sNCAM as a specific marker of peripheral demyelination

• Published in: Immunology letters Vol. 185; pp. 93 - 97
• Main Authors: Niezgoda, Adam, Michalak, Sławomir, Losy, Jacek, Kalinowska-Łyszczarz, Alicja, Kozubski, Wojciech
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2017
• Subjects: Adhesion molecules; Adult; Aged; Allergy and Immunology; Axonal polyneuropathy; Axons - metabolism; Axons - pathology; Biomarkers - blood; Demyelinating Diseases - diagnosis; Demyelinating polyneuropathy; Disease Progression; Electroneurography; ELISA immune assay; Female; Humans; Male; Middle Aged; NCAM; Neural Cell Adhesion Molecules - blood; Neural Conduction; Overall Neuropathy Limitations Scale; Peripheral nerve inflammation; Peripheral Nervous System Diseases - diagnosis; Severity of Illness Index; Young Adult; NCAM; Peripheral nerve inflammation; ELISA immune assay; Adhesion molecules; Demyelinating polyneuropathy; Axonal polyneuropathy; Electroneurography; Overall Neuropathy Limitations Scale
• ISSN: 0165-2478; 1879-0542; 1879-0542
• DOI: 10.1016/j.imlet.2017.03.011

•sNCAM was measured in sera of patients with various types of polyneuropathies.•Increased sNCAM was found in demyelinating versus axonal polyneuropathies and in axonal polyneuropathies versus healthy controls.•sNCAM concentration positively correlated with ONLS and negatively with the lowest conduction velocity. Adhesion molecules are involved in nerve growth, synaptic plasticity and myelin formation and maintenance process. Neural cell adhesion molecule (CD56 or NCAM) seems to play a crucial role in all the above-mentioned events. Having found poly-sialylated NCAM increased re-expression on demyelinated axons within multiple sclerosis plaques we assessed soluble NCAM (sNCAM) in sera of patients with various types of peripheral nerve affections − demyelinating, axonal “inflammatory”, axonal metabolic polyneuropathies and healthy controls. These data were compared with the clinical state using Overall Neuropathy Limitations Scale (ONLS) and nerve conduction studies. We found significantly increased sNCAM concentration in demyelinating polyneuropathies in comparison to axonal group and healthy controls as well as significantly increased sNCAM level in axonal group in comparison to healthy subjects. We also found high positive correlation between sNCAM and ONLS and strong negative correlation between sNCAM level and the lowest conduction velocity (Vmin) found in a patient. We conclude that sNCAM might be thought as a specific marker of peripheral nerve demyelination and as a sensitive marker of peripheral nerve injuries.