Rhein Induces Apoptosis in Human Breast Cancer Cells
Human breast cancers cells overexpressing HER2/neu are more aggressive tumors with poor prognosis, and resistance to chemotherapy. This study investigates antiproliferation effects of anthraquinone derivatives of rhubarb root on human breast cancer cells. Of 7 anthraquinone derivatives, only rhein s...
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| Published in | Evidence-based complementary and alternative medicine Vol. 2012; no. 2012; pp. 1 - 8 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cairo, Egypt
Hindawi Publishing Corporation
01.01.2012
John Wiley & Sons, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1741-427X 1741-4288 1741-4288 |
| DOI | 10.1155/2012/952504 |
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| Abstract | Human breast cancers cells overexpressing HER2/neu are more aggressive tumors with poor prognosis, and resistance to chemotherapy. This study investigates antiproliferation effects of anthraquinone derivatives of rhubarb root on human breast cancer cells. Of 7 anthraquinone derivatives, only rhein showed antiproliferative and apoptotic effects on both HER2-overexpressing MCF-7 (MCF-7/HER2) and control vector MCF-7 (MCF-7/VEC) cells. Rhein induced dose- and time-dependent manners increase in caspase-9-mediated apoptosis correlating with activation of ROS-mediated activation of NF-κB- and p53-signaling pathways in both cell types. Therefore, this study highlighted rhein as processing anti-proliferative activity against HER2 overexpression or HER2-basal expression in breast cancer cells and playing important roles in apoptotic induction of human breast cancer cells. |
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| AbstractList | Human breast cancers cells overexpressing HER2/neu are more aggressive tumors with poor prognosis, and resistance to chemotherapy. This study investigates antiproliferation effects of anthraquinone derivatives of rhubarb root on human breast cancer cells. Of 7 anthraquinone derivatives, only rhein showed antiproliferative and apoptotic effects on both HER2-overexpressing MCF-7 (MCF-7/HER2) and control vector MCF-7 (MCF-7/VEC) cells. Rhein induced dose- and time-dependent manners increase in caspase-9-mediated apoptosis correlating with activation of ROS-mediated activation of NF-κB- and p53-signaling pathways in both cell types. Therefore, this study highlighted rhein as processing anti-proliferative activity against HER2 overexpression or HER2-basal expression in breast cancer cells and playing important roles in apoptotic induction of human breast cancer cells. Human breast cancers cells overexpressing HER2/ neu are more aggressive tumors with poor prognosis, and resistance to chemotherapy. This study investigates antiproliferation effects of anthraquinone derivatives of rhubarb root on human breast cancer cells. Of 7 anthraquinone derivatives, only rhein showed antiproliferative and apoptotic effects on both HER2-overexpressing MCF-7 (MCF-7/HER2) and control vector MCF-7 (MCF-7/VEC) cells. Rhein induced dose- and time-dependent manners increase in caspase-9-mediated apoptosis correlating with activation of ROS-mediated activation of NF- κ B- and p53-signaling pathways in both cell types. Therefore, this study highlighted rhein as processing anti-proliferative activity against HER2 overexpression or HER2-basal expression in breast cancer cells and playing important roles in apoptotic induction of human breast cancer cells. Human breast cancers cells overexpressing HER2/neu are more aggressive tumors with poor prognosis, and resistance to chemotherapy. This study investigates antiproliferation effects of anthraquinone derivatives of rhubarb root on human breast cancer cells. Of 7 anthraquinone derivatives, only rhein showed antiproliferative and apoptotic effects on both HER2-overexpressing MCF-7 (MCF-7/HER2) and control vector MCF-7 (MCF-7/VEC) cells. Rhein induced dose- and time-dependent manners increase in caspase-9-mediated apoptosis correlating with activation of ROS-mediated activation of NF-κB- and p53-signaling pathways in both cell types. Therefore, this study highlighted rhein as processing anti-proliferative activity against HER2 overexpression or HER2-basal expression in breast cancer cells and playing important roles in apoptotic induction of human breast cancer cells.Human breast cancers cells overexpressing HER2/neu are more aggressive tumors with poor prognosis, and resistance to chemotherapy. This study investigates antiproliferation effects of anthraquinone derivatives of rhubarb root on human breast cancer cells. Of 7 anthraquinone derivatives, only rhein showed antiproliferative and apoptotic effects on both HER2-overexpressing MCF-7 (MCF-7/HER2) and control vector MCF-7 (MCF-7/VEC) cells. Rhein induced dose- and time-dependent manners increase in caspase-9-mediated apoptosis correlating with activation of ROS-mediated activation of NF-κB- and p53-signaling pathways in both cell types. Therefore, this study highlighted rhein as processing anti-proliferative activity against HER2 overexpression or HER2-basal expression in breast cancer cells and playing important roles in apoptotic induction of human breast cancer cells. |
| Author | Lin, Cheng-Wen Lin, Hui-Yi Kao, Ming-Ching Way, Tzong-Der Song, Ming-Zhang Chang, Ching-Yao Chan, Hong-Lin Lin, Ying-Ju |
| AuthorAffiliation | 3 School of Pharmacy, China Medical University, Taichung 404, Taiwan 2 Institute of Bioinformatics and Structural Biology, Department of Medical Science, National Tsing Hua University, Hsinchu 300, Taiwan 6 Department of Medical Genetics and Medical Research, China Medical University Hospital, Taichung 404, Taiwan 1 Department of Biotechnology, Asia University, Taichung 413, Taiwan 4 Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan 5 Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan |
| AuthorAffiliation_xml | – name: 2 Institute of Bioinformatics and Structural Biology, Department of Medical Science, National Tsing Hua University, Hsinchu 300, Taiwan – name: 4 Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan – name: 6 Department of Medical Genetics and Medical Research, China Medical University Hospital, Taichung 404, Taiwan – name: 3 School of Pharmacy, China Medical University, Taichung 404, Taiwan – name: 5 Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan – name: 1 Department of Biotechnology, Asia University, Taichung 413, Taiwan |
| Author_xml | – sequence: 1 fullname: Lin, Cheng-Wen – sequence: 2 fullname: Song, Ming-Zhang – sequence: 3 fullname: Kao, Ming-Ching – sequence: 4 fullname: Way, Tzong-Der – sequence: 5 fullname: Lin, Hui-Yi – sequence: 6 fullname: Chan, Hong-Lin – sequence: 7 fullname: Chang, Ching-Yao – sequence: 8 fullname: Lin, Ying-Ju |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22007260$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1093/carcin/bgi231 10.1007/s00018-004-4277-7 10.1016/j.freeradbiomed.2004.09.016 10.1074/jbc.274.13.8708 10.1016/S0024-3205(02)01900-8 10.1136/bmj.314.7098.1843 10.1054/bjoc.2001.2174 10.1016/S0006-2952(99)00296-8 10.1074/jbc.M305529200 10.1016/j.jep.2010.09.021 10.1016/S0006-2952(01)00907-8 10.1016/j.lfs.2007.04.010 10.1016/j.abb.2003.08.004 10.1074/jbc.M410119200 10.1055/s-2004-815448 10.1142/S0192415X08006259 10.1038/sj.onc.1203128 10.1007/s00018-005-5050-2 10.1016/j.jep.2008.11.008 10.2337/db05-1187 10.1200/JCO.1992.10.7.1044 10.1023/A:1020031023947 10.1038/cr.2009.19 10.1142/S0192415X09007417 10.4161/cbt.11.9.15045 10.1002/med.20094 10.1038/onc.2008.460 10.1126/science.3798106 10.1097/00001813-199306000-00019 10.1186/bcr738 10.1007/s00018-006-6399-6 10.1038/35009130 10.1097/CAD.0b013e3283182913 10.1016/S0006-2952(02)01296-0 10.1016/j.bbcan.2006.02.001 |
| ContentType | Journal Article |
| Copyright | Copyright © 2012 Ching-Yao Chang et al. Copyright © 2012 Ching-Yao Chang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0 Copyright © 2012 Ching-Yao Chang et al. 2012 |
| Copyright_xml | – notice: Copyright © 2012 Ching-Yao Chang et al. – notice: Copyright © 2012 Ching-Yao Chang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0 – notice: Copyright © 2012 Ching-Yao Chang et al. 2012 |
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| References | (17) 2011; 133 (35) 2001; 85 (39) 2005; 280 (4) 2004; 37 (13) 2004; 61 (22) 2006; 27 (14) 2004; 6 (27) 1999; 18 (38) 2000; 59 (31) 2007; 27 (30) 2003; 418 (10) 1987; 235 (32) 2009; 28 (40) 2002; 63 (33) 2006; 1766 (36) 1999; 274 (20) 2010; 30 (3) 2003; 2 (11) 1997; 314 (37) 2002; 7 (19) 2008; 36 (21) 2009; 37 (8) 2009; 121 (29) 2006; 55 (1) 2007; 27 (9) 1993; 4 (28) 2009; 19 (34) 2000; 404 (18) 2009; 20 (41) 2004; 70 (24) 2009; 23 (23) 2002; 64 (2) 2005; 62 (12) 1992; 10 (15) 2004; 279 (25) 2009; 29 (26) 2007; 27 (5) 2007; 80 (7) 2006; 63 (6) 2002; 71 (16) 2011; 11 22 23 28 29 30 32 33 34 13 36 15 37 16 38 17 39 18 19 1 2 4 5 6 7 8 40 41 21 19331167 - Anticancer Res. 2009 Jan;29(1):309-18 12392819 - Biochem Pharmacol. 2002 Nov 1;64(9):1375-86 19238172 - Cell Res. 2009 Apr;19(4):449-57 11747334 - Br J Cancer. 2001 Dec 14;85(12):1914-21 17512021 - Life Sci. 2007 Jun 6;80(26):2481-8 18711776 - Am J Chin Med. 2008;36(4):805-13 8358069 - Anticancer Drugs. 1993 Jun;4(3):407-14 16563635 - Biochim Biophys Acta. 2006 Aug;1766(1):53-62 17970076 - Anticancer Res. 2007 Sep-Oct;27(5A):3313-22 19343002 - Anticancer Drugs. 2009 Jan;20(1):65-72 14680497 - Breast Cancer Res. 2004;6(1):R24-30 11992635 - Biochem Pharmacol. 2002 Feb 15;63(4):677-88 20393018 - Anticancer Res. 2010 Mar;30(3):945-51 20883766 - J Ethnopharmacol. 2011 Jan 7;133(1):126-31 10557101 - Oncogene. 1999 Nov 1;18(45):6104-11 15928809 - Cell Mol Life Sci. 2005 May;62(10 ):1167-75 12207174 - Apoptosis. 2002 Oct;7(5):413-20 16644673 - Diabetes. 2006 May;55(5):1197-204 9224112 - BMJ. 1997 Jun 28;314(7098):1843-4 15671037 - J Biol Chem. 2005 Apr 29;280(17 ):16843-50 12657721 - Mol Cancer Ther. 2003 Mar;2(3):265-71 19137016 - Oncogene. 2009 Feb 26;28(8):1151-61 19885952 - Am J Chin Med. 2009;37(5):923-31 21307659 - Cancer Biol Ther. 2011 May 1;11(9):793-800 10786798 - Nature. 2000 Apr 20;404(6780):892-7 19061946 - J Ethnopharmacol. 2009 Jan 21;121(2):313-7 16195238 - Carcinogenesis. 2006 Mar;27(3):551-9 14765286 - Planta Med. 2004 Jan;70(1):12-6 10605930 - Biochem Pharmacol. 2000 Jan 1;59(1):13-23 15544921 - Free Radic Biol Med. 2004 Dec 15;37(12):2027-41 10085110 - J Biol Chem. 1999 Mar 26;274(13):8708-16 14522581 - Arch Biochem Biophys. 2003 Oct 15;418(2):99-107 17352257 - Anticancer Res. 2007 Jan-Feb;27(1A):379-89 17022020 - Med Res Rev. 2007 Sep;27(5):609-30 12175703 - Life Sci. 2002 Sep 6;71(16):1879-92 1351537 - J Clin Oncol. 1992 Jul;10(7):1044-8 15583858 - Cell Mol Life Sci. 2004 Dec;61(23):2965-78 19414420 - In Vivo. 2009 Mar-Apr;23(2):309-16 17131052 - Cell Mol Life Sci. 2006 Dec;63(24):3083-9 3798106 - Science. 1987 Jan 9;235(4785):177-82 14602723 - J Biol Chem. 2004 Feb 6;279(6):4479-89 |
| References_xml | – volume: 63 start-page: 677 issue: 4 year: 2002 end-page: 688 ident: 40 article-title: Monoamine neurotoxins-induced apoptosis in lymphocytes by a common oxidative stress mechanism: involvement of hydrogen peroxide (H2O2), caspase-3, and nuclear factor kappa-B (NF- B), p53, c-Jun transcription factors – volume: 7 start-page: 413 issue: 5 year: 2002 end-page: 420 ident: 37 article-title: Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) up-regulates death receptor 5 (DR5) mediated by NF B activation in epithelial derived cell lines – volume: 27 start-page: 379 issue: 1 year: 2007 end-page: 389 ident: 26 article-title: The role of Ca+2 on rhein-induced apoptosis in human cervical cancer Ca Ski cells – volume: 19 start-page: 449 issue: 4 year: 2009 end-page: 457 ident: 28 article-title: Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1 – volume: 28 start-page: 1151 issue: 8 year: 2009 end-page: 1161 ident: 32 article-title: 9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF- B and p53 pathways – volume: 85 start-page: 1914 issue: 12 year: 2001 end-page: 1921 ident: 35 article-title: relA over-expression reduces tumorigenicity and activates apoptosis in human cancer cells – volume: 70 start-page: 12 issue: 1 year: 2004 end-page: 16 ident: 41 article-title: Rhein inhibits the growth and induces the apoptosis of Hep G2 cells – volume: 37 start-page: 923 issue: 5 year: 2009 end-page: 931 ident: 21 article-title: Rhein lysinate suppresses the growth of tumor cells and increases the anti-tumor activity of Taxol in mice – volume: 4 start-page: 407 issue: 3 year: 1993 end-page: 414 ident: 9 article-title: Rhein inhibits glucose uptake in Ehrlich ascites tumor cells by alteration of membrane-associated functions – volume: 71 start-page: 1879 issue: 16 year: 2002 end-page: 1892 ident: 6 article-title: The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines – volume: 27 start-page: 3313 issue: 5 year: 2007 end-page: 3322 ident: 31 article-title: Rhein induces apoptosis through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death pathway in human nasopharyngeal carcinoma cells – volume: 63 start-page: 3083 issue: 24 year: 2006 end-page: 3089 ident: 7 article-title: Evaluation of the anti-angiogenic effect of aloe-emodin – volume: 37 start-page: 2027 issue: 12 year: 2004 end-page: 2041 ident: 4 article-title: Anthraquinones sensitize tumor cells to arsenic cytotoxicity in vitro and in vivo via reactive oxygen species-mediated dual regulation of apoptosis – volume: 59 start-page: 13 issue: 1 year: 2000 end-page: 23 ident: 38 article-title: Oxidative stress and nuclear factor- B activation: a reassessment of the evidence in the light of recent discoveries – volume: 6 start-page: R24 issue: 1 year: 2004 end-page: R30 ident: 14 article-title: Coexistence of HER2/neu over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer – volume: 280 start-page: 16843 issue: 17 year: 2005 end-page: 16850 ident: 39 article-title: Function of polo-like kinase 3 in NF- B-mediated proapoptotic response – volume: 18 start-page: 6104 issue: 45 year: 1999 end-page: 6111 ident: 27 article-title: Role of redox potential and reactive oxygen species in stress signaling – volume: 30 start-page: 945 issue: 3 year: 2010 end-page: 952 ident: 20 article-title: Emodin, aloe-emodin and rhein induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells – volume: 274 start-page: 8708 issue: 13 year: 1999 end-page: 8716 ident: 36 article-title: Overexpression of RelA causes G1 arrest and apoptosis in a pro-B cell line – volume: 418 start-page: 99 issue: 2 year: 2003 end-page: 107 ident: 30 article-title: Rhein induces apoptosis in HL-60 cells via reactive oxygen species-independent mitochondrial death pathway – volume: 61 start-page: 2965 issue: 23 year: 2004 end-page: 2978 ident: 13 article-title: Role of HER2/neu in tumor progression and therapy – volume: 279 start-page: 4479 issue: 6 year: 2004 end-page: 4489 ident: 15 article-title: Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway – volume: 121 start-page: 313 issue: 2 year: 2009 end-page: 317 ident: 8 article-title: Anti-angiogenic effects of rhubarb and its anthraquinone derivatives – volume: 10 start-page: 1044 issue: 7 year: 1992 end-page: 1048 ident: 12 article-title: Prognostic significance of HER-2 oncoprotein expression in breast cancer: a 30-year follow-up – volume: 133 start-page: 126 issue: 1 year: 2011 end-page: 131 ident: 17 article-title: Induction of apoptotic cell death by Pharbitis nil extract in HER2-overexpressing MCF-7 cells – volume: 36 start-page: 805 issue: 4 year: 2008 end-page: 813 ident: 19 article-title: Rhein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma BEL-7402 cells – volume: 55 start-page: 1197 issue: 5 year: 2006 end-page: 1204 ident: 29 article-title: Impact of mitochondrial reactive oxygen species and apoptosis signal-regulating kinase 1 on insulin signaling – volume: 1766 start-page: 53 issue: 1 year: 2006 end-page: 62 ident: 33 article-title: Pro-apoptotic role of NF- B: implications for cancer therapy – volume: 80 start-page: 2481 issue: 26 year: 2007 end-page: 2488 ident: 5 article-title: Emodin suppresses interleukin-1 induced mesangial cells proliferation and extracellular matrix production via inhibiting P38 MAPK – volume: 27 start-page: 551 issue: 3 year: 2006 end-page: 559 ident: 22 article-title: Growth inhibition of carcinogen-transformed MCF-12F breast epithelial cells and hormone-sensitive BT-474 breast cancer cells by 1 -hydroxyvitamin D5 – volume: 23 start-page: 309 issue: 2 year: 2009 end-page: 316 ident: 24 article-title: Rhein induced apoptosis through the endoplasmic reticulum stress, caspase- and mitochondria-dependent pathways in SCC-4 human tongue squamous cancer cells – volume: 64 start-page: 1375 issue: 9 year: 2002 end-page: 1386 ident: 23 article-title: The antiproliferative activity of resveratrol results in apoptosis in MCF-7 but not in MDA-MB-231 human breast cancer cells: cell-specific alteration of the cell cycle – volume: 235 start-page: 177 issue: 4785 year: 1987 end-page: 182 ident: 10 article-title: Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene – volume: 314 start-page: 1843 issue: 7098 year: 1997 end-page: 1844 ident: 11 article-title: Oestrogen receptors and breast cancer – volume: 62 start-page: 1167 issue: 10 year: 2005 end-page: 1175 ident: 2 article-title: Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathway – volume: 20 start-page: 65 issue: 1 year: 2009 end-page: 72 ident: 18 article-title: Rhein lysinate suppresses the growth of breast cancer cells and potentiates the inhibitory effect of Taxol in athymic mice – volume: 29 start-page: 309 issue: 1 year: 2009 end-page: 318 ident: 25 article-title: The roles of endoplasmic reticulum stress and Ca2+ on rhein-induced apoptosis in A-549 human lung cancer cells – volume: 27 start-page: 609 issue: 5 year: 2007 end-page: 630 ident: 1 article-title: Anti-cancer properties of anthraquinones from rhubarb – volume: 2 start-page: 265 issue: 3 year: 2003 end-page: 271 ident: 3 article-title: Celecoxib acts in a cyclooxygenase-2-independent manner and in synergy with emodin to suppress rat cholangiocarcinoma growth in vitro through a mechanism involving enhanced Akt inactivation and increased activation of caspases-9 and -3 – volume: 404 start-page: 892 issue: 6780 year: 2000 end-page: 897 ident: 34 article-title: Role of NF- B in p53-mediated programmed cell death – volume: 11 start-page: 793 issue: 9 year: 2011 end-page: 800 ident: 16 article-title: Resistance to HER2-directed antibodies and tyrosine kinase inhibitors: mechanisms and clinical implications – ident: 22 doi: 10.1093/carcin/bgi231 – volume: 29 start-page: 309 issue: 1 year: 2009 ident: 25 publication-title: Anticancer Research – ident: 13 doi: 10.1007/s00018-004-4277-7 – ident: 4 doi: 10.1016/j.freeradbiomed.2004.09.016 – volume: 23 start-page: 309 issue: 2 year: 2009 ident: 24 publication-title: In Vivo – ident: 36 doi: 10.1074/jbc.274.13.8708 – volume: 30 start-page: 945 issue: 3 year: 2010 ident: 20 publication-title: Anticancer Research – ident: 6 doi: 10.1016/S0024-3205(02)01900-8 – volume: 314 start-page: 1843 issue: 7098 year: 1997 ident: 11 publication-title: The British Medical Journal doi: 10.1136/bmj.314.7098.1843 – volume: 85 start-page: 1914 issue: 12 year: 2001 ident: 35 publication-title: The British Journal of Cancer doi: 10.1054/bjoc.2001.2174 – ident: 38 doi: 10.1016/S0006-2952(99)00296-8 – ident: 15 doi: 10.1074/jbc.M305529200 – ident: 17 doi: 10.1016/j.jep.2010.09.021 – ident: 40 doi: 10.1016/S0006-2952(01)00907-8 – ident: 5 doi: 10.1016/j.lfs.2007.04.010 – ident: 30 doi: 10.1016/j.abb.2003.08.004 – ident: 39 doi: 10.1074/jbc.M410119200 – ident: 41 doi: 10.1055/s-2004-815448 – ident: 19 doi: 10.1142/S0192415X08006259 – volume: 18 start-page: 6104 issue: 45 year: 1999 ident: 27 publication-title: Oncogene doi: 10.1038/sj.onc.1203128 – ident: 2 doi: 10.1007/s00018-005-5050-2 – ident: 8 doi: 10.1016/j.jep.2008.11.008 – ident: 29 doi: 10.2337/db05-1187 – volume: 10 start-page: 1044 issue: 7 year: 1992 ident: 12 publication-title: Journal of Clinical Oncology doi: 10.1200/JCO.1992.10.7.1044 – ident: 37 doi: 10.1023/A:1020031023947 – ident: 28 doi: 10.1038/cr.2009.19 – ident: 21 doi: 10.1142/S0192415X09007417 – volume: 27 start-page: 3313 issue: 5 year: 2007 ident: 31 publication-title: Anticancer Research – ident: 16 doi: 10.4161/cbt.11.9.15045 – ident: 1 doi: 10.1002/med.20094 – ident: 32 doi: 10.1038/onc.2008.460 – volume: 235 start-page: 177 issue: 4785 year: 1987 ident: 10 publication-title: Science doi: 10.1126/science.3798106 – volume: 4 start-page: 407 issue: 3 year: 1993 ident: 9 publication-title: Anti-Cancer Drugs doi: 10.1097/00001813-199306000-00019 – volume: 6 start-page: R24 issue: 1 year: 2004 ident: 14 publication-title: Breast Cancer Research doi: 10.1186/bcr738 – ident: 7 doi: 10.1007/s00018-006-6399-6 – ident: 34 doi: 10.1038/35009130 – volume: 2 start-page: 265 issue: 3 year: 2003 ident: 3 publication-title: Molecular Cancer Therapeutics – ident: 18 doi: 10.1097/CAD.0b013e3283182913 – ident: 23 doi: 10.1016/S0006-2952(02)01296-0 – ident: 33 doi: 10.1016/j.bbcan.2006.02.001 – volume: 27 start-page: 379 issue: 1 year: 2007 ident: 26 publication-title: Anticancer Research – reference: 18711776 - Am J Chin Med. 2008;36(4):805-13 – reference: 12175703 - Life Sci. 2002 Sep 6;71(16):1879-92 – reference: 15928809 - Cell Mol Life Sci. 2005 May;62(10 ):1167-75 – reference: 11747334 - Br J Cancer. 2001 Dec 14;85(12):1914-21 – reference: 14522581 - Arch Biochem Biophys. 2003 Oct 15;418(2):99-107 – reference: 11992635 - Biochem Pharmacol. 2002 Feb 15;63(4):677-88 – reference: 19238172 - Cell Res. 2009 Apr;19(4):449-57 – reference: 3798106 - Science. 1987 Jan 9;235(4785):177-82 – reference: 12657721 - Mol Cancer Ther. 2003 Mar;2(3):265-71 – reference: 16195238 - Carcinogenesis. 2006 Mar;27(3):551-9 – reference: 9224112 - BMJ. 1997 Jun 28;314(7098):1843-4 – reference: 17512021 - Life Sci. 2007 Jun 6;80(26):2481-8 – reference: 20883766 - J Ethnopharmacol. 2011 Jan 7;133(1):126-31 – reference: 19331167 - Anticancer Res. 2009 Jan;29(1):309-18 – reference: 10786798 - Nature. 2000 Apr 20;404(6780):892-7 – reference: 15583858 - Cell Mol Life Sci. 2004 Dec;61(23):2965-78 – reference: 20393018 - Anticancer Res. 2010 Mar;30(3):945-51 – reference: 10605930 - Biochem Pharmacol. 2000 Jan 1;59(1):13-23 – reference: 10085110 - J Biol Chem. 1999 Mar 26;274(13):8708-16 – reference: 14680497 - Breast Cancer Res. 2004;6(1):R24-30 – reference: 16644673 - Diabetes. 2006 May;55(5):1197-204 – reference: 15544921 - Free Radic Biol Med. 2004 Dec 15;37(12):2027-41 – reference: 14602723 - J Biol Chem. 2004 Feb 6;279(6):4479-89 – reference: 1351537 - J Clin Oncol. 1992 Jul;10(7):1044-8 – reference: 17131052 - Cell Mol Life Sci. 2006 Dec;63(24):3083-9 – reference: 16563635 - Biochim Biophys Acta. 2006 Aug;1766(1):53-62 – reference: 19343002 - Anticancer Drugs. 2009 Jan;20(1):65-72 – reference: 8358069 - Anticancer Drugs. 1993 Jun;4(3):407-14 – reference: 21307659 - Cancer Biol Ther. 2011 May 1;11(9):793-800 – reference: 17022020 - Med Res Rev. 2007 Sep;27(5):609-30 – reference: 12207174 - Apoptosis. 2002 Oct;7(5):413-20 – reference: 10557101 - Oncogene. 1999 Nov 1;18(45):6104-11 – reference: 19414420 - In Vivo. 2009 Mar-Apr;23(2):309-16 – reference: 14765286 - Planta Med. 2004 Jan;70(1):12-6 – reference: 19137016 - Oncogene. 2009 Feb 26;28(8):1151-61 – reference: 12392819 - Biochem Pharmacol. 2002 Nov 1;64(9):1375-86 – reference: 17352257 - Anticancer Res. 2007 Jan-Feb;27(1A):379-89 – reference: 19061946 - J Ethnopharmacol. 2009 Jan 21;121(2):313-7 – reference: 15671037 - J Biol Chem. 2005 Apr 29;280(17 ):16843-50 – reference: 19885952 - Am J Chin Med. 2009;37(5):923-31 – reference: 17970076 - Anticancer Res. 2007 Sep-Oct;27(5A):3313-22 |
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| Snippet | Human breast cancers cells overexpressing HER2/neu are more aggressive tumors with poor prognosis, and resistance to chemotherapy. This study investigates... Human breast cancers cells overexpressing HER2/ neu are more aggressive tumors with poor prognosis, and resistance to chemotherapy. This study investigates... |
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| SubjectTerms | Anthraquinone Apoptosis Breast cancer Cancer therapies Caspase Caspase-9 Cell cycle Chemotherapy ErbB-2 protein Flow cytometry Gene amplification Kinases Medical prognosis Metastasis NF-κB protein Oxidative stress p53 Protein Plasmids Tumors |
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| Title | Rhein Induces Apoptosis in Human Breast Cancer Cells |
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