Effects of acute angiotensin‐converting enzyme inhibition on diastolic ventricular interaction in the dilated heart
Background: The normal and dilated heart behaves as a single functional unit during preload reduction; volume unloading in the setting of diastolic ventricular interaction allows for increased left ventricular (LV) filling. Hypothesis: We hypothesized that reduction of venous return induced by a phy...
Saved in:
| Published in | Clinical cardiology (Mahwah, N.J.) Vol. 26; no. 9; pp. 424 - 430 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Wiley Periodicals, Inc
01.09.2003
Wiley |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0160-9289 1932-8737 |
| DOI | 10.1002/clc.4960260909 |
Cover
| Abstract | Background: The normal and dilated heart behaves as a single functional unit during preload reduction; volume unloading in the setting of diastolic ventricular interaction allows for increased left ventricular (LV) filling.
Hypothesis: We hypothesized that reduction of venous return induced by a physiologic stimulus (tilting) or by acute angiotensin‐converting enzyme (ACE) inhibitors in dilated heart is likely to have a marked and similar effect on ventricular chamber geometry and filling. This study was designed to assess how the normal and dilated heart adapts to preload reduction.
Methods: Twenty normal subjects and 20 patients with moderate heart failure due to dilated cardiomyopathy were studied with two‐dimensional and Doppler echocardiography in supine position (B) and after 40° of head‐up tilting (T). The following day, patients repeated supine (C) and tilting test (TC) after administration of captopril (25 mgs.1.). Right ventricular (RV) and LV dimensions, LV geometry, and tricuspid, mitral, and pulmonary venous flow patterns were recorded at each step of the study.
Results: In the two groups, T was associated with reduction of RV area and LV volumes; C and TC produced a similar effect on RV and LV. Changes in LV septal‐lateral diameter and anterior‐posterior diameter were different at each step of the study: during T (both groups) and after C and TC, the septallateral diameter increased slightly while the anterior‐posterior diameter decreased. During T, mitral and tricuspid peak flow velocities decreased, peak late velocities were unchanged, and the deceleration time of mitral flow increased; the systolic forward flow of pulmonary venous flow decreased, the diastolic forward flow did not change, and the difference in duration between reverse pulmonary flow and mitral peak late flow decreased; C and CT induced similar changes.
Conclusion: Preload reduction induced by tilting or by ACE inhibitors induces profound and similar effects on LV and RV dimensions, LV geometry, and biventricular filling. Reduction of RV dimension is associated with adaptation of LV geometry and decrease of LV diastolic pressure, which facilitates LV filling and pulmonary venous drainage; ACE inhibition associated with tilting exerts an additional effect on these changes. These data confirm the role of ventricular interaction in modulating LV filling in heart failure. |
|---|---|
| AbstractList | The normal and dilated heart behaves as a single functional unit during preload reduction: volume unloading in the setting of diastolic ventricular interaction allows for increased left ventricular (LV) filling.
We hypothesized that reduction of venous return induced by a physiologic stimulus (tilting) or by acute angiotensin-converting enzyme (ACE) inhibitors in dilated heart is likely to have a marked and similar effect on ventricular chamber geometry and filling. This study was designed to assess how the normal and dilated heart adapts to preload reduction.
Twenty normal subjects and 20 patients with moderate heart failure due to dilated cardiomyopathy were studied with two-dimensional and Doppler echocardiography in supine position (B) and after 40 degrees of head-up tilting (T). The following day, patients repeated supine (C) and tilting test (TC) after administration of captopril (25 mg s.l.). Right ventricular (RV) and LV dimensions, LV geometry, and tricuspid, mitral, and pulmonary venous flow patterns were recorded at each step of the study.
In the two groups, T was associated with reduction of RV area and LV volumes; C and TC produced a similar effect on RV and LV. Changes in LV septal-lateral diameter and anterior-posterior diameter were different at each step of the study: during T (both groups) and after C and TC, the septallateral diameter increased slightly while the anterior-posterior diameter decreased. During T, mitral and tricuspid peak flow velocities decreased, peak late velocities were unchanged, and the deceleration time of mitral flow increased; the systolic forward flow of pulmonary venous flow decreased, the diastolic forward flow did not change, and the difference in duration between reverse pulmonary flow and mitral peak late flow decreased: C and CT induced similar changes.
Preload reduction induced by tilting or by ACE inhibitors induces profound and similar effects on LV and RV dimensions, LV geometry, and biventricular filling. Reduction of RV dimension is associated with adaptation of LV geometry and decrease of LV diastolic pressure, which facilitates LV filling and pulmonary venous drainage: ACE inhibition associated with tilting exerts an additional effect on these changes. These data confirm the role of ventricular interaction in modulating LV filling in heart failure. Background : The normal and dilated heart behaves as a single functional unit during preload reduction; volume unloading in the setting of diastolic ventricular interaction allows for increased left ventricular (LV) filling. Hypothesis : We hypothesized that reduction of venous return induced by a physiologic stimulus (tilting) or by acute angiotensin‐converting enzyme (ACE) inhibitors in dilated heart is likely to have a marked and similar effect on ventricular chamber geometry and filling. This study was designed to assess how the normal and dilated heart adapts to preload reduction. Methods : Twenty normal subjects and 20 patients with moderate heart failure due to dilated cardiomyopathy were studied with two‐dimensional and Doppler echocardiography in supine position (B) and after 40° of head‐up tilting (T). The following day, patients repeated supine (C) and tilting test (TC) after administration of captopril (25 mgs.1.). Right ventricular (RV) and LV dimensions, LV geometry, and tricuspid, mitral, and pulmonary venous flow patterns were recorded at each step of the study. Results : In the two groups, T was associated with reduction of RV area and LV volumes; C and TC produced a similar effect on RV and LV. Changes in LV septal‐lateral diameter and anterior‐posterior diameter were different at each step of the study: during T (both groups) and after C and TC, the septallateral diameter increased slightly while the anterior‐posterior diameter decreased. During T, mitral and tricuspid peak flow velocities decreased, peak late velocities were unchanged, and the deceleration time of mitral flow increased; the systolic forward flow of pulmonary venous flow decreased, the diastolic forward flow did not change, and the difference in duration between reverse pulmonary flow and mitral peak late flow decreased; C and CT induced similar changes. Conclusion : Preload reduction induced by tilting or by ACE inhibitors induces profound and similar effects on LV and RV dimensions, LV geometry, and biventricular filling. Reduction of RV dimension is associated with adaptation of LV geometry and decrease of LV diastolic pressure, which facilitates LV filling and pulmonary venous drainage; ACE inhibition associated with tilting exerts an additional effect on these changes. These data confirm the role of ventricular interaction in modulating LV filling in heart failure. Background: The normal and dilated heart behaves as a single functional unit during preload reduction; volume unloading in the setting of diastolic ventricular interaction allows for increased left ventricular (LV) filling. Hypothesis: We hypothesized that reduction of venous return induced by a physiologic stimulus (tilting) or by acute angiotensin‐converting enzyme (ACE) inhibitors in dilated heart is likely to have a marked and similar effect on ventricular chamber geometry and filling. This study was designed to assess how the normal and dilated heart adapts to preload reduction. Methods: Twenty normal subjects and 20 patients with moderate heart failure due to dilated cardiomyopathy were studied with two‐dimensional and Doppler echocardiography in supine position (B) and after 40° of head‐up tilting (T). The following day, patients repeated supine (C) and tilting test (TC) after administration of captopril (25 mgs.1.). Right ventricular (RV) and LV dimensions, LV geometry, and tricuspid, mitral, and pulmonary venous flow patterns were recorded at each step of the study. Results: In the two groups, T was associated with reduction of RV area and LV volumes; C and TC produced a similar effect on RV and LV. Changes in LV septal‐lateral diameter and anterior‐posterior diameter were different at each step of the study: during T (both groups) and after C and TC, the septallateral diameter increased slightly while the anterior‐posterior diameter decreased. During T, mitral and tricuspid peak flow velocities decreased, peak late velocities were unchanged, and the deceleration time of mitral flow increased; the systolic forward flow of pulmonary venous flow decreased, the diastolic forward flow did not change, and the difference in duration between reverse pulmonary flow and mitral peak late flow decreased; C and CT induced similar changes. Conclusion: Preload reduction induced by tilting or by ACE inhibitors induces profound and similar effects on LV and RV dimensions, LV geometry, and biventricular filling. Reduction of RV dimension is associated with adaptation of LV geometry and decrease of LV diastolic pressure, which facilitates LV filling and pulmonary venous drainage; ACE inhibition associated with tilting exerts an additional effect on these changes. These data confirm the role of ventricular interaction in modulating LV filling in heart failure. The normal and dilated heart behaves as a single functional unit during preload reduction: volume unloading in the setting of diastolic ventricular interaction allows for increased left ventricular (LV) filling.BACKGROUNDThe normal and dilated heart behaves as a single functional unit during preload reduction: volume unloading in the setting of diastolic ventricular interaction allows for increased left ventricular (LV) filling.We hypothesized that reduction of venous return induced by a physiologic stimulus (tilting) or by acute angiotensin-converting enzyme (ACE) inhibitors in dilated heart is likely to have a marked and similar effect on ventricular chamber geometry and filling. This study was designed to assess how the normal and dilated heart adapts to preload reduction.HYPOTHESISWe hypothesized that reduction of venous return induced by a physiologic stimulus (tilting) or by acute angiotensin-converting enzyme (ACE) inhibitors in dilated heart is likely to have a marked and similar effect on ventricular chamber geometry and filling. This study was designed to assess how the normal and dilated heart adapts to preload reduction.Twenty normal subjects and 20 patients with moderate heart failure due to dilated cardiomyopathy were studied with two-dimensional and Doppler echocardiography in supine position (B) and after 40 degrees of head-up tilting (T). The following day, patients repeated supine (C) and tilting test (TC) after administration of captopril (25 mg s.l.). Right ventricular (RV) and LV dimensions, LV geometry, and tricuspid, mitral, and pulmonary venous flow patterns were recorded at each step of the study.METHODSTwenty normal subjects and 20 patients with moderate heart failure due to dilated cardiomyopathy were studied with two-dimensional and Doppler echocardiography in supine position (B) and after 40 degrees of head-up tilting (T). The following day, patients repeated supine (C) and tilting test (TC) after administration of captopril (25 mg s.l.). Right ventricular (RV) and LV dimensions, LV geometry, and tricuspid, mitral, and pulmonary venous flow patterns were recorded at each step of the study.In the two groups, T was associated with reduction of RV area and LV volumes; C and TC produced a similar effect on RV and LV. Changes in LV septal-lateral diameter and anterior-posterior diameter were different at each step of the study: during T (both groups) and after C and TC, the septallateral diameter increased slightly while the anterior-posterior diameter decreased. During T, mitral and tricuspid peak flow velocities decreased, peak late velocities were unchanged, and the deceleration time of mitral flow increased; the systolic forward flow of pulmonary venous flow decreased, the diastolic forward flow did not change, and the difference in duration between reverse pulmonary flow and mitral peak late flow decreased: C and CT induced similar changes.RESULTSIn the two groups, T was associated with reduction of RV area and LV volumes; C and TC produced a similar effect on RV and LV. Changes in LV septal-lateral diameter and anterior-posterior diameter were different at each step of the study: during T (both groups) and after C and TC, the septallateral diameter increased slightly while the anterior-posterior diameter decreased. During T, mitral and tricuspid peak flow velocities decreased, peak late velocities were unchanged, and the deceleration time of mitral flow increased; the systolic forward flow of pulmonary venous flow decreased, the diastolic forward flow did not change, and the difference in duration between reverse pulmonary flow and mitral peak late flow decreased: C and CT induced similar changes.Preload reduction induced by tilting or by ACE inhibitors induces profound and similar effects on LV and RV dimensions, LV geometry, and biventricular filling. Reduction of RV dimension is associated with adaptation of LV geometry and decrease of LV diastolic pressure, which facilitates LV filling and pulmonary venous drainage: ACE inhibition associated with tilting exerts an additional effect on these changes. These data confirm the role of ventricular interaction in modulating LV filling in heart failure.CONCLUSIONPreload reduction induced by tilting or by ACE inhibitors induces profound and similar effects on LV and RV dimensions, LV geometry, and biventricular filling. Reduction of RV dimension is associated with adaptation of LV geometry and decrease of LV diastolic pressure, which facilitates LV filling and pulmonary venous drainage: ACE inhibition associated with tilting exerts an additional effect on these changes. These data confirm the role of ventricular interaction in modulating LV filling in heart failure. |
| Author | Muratori, Manuela Susini, Francesca Tamborini, Gloria Celeste, Fabrizio Pepi, Mauro Maltagliati, Anna Berna, Giovanni Guazzi, Marco |
| AuthorAffiliation | 1 Centro Cardiologico Monzino, IRCCS, Istituto di Cardiologia dell'Università degli Studi, Milan, Italy |
| AuthorAffiliation_xml | – name: 1 Centro Cardiologico Monzino, IRCCS, Istituto di Cardiologia dell'Università degli Studi, Milan, Italy |
| Author_xml | – sequence: 1 givenname: Mauro surname: Pepi fullname: Pepi, Mauro email: mpepi@cardiologicomonzino.it – sequence: 2 givenname: Gloria surname: Tamborini fullname: Tamborini, Gloria – sequence: 3 givenname: Anna surname: Maltagliati fullname: Maltagliati, Anna – sequence: 4 givenname: Marco surname: Guazzi fullname: Guazzi, Marco – sequence: 5 givenname: Giovanni surname: Berna fullname: Berna, Giovanni – sequence: 6 givenname: Francesca surname: Susini fullname: Susini, Francesca – sequence: 7 givenname: Manuela surname: Muratori fullname: Muratori, Manuela – sequence: 8 givenname: Fabrizio surname: Celeste fullname: Celeste, Fabrizio |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15105947$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/14524600$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkUFvEzEQhS1URNPAlSPaC9wSvLteO74goagFpEhc4GzNeseJkWMX25sqnPgJ_Mb-EhwS2oKEkCz5MN97M3rvgpz54JGQ5zWd15Q2r7XTcyY5bTiVVD4ik1q2zWwhWnFGJrTmdCabhTwnFyl9KTxdNO0Tcl6zrmGc0gkZL41BnVMVTAV6zFiBX9uQ0Sfrb7__0MHvMGbr1xX6b_stVtZvbG-zDb4qb7CQcnBWVzv0OVo9OoiFyRhB_4Ksr_IGC-gg41BtEGJ-Sh4bcAmfnf4p-Xx1-Wn5frb6-O7D8u1qphnnspxuWo5MQGuAMaA9DAP0nRjkwAa2qNFI2Qoq0VDd9sxwHLRuNKVaSFML3k7Jm6Pv9dhvy_BwIjh1He0W4l4FsOrPibcbtQ47xXnHuhLllLw6GcTwdcSU1dYmjc6BxzAmJTrBRNstCvji4aa7Fb-TLsDLEwBJgzMRvLbpnutq2sniNSXsyOkYUopolLYZDkmWA61TNVWH4lUpXt0XX2Tzv2R3zv8SyKPgxjrc_4dWy9XygfYnmLXFVQ |
| CODEN | CLCADC |
| CitedBy_id | crossref_primary_10_1139_h06_086 |
| Cites_doi | 10.1016/0735-1097(93)90195-7 10.1016/S0735-1097(97)00144-7 10.1002/clc.4960230907 10.1016/S0735-1097(97)00390-2 10.1136/hrt.70.2.135 10.1161/01.CIR.58.5.770 10.1161/01.CIR.92.4.819 10.1016/0735-1097(93)90388-H 10.1016/0735-1097(93)90787-2 10.1016/S0735-1097(98)00412-4 10.1016/0002-9149(90)90091-E 10.1046/j.1540-8175.2003.03020.x 10.1002/clc.4960190108 10.1161/01.CIR.90.6.2772 10.1161/01.CIR.84.3.977 10.1016/S1388-9842(99)00003-3 10.1016/0002-9149(90)90939-X 10.1161/01.RES.64.5.827 10.1016/S0140-6736(96)05109-4 10.1053/pcad.1999.0410265 10.1016/S0735-1097(98)00165-X 10.1016/0735-1097(95)00370-3 10.1161/01.CIR.95.5.1222 10.1056/NEJM199108013250501 10.1159/000470260 10.1016/0033-0620(81)90022-0 10.1016/S0735-1097(00)00698-7 10.1016/0735-1097(90)90356-T 10.1016/S0735-1097(97)00483-X 10.1161/01.CIR.76.4.875 10.1016/S0735-1097(87)80273-5 10.1016/S0735-1097(86)80263-7 10.1161/01.CIR.78.6.1459 10.1136/hrt.40.10.1134 |
| ContentType | Journal Article |
| Copyright | Copyright © 2003 Wiley Periodicals, Inc. 2004 INIST-CNRS |
| Copyright_xml | – notice: Copyright © 2003 Wiley Periodicals, Inc. – notice: 2004 INIST-CNRS |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.1002/clc.4960260909 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE CrossRef MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | Diastolic ventricular interaction in dilated heart |
| EISSN | 1932-8737 |
| EndPage | 430 |
| ExternalDocumentID | PMC6654519 14524600 15105947 10_1002_clc_4960260909 CLC4960260909 |
| Genre | article Journal Article Comparative Study |
| GroupedDBID | --- .GJ 05W 0R~ 10A 1OC 24P 29B 31~ 4.4 50Y 51W 51X 52M 52N 52P 52R 52S 52X 53G 5GY 5RE 5VS 7PT 7X7 8-1 8FI 8FJ 8UM AAHHS AAZKR ABCQN ABEML ABOCM ABUWG ACCFJ ACCMX ACSCC ACXQS ADBBV ADKYN ADZMN ADZOD AEEZP AENEX AEQDE AFBPY AFKRA AFPKN AHMBA AIWBW AJBDE ALAGY ALIPV ALMA_UNASSIGNED_HOLDINGS ALUQN AVUZU BCNDV BENPR BFHJK BY8 CCPQU CS3 DU5 EBS EJD EMOBN F5P FYUFA G-S GODZA GROUPED_DOAJ HF~ HMCUK HYE HZ~ IAO IHR INH ITC J0M LAW LC2 LC3 LH4 LW6 MY~ O9- OIG OK1 P6G PIMPY PQQKQ Q11 QRW RPM RX1 SUPJJ TR2 UKHRP WIN WQJ WXI XG1 XV2 ZGI ZXP AAFWJ AAYXX CITATION PHGZM PHGZT AAMMB AEFGJ AGXDD AIDQK AIDYY IQODW CGR CUY CVF ECM EIF NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c4669-92f36e47a3fa44a0baddab57d9d4d481ef993709ef0c3b4f6edcc2c00c79f1763 |
| ISSN | 0160-9289 |
| IngestDate | Thu Aug 21 14:08:47 EDT 2025 Fri Sep 05 11:11:36 EDT 2025 Wed Feb 19 02:31:56 EST 2025 Mon Jul 21 09:16:19 EDT 2025 Thu Apr 24 22:57:43 EDT 2025 Tue Jul 01 03:58:23 EDT 2025 Wed Jan 22 17:10:13 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Keywords | Sonography Human Prognosis Vasodilator agent Diastole Enzyme Enzyme inhibitor Cardiovascular disease angiotensin-converting enzyme inhibition Duplex ultrasonography Myocardial disease Peptidases Chemotherapy Treatment Doppler echocardiography Congestive hypertrophic cardiomyopathy Peptidyl-dipeptidase A Heart disease Hydrolases Medical imagery Peptidyl-dipeptidases Left ventricle performance ventricular interdependence dilated cardiomyopathy |
| Language | English |
| License | http://onlinelibrary.wiley.com/termsAndConditions#vor CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c4669-92f36e47a3fa44a0baddab57d9d4d481ef993709ef0c3b4f6edcc2c00c79f1763 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| OpenAccessLink | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/clc.4960260909 |
| PMID | 14524600 |
| PQID | 75747358 |
| PQPubID | 23479 |
| PageCount | 7 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_6654519 proquest_miscellaneous_75747358 pubmed_primary_14524600 pascalfrancis_primary_15105947 crossref_citationtrail_10_1002_clc_4960260909 crossref_primary_10_1002_clc_4960260909 wiley_primary_10_1002_clc_4960260909_CLC4960260909 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | September 2003 |
| PublicationDateYYYYMMDD | 2003-09-01 |
| PublicationDate_xml | – month: 09 year: 2003 text: September 2003 |
| PublicationDecade | 2000 |
| PublicationPlace | New York |
| PublicationPlace_xml | – name: New York – name: Hoboken, NJ – name: United States |
| PublicationTitle | Clinical cardiology (Mahwah, N.J.) |
| PublicationTitleAlternate | Clin Cardiol |
| PublicationYear | 2003 |
| Publisher | Wiley Periodicals, Inc Wiley |
| Publisher_xml | – name: Wiley Periodicals, Inc – name: Wiley |
| References | 1993; 7 1989; 2 1995; 92 1987; 10 1987; 76 1989; 64 1994; 90 1996; 19 1990; 16 2000; 23 1993; 22 1993; 21 1986; 250 1988; 78 1999; 41 1978; 58 1999; 1 1990; 81 1981; 23 1990; 65 1990; 66 1997; 95 1997; 349 1990 2000; 36 1986; 7 1995; 26 1997; 30 1993; 70 1978; 40 1991; 84 1998; 32 1991; 325 1998; 31 e_1_2_1_22_2 e_1_2_1_20_2 e_1_2_1_21_2 e_1_2_1_26_2 e_1_2_1_27_2 e_1_2_1_24_2 Lee J (e_1_2_1_13_2) 1986; 250 e_1_2_1_25_2 e_1_2_1_29_2 e_1_2_1_6_2 e_1_2_1_30_2 e_1_2_1_7_2 e_1_2_1_4_2 e_1_2_1_5_2 e_1_2_1_2_2 e_1_2_1_11_2 e_1_2_1_34_2 e_1_2_1_3_2 e_1_2_1_12_2 e_1_2_1_33_2 e_1_2_1_32_2 e_1_2_1_10_2 e_1_2_1_31_2 e_1_2_1_15_2 e_1_2_1_38_2 e_1_2_1_16_2 e_1_2_1_37_2 e_1_2_1_36_2 e_1_2_1_14_2 Pepi M (e_1_2_1_23_2) 1993; 7 e_1_2_1_35_2 e_1_2_1_19_2 e_1_2_1_8_2 e_1_2_1_17_2 e_1_2_1_9_2 e_1_2_1_18_2 Konstam M (e_1_2_1_28_2) 1990; 81 |
| References_xml | – volume: 58 start-page: 770 year: 1978 end-page: 776 article-title: Angiotensin‐converting enzyme inhibition in patients with congestive heart failure publication-title: Circulation – volume: 95 start-page: 1222 year: 1997 end-page: 1230 article-title: Loading manipulation improve the prognostic value of Doppler evaluation of mitral flow in patients with chronic heart failure publication-title: Circulation – volume: 41 start-page: 265 year: 1999 end-page: 300 article-title: Angiotensin‐converting enzyme inhibitors and angiotensin II receptor antagonists in the treatment of heart failure caused by left ventricular systolic dysfunction publication-title: Progr Cardiovasc Dis – volume: 66 start-page: 995 year: 1990 end-page: 1001 article-title: Effects of preload reduction on mitral flow velocity pattern in normal subjects publication-title: Am J Cardiol – volume: 7 start-page: 82 year: 1986 end-page: 88 article-title: Semiquantitative grading of severity of mitral regurgitation by real‐time two‐dimensional Doppler flow imaging technique publication-title: J Am Coll Cardiol – volume: 40 start-page: 1134 year: 1978 end-page: 1142 article-title: Congestive heart failure in normotensive man. Hemodynamics, renin, and angiotensin‐II blockade publication-title: Br Heart J – volume: 65 start-page: 237 year: 1990 end-page: 241 article-title: Doppler echocardiographic‐determined changes in left ventricular diastolic filling flow velocity during the lower body positive and negative pressure method publication-title: Am J Cardiol – volume: 21 start-page: 1687 year: 1993 end-page: 1696 article-title: Pulmonary venous flow velocities recorded by trans‐thoracic Doppler ultrasound: Relation to left ventricular diastolic pressures publication-title: J Am Coll Cardiol – volume: 31 start-page: 413 year: 1998 end-page: 418 article-title: Restrictive left ventricular filling patterns are predictive of diastolic ventricular interaction in chronic heart failure publication-title: J Am Coll Cardiol – start-page: III‐15 year: 1990 end-page: III‐20 – volume: 31 start-page: 1591 year: 1998 end-page: 1597 article-title: Reversible restrictive left ventricular diastolic filling with optimized oral therapy predicts a more favorable prognosis in patients with chronic heart failure publication-title: J Am Coll Cardiol – volume: 84 start-page: 977 year: 1991 end-page: 990 article-title: Echocardiographic Doppler evaluation of left ventricular diastolic function. Physics and physiology publication-title: Circulation – volume: 250 start-page: H464 year: 1986 end-page: H473 article-title: Preload reserve and mechanisms of after‐load mismatch in normal conscious dog publication-title: Am J Physiol – volume: 78 start-page: 1459 year: 1988 end-page: 1468 article-title: The transmitral pressure‐flow velocity relation. Effect of abrupt preload reduction publication-title: Circulation – volume: 36 start-page: 185 year: 2000 end-page: 193 article-title: How the left and right sides of the heart, as well as pulmonary venous drainage, adapt to an increasing degree of head‐up tilting in hypertrophic cardiomyopathy: Differences from the normal heart publication-title: J Am Coll Cardiol – volume: 22 start-page: 808 year: 1993 end-page: 815 article-title: Restrictive left ventricular filling pattern in dilated cardiomyopathy assessed by Doppler echocardiography: Clinical, echocardiographic and hemodynamic correlations and prognostic implications publication-title: J Am Coll Cardiol – volume: 90 start-page: 2772 year: 1994 end-page: 2779 article-title: Systolic and diastolic dysfunction in patients with clinical diagnosis of dilated cardiomyopathy. Relation to symptoms and prognosis publication-title: Circulation – volume: 23 start-page: 665 year: 2000 end-page: 672 article-title: Diastolic ventricular interaction in normal and dilated heart during head‐up tilting publication-title: Clin Cardiol – volume: 70 start-page: 135 year: 1993 end-page: 140 article-title: Sustained cardiac diastolic changes elicited by ultrafiltration in patients with moderate congestive heart failure: Pathophysiological correlates publication-title: Br Heart J – volume: 92 start-page: 819 year: 1995 end-page: 824 article-title: Pressure and volume loading of the right ventricle have opposite effects on left ventricular ejection fraction publication-title: Circulation – volume: 23 start-page: 365 year: 1981 end-page: 387 article-title: Ventricular interdependence publication-title: Prog Cardiovasc Dis – volume: 19 start-page: 38 year: 1996 end-page: 44 article-title: Changes in left ventricular inflow and pulmonary venous flow velocities during preload alteration in dilated heart publication-title: Clin Cardiol – volume: 30 start-page: 8 year: 1997 end-page: 18 article-title: Evaluation of diastolic filling of left ventricle in health and disease: Doppler echocardiography is the clinician's Rosetta stone publication-title: J Am Coll Cardiol – volume: 22 start-page: 1972 year: 1993 end-page: 1982 article-title: Estimation of left ventricular filling pressure using two‐dimensional and Doppler echocardiography in adult patients with cardiac diseases. Additional value of analyzing left atrial size, left atrial ejection fraction and the difference in duration of pulmonary venous and mitral flow velocity at atrial contraction publication-title: J Am Coll Cardiol – volume: 349 start-page: 1720 year: 1997 end-page: 1724 article-title: Diastolic ventricular interaction in chronic heart failure publication-title: Lancet – volume: 64 start-page: 827 year: 1989 end-page: 852 article-title: Determinants of left ventricular filling and of the diastolic pressure‐volume relation publication-title: Circulation – volume: 16 start-page: 644 year: 1990 end-page: 655 article-title: Analysis of the early transmitral Doppler velocity curve: Effect of primary physiologic changes and compensatory preload adjustment publication-title: J Am Coll Cardiol – volume: 10 start-page: 800 year: 1987 end-page: 808 article-title: Preload dependence of Doppler‐derived indexes of left ventricular diastolic function in humans publication-title: J Am Coll Cardiol – volume: 2 start-page: 358 year: 1989 end-page: 367 article-title: Recommendations for quantitation of the left ventricle by two‐dimensional echocardiography publication-title: J Am Soc Echocardiogr – volume: 1 start-page: 161 year: 1999 end-page: 167 article-title: The influence of diastolic and systolic function on exercise performance in heart failure due to dilated cardiomyopathy or is‐chemic heart disease publication-title: Eur J Heart Failure – volume: 30 start-page: 1819 year: 1997 end-page: 1826 article-title: Determination of left ventricular filling pressure by Doppler echocardiography in patients with coronary artery disease: Critical role of left ventricular systolic function publication-title: J Am Coll Cardiol – volume: 81 issue: suppl III year: 1990 article-title: Effect of acute converting enzyme inhibition on left ventricular filling in patients with congestive heart failure. Relation to right ventricular volumes publication-title: Circulation – volume: 26 start-page: 1732 year: 1995 end-page: 1740 article-title: How the two sides of the heart adapt to graded impedance to venous return with head‐up titlting publication-title: J Am Coll Cardiol – volume: 32 start-page: 1187 year: 1998 end-page: 1193 article-title: Angiotensin‐converting enzyme inhibitors revert abnormal right ventricular filling in patients with restrictive left ventricular disease publication-title: J Am Coll Cardiol – volume: 325 start-page: 293 year: 1991 end-page: 302 article-title: Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure publication-title: N Engl J Med – volume: 7 start-page: 106 year: 1993 end-page: 112 article-title: Volume and pressure dependence of left and right ventricular filling in dilated cardiomyopathy publication-title: Am J Noninvas Cardiol – volume: 76 start-page: 875 year: 1987 end-page: 883 article-title: Modulation of vascular capacitance by angiotensin and nitroprusside: A mechanism of changes in pericardial pressure publication-title: Circulation – ident: e_1_2_1_31_2 doi: 10.1016/0735-1097(93)90195-7 – ident: e_1_2_1_21_2 doi: 10.1016/S0735-1097(97)00144-7 – ident: e_1_2_1_7_2 doi: 10.1002/clc.4960230907 – ident: e_1_2_1_22_2 doi: 10.1016/S0735-1097(97)00390-2 – ident: e_1_2_1_24_2 doi: 10.1136/hrt.70.2.135 – ident: e_1_2_1_27_2 doi: 10.1161/01.CIR.58.5.770 – ident: e_1_2_1_5_2 doi: 10.1161/01.CIR.92.4.819 – ident: e_1_2_1_19_2 doi: 10.1016/0735-1097(93)90388-H – ident: e_1_2_1_38_2 doi: 10.1016/0735-1097(93)90787-2 – ident: e_1_2_1_29_2 doi: 10.1016/S0735-1097(98)00412-4 – ident: e_1_2_1_8_2 doi: 10.1016/0002-9149(90)90091-E – ident: e_1_2_1_18_2 doi: 10.1046/j.1540-8175.2003.03020.x – ident: e_1_2_1_14_2 doi: 10.1002/clc.4960190108 – ident: e_1_2_1_32_2 doi: 10.1161/01.CIR.90.6.2772 – ident: e_1_2_1_16_2 doi: 10.1161/01.CIR.84.3.977 – ident: e_1_2_1_33_2 doi: 10.1016/S1388-9842(99)00003-3 – ident: e_1_2_1_9_2 doi: 10.1016/0002-9149(90)90939-X – ident: e_1_2_1_3_2 doi: 10.1161/01.RES.64.5.827 – ident: e_1_2_1_6_2 doi: 10.1016/S0140-6736(96)05109-4 – ident: e_1_2_1_2_2 – ident: e_1_2_1_37_2 doi: 10.1053/pcad.1999.0410265 – ident: e_1_2_1_36_2 doi: 10.1016/S0735-1097(98)00165-X – ident: e_1_2_1_15_2 doi: 10.1016/0735-1097(95)00370-3 – ident: e_1_2_1_35_2 doi: 10.1161/01.CIR.95.5.1222 – ident: e_1_2_1_34_2 doi: 10.1056/NEJM199108013250501 – volume: 7 start-page: 106 year: 1993 ident: e_1_2_1_23_2 article-title: Volume and pressure dependence of left and right ventricular filling in dilated cardiomyopathy publication-title: Am J Noninvas Cardiol doi: 10.1159/000470260 – ident: e_1_2_1_4_2 doi: 10.1016/0033-0620(81)90022-0 – ident: e_1_2_1_17_2 doi: 10.1016/S0735-1097(00)00698-7 – ident: e_1_2_1_12_2 doi: 10.1016/0735-1097(90)90356-T – volume: 250 start-page: H464 year: 1986 ident: e_1_2_1_13_2 article-title: Preload reserve and mechanisms of after‐load mismatch in normal conscious dog publication-title: Am J Physiol – ident: e_1_2_1_25_2 doi: 10.1016/S0735-1097(97)00483-X – ident: e_1_2_1_30_2 doi: 10.1161/01.CIR.76.4.875 – ident: e_1_2_1_11_2 doi: 10.1016/S0735-1097(87)80273-5 – ident: e_1_2_1_20_2 doi: 10.1016/S0735-1097(86)80263-7 – ident: e_1_2_1_10_2 doi: 10.1161/01.CIR.78.6.1459 – ident: e_1_2_1_26_2 doi: 10.1136/hrt.40.10.1134 – volume: 81 year: 1990 ident: e_1_2_1_28_2 article-title: Effect of acute converting enzyme inhibition on left ventricular filling in patients with congestive heart failure. Relation to right ventricular volumes publication-title: Circulation |
| SSID | ssj0020823 |
| Score | 1.6477727 |
| Snippet | Background: The normal and dilated heart behaves as a single functional unit during preload reduction; volume unloading in the setting of diastolic ventricular... Background : The normal and dilated heart behaves as a single functional unit during preload reduction; volume unloading in the setting of diastolic... The normal and dilated heart behaves as a single functional unit during preload reduction: volume unloading in the setting of diastolic ventricular interaction... |
| SourceID | pubmedcentral proquest pubmed pascalfrancis crossref wiley |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 424 |
| SubjectTerms | Adult Aged Angiotensin-Converting Enzyme Inhibitors - therapeutic use angiotensin‐converting enzyme inhibition Biological and medical sciences Blood Pressure - drug effects Blood Pressure - physiology Captopril - therapeutic use Cardiomyopathy, Dilated - drug therapy Cardiomyopathy, Dilated - physiopathology Cardiovascular system Clinical Investigation Clinical Investigations Diastole - drug effects Diastole - physiology dilated cardiomyopathy Doppler echocardiography Echocardiography, Doppler Follow-Up Studies Heart Rate - drug effects Heart Rate - physiology Heart Ventricles - diagnostic imaging Heart Ventricles - drug effects Heart Ventricles - physiopathology Humans Italy Medical sciences Middle Aged Mitral Valve - diagnostic imaging Mitral Valve - drug effects Mitral Valve - physiopathology Observer Variation Pharmacology. Drug treatments Regional Blood Flow - drug effects Regional Blood Flow - physiology Statistics as Topic Stroke Volume - drug effects Stroke Volume - physiology Systole - drug effects Systole - physiology Tilt-Table Test Time Factors Treatment Outcome Tricuspid Valve - diagnostic imaging Tricuspid Valve - drug effects Tricuspid Valve - physiopathology Vasodilator agents. Cerebral vasodilators Ventricular Dysfunction, Left - drug therapy Ventricular Dysfunction, Left - physiopathology ventricular interdependence |
| Title | Effects of acute angiotensin‐converting enzyme inhibition on diastolic ventricular interaction in the dilated heart |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fclc.4960260909 https://www.ncbi.nlm.nih.gov/pubmed/14524600 https://www.proquest.com/docview/75747358 https://pubmed.ncbi.nlm.nih.gov/PMC6654519 |
| Volume | 26 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 1932-8737 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0020823 issn: 0160-9289 databaseCode: RPM dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVWIB databaseName: KBPluse Wiley Online Library: Open Access customDbUrl: eissn: 1932-8737 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0020823 issn: 0160-9289 databaseCode: AVUZU dateStart: 19780101 isFulltext: true titleUrlDefault: https://www.kbplus.ac.uk/kbplus7/publicExport/pkg/559 providerName: Wiley-Blackwell |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Li9swEBZpFkqhlD637mOrQ2lP3tqObMfHJWRZlmTbQ1JCL0ZW5I0ha6d5UJpb_3lnJPnFpmxbCCaxFcfx91kajb6ZIeR9Mmd9Hrq-DaONsFkYcDtxeWTLUIL12vNZyDE4eXwVXEzZ5cyfdTq_mtEl2-RU7A_GlfwPqrAPcMUo2X9Atjop7ID3gC9sAWHY_hXGw1qMwQUu-PP8OiuUJj23lZ58rVTNMt__vMHsIIssybSJmKPXFQw_zHGNkkflB0RBKt5oUz_cSCDn2ZKjXYq1r1ue_EEZVSmUqFUlcwKDdcwXP_hCh3FdnjZcDV_kKtPxQbt1UbsMbrA6l6oshdoPLXs2XvLlll8vkTxae5lXh4DZ-7052VoULd9FrxJnVe7MwLEjTxcRKvtjHUFveBc1Olemo61vdfo6iSwGr7MIK2o5kRPVw1u5pH_1OT6fjkbxZDibfFh9t7HwGC7Qmyos98iRFwaB1yVHZ1-n36bVrB2XInWCeH2pZeZPx_vU_smWZfNwxTcAQKqroxyavtxW4TZnR8q8mTwmj8y8hJ5pkj0hHZk_JffHRnnxjGwM12iRUsU1ephrVHON1lyj8Kq4Rhtcow2uwXsKXKOGa1Rx7TmZng8ngwvbFOywBQuCCG5P2gskPN69lDPGnQQGT5744TyaM-gTXJmiNexEMnVEL2FpAH9eeMJxRBilLox0L0g3L3L5klABhjTmbkwcJpnrSu4DDHPuCjB5-yKKLGKXNzsWJps9FlVZxjoPtxcDOHENjkU-Vu1XOo_LH1uetLCrm6u5CAst8q4EM4a-GBfYeC6L3SYO_RArefctcqyhrb_LfI_B3MIiYQv0qgFmeW8fybOFyvaO5cFhmmURT9HjjquPB6NB_enVnZf6mjyoH8w3pLtd7-RbMLO3yYl5EH4DlXbZrA |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwEB6hrgRICPEmPHZ9QOIUrZM6cX1cVawKtHvaIsQlchxnN1JxV30cdk_8BH4jv4QZO22IACEh5ZAokyjx58dne-YbgDdlJUZaJlmMo42Jhcx1XCZaxVZaZK_DTEhNwcmzs3wyFx8-ZztvQoqFCfoQ-wU3ahm-v6YGTgvSx51qKEUrC0UplLiiEL6DDIfTbAAHJ5_mX-b7WRdtJQWBbx4rnF7slBt5etx_Q29kunel11hIdchu8Sf6-bsX5a_s1g9Ppw_gfssr2UmoCA_hlnWP4Pas3Tl_DNsgU7xmy5pps91Ypt1Fs_T-6-7Ht-_e-5wUBS6YdTfXXy1r3GVTeocuhgdWI6SJi8YwcpD0q4Z6xUhsYhVCI_CcIZlEwwXS14pRpuzNE5ifvjsfT-I25UJsRJ4rLKB6mFsEaFhrITQvsfvTZSYrVQlENbE18RmubM3NsBR1jr9vUsO5kapOsK96CgO3dPY5MINUiNT3Si6sSBKrMwSi0olB0jIySkUQ74q7MK0eOaXFWBRBSTktEJ6igyeCt3v7q6DE8VfLwx56nblnk0JGcLSDs8DWRFsk2tnldl3ITFIu5lEEzwK43bMiSwWywwhkD_a9Ael09--45tLrdVOCZyTKEaS-gvzj64vxdNxdvfifh47gzuR8Ni2m788-voS73v_Qu8W9gsFmtbWvkUdtysO2pfwEWPQYoA |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6hVqqQEOLdFGh9QOIU1ck68fpYLawKtBUHFlVcIsdx2kiLd7WPQznxE_iN_BJm7OymESAkpBwSZRIl_vz4bM98A_CqrMRQyySLcbQxsZC5jstEq9hKi-x1kAmpKTj5_CI_nYj3l9nlrSj-oA-xXXCjluH7a2rg86o-7kRDKVhZKMqgxBVF8O3iWC6wju-efJ58mWwnXbSTFPS9eaxwdrERbuTpcf8NvYHp3lwvsYzqkNziT-zzdyfK2-TWj07jB3C_pZXsJNSDh3DHukewd95unD-GdVApXrJZzbRZryzT7qqZefd19_P7D-98ToICV8y6bzdfLWvcdVN6fy6GB9YiZInTxjDyj_SLhnrBSGtiESIj8Jwhl0TDKbLXilGi7NUTmIzffhqdxm3GhdiIPFdYQPUgt4jPoNZCaF5i76fLTFaqEghqYmuiM1zZmptBKeocf9-khnMjVZ1gV_UUdtzM2X1gBpkQie-VXFiRJFZnCESlE4OcZWiUiiDeFHdhWjlyyooxLYKQclogPEUHTwSvt_bzIMTxV8vDHnqduSeTQkZwtIGzwMZEOyTa2dl6WchMUirmYQTPArjdsyJLBZLDCGQP9q0ByXT377jm2st1U35n5MkRpL6C_OPri9HZqLs6-J-HjmDv45txcfbu4sNzuOu9D71T3AvYWS3W9iWyqFV52DaUX4ZZF8k |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effects+of+acute+angiotensin-converting+enzyme+inhibition+on+diastolic+ventricular+interaction+in+the+dilated+heart&rft.jtitle=Clinical+cardiology+%28Mahwah%2C+N.J.%29&rft.au=Pepi%2C+Mauro&rft.au=Tamborini%2C+Gloria&rft.au=Maltagliati%2C+Anna&rft.au=Guazzi%2C+Marco&rft.date=2003-09-01&rft.issn=0160-9289&rft.volume=26&rft.issue=9&rft.spage=424&rft_id=info:doi/10.1002%2Fclc.4960260909&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0160-9289&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0160-9289&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0160-9289&client=summon |