In vitro and in vivo proves of concept for the use of a chemically cross-linked poly(ester-urethane-urea) scaffold as an easy handling elastomeric biomaterial for bone regeneration

Abstract Bone loss can occur as a result of various pathologies, traumas and injuries and poor bone healing leads to functionally debilitating condition, loss of self-sufficiency and deterioration in life quality. Given the increasing incidence of facial trauma and the emergence of new procedural te...

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Published inRegenerative biomaterials Vol. 6; no. 6; pp. 311 - 323
Main Authors Rohman, Géraldine, Changotade, Sylvie, Frasca, Sophie, Ramtani, Salah, Consalus, Anne, Langueh, Credson, Collombet, Jean-Marc, Lutomski, Didier
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.12.2019
Subjects
Biomedical materials
Bone biomaterials
Bone growth
Bone healing
Bone loss
Bones
Cell adhesion & migration
Cell migration
Cell proliferation
Crosslinking
Cytotoxicity
Defects
Differentiation (biology)
Elastomers
Ethyl carbamate
Histology
Mechanical properties
Microtomography
Protein seeding
Quality of life
Regeneration
Regeneration (physiology)
Scaffolds
Skin & tissue grafts
Stem cells
Substitutes
Surgery
Tissue engineering
Trauma
Urea
PEUU
bone regeneration
elastomer
PCLU
scaffold
Online AccessGet full text
ISSN2056-3418
2056-3426
DOI10.1093/rb/rbz020

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Abstract Abstract Bone loss can occur as a result of various pathologies, traumas and injuries and poor bone healing leads to functionally debilitating condition, loss of self-sufficiency and deterioration in life quality. Given the increasing incidence of facial trauma and the emergence of new procedural techniques, advanced scaffolds are currently developed as substitutes for bone tissue engineering. In this study, we investigated the capability of a chemically cross-linked ε-caprolactone-based poly(ester-urethane-urea) (PCLU) scaffold to support bone regeneration. In vitro assays demonstrated that PCLU scaffolds could be colonized by cells through direct cell seeding and cell migration from outside to scaffold inside. Moreover, PCLU scaffolds could provide a suitable environment for stem cells proliferation in a 3D spatial arrangement, and allowed osteogenic differentiation under appropriate induction. In vivo results revealed the osteogenic properties of PCLU scaffolds through a drilled-hole femoral bone defect repair improvement in rats. Using histology and microtomography analysis, we showed that PCLU scaffolds fit well the bone cavity and were eventually entrapped between the newly formed trabeculae. Finally, no sign of inflammation or rejection was noticed. We envision that PCLU scaffolds can provide the clinicians with a substitute having appropriate characteristics for the treatment of bone defects.
AbstractList Bone loss can occur as a result of various pathologies, traumas and injuries and poor bone healing leads to functionally debilitating condition, loss of self-sufficiency and deterioration in life quality. Given the increasing incidence of facial trauma and the emergence of new procedural techniques, advanced scaffolds are currently developed as substitutes for bone tissue engineering. In this study, we investigated the capability of a chemically cross-linked ε-caprolactone-based poly(ester-urethane-urea) (PCLU) scaffold to support bone regeneration. assays demonstrated that PCLU scaffolds could be colonized by cells through direct cell seeding and cell migration from outside to scaffold inside. Moreover, PCLU scaffolds could provide a suitable environment for stem cells proliferation in a 3D spatial arrangement, and allowed osteogenic differentiation under appropriate induction. results revealed the osteogenic properties of PCLU scaffolds through a drilled-hole femoral bone defect repair improvement in rats. Using histology and microtomography analysis, we showed that PCLU scaffolds fit well the bone cavity and were eventually entrapped between the newly formed trabeculae. Finally, no sign of inflammation or rejection was noticed. We envision that PCLU scaffolds can provide the clinicians with a substitute having appropriate characteristics for the treatment of bone defects.
Bone loss can occur as a result of various pathologies, traumas and injuries and poor bone healing leads to functionally debilitating condition, loss of self-sufficiency and deterioration in life quality. Given the increasing incidence of facial trauma and the emergence of new procedural techniques, advanced scaffolds are currently developed as substitutes for bone tissue engineering. In this study, we investigated the capability of a chemically cross-linked ε-caprolactone-based poly(ester-urethane-urea) (PCLU) scaffold to support bone regeneration. In vitro assays demonstrated that PCLU scaffolds could be colonized by cells through direct cell seeding and cell migration from outside to scaffold inside. Moreover, PCLU scaffolds could provide a suitable environment for stem cells proliferation in a 3D spatial arrangement, and allowed osteogenic differentiation under appropriate induction. In vivo results revealed the osteogenic properties of PCLU scaffolds through a drilled-hole femoral bone defect repair improvement in rats. Using histology and microtomography analysis, we showed that PCLU scaffolds fit well the bone cavity and were eventually entrapped between the newly formed trabeculae. Finally, no sign of inflammation or rejection was noticed. We envision that PCLU scaffolds can provide the clinicians with a substitute having appropriate characteristics for the treatment of bone defects.
Bone loss can occur as a result of various pathologies, traumas and injuries and poor bone healing leads to functionally debilitating condition, loss of self-sufficiency and deterioration in life quality. Given the increasing incidence of facial trauma and the emergence of new procedural techniques, advanced scaffolds are currently developed as substitutes for bone tissue engineering. In this study, we investigated the capability of a chemically cross-linked ε-caprolactone-based poly(ester-urethane-urea) (PCLU) scaffold to support bone regeneration. In vitro assays demonstrated that PCLU scaffolds could be colonized by cells through direct cell seeding and cell migration from outside to scaffold inside. Moreover, PCLU scaffolds could provide a suitable environment for stem cells proliferation in a 3D spatial arrangement, and allowed osteogenic differentiation under appropriate induction. In vivo results revealed the osteogenic properties of PCLU scaffolds through a drilled-hole femoral bone defect repair improvement in rats. Using histology and microtomography analysis, we showed that PCLU scaffolds fit well the bone cavity and were eventually entrapped between the newly formed trabeculae. Finally, no sign of inflammation or rejection was noticed. We envision that PCLU scaffolds can provide the clinicians with a substitute having appropriate characteristics for the treatment of bone defects.
Abstract Bone loss can occur as a result of various pathologies, traumas and injuries and poor bone healing leads to functionally debilitating condition, loss of self-sufficiency and deterioration in life quality. Given the increasing incidence of facial trauma and the emergence of new procedural techniques, advanced scaffolds are currently developed as substitutes for bone tissue engineering. In this study, we investigated the capability of a chemically cross-linked ε-caprolactone-based poly(ester-urethane-urea) (PCLU) scaffold to support bone regeneration. In vitro assays demonstrated that PCLU scaffolds could be colonized by cells through direct cell seeding and cell migration from outside to scaffold inside. Moreover, PCLU scaffolds could provide a suitable environment for stem cells proliferation in a 3D spatial arrangement, and allowed osteogenic differentiation under appropriate induction. In vivo results revealed the osteogenic properties of PCLU scaffolds through a drilled-hole femoral bone defect repair improvement in rats. Using histology and microtomography analysis, we showed that PCLU scaffolds fit well the bone cavity and were eventually entrapped between the newly formed trabeculae. Finally, no sign of inflammation or rejection was noticed. We envision that PCLU scaffolds can provide the clinicians with a substitute having appropriate characteristics for the treatment of bone defects.
Author Collombet, Jean-Marc
Lutomski, Didier
Changotade, Sylvie
Langueh, Credson
Ramtani, Salah
Frasca, Sophie
Rohman, Géraldine
Consalus, Anne
AuthorAffiliation 3 Université Paris 13, Sorbonne Paris Cité, LBPS Team, CSPBAT, UMR CNRS 7244, 99 Avenue Jean-Baptiste Clément , 93430 Villetaneuse, France
2 Département Soutien Médico-Chirurgical des Forces (SMCF), BP73, Institut de Recherche Biomédicale des Armées (IRBA) , 91223 Brétigny-sur-Orge Cedex, France
1 Université Paris 13, Sorbonne Paris Cité, Tissue Engineering and Proteomics (TIP) Team, CSPBAT, UMR CNRS 7244, 74 rue Marcel Cachin , 93000 Bobigny, France
AuthorAffiliation_xml – name: 1 Université Paris 13, Sorbonne Paris Cité, Tissue Engineering and Proteomics (TIP) Team, CSPBAT, UMR CNRS 7244, 74 rue Marcel Cachin , 93000 Bobigny, France
– name: 3 Université Paris 13, Sorbonne Paris Cité, LBPS Team, CSPBAT, UMR CNRS 7244, 99 Avenue Jean-Baptiste Clément , 93430 Villetaneuse, France
– name: 2 Département Soutien Médico-Chirurgical des Forces (SMCF), BP73, Institut de Recherche Biomédicale des Armées (IRBA) , 91223 Brétigny-sur-Orge Cedex, France
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  givenname: Credson
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  givenname: Didier
  surname: Lutomski
  fullname: Lutomski, Didier
  organization: Université Paris 13, Sorbonne Paris Cité, Tissue Engineering and Proteomics (TIP) Team, CSPBAT, UMR CNRS 7244, 74 rue Marcel Cachin, 93000 Bobigny, France
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31827885$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_1002_adhm_202303765
crossref_primary_10_3390_polym11061016
crossref_primary_10_1039_D3CS00923H
crossref_primary_10_1016_j_polymdegradstab_2020_109454
Cites_doi 10.1016/j.biomaterials.2006.01.031
10.1073/pnas.94.25.13661
10.1021/bm401911p
10.1007/BF01752281
10.1533/9780857096517.2.164
10.1016/S0020-1383(08)70003-2
10.1038/emm.2013.118
10.1039/b803718n
10.1016/j.injury.2005.07.029
10.1002/jbm.a.30834
10.1371/journal.pone.0067649
10.1634/stemcells.2008-0432
10.1016/0969-806X(94)00134-6
10.1016/j.progpolymsci.2010.04.002
10.1111/j.1582-4934.2010.01224.x
10.1007/s10856-015-5509-0
10.1023/B:ABME.0000017544.36001.8e
10.2174/1874325000802010103
10.1002/adma.200802106
10.1021/ma0501390
10.1002/jbm.b.30118
10.1177/10454411010120010501
10.1055/s-0029-1224777
10.1016/j.biomaterials.2005.05.106
10.1006/jcis.1993.1044
10.1016/j.progpolymsci.2012.05.003
10.1002/jbm.a.10148
10.1016/j.polymdegradstab.2012.04.008
10.3171/2010.9.FOCUS10201
10.1016/B978-0-444-88654-5.50009-1
10.1155/2015/283796
10.1007/978-1-84628-366-6_7
10.1007/s00264-010-1189-z
10.1016/j.biomaterials.2008.06.021
10.1002/term.1753
10.1002/1097-4636(20001205)52:3<498::AID-JBM8>3.0.CO;2-P
10.1016/j.actbio.2010.06.012
10.1016/S0006-3495(00)76279-5
10.1055/s-0034-1393724
10.1529/biophysj.105.070144
10.1016/S0020-1383(08)70011-1
10.1016/j.biomaterials.2005.05.079
10.1016/j.bone.2009.09.031
10.1016/j.actbio.2014.07.020
10.22203/eCM.v005a03
10.1016/j.bpj.2010.12.3744
10.1016/j.gendis.2015.09.004
10.1002/jbm.a.30669
10.1016/j.jcms.2015.09.004
10.1038/boneres.2017.14
10.1038/srep05188
10.1039/b811392k
10.1021/bp970120j
ContentType Journal Article
Copyright The Author(s) 2019. Published by Oxford University Press. 2019
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Issue 6
Keywords PEUU
bone regeneration
elastomer
PCLU
scaffold
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References Guo (2019120611330723400_rbz020-B51) 2006; 90
Eglin (2019120611330723400_rbz020-B20) 2009; 5
Bertoldi (2019120611330723400_rbz020-B36) 2015; 26
Yang (2019120611330723400_rbz020-B28) 2006; 27
Liu (2019120611330723400_rbz020-B21) 2014; 15
Adhikari (2019120611330723400_rbz020-B38) 2008; 29
Mastrogiacomo (2019120611330723400_rbz020-B47) 2006; 27
Tamada (2019120611330723400_rbz020-B46) 1993; 155
Brannon-Peppas (2019120611330723400_rbz020-B25) 1990; 8
Zhang (2019120611330723400_rbz020-B56) 2013; 8
Pryor (2019120611330723400_rbz020-B5) 2009; 2
Rohman (2019120611330723400_rbz020-B27) 2005; 38
Changotade (2019120611330723400_rbz020-B24) 2015; 2015
Giannoudis (2019120611330723400_rbz020-B7) 2007; 38
Liu (2019120611330723400_rbz020-B14) 2017; 5
Ruiz (2019120611330723400_rbz020-B32) 2008; 26
Barlkani (2019120611330723400_rbz020-B26) 1992; 1
Gorna (2019120611330723400_rbz020-B23) 2003; 67A
Tollemar (2019120611330723400_rbz020-B4) 2016; 3
Zhang (2019120611330723400_rbz020-B17) 2014; 10
Woodruff (2019120611330723400_rbz020-B40) 2010; 35
Le Guehennec (2019120611330723400_rbz020-B52) 2005; 72B
Vunjak-Novakovic (2019120611330723400_rbz020-B44) 1998; 14
Alsberg (2019120611330723400_rbz020-B1) 2001; 12
Tao (2019120611330723400_rbz020-B55) 2015; 43
Arvidson (2019120611330723400_rbz020-B8) 2011; 15
Tee (2019120611330723400_rbz020-B34) 2011; 100
Szpalski (2019120611330723400_rbz020-B6) 2010; 29
Lo (2019120611330723400_rbz020-B49) 2000; 79
Santerre (2019120611330723400_rbz020-B39) 2005; 26
Giannoudis (2019120611330723400_rbz020-B3) 2005; 36
Lee (2019120611330723400_rbz020-B33) 2014; 4
Hirata (2019120611330723400_rbz020-B35) 1995; 46
Gogolewski (2019120611330723400_rbz020-B18) 2006; 77
Ko (2019120611330723400_rbz020-B42) 2013; 45
Drosse (2019120611330723400_rbz020-B11) 2008; 39
Brugmans (2019120611330723400_rbz020-B43) 2015; 9
Tabatabaei (2019120611330723400_rbz020-B10) 2012; 30
Chen (2019120611330723400_rbz020-B22) 2013; 38
Burkhardt (2019120611330723400_rbz020-B30) 1966; 44
Breuls (2019120611330723400_rbz020-B48) 2008; 2
Melchels (2019120611330723400_rbz020-B45) 2010; 6
Cooper (2019120611330723400_rbz020-B37) 2016
Knabe (2019120611330723400_rbz020-B54) 2000; 52
Migliaresi (2019120611330723400_rbz020-B15) 2007
Liu (2019120611330723400_rbz020-B13) 2004; 32
Slaughter (2019120611330723400_rbz020-B16) 2009; 21
Cao (2019120611330723400_rbz020-B53) 2010; 46
Sachlos (2019120611330723400_rbz020-B9) 2003; 5
Place (2019120611330723400_rbz020-B31) 2009; 38
Pelham (2019120611330723400_rbz020-B50) 1997; 94
Gogolewski (2019120611330723400_rbz020-B19) 2007; 80
Mondal (2019120611330723400_rbz020-B41) 2012; 97
Mahomed (2019120611330723400_rbz020-B29) 2012
Cox (2019120611330723400_rbz020-B2) 2011; 35
Fishero (2019120611330723400_rbz020-B12) 2014; 08
References_xml – volume: 27
  start-page: 3230
  year: 2006
  ident: 2019120611330723400_rbz020-B47
  article-title: Role of scaffold internal structure on in vivo bone formation in macroporous calcium phosphate bioceramics
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2006.01.031
– volume: 94
  start-page: 13661
  year: 1997
  ident: 2019120611330723400_rbz020-B50
  article-title: Cell locomotion and focal adhesions are regulated by substrate flexibility
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.94.25.13661
– volume: 15
  start-page: 1019
  year: 2014
  ident: 2019120611330723400_rbz020-B21
  article-title: Delivery of growth factors using a smart porous nanocomposite scaffold to repair a mandibular bone defect
  publication-title: Biomacromolecules
  doi: 10.1021/bm401911p
– volume: 44
  start-page: 326
  year: 1966
  ident: 2019120611330723400_rbz020-B30
  article-title: Technische verbesserungen und anwendungsbereich der histo-biopsie von knochenmark und knochen
  publication-title: Klin Wochenschr
  doi: 10.1007/BF01752281
– start-page: 164
  volume-title: Durability and Reliability of Medical Polymers
  year: 2012
  ident: 2019120611330723400_rbz020-B29
  doi: 10.1533/9780857096517.2.164
– volume: 38
  start-page: S3
  year: 2007
  ident: 2019120611330723400_rbz020-B7
  article-title: Fracture healing: the diamond concept
  publication-title: Injury
  doi: 10.1016/S0020-1383(08)70003-2
– volume: 45
  start-page: e57.
  year: 2013
  ident: 2019120611330723400_rbz020-B42
  article-title: In situ tissue regeneration through host stem cell recruitment
  publication-title: Exp Mol Med
  doi: 10.1038/emm.2013.118
– volume: 5
  start-page: 938
  year: 2009
  ident: 2019120611330723400_rbz020-B20
  article-title: Degradation of synthetic polymeric scaffolds for bone and cartilage tissue repairs
  publication-title: Soft Matter
  doi: 10.1039/b803718n
– volume: 36
  start-page: S20
  year: 2005
  ident: 2019120611330723400_rbz020-B3
  article-title: Bone substitutes: an update
  publication-title: Injury
  doi: 10.1016/j.injury.2005.07.029
– volume: 80
  start-page: 94
  year: 2007
  ident: 2019120611330723400_rbz020-B19
  article-title: Biodegradable polyurethane cancellous bone graft substitutes in the treatment of iliac crest defects
  publication-title: J Biomed Mater Res A
  doi: 10.1002/jbm.a.30834
– volume: 8
  start-page: e67649.
  year: 2013
  ident: 2019120611330723400_rbz020-B56
  article-title: Acceleration of bone repair in NOD/SCID mice by human monoosteophils, novel LL-37-activated monocytes
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0067649
– volume: 26
  start-page: 2921
  year: 2008
  ident: 2019120611330723400_rbz020-B32
  article-title: Emergence of patterned stem cell differentiation within multicellular structures
  publication-title: Stem Cells
  doi: 10.1634/stemcells.2008-0432
– volume: 46
  start-page: 377
  year: 1995
  ident: 2019120611330723400_rbz020-B35
  article-title: Gamma-ray irradiation, autoclave and ethylene oxide sterilization to thermosetting polyurethane: sterilization to polyurethane
  publication-title: Radiat Phys Chem
  doi: 10.1016/0969-806X(94)00134-6
– volume: 35
  start-page: 1217
  year: 2010
  ident: 2019120611330723400_rbz020-B40
  article-title: The return of a forgotten polymer - polycaprolactone in the 21st century
  publication-title: Prog Polym Sci
  doi: 10.1016/j.progpolymsci.2010.04.002
– volume: 15
  start-page: 718
  year: 2011
  ident: 2019120611330723400_rbz020-B8
  article-title: Bone regeneration and stem cells
  publication-title: J Cell Mol Med
  doi: 10.1111/j.1582-4934.2010.01224.x
– volume: 26
  start-page: 182.
  year: 2015
  ident: 2019120611330723400_rbz020-B36
  article-title: Exploiting novel sterilization techniques for porous polyurethane scaffolds
  publication-title: J Mater Sci Mater Med
  doi: 10.1007/s10856-015-5509-0
– volume: 32
  start-page: 477
  year: 2004
  ident: 2019120611330723400_rbz020-B13
  article-title: Polymeric scaffolds for bone tissue engineering
  publication-title: Ann Biomed Eng
  doi: 10.1023/B:ABME.0000017544.36001.8e
– volume: 2
  start-page: 103
  year: 2008
  ident: 2019120611330723400_rbz020-B48
  article-title: Scaffold stiffness influences cell behavior: opportunities for skeletal tissue engineering
  publication-title: Open Orthop J
  doi: 10.2174/1874325000802010103
– volume: 21
  start-page: 3307
  year: 2009
  ident: 2019120611330723400_rbz020-B16
  article-title: Hydrogels in regenerative medicine
  publication-title: Adv Mater
  doi: 10.1002/adma.200802106
– volume: 38
  start-page: 7274
  year: 2005
  ident: 2019120611330723400_rbz020-B27
  article-title: Design of porous polymeric materials from interpenetrating polymer networks (IPNs): poly(dl-lactide)/poly(methyl methacrylate)-based semi-IPN systems
  publication-title: Macromolecules
  doi: 10.1021/ma0501390
– volume: 72B
  start-page: 69
  year: 2005
  ident: 2019120611330723400_rbz020-B52
  article-title: Small-animal models for testing macroporous ceramic bone substitutes
  publication-title: J Biomed Mater Res
  doi: 10.1002/jbm.b.30118
– volume: 12
  start-page: 64
  year: 2001
  ident: 2019120611330723400_rbz020-B1
  article-title: Craniofacial tissue engineering
  publication-title: Crit Rev Oral Biol Med
  doi: 10.1177/10454411010120010501
– volume: 2
  start-page: 151
  year: 2009
  ident: 2019120611330723400_rbz020-B5
  article-title: Review of bone substitutes
  publication-title: Craniomaxillofac Trauma Reconstr
  doi: 10.1055/s-0029-1224777
– volume: 27
  start-page: 1889
  year: 2006
  ident: 2019120611330723400_rbz020-B28
  article-title: Synthesis and evaluation of poly(diol citrate) biodegradable elastomers
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2005.05.106
– volume: 1
  start-page: 1
  year: 1992
  ident: 2019120611330723400_rbz020-B26
  article-title: Determination of crosslink density by swelling in the castable polyurethane elastomer based on 1/4-cyclohexane diisocyanate and para-phenylene diisocyanate
  publication-title: Iran J Polym Sci Technol
– volume: 155
  start-page: 334
  year: 1993
  ident: 2019120611330723400_rbz020-B46
  article-title: Effect of preadsorbed proteins on cell adhesion to polymer surfaces
  publication-title: J Colloid Interface Sci
  doi: 10.1006/jcis.1993.1044
– volume: 38
  start-page: 584
  year: 2013
  ident: 2019120611330723400_rbz020-B22
  article-title: Elastomeric biomaterials for tissue engineering
  publication-title: Prog Polym Sci
  doi: 10.1016/j.progpolymsci.2012.05.003
– volume: 67A
  start-page: 813
  year: 2003
  ident: 2019120611330723400_rbz020-B23
  article-title: Preparation, degradation, and calcification of biodegradable polyurethane foams for bone graft substitutes
  publication-title: J Biomed Mater Res
  doi: 10.1002/jbm.a.10148
– volume: 97
  start-page: 1553
  year: 2012
  ident: 2019120611330723400_rbz020-B41
  article-title: Hydrolytic degradation of segmented polyurethane copolymers for biomedical applications
  publication-title: Polym Degrad Stab
  doi: 10.1016/j.polymdegradstab.2012.04.008
– volume: 29
  start-page: E8.
  year: 2010
  ident: 2019120611330723400_rbz020-B6
  article-title: Cranial bone defects: current and future strategies
  publication-title: Neurosurg Focus
  doi: 10.3171/2010.9.FOCUS10201
– volume: 8
  start-page: 67
  year: 1990
  ident: 2019120611330723400_rbz020-B25
  article-title: The equilibrium swelling behavior of porous and non-porous hydrogels
  publication-title: Stud Polym Sci
  doi: 10.1016/B978-0-444-88654-5.50009-1
– volume: 2015
  start-page: 283796
  year: 2015
  ident: 2019120611330723400_rbz020-B24
  article-title: Preliminary in vitro assessment of stem cell compatibility with cross-linked poly(ε-caprolactone urethane) scaffolds designed through high internal phase emulsions
  publication-title: Stem Cells Int
  doi: 10.1155/2015/283796
– start-page: 95
  volume-title: Engineering of Functional Skeletal Tissues. Topics in Bone Biology
  year: 2007
  ident: 2019120611330723400_rbz020-B15
  doi: 10.1007/978-1-84628-366-6_7
– volume: 35
  start-page: 951
  year: 2011
  ident: 2019120611330723400_rbz020-B2
  article-title: Reamer-irrigator-aspirator indications and clinical results: a systematic review
  publication-title: Int Orthop
  doi: 10.1007/s00264-010-1189-z
– volume: 29
  start-page: 3762
  year: 2008
  ident: 2019120611330723400_rbz020-B38
  article-title: Biodegradable injectable polyurethanes: synthesis and evaluation for orthopaedic applications
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2008.06.021
– volume: 9
  start-page: E289
  year: 2015
  ident: 2019120611330723400_rbz020-B43
  article-title: Poly-ε-caprolactone scaffold and reduced in vitro cell culture: beneficial effect on compaction and improved valvular tissue formation
  publication-title: J Tissue Eng Regen Med
  doi: 10.1002/term.1753
– volume: 52
  start-page: 498
  year: 2000
  ident: 2019120611330723400_rbz020-B54
  article-title: Evaluation of calcium phosphates and experimental calcium phosphate bone cements using osteogenic cultures
  publication-title: J Biomed Mater Res
  doi: 10.1002/1097-4636(20001205)52:3<498::AID-JBM8>3.0.CO;2-P
– volume: 6
  start-page: 4208
  year: 2010
  ident: 2019120611330723400_rbz020-B45
  article-title: Effects of the architecture of tissue engineering scaffolds on cell seeding and culturing
  publication-title: Acta Biomater
  doi: 10.1016/j.actbio.2010.06.012
– volume: 79
  start-page: 144
  year: 2000
  ident: 2019120611330723400_rbz020-B49
  article-title: Cell movement is guided by the rigidity of the substrate
  publication-title: Biophys J
  doi: 10.1016/S0006-3495(00)76279-5
– volume: 08
  start-page: 023
  year: 2014
  ident: 2019120611330723400_rbz020-B12
  article-title: Current concepts of bone tissue engineering for craniofacial bone defect repair
  publication-title: Craniomaxillofac Trauma Reconstr
  doi: 10.1055/s-0034-1393724
– volume: 90
  start-page: 2213
  year: 2006
  ident: 2019120611330723400_rbz020-B51
  article-title: Substrate rigidity regulates the formation and maintenance of tissues
  publication-title: Biophys J
  doi: 10.1529/biophysj.105.070144
– volume: 39
  start-page: S9
  year: 2008
  ident: 2019120611330723400_rbz020-B11
  article-title: Tissue engineering for bone defect healing: an update on a multi-component approach
  publication-title: Injury
  doi: 10.1016/S0020-1383(08)70011-1
– volume: 26
  start-page: 7457
  year: 2005
  ident: 2019120611330723400_rbz020-B39
  article-title: Understanding the biodegradation of polyurethanes: from classical implants to tissue engineering materials
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2005.05.079
– volume: 46
  start-page: 386
  year: 2010
  ident: 2019120611330723400_rbz020-B53
  article-title: A biodegradable porous composite scaffold of PGA/β-TCP for bone tissue engineering
  publication-title: Bone
  doi: 10.1016/j.bone.2009.09.031
– volume: 10
  start-page: 4597
  year: 2014
  ident: 2019120611330723400_rbz020-B17
  article-title: A bioactive “self-fitting” shape memory polymer scaffold with potential to treat cranio-maxillo facial bone defects
  publication-title: Acta Biomater
  doi: 10.1016/j.actbio.2014.07.020
– volume: 5
  start-page: 29
  year: 2003
  ident: 2019120611330723400_rbz020-B9
  article-title: Making tissue engineering scaffolds work. Review: the application of solid freeform fabrication technology to the production of tissue engineering scaffolds
  publication-title: Eur Cell Mater
  doi: 10.22203/eCM.v005a03
– volume: 100
  start-page: L25
  year: 2011
  ident: 2019120611330723400_rbz020-B34
  article-title: Cell shape and substrate rigidity both regulate cell stiffness
  publication-title: Biophys J
  doi: 10.1016/j.bpj.2010.12.3744
– volume: 3
  start-page: 56
  year: 2016
  ident: 2019120611330723400_rbz020-B4
  article-title: Stem cells, growth factors and scaffolds in craniofacial regenerative medicine
  publication-title: Genes Dis
  doi: 10.1016/j.gendis.2015.09.004
– volume: 77
  start-page: 802
  year: 2006
  ident: 2019120611330723400_rbz020-B18
  article-title: Regeneration of bicortical defects in the iliac crest of estrogen-deficient sheep, using new biodegradable polyurethane bone graft substitutes
  publication-title: J Biomed Mater Res A
  doi: 10.1002/jbm.a.30669
– volume: 43
  start-page: 2136
  year: 2015
  ident: 2019120611330723400_rbz020-B55
  article-title: Treatment study of distal femur for parathyroid hormone (1–34) and β-tricalcium phosphate on bone formation in critical-sized defects in osteopenic rats
  publication-title: J Craniomaxillofac Surg
  doi: 10.1016/j.jcms.2015.09.004
– volume-title: Advances in Polyurethane Biomaterials
  year: 2016
  ident: 2019120611330723400_rbz020-B37
– volume: 30
  start-page: 115
  year: 2012
  ident: 2019120611330723400_rbz020-B10
  article-title: Craniomaxillofacial bone engineering by scaffolds loaded with stem cells: a systematic review
  publication-title: J Dent Sch
– volume: 5
  start-page: 17014.
  year: 2017
  ident: 2019120611330723400_rbz020-B14
  article-title: Injectable hydrogels for cartilage and bone tissue engineering
  publication-title: Bone Res
  doi: 10.1038/boneres.2017.14
– volume: 4
  start-page: 5188.
  year: 2014
  ident: 2019120611330723400_rbz020-B33
  article-title: Rewiring mesenchymal stem cell lineage specification by switching the biophysical microenvironment
  publication-title: Sci Rep
  doi: 10.1038/srep05188
– volume: 38
  start-page: 1139
  year: 2009
  ident: 2019120611330723400_rbz020-B31
  article-title: Synthetic polymer scaffolds for tissue engineering
  publication-title: Chem Soc Rev
  doi: 10.1039/b811392k
– volume: 14
  start-page: 193
  year: 1998
  ident: 2019120611330723400_rbz020-B44
  article-title: Dynamic cell seeding of polymer scaffolds for cartilage tissue engineering
  publication-title: Biotechnol Prog
  doi: 10.1021/bp970120j
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Snippet Abstract Bone loss can occur as a result of various pathologies, traumas and injuries and poor bone healing leads to functionally debilitating condition, loss...
Bone loss can occur as a result of various pathologies, traumas and injuries and poor bone healing leads to functionally debilitating condition, loss of...
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Enrichment Source
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StartPage 311
SubjectTerms Biomedical materials
Bone biomaterials
Bone growth
Bone healing
Bone loss
Bones
Cell adhesion & migration
Cell migration
Cell proliferation
Crosslinking
Cytotoxicity
Defects
Differentiation (biology)
Elastomers
Ethyl carbamate
Histology
Mechanical properties
Microtomography
Protein seeding
Quality of life
Regeneration
Regeneration (physiology)
Scaffolds
Skin & tissue grafts
Stem cells
Substitutes
Surgery
Tissue engineering
Trauma
Urea
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Title In vitro and in vivo proves of concept for the use of a chemically cross-linked poly(ester-urethane-urea) scaffold as an easy handling elastomeric biomaterial for bone regeneration
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