but not galactose enhances oxidative mitochondrial metabolism in C2C12 myoblasts and myotubes publication-title: PLoS ONE doi: 10.1371/journal.pone.0070772 – volume: 1 start-page: 858 year: 2019 ident: 10.1016/j.mito.2021.03.014_b0015 article-title: Oxygen and mammalian cell culture: are we repeating the experiment of Dr. Ox? publication-title: Nat. Metab. doi: 10.1038/s42255-019-0105-0 – volume: 3 start-page: 9 year: 2014 ident: 10.1016/j.mito.2021.03.014_b0135 article-title: Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture publication-title: Biores. Open Access doi: 10.1089/biores.2013.0051 – volume: 28 start-page: 249 year: 2010 ident: 10.1016/j.mito.2021.03.014_b0100 article-title: Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis publication-title: Nat. Biotechnol. doi: 10.1038/nbt.1606 – volume: 5 start-page: 1656 year: 2013 ident: 10.1016/j.mito.2021.03.014_b0125 article-title: Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry publication-title: Metallomics doi: 10.1039/c3mt00227f – volume: 225 start-page: 1153 year: 1973 ident: 10.1016/j.mito.2021.03.014_b0020 article-title: Glucose metabolism by isolated rat lung cells publication-title: Am. J. Physiol. doi: 10.1152/ajplegacy.1973.225.5.1153 – volume: 38 start-page: 257 year: 2005 ident: 10.1016/j.mito.2021.03.014_b0235 article-title: Pericellular oxygen depletion during ordinary tissue culturing, measured with oxygen microsensors publication-title: Cell Prolif. doi: 10.1111/j.1365-2184.2005.00345.x – volume: 39 start-page: 489 year: 2018 ident: 10.1016/j.mito.2021.03.014_b0270 article-title: Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease publication-title: Endocr. Rev. doi: 10.1210/er.2017-00211 – volume: 324 start-page: 1029 year: 2009 ident: 10.1016/j.mito.2021.03.014_b0295 article-title: Understanding the Warburg effect: the metabolic requirements of cell proliferation publication-title: Science doi: 10.1126/science.1160809 – ident: 10.1016/j.mito.2021.03.014_b0265 doi: 10.1136/bmj.g7647 – volume: 33 start-page: 2613 year: 2015 ident: 10.1016/j.mito.2021.03.014_b0260 article-title: Glutamine Regulates Cardiac Progenitor Cell Metabolism and Proliferation publication-title: Stem Cells doi: 10.1002/stem.2047 – volume: 123 start-page: 309 year: 1956 ident: 10.1016/j.mito.2021.03.014_b0310 article-title: On the origin of cancer cells publication-title: Science doi: 10.1126/science.123.3191.309 – volume: 254 start-page: F407 year: 1988 ident: 10.1016/j.mito.2021.03.014_b0035 article-title: Metabolic substrate utilization by rabbit proximal tubule. An NADH fluorescence study publication-title: Am. J. Physiol. – volume: 271 start-page: F689 year: 1996 ident: 10.1016/j.mito.2021.03.014_b0210 article-title: Autocrine production and TGF-beta 1-mediated effects on metabolism and viability in renal cells publication-title: Am. J. Physiol. – volume: 633 start-page: 19 year: 2010 ident: 10.1016/j.mito.2021.03.014_b0095 article-title: Derivation of primary mouse embryonic fibroblast (PMEF) cultures publication-title: Methods Mol. Biol. doi: 10.1007/978-1-59745-019-5_2 – volume: 1139–1146 start-page: 2016 year: 1857 ident: 10.1016/j.mito.2021.03.014_b0120 article-title: The Crabtree and Warburg effects: Do metabolite-induced regulations participate in their induction? publication-title: Biochim. Biophys. Acta – volume: 60 start-page: 823 year: 1978 ident: 10.1016/j.mito.2021.03.014_b0025 article-title: Glucose inhibition of oxygen utilization by isolated rat lung cells publication-title: Biochimie doi: 10.1016/S0300-9084(78)80030-3 – volume: 49 start-page: 439 year: 1996 ident: 10.1016/j.mito.2021.03.014_b0205 article-title: Hypoxia and proliferation are primarily responsible for induction of lactate dehydrogenase activity in cultured cells publication-title: J. Toxicol. Environ. Health doi: 10.1080/009841096160808 – volume: 63 start-page: 363 year: 2004 ident: 10.1016/j.mito.2021.03.014_b0275 article-title: Metabolic flexibility publication-title: Proc. Nutr. Soc. doi: 10.1079/PNS2004349 – volume: 23 start-page: 536 year: 1929 ident: 10.1016/j.mito.2021.03.014_b0050 article-title: Observations on the carbohydrate metabolism of tumours publication-title: Biochem. J. doi: 10.1042/bj0230536 – volume: 269 start-page: C1317 year: 1995 ident: 10.1016/j.mito.2021.03.014_b0215 article-title: Integrative effects of EGF on metabolism and proliferation in renal proximal tubular cells publication-title: Am. J. Physiol. doi: 10.1152/ajpcell.1995.269.5.C1317 – volume: 27 start-page: 441 year: 2011 ident: 10.1016/j.mito.2021.03.014_b0170 article-title: Aerobic glycolysis: meeting the metabolic requirements of cell proliferation publication-title: Annu. Rev. Cell Dev. Biol. doi: 10.1146/annurev-cellbio-092910-154237 – volume: 99 start-page: 161 year: 2019 ident: 10.1016/j.mito.2021.03.014_b0150 article-title: Defining Physiological Normoxia for Improved Translation of Cell Physiology to Animal Models and Humans publication-title: Physiol. Rev. doi: 10.1152/physrev.00041.2017 – volume: 79 start-page: 128 year: 2016 ident: 10.1016/j.mito.2021.03.014_b0190 article-title: Circumventing the Crabtree Effect: A method to induce lactate consumption and increase oxidative phosphorylation in cell culture publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/j.biocel.2016.08.029 – volume: 29 start-page: 649 year: 1993 ident: 10.1016/j.mito.2021.03.014_b0110 article-title: The role of short chain fatty acid substrates in aerobic and glycolytic metabolism in primary cultures of renal proximal tubule cells publication-title: In Vitro Cell Dev. Biol. Anim. doi: 10.1007/BF02634554 |
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| SubjectTerms | Cell culture Cell Culture Techniques - methods Crabtree effect Culture Media - chemistry Glucose - pharmacology Glycolysis Humans Metabolism Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondrial Dynamics - drug effects Oxidative Phosphorylation |
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| Title | Circumventing the Crabtree effect in cell culture: A systematic review |
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