MARK-AGE standard operating procedures (SOPs): A successful effort
•Standard operating procedures for sample collection and preparation within MARK-AGE.•Samples processing following a master protocol elaborated for MARK-AGE purposes.•Temporary storage of MARK-AGE samples at a central Biobank.•Logistic challenges of MARK-AGE project. Within the MARK-AGE project, a p...
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| Published in | Mechanisms of ageing and development Vol. 151; pp. 18 - 25 |
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| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Ireland
Elsevier Ireland Ltd
01.11.2015
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0047-6374 1872-6216 1872-6216 |
| DOI | 10.1016/j.mad.2015.03.007 |
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| Abstract | •Standard operating procedures for sample collection and preparation within MARK-AGE.•Samples processing following a master protocol elaborated for MARK-AGE purposes.•Temporary storage of MARK-AGE samples at a central Biobank.•Logistic challenges of MARK-AGE project.
Within the MARK-AGE project, a population study (3337 subjects) was conducted to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any single marker. The MARK-AGE project involves 14 European countries and a total of 26 research centres. In such a study, standard operating procedures (SOPs) are an essential task, which are binding for all MARK-AGE Beneficiaries. The SOPs cover all aspects of subject’s recruitment, collection, shipment and distribution of biological samples (blood and its components, buccal mucosa cells or BMC and urine) as well as the anthropometric measurements and questionnaires. |
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| AbstractList | Within the MARK-AGE project, a population study (3337 subjects) was conducted to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any single marker. The MARK-AGE project involves 14 European countries and a total of 26 research centres. In such a study, standard operating procedures (SOPs) are an essential task, which are binding for all MARK-AGE Beneficiaries. The SOPs cover all aspects of subject's recruitment, collection, shipment and distribution of biological samples (blood and its components, buccal mucosa cells or BMC and urine) as well as the anthropometric measurements and questionnaires. •Standard operating procedures for sample collection and preparation within MARK-AGE.•Samples processing following a master protocol elaborated for MARK-AGE purposes.•Temporary storage of MARK-AGE samples at a central Biobank.•Logistic challenges of MARK-AGE project. Within the MARK-AGE project, a population study (3337 subjects) was conducted to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any single marker. The MARK-AGE project involves 14 European countries and a total of 26 research centres. In such a study, standard operating procedures (SOPs) are an essential task, which are binding for all MARK-AGE Beneficiaries. The SOPs cover all aspects of subject’s recruitment, collection, shipment and distribution of biological samples (blood and its components, buccal mucosa cells or BMC and urine) as well as the anthropometric measurements and questionnaires. Within the MARK-AGE project, a population study (3337 subjects) was conducted to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any single marker. The MARK-AGE project involves 14 European countries and a total of 26 research centres. In such a study, standard operating procedures (SOPs) are an essential task, which are binding for all MARK-AGE Beneficiaries. The SOPs cover all aspects of subject's recruitment, collection, shipment and distribution of biological samples (blood and its components, buccal mucosa cells or BMC and urine) as well as the anthropometric measurements and questionnaires.Within the MARK-AGE project, a population study (3337 subjects) was conducted to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any single marker. The MARK-AGE project involves 14 European countries and a total of 26 research centres. In such a study, standard operating procedures (SOPs) are an essential task, which are binding for all MARK-AGE Beneficiaries. The SOPs cover all aspects of subject's recruitment, collection, shipment and distribution of biological samples (blood and its components, buccal mucosa cells or BMC and urine) as well as the anthropometric measurements and questionnaires. |
| Author | Hervonen, Antti Breusing, Nicolle Franceschi, Claudio Craen, Anton J.M.de Hurme, Mikko Schön, Christiane Moreno-Villanueva, María Grune, Tilman Bürkle, Alexander Siepelmeyer, Anne Capri, Miriam Sevini, Federica Ghezzo, Alessandro |
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| Cites_doi | 10.1001/archpsyc.1965.01720310065008 10.1196/annals.1395.003 10.1076/jcen.20.2.211.1169 10.1037/h0054651 10.1186/1477-5956-11-10 10.1371/journal.pone.0113111 10.1089/rej.2007.0556 10.1080/00221309.1985.9711004 10.1007/s10522-011-9340-9 10.1016/j.arr.2012.02.002 10.1111/acel.12005 10.1016/S0277-9536(96)00057-3 10.1371/journal.pone.0056564 |
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