Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial
Visceral adipose tissue is harmful to metabolic health. Exercise training reduces visceral adipose tissue mass, but the underlying mechanisms are not known. Interleukin-6 (IL-6) stimulates lipolysis and is released from skeletal muscle during exercise. We hypothesized that exercise-induced reduction...
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| Published in | Cell metabolism Vol. 29; no. 4; pp. 844 - 855.e3 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
02.04.2019
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| Online Access | Get full text |
| ISSN | 1550-4131 1932-7420 1932-7420 |
| DOI | 10.1016/j.cmet.2018.12.007 |
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| Abstract | Visceral adipose tissue is harmful to metabolic health. Exercise training reduces visceral adipose tissue mass, but the underlying mechanisms are not known. Interleukin-6 (IL-6) stimulates lipolysis and is released from skeletal muscle during exercise. We hypothesized that exercise-induced reductions in visceral adipose tissue mass are mediated by IL-6. In this randomized placebo-controlled trial, we assigned abdominally obese adults to tocilizumab (IL-6 receptor antibody) or placebo during a 12-week intervention with either bicycle exercise or no exercise. While exercise reduced visceral adipose tissue mass, this effect of exercise was abolished in the presence of IL-6 blockade. Changes in body weight and total adipose tissue mass showed similar tendencies, whereas lean body mass did not differ between groups. Also, IL-6 blockade increased cholesterol levels, an effect not reversed by exercise. Thus, IL-6 is required for exercise to reduce visceral adipose tissue mass and emphasizes a potentially important metabolic consequence of IL-6 blockade.
[Display omitted]
•Exercise reduces visceral adipose tissue mass•Loss of visceral adipose tissue mass following exercise is dependent on IL-6•IL-6 receptor blockade increases total cholesterol and is not influenced by exercise•Improvements in cardiorespiratory fitness following exercise are not IL-6 dependent
Wedell-Neergaard et al. show that in abdominally obese people, exercise-mediated loss of visceral adipose tissue mass requires IL-6 receptor signaling. Given that abdominal fat is metabolically harmful to health, this study raises a potentially important side effect of IL-6 receptor antibodies, such as tocilizumab, used to treat some forms of arthritis. |
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| AbstractList | Visceral adipose tissue is harmful to metabolic health. Exercise training reduces visceral adipose tissue mass, but the underlying mechanisms are not known. Interleukin-6 (IL-6) stimulates lipolysis and is released from skeletal muscle during exercise. We hypothesized that exercise-induced reductions in visceral adipose tissue mass are mediated by IL-6. In this randomized placebo-controlled trial, we assigned abdominally obese adults to tocilizumab (IL-6 receptor antibody) or placebo during a 12-week intervention with either bicycle exercise or no exercise. While exercise reduced visceral adipose tissue mass, this effect of exercise was abolished in the presence of IL-6 blockade. Changes in body weight and total adipose tissue mass showed similar tendencies, whereas lean body mass did not differ between groups. Also, IL-6 blockade increased cholesterol levels, an effect not reversed by exercise. Thus, IL-6 is required for exercise to reduce visceral adipose tissue mass and emphasizes a potentially important metabolic consequence of IL-6 blockade.Visceral adipose tissue is harmful to metabolic health. Exercise training reduces visceral adipose tissue mass, but the underlying mechanisms are not known. Interleukin-6 (IL-6) stimulates lipolysis and is released from skeletal muscle during exercise. We hypothesized that exercise-induced reductions in visceral adipose tissue mass are mediated by IL-6. In this randomized placebo-controlled trial, we assigned abdominally obese adults to tocilizumab (IL-6 receptor antibody) or placebo during a 12-week intervention with either bicycle exercise or no exercise. While exercise reduced visceral adipose tissue mass, this effect of exercise was abolished in the presence of IL-6 blockade. Changes in body weight and total adipose tissue mass showed similar tendencies, whereas lean body mass did not differ between groups. Also, IL-6 blockade increased cholesterol levels, an effect not reversed by exercise. Thus, IL-6 is required for exercise to reduce visceral adipose tissue mass and emphasizes a potentially important metabolic consequence of IL-6 blockade. Visceral adipose tissue is harmful to metabolic health. Exercise training reduces visceral adipose tissue mass, but the underlying mechanisms are not known. Interleukin-6 (IL-6) stimulates lipolysis and is released from skeletal muscle during exercise. We hypothesized that exercise-induced reductions in visceral adipose tissue mass are mediated by IL-6. In this randomized placebo-controlled trial, we assigned abdominally obese adults to tocilizumab (IL-6 receptor antibody) or placebo during a 12-week intervention with either bicycle exercise or no exercise. While exercise reduced visceral adipose tissue mass, this effect of exercise was abolished in the presence of IL-6 blockade. Changes in body weight and total adipose tissue mass showed similar tendencies, whereas lean body mass did not differ between groups. Also, IL-6 blockade increased cholesterol levels, an effect not reversed by exercise. Thus, IL-6 is required for exercise to reduce visceral adipose tissue mass and emphasizes a potentially important metabolic consequence of IL-6 blockade. Visceral adipose tissue is harmful to metabolic health. Exercise training reduces visceral adipose tissue mass, but the underlying mechanisms are not known. Interleukin-6 (IL-6) stimulates lipolysis and is released from skeletal muscle during exercise. We hypothesized that exercise-induced reductions in visceral adipose tissue mass are mediated by IL-6. In this randomized placebo-controlled trial, we assigned abdominally obese adults to tocilizumab (IL-6 receptor antibody) or placebo during a 12-week intervention with either bicycle exercise or no exercise. While exercise reduced visceral adipose tissue mass, this effect of exercise was abolished in the presence of IL-6 blockade. Changes in body weight and total adipose tissue mass showed similar tendencies, whereas lean body mass did not differ between groups. Also, IL-6 blockade increased cholesterol levels, an effect not reversed by exercise. Thus, IL-6 is required for exercise to reduce visceral adipose tissue mass and emphasizes a potentially important metabolic consequence of IL-6 blockade. [Display omitted] •Exercise reduces visceral adipose tissue mass•Loss of visceral adipose tissue mass following exercise is dependent on IL-6•IL-6 receptor blockade increases total cholesterol and is not influenced by exercise•Improvements in cardiorespiratory fitness following exercise are not IL-6 dependent Wedell-Neergaard et al. show that in abdominally obese people, exercise-mediated loss of visceral adipose tissue mass requires IL-6 receptor signaling. Given that abdominal fat is metabolically harmful to health, this study raises a potentially important side effect of IL-6 receptor antibodies, such as tocilizumab, used to treat some forms of arthritis. |
| Author | Fagerlind, Sabrina Ravn Seide, Sidsel Kofoed Vinum, Nicole Christensen, Robin Wedell-Neergaard, Anne-Sophie Lang Lehrskov, Louise Christensen, Regitse Højgaard Launbo, Natja Larsen, Monica Korsager Ried-Larsen, Mathias Krogh-Madsen, Rikke Henneberg, Marie Rosenmeier, Jaya Birgitte Pedersen, Bente Klarlund Dahl, Camilla Noerfelt Legaard, Grit Elster Dorph, Emma Ball, Maria Karstoft, Kristian Nybing, Janus Damm Ellingsgaard, Helga Nymand, Stine |
| Author_xml | – sequence: 1 givenname: Anne-Sophie surname: Wedell-Neergaard fullname: Wedell-Neergaard, Anne-Sophie organization: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark – sequence: 2 givenname: Louise surname: Lang Lehrskov fullname: Lang Lehrskov, Louise organization: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark – sequence: 3 givenname: Regitse Højgaard surname: Christensen fullname: Christensen, Regitse Højgaard organization: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark – sequence: 4 givenname: Grit Elster surname: Legaard fullname: Legaard, Grit Elster organization: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark – sequence: 5 givenname: Emma surname: Dorph fullname: Dorph, Emma organization: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark – sequence: 6 givenname: Monica Korsager surname: Larsen fullname: Larsen, Monica Korsager organization: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark – sequence: 7 givenname: Natja surname: Launbo fullname: Launbo, Natja organization: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark – sequence: 8 givenname: Sabrina Ravn surname: Fagerlind fullname: Fagerlind, Sabrina Ravn organization: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark – sequence: 9 givenname: Sidsel Kofoed surname: Seide fullname: Seide, Sidsel Kofoed organization: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark – sequence: 10 givenname: Stine surname: Nymand fullname: Nymand, Stine organization: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark – sequence: 11 givenname: Maria surname: Ball fullname: Ball, Maria organization: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark – sequence: 12 givenname: Nicole surname: Vinum fullname: Vinum, Nicole organization: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark – sequence: 13 givenname: Camilla Noerfelt surname: Dahl fullname: Dahl, Camilla Noerfelt organization: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark – sequence: 14 givenname: Marie surname: Henneberg fullname: Henneberg, Marie organization: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark – sequence: 15 givenname: Mathias surname: Ried-Larsen fullname: Ried-Larsen, Mathias organization: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark – sequence: 16 givenname: Janus Damm surname: Nybing fullname: Nybing, Janus Damm organization: Department of Radiology, Copenhagen University Hospital Bispebjerg, 2400 Copenhagen, Denmark – sequence: 17 givenname: Robin surname: Christensen fullname: Christensen, Robin organization: Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Copenhagen, Denmark – sequence: 18 givenname: Jaya Birgitte surname: Rosenmeier fullname: Rosenmeier, Jaya Birgitte organization: Department of Cardiology, Copenhagen University Hospital Bispebjerg, Copenhagen, 2400 Copenhagen, Denmark – sequence: 19 givenname: Kristian surname: Karstoft fullname: Karstoft, Kristian organization: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark – sequence: 20 givenname: Bente Klarlund surname: Pedersen fullname: Pedersen, Bente Klarlund organization: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark – sequence: 21 givenname: Helga surname: Ellingsgaard fullname: Ellingsgaard, Helga email: helga.ellingsgaard@regionh.dk organization: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark – sequence: 22 givenname: Rikke surname: Krogh-Madsen fullname: Krogh-Madsen, Rikke organization: The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30595477$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1212/01.wnl.0000306313.89165.ef 10.1186/s13063-018-2637-0 10.3168/jds.2013-7296 10.1371/journal.pone.0190645 10.1111/j.1469-7793.1998.949bp.x 10.1016/j.jcm.2016.02.012 10.1152/japplphysiol.00164.2004 10.1002/jmri.20167 10.1007/s00125-004-1598-x 10.1016/S0140-6736(08)60453-5 10.1249/MSS.0b013e318213fefb 10.1152/japplphysiol.01208.2006 10.1371/journal.pone.0085276 10.1381/096089204323093345 10.1113/jphysiol.2009.168906 10.1016/S0140-6736(05)66585-3 10.1056/NEJMoa0801891 10.1152/ajpendo.2000.279.3.E585 10.1152/ajpendo.00257.2004 10.1016/j.cmet.2007.11.011 10.1186/s12966-017-0525-8 10.1111/j.1469-7793.2000.00237.x 10.1038/oby.2012.70 10.1152/ajpendo.00074.2003 10.1038/nrrheum.2014.193 10.1001/jama.299.11.1259 10.1016/j.cyto.2016.08.033 10.1136/bmj.322.7288.716 10.2337/db05-1404 10.2337/diabetes.53.7.1643 10.1152/jappl.1953.6.4.252 10.1210/jc.2002-021687 10.1016/j.cmet.2018.04.008 10.1136/bmj.323.7321.1123 10.1016/j.diabet.2016.12.006 10.1093/eurheartj/ehx144 10.1161/CIRCULATIONAHA.107.739714 10.1152/ajpheart.2000.279.6.H2954 10.1038/nm0102-75 10.1152/physrev.90100.2007 10.1016/j.cytogfr.2018.04.004 10.1161/CIRCULATIONAHA.106.675355 10.1016/j.amjmed.2007.06.006 10.1038/oby.2006.43 10.1210/en.2003-1319 10.1136/bmj.311.6998.158 10.1016/j.cmet.2017.05.018 10.1002/jmri.1880010315 |
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| References | Carey, Steinberg, Macaulay, Thomas, Holmes, Ramm, Prelovsek, Hohnen-Behrens, Watt, James (bib2) 2006; 55 Wallenius, Wallenius, Ahrén, Rudling, Carlsten, Dickson, Ohlsson, Jansson (bib39) 2002; 8 Enevoldsen, Stallknecht, Fluckey, Galbo (bib8) 2000; 279 Smolen, Beaulieu, Rubbert-Roth, Ramos-Remus, Rovensky, Alecock, Woodworth, Alten, Investigators (bib31) 2008; 371 Després, Lemieux, Prud’homme (bib6) 2001; 322 Lean, Han, Morrison (bib48) 1995; 311 Petersen, Pedersen (bib26) 2005; 98 Olsen, Krogh-Madsen, Thomsen, Booth, Pedersen (bib22) 2008; 299 Lancaster, Ghiatas, Alyassin, Kilcoyne, Bonora, DeFronzo (bib47) 1991; 1 Cottam, Mattar, Barinas-Mitchell, Eid, Kuller, Kelley, Schauer (bib4) 2004; 14 Koo, Li (bib46) 2016; 15 Pedersen, Febbraio (bib24) 2007; 102 Tremblay, Aubert, Barnes, Saunders, Carson, Latimer-Cheung, Chastin, Altenburg, Chinapaw (bib50) 2017; 14 Ji, Drackley, Khan, Loor (bib15) 2014; 97 Serrano, Baeza-Raja, Perdiguero, Jardí, Muñoz-Cánoves (bib30) 2008; 7 Haffner (bib14) 2007; 120 Fäldt, Wernstedt, Fitzgerald, Wallenius, Bergström, Jansson (bib9) 2004; 145 Moots, Sebba, Rigby, Ostor, Porter-Brown, Donaldson, Dimonaco, Rubbert-Roth, van Vollenhoven, Genovese (bib20) 2017; 56 Sabag, Way, Keating, Sultana, O’Connor, Baker, Chuter, George, Johnson (bib29) 2017; 43 Fidanza, Keys, Anderson (bib12) 1953; 6 Vickers, Altman (bib38) 2001; 323 Garber, Blissmer, Deschenes, Franklin, Lamonte, Lee, Nieman, Swain (bib45) 2011; 43 Benatti, Pedersen (bib1) 2015; 11 Zhang, Rexrode, van Dam, Li, Hu (bib44) 2008; 117 Nordby, Auerbach, Rosenkilde, Kristiansen, Thomasen, Rygaard, Groth, Brandt, Helge, Richter (bib21) 2012; 20 Theurich, Tsaousidou, Hanssen, Lempradl, Mauer, Timper, Schilbach, Folz-Donahue, Heilinger, Sexl (bib35) 2017; 26 Christensen, Wedell-Neergaard, Lehrskov, Legård, Dorph, Nymand, Ball, Zacho, Christensen, Ellingsgaard (bib3) 2018; 19 Steensberg, Fischer, Keller, Møller, Pedersen (bib33) 2003; 285 Edvardsen, Hem, Anderssen (bib7) 2014; 9 Kuk, Katzmarzyk, Nichaman, Church, Blair, Ross (bib16) 2006; 14 Watt, Carey, Wolsk-Petersen, Kraemer, Pedersen, Febbraio (bib40) 2005; 48 Yudkin, Eringa, Stehouwer (bib43) 2005; 365 Whitmer, Gustafson, Barrett-Connor, Haan, Gunderson, Yaffe (bib42) 2008; 71 Steensberg, van Hall, Osada, Sacchetti, Saltin, Klarlund Pedersen (bib32) 2000; 529 Pedersen, Febbraio (bib25) 2008; 88 Ostrowski, Rohde, Zacho, Asp, Pedersen (bib23) 1998; 508 Febbraio, Hiscock, Sacchetti, Fischer, Pedersen (bib10) 2004; 53 Ma, Zhang, Yin, Guo, Ma, Wang, Shu, Dong (bib19) 2016; 88 Suwa, Hogg, English, Van Eeden (bib34) 2000; 279 Wedell-Neergaard, Eriksen, Grønbæk, Pedersen, Krogh-Madsen, Tolstrup (bib41) 2018; 13 Treuth, Schmitz, Catellier, McMurray, Murray, Almeida, Going, Norman, Pate (bib51) 2004; 36 Unver, McAllister (bib36) 2018; 41 Lang Lehrskov, Lyngbaek, Soederlund, Legaard, Ehses, Heywood, Wewer Albrechtsen, Holst, Karstoft, Pedersen, Ellingsgaard (bib17) 2018; 27 Fox, Massaro, Hoffmann, Pou, Maurovich-Horvat, Liu, Vasan, Murabito, Meigs, Cupples (bib13) 2007; 116 Petersen, Carey, Sacchetti, Steinberg, Macaulay, Febbraio, Pedersen (bib27) 2005; 288 Pischon, Boeing, Hoffmann, Bergmann, Schulze, Overvad, van der Schouw, Spencer, Moons, Tjønneland (bib28) 2008; 359 van Hall, Steensberg, Sacchetti, Fischer, Keller, Schjerling, Hiscock, Møller, Saltin, Febbraio, Pedersen (bib37) 2003; 88 de Glisezinski, Larrouy, Bajzova, Koppo, Polak, Berlan, Bulow, Langin, Marques, Crampes (bib5) 2009; 587 Ference, Ginsberg, Graham, Ray, Packard, Bruckert, Hegele, Krauss, Raal, Schunkert (bib11) 2017; 38 Positano, Gastaldelli, Sironi, Santarelli, Lombardi, Landini (bib49) 2004; 20 Enevoldsen (10.1016/j.cmet.2018.12.007_bib8) 2000; 279 Febbraio (10.1016/j.cmet.2018.12.007_bib10) 2004; 53 Moots (10.1016/j.cmet.2018.12.007_bib20) 2017; 56 Edvardsen (10.1016/j.cmet.2018.12.007_bib7) 2014; 9 Ostrowski (10.1016/j.cmet.2018.12.007_bib23) 1998; 508 Theurich (10.1016/j.cmet.2018.12.007_bib35) 2017; 26 Treuth (10.1016/j.cmet.2018.12.007_bib51) 2004; 36 Steensberg (10.1016/j.cmet.2018.12.007_bib33) 2003; 285 Smolen (10.1016/j.cmet.2018.12.007_bib31) 2008; 371 Whitmer (10.1016/j.cmet.2018.12.007_bib42) 2008; 71 van Hall (10.1016/j.cmet.2018.12.007_bib37) 2003; 88 Kuk (10.1016/j.cmet.2018.12.007_bib16) 2006; 14 Watt (10.1016/j.cmet.2018.12.007_bib40) 2005; 48 Zhang (10.1016/j.cmet.2018.12.007_bib44) 2008; 117 Wedell-Neergaard (10.1016/j.cmet.2018.12.007_bib41) 2018; 13 Carey (10.1016/j.cmet.2018.12.007_bib2) 2006; 55 Sabag (10.1016/j.cmet.2018.12.007_bib29) 2017; 43 Haffner (10.1016/j.cmet.2018.12.007_bib14) 2007; 120 Lang Lehrskov (10.1016/j.cmet.2018.12.007_bib17) 2018; 27 Olsen (10.1016/j.cmet.2018.12.007_bib22) 2008; 299 Wallenius (10.1016/j.cmet.2018.12.007_bib39) 2002; 8 Christensen (10.1016/j.cmet.2018.12.007_bib3) 2018; 19 Koo (10.1016/j.cmet.2018.12.007_bib46) 2016; 15 Fox (10.1016/j.cmet.2018.12.007_bib13) 2007; 116 Benatti (10.1016/j.cmet.2018.12.007_bib1) 2015; 11 Lancaster (10.1016/j.cmet.2018.12.007_bib47) 1991; 1 Yudkin (10.1016/j.cmet.2018.12.007_bib43) 2005; 365 Ma (10.1016/j.cmet.2018.12.007_bib19) 2016; 88 Positano (10.1016/j.cmet.2018.12.007_bib49) 2004; 20 Garber (10.1016/j.cmet.2018.12.007_bib45) 2011; 43 Pedersen (10.1016/j.cmet.2018.12.007_bib25) 2008; 88 Serrano (10.1016/j.cmet.2018.12.007_bib30) 2008; 7 Pischon (10.1016/j.cmet.2018.12.007_bib28) 2008; 359 Steensberg (10.1016/j.cmet.2018.12.007_bib32) 2000; 529 Lean (10.1016/j.cmet.2018.12.007_bib48) 1995; 311 Cottam (10.1016/j.cmet.2018.12.007_bib4) 2004; 14 de Glisezinski (10.1016/j.cmet.2018.12.007_bib5) 2009; 587 Ji (10.1016/j.cmet.2018.12.007_bib15) 2014; 97 Tremblay (10.1016/j.cmet.2018.12.007_bib50) 2017; 14 Petersen (10.1016/j.cmet.2018.12.007_bib27) 2005; 288 Fäldt (10.1016/j.cmet.2018.12.007_bib9) 2004; 145 Suwa (10.1016/j.cmet.2018.12.007_bib34) 2000; 279 Després (10.1016/j.cmet.2018.12.007_bib6) 2001; 322 Ference (10.1016/j.cmet.2018.12.007_bib11) 2017; 38 Vickers (10.1016/j.cmet.2018.12.007_bib38) 2001; 323 Pedersen (10.1016/j.cmet.2018.12.007_bib24) 2007; 102 Nordby (10.1016/j.cmet.2018.12.007_bib21) 2012; 20 Unver (10.1016/j.cmet.2018.12.007_bib36) 2018; 41 Fidanza (10.1016/j.cmet.2018.12.007_bib12) 1953; 6 Petersen (10.1016/j.cmet.2018.12.007_bib26) 2005; 98 30675026 - Nat Rev Gastroenterol Hepatol. 2019 Mar;16(3):140 30792542 - Nat Rev Rheumatol. 2019 Apr;15(4):192-194 |
| References_xml | – volume: 371 start-page: 987 year: 2008 end-page: 997 ident: bib31 article-title: Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial publication-title: Lancet – volume: 71 start-page: 1057 year: 2008 end-page: 1064 ident: bib42 article-title: Central obesity and increased risk of dementia more than three decades later publication-title: Neurology – volume: 43 start-page: 195 year: 2017 end-page: 210 ident: bib29 article-title: Exercise and ectopic fat in type 2 diabetes: a systematic review and meta-analysis publication-title: Diabetes Metab. – volume: 9 start-page: e85276 year: 2014 ident: bib7 article-title: End criteria for reaching maximal oxygen uptake must be strict and adjusted to sex and age: a cross-sectional study publication-title: PLoS One – volume: 36 start-page: 1259 year: 2004 end-page: 1266 ident: bib51 article-title: Defining accelerometer thresholds for activity intensities in adolescent girls publication-title: Med. Sci. Sports Exerc. – volume: 41 start-page: 10 year: 2018 end-page: 17 ident: bib36 article-title: IL-6 family cytokines: key inflammatory mediators as biomarkers and potential therapeutic targets publication-title: Cytokine Growth Factor Rev. – volume: 359 start-page: 2105 year: 2008 end-page: 2120 ident: bib28 article-title: General and abdominal adiposity and risk of death in Europe publication-title: N. Engl. J. Med. – volume: 38 start-page: 2459 year: 2017 end-page: 2472 ident: bib11 article-title: Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel publication-title: Eur. Heart J. – volume: 20 start-page: 684 year: 2004 end-page: 689 ident: bib49 article-title: An accurate and robust method for unsupervised assessment of abdominal fat by MRI publication-title: J. Magn. Reson. Imaging – volume: 299 start-page: 1261 year: 2008 end-page: 1263 ident: bib22 article-title: Metabolic responses to reduced daily steps in healthy nonexercising men publication-title: JAMA – volume: 15 start-page: 155 year: 2016 end-page: 163 ident: bib46 article-title: CA Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research publication-title: J. Chiropr. Med. – volume: 56 start-page: 541 year: 2017 end-page: 549 ident: bib20 article-title: Effect of tocilizumab on neutrophils in adult patients with rheumatoid arthritis: pooled analysis of data from phase 3 and 4 clinical trials publication-title: Rheumatology (Oxford) – volume: 97 start-page: 3441 year: 2014 end-page: 3448 ident: bib15 article-title: Inflammation- and lipid metabolism-related gene network expression in visceral and subcutaneous adipose depots of Holstein cows publication-title: J. Dairy Sci. – volume: 88 start-page: 126 year: 2016 end-page: 135 ident: bib19 article-title: Role of interleukin-6 to differentiate sepsis from non-infectious systemic inflammatory response syndrome publication-title: Cytokine – volume: 27 start-page: 1201 year: 2018 end-page: 1211.e3 ident: bib17 article-title: Interleukin-6 delays gastric emptying in humans with direct effects on glycemic control publication-title: Cell Metab. – volume: 88 start-page: 1379 year: 2008 end-page: 1406 ident: bib25 article-title: Muscle as an endocrine organ: focus on muscle-derived interleukin-6 publication-title: Physiol. Rev. – volume: 13 start-page: e0190645 year: 2018 ident: bib41 article-title: Low fitness is associated with abdominal adiposity and low-grade inflammation independent of BMI publication-title: PLoS One – volume: 279 start-page: H2954 year: 2000 end-page: H2960 ident: bib34 article-title: Interleukin-6 induces demargination of intravascular neutrophils and shortens their transit in marrow publication-title: Am. J. Physiol. Heart Circ. Physiol. – volume: 279 start-page: E585 year: 2000 end-page: E592 ident: bib8 article-title: Effect of exercise training on in vivo lipolysis in intra-abdominal adipose tissue in rats publication-title: Am. J. Physiol. Endocrinol. Metab. – volume: 1 start-page: 363 year: 1991 end-page: 369 ident: bib47 article-title: Measurement of abdominal fat with T1-weighted MR images publication-title: J. Magn. Reson. Imaging – volume: 43 start-page: 1334 year: 2011 end-page: 1359 ident: bib45 article-title: American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise publication-title: Med. Sci. Sports Exerc. – volume: 55 start-page: 2688 year: 2006 end-page: 2697 ident: bib2 article-title: Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase publication-title: Diabetes – volume: 587 start-page: 3393 year: 2009 end-page: 3404 ident: bib5 article-title: Adrenaline but not noradrenaline is a determinant of exercise-induced lipid mobilization in human subcutaneous adipose tissue publication-title: J. Physiol. – volume: 117 start-page: 1658 year: 2008 end-page: 1667 ident: bib44 article-title: Abdominal obesity and the risk of all-cause, cardiovascular, and cancer mortality: sixteen years of follow-up in US women publication-title: Circulation – volume: 6 start-page: 252 year: 1953 end-page: 256 ident: bib12 article-title: Density of body fat in man and other mammals publication-title: J. Appl. Physiol. – volume: 98 start-page: 1154 year: 2005 end-page: 1162 ident: bib26 article-title: The anti-inflammatory effect of exercise publication-title: J. Appl. Physiol. – volume: 53 start-page: 1643 year: 2004 end-page: 1648 ident: bib10 article-title: Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction publication-title: Diabetes – volume: 508 start-page: 949 year: 1998 end-page: 953 ident: bib23 article-title: Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running publication-title: J. Physiol. – volume: 102 start-page: 814 year: 2007 end-page: 816 ident: bib24 article-title: Point: Interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis publication-title: J. Appl. Physiol. – volume: 11 start-page: 86 year: 2015 end-page: 97 ident: bib1 article-title: Exercise as an anti-inflammatory therapy for rheumatic diseases-myokine regulation publication-title: Nat. Rev. Rheumatol. – volume: 88 start-page: 3005 year: 2003 end-page: 3010 ident: bib37 article-title: Interleukin-6 stimulates lipolysis and fat oxidation in humans publication-title: J. Clin. Endocrinol. Metab. – volume: 14 start-page: 589 year: 2004 end-page: 600 ident: bib4 article-title: The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: implications and effects of weight loss publication-title: Obes. Surg. – volume: 120 start-page: S10 year: 2007 end-page: S16 ident: bib14 article-title: Abdominal adiposity and cardiometabolic risk: do we have all the answers? publication-title: Am. J. Med. – volume: 26 start-page: 171 year: 2017 end-page: 184.e6 ident: bib35 article-title: IL-6/Stat3-dependent induction of a distinct, obesity-associated NK cell subpopulation deteriorates energy and glucose homeostasis publication-title: Cell Metab. – volume: 145 start-page: 2680 year: 2004 end-page: 2686 ident: bib9 article-title: Reduced exercise endurance in interleukin-6-deficient mice publication-title: Endocrinology – volume: 8 start-page: 75 year: 2002 end-page: 79 ident: bib39 article-title: Interleukin-6-deficient mice develop mature-onset obesity publication-title: Nat. Med. – volume: 322 start-page: 716 year: 2001 end-page: 720 ident: bib6 article-title: Treatment of obesity: need to focus on high risk abdominally obese patients publication-title: BMJ – volume: 14 start-page: 336 year: 2006 end-page: 341 ident: bib16 article-title: Visceral fat is an independent predictor of all-cause mortality in men publication-title: Obesity (Silver Spring) – volume: 365 start-page: 1817 year: 2005 end-page: 1820 ident: bib43 article-title: “Vasocrine” signalling from perivascular fat: a mechanism linking insulin resistance to vascular disease publication-title: Lancet – volume: 311 start-page: 158 year: 1995 end-page: 161 ident: bib48 article-title: Waist circumference as a measure for indicating need for weight management publication-title: BMJ – volume: 14 start-page: 75 year: 2017 ident: bib50 article-title: Sedentary Behavior Research Network (SBRN) - Terminology Consensus Project process and outcome publication-title: Int. J. Behav. Nutr. Phys. Act. – volume: 288 start-page: E155 year: 2005 end-page: E162 ident: bib27 article-title: Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro publication-title: Am. J. Physiol. Endocrinol. Metab. – volume: 285 start-page: E433 year: 2003 end-page: E437 ident: bib33 article-title: IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans publication-title: Am. J. Physiol. Endocrinol. Metab. – volume: 529 start-page: 237 year: 2000 end-page: 242 ident: bib32 article-title: Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6 publication-title: J. Physiol. – volume: 20 start-page: 2202 year: 2012 end-page: 2212 ident: bib21 article-title: Endurance training per se increases metabolic health in young, moderately overweight men publication-title: Obesity (Silver Spring) – volume: 323 start-page: 1123 year: 2001 end-page: 1124 ident: bib38 article-title: Statistics notes: analysing controlled trials with baseline and follow up measurements publication-title: BMJ – volume: 48 start-page: 105 year: 2005 end-page: 112 ident: bib40 article-title: Hormone-sensitive lipase is reduced in the adipose tissue of patients with type 2 diabetes mellitus: influence of IL-6 infusion publication-title: Diabetologia – volume: 7 start-page: 33 year: 2008 end-page: 44 ident: bib30 article-title: Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy publication-title: Cell Metab. – volume: 116 start-page: 39 year: 2007 end-page: 48 ident: bib13 article-title: Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study publication-title: Circulation – volume: 19 start-page: 266 year: 2018 ident: bib3 article-title: The role of exercise combined with tocilizumab in visceral and epicardial adipose tissue and gastric emptying rate in abdominally obese participants: protocol for a randomised controlled trial publication-title: Trials – volume: 71 start-page: 1057 year: 2008 ident: 10.1016/j.cmet.2018.12.007_bib42 article-title: Central obesity and increased risk of dementia more than three decades later publication-title: Neurology doi: 10.1212/01.wnl.0000306313.89165.ef – volume: 19 start-page: 266 year: 2018 ident: 10.1016/j.cmet.2018.12.007_bib3 article-title: The role of exercise combined with tocilizumab in visceral and epicardial adipose tissue and gastric emptying rate in abdominally obese participants: protocol for a randomised controlled trial publication-title: Trials doi: 10.1186/s13063-018-2637-0 – volume: 97 start-page: 3441 year: 2014 ident: 10.1016/j.cmet.2018.12.007_bib15 article-title: Inflammation- and lipid metabolism-related gene network expression in visceral and subcutaneous adipose depots of Holstein cows publication-title: J. Dairy Sci. doi: 10.3168/jds.2013-7296 – volume: 13 start-page: e0190645 year: 2018 ident: 10.1016/j.cmet.2018.12.007_bib41 article-title: Low fitness is associated with abdominal adiposity and low-grade inflammation independent of BMI publication-title: PLoS One doi: 10.1371/journal.pone.0190645 – volume: 508 start-page: 949 year: 1998 ident: 10.1016/j.cmet.2018.12.007_bib23 article-title: Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running publication-title: J. Physiol. doi: 10.1111/j.1469-7793.1998.949bp.x – volume: 15 start-page: 155 year: 2016 ident: 10.1016/j.cmet.2018.12.007_bib46 article-title: CA Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research publication-title: J. Chiropr. Med. doi: 10.1016/j.jcm.2016.02.012 – volume: 98 start-page: 1154 year: 2005 ident: 10.1016/j.cmet.2018.12.007_bib26 article-title: The anti-inflammatory effect of exercise publication-title: J. Appl. Physiol. doi: 10.1152/japplphysiol.00164.2004 – volume: 20 start-page: 684 year: 2004 ident: 10.1016/j.cmet.2018.12.007_bib49 article-title: An accurate and robust method for unsupervised assessment of abdominal fat by MRI publication-title: J. Magn. Reson. Imaging doi: 10.1002/jmri.20167 – volume: 48 start-page: 105 year: 2005 ident: 10.1016/j.cmet.2018.12.007_bib40 article-title: Hormone-sensitive lipase is reduced in the adipose tissue of patients with type 2 diabetes mellitus: influence of IL-6 infusion publication-title: Diabetologia doi: 10.1007/s00125-004-1598-x – volume: 371 start-page: 987 year: 2008 ident: 10.1016/j.cmet.2018.12.007_bib31 article-title: Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial publication-title: Lancet doi: 10.1016/S0140-6736(08)60453-5 – volume: 43 start-page: 1334 year: 2011 ident: 10.1016/j.cmet.2018.12.007_bib45 article-title: American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise publication-title: Med. Sci. Sports Exerc. doi: 10.1249/MSS.0b013e318213fefb – volume: 102 start-page: 814 year: 2007 ident: 10.1016/j.cmet.2018.12.007_bib24 article-title: Point: Interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis publication-title: J. Appl. Physiol. doi: 10.1152/japplphysiol.01208.2006 – volume: 9 start-page: e85276 year: 2014 ident: 10.1016/j.cmet.2018.12.007_bib7 article-title: End criteria for reaching maximal oxygen uptake must be strict and adjusted to sex and age: a cross-sectional study publication-title: PLoS One doi: 10.1371/journal.pone.0085276 – volume: 14 start-page: 589 year: 2004 ident: 10.1016/j.cmet.2018.12.007_bib4 article-title: The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: implications and effects of weight loss publication-title: Obes. Surg. doi: 10.1381/096089204323093345 – volume: 587 start-page: 3393 year: 2009 ident: 10.1016/j.cmet.2018.12.007_bib5 article-title: Adrenaline but not noradrenaline is a determinant of exercise-induced lipid mobilization in human subcutaneous adipose tissue publication-title: J. Physiol. doi: 10.1113/jphysiol.2009.168906 – volume: 365 start-page: 1817 year: 2005 ident: 10.1016/j.cmet.2018.12.007_bib43 article-title: “Vasocrine” signalling from perivascular fat: a mechanism linking insulin resistance to vascular disease publication-title: Lancet doi: 10.1016/S0140-6736(05)66585-3 – volume: 56 start-page: 541 year: 2017 ident: 10.1016/j.cmet.2018.12.007_bib20 article-title: Effect of tocilizumab on neutrophils in adult patients with rheumatoid arthritis: pooled analysis of data from phase 3 and 4 clinical trials publication-title: Rheumatology (Oxford) – volume: 359 start-page: 2105 year: 2008 ident: 10.1016/j.cmet.2018.12.007_bib28 article-title: General and abdominal adiposity and risk of death in Europe publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa0801891 – volume: 279 start-page: E585 year: 2000 ident: 10.1016/j.cmet.2018.12.007_bib8 article-title: Effect of exercise training on in vivo lipolysis in intra-abdominal adipose tissue in rats publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.2000.279.3.E585 – volume: 288 start-page: E155 year: 2005 ident: 10.1016/j.cmet.2018.12.007_bib27 article-title: Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00257.2004 – volume: 7 start-page: 33 year: 2008 ident: 10.1016/j.cmet.2018.12.007_bib30 article-title: Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy publication-title: Cell Metab. doi: 10.1016/j.cmet.2007.11.011 – volume: 14 start-page: 75 year: 2017 ident: 10.1016/j.cmet.2018.12.007_bib50 article-title: Sedentary Behavior Research Network (SBRN) - Terminology Consensus Project process and outcome publication-title: Int. J. Behav. Nutr. Phys. Act. doi: 10.1186/s12966-017-0525-8 – volume: 529 start-page: 237 year: 2000 ident: 10.1016/j.cmet.2018.12.007_bib32 article-title: Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6 publication-title: J. Physiol. doi: 10.1111/j.1469-7793.2000.00237.x – volume: 20 start-page: 2202 year: 2012 ident: 10.1016/j.cmet.2018.12.007_bib21 article-title: Endurance training per se increases metabolic health in young, moderately overweight men publication-title: Obesity (Silver Spring) doi: 10.1038/oby.2012.70 – volume: 285 start-page: E433 year: 2003 ident: 10.1016/j.cmet.2018.12.007_bib33 article-title: IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00074.2003 – volume: 11 start-page: 86 year: 2015 ident: 10.1016/j.cmet.2018.12.007_bib1 article-title: Exercise as an anti-inflammatory therapy for rheumatic diseases-myokine regulation publication-title: Nat. Rev. Rheumatol. doi: 10.1038/nrrheum.2014.193 – volume: 299 start-page: 1261 year: 2008 ident: 10.1016/j.cmet.2018.12.007_bib22 article-title: Metabolic responses to reduced daily steps in healthy nonexercising men publication-title: JAMA doi: 10.1001/jama.299.11.1259 – volume: 88 start-page: 126 year: 2016 ident: 10.1016/j.cmet.2018.12.007_bib19 article-title: Role of interleukin-6 to differentiate sepsis from non-infectious systemic inflammatory response syndrome publication-title: Cytokine doi: 10.1016/j.cyto.2016.08.033 – volume: 322 start-page: 716 year: 2001 ident: 10.1016/j.cmet.2018.12.007_bib6 article-title: Treatment of obesity: need to focus on high risk abdominally obese patients publication-title: BMJ doi: 10.1136/bmj.322.7288.716 – volume: 55 start-page: 2688 year: 2006 ident: 10.1016/j.cmet.2018.12.007_bib2 article-title: Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase publication-title: Diabetes doi: 10.2337/db05-1404 – volume: 53 start-page: 1643 year: 2004 ident: 10.1016/j.cmet.2018.12.007_bib10 article-title: Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction publication-title: Diabetes doi: 10.2337/diabetes.53.7.1643 – volume: 6 start-page: 252 year: 1953 ident: 10.1016/j.cmet.2018.12.007_bib12 article-title: Density of body fat in man and other mammals publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1953.6.4.252 – volume: 88 start-page: 3005 year: 2003 ident: 10.1016/j.cmet.2018.12.007_bib37 article-title: Interleukin-6 stimulates lipolysis and fat oxidation in humans publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2002-021687 – volume: 27 start-page: 1201 year: 2018 ident: 10.1016/j.cmet.2018.12.007_bib17 article-title: Interleukin-6 delays gastric emptying in humans with direct effects on glycemic control publication-title: Cell Metab. doi: 10.1016/j.cmet.2018.04.008 – volume: 323 start-page: 1123 year: 2001 ident: 10.1016/j.cmet.2018.12.007_bib38 article-title: Statistics notes: analysing controlled trials with baseline and follow up measurements publication-title: BMJ doi: 10.1136/bmj.323.7321.1123 – volume: 43 start-page: 195 year: 2017 ident: 10.1016/j.cmet.2018.12.007_bib29 article-title: Exercise and ectopic fat in type 2 diabetes: a systematic review and meta-analysis publication-title: Diabetes Metab. doi: 10.1016/j.diabet.2016.12.006 – volume: 38 start-page: 2459 year: 2017 ident: 10.1016/j.cmet.2018.12.007_bib11 article-title: Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel publication-title: Eur. Heart J. doi: 10.1093/eurheartj/ehx144 – volume: 117 start-page: 1658 year: 2008 ident: 10.1016/j.cmet.2018.12.007_bib44 article-title: Abdominal obesity and the risk of all-cause, cardiovascular, and cancer mortality: sixteen years of follow-up in US women publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.107.739714 – volume: 36 start-page: 1259 year: 2004 ident: 10.1016/j.cmet.2018.12.007_bib51 article-title: Defining accelerometer thresholds for activity intensities in adolescent girls publication-title: Med. Sci. Sports Exerc. – volume: 279 start-page: H2954 year: 2000 ident: 10.1016/j.cmet.2018.12.007_bib34 article-title: Interleukin-6 induces demargination of intravascular neutrophils and shortens their transit in marrow publication-title: Am. J. Physiol. Heart Circ. Physiol. doi: 10.1152/ajpheart.2000.279.6.H2954 – volume: 8 start-page: 75 year: 2002 ident: 10.1016/j.cmet.2018.12.007_bib39 article-title: Interleukin-6-deficient mice develop mature-onset obesity publication-title: Nat. Med. doi: 10.1038/nm0102-75 – volume: 88 start-page: 1379 year: 2008 ident: 10.1016/j.cmet.2018.12.007_bib25 article-title: Muscle as an endocrine organ: focus on muscle-derived interleukin-6 publication-title: Physiol. Rev. doi: 10.1152/physrev.90100.2007 – volume: 41 start-page: 10 year: 2018 ident: 10.1016/j.cmet.2018.12.007_bib36 article-title: IL-6 family cytokines: key inflammatory mediators as biomarkers and potential therapeutic targets publication-title: Cytokine Growth Factor Rev. doi: 10.1016/j.cytogfr.2018.04.004 – volume: 116 start-page: 39 year: 2007 ident: 10.1016/j.cmet.2018.12.007_bib13 article-title: Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.106.675355 – volume: 120 start-page: S10 issue: 9, Suppl 1 year: 2007 ident: 10.1016/j.cmet.2018.12.007_bib14 article-title: Abdominal adiposity and cardiometabolic risk: do we have all the answers? publication-title: Am. J. Med. doi: 10.1016/j.amjmed.2007.06.006 – volume: 14 start-page: 336 year: 2006 ident: 10.1016/j.cmet.2018.12.007_bib16 article-title: Visceral fat is an independent predictor of all-cause mortality in men publication-title: Obesity (Silver Spring) doi: 10.1038/oby.2006.43 – volume: 145 start-page: 2680 year: 2004 ident: 10.1016/j.cmet.2018.12.007_bib9 article-title: Reduced exercise endurance in interleukin-6-deficient mice publication-title: Endocrinology doi: 10.1210/en.2003-1319 – volume: 311 start-page: 158 year: 1995 ident: 10.1016/j.cmet.2018.12.007_bib48 article-title: Waist circumference as a measure for indicating need for weight management publication-title: BMJ doi: 10.1136/bmj.311.6998.158 – volume: 26 start-page: 171 year: 2017 ident: 10.1016/j.cmet.2018.12.007_bib35 article-title: IL-6/Stat3-dependent induction of a distinct, obesity-associated NK cell subpopulation deteriorates energy and glucose homeostasis publication-title: Cell Metab. doi: 10.1016/j.cmet.2017.05.018 – volume: 1 start-page: 363 year: 1991 ident: 10.1016/j.cmet.2018.12.007_bib47 article-title: Measurement of abdominal fat with T1-weighted MR images publication-title: J. Magn. Reson. Imaging doi: 10.1002/jmri.1880010315 – reference: 30792542 - Nat Rev Rheumatol. 2019 Apr;15(4):192-194 – reference: 30675026 - Nat Rev Gastroenterol Hepatol. 2019 Mar;16(3):140 |
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| Title | Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial |
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