Fine Mapping Analysis of the MHC Region to Identify Variants Associated With Chinese Vitiligo and SLE and Association Across These Diseases

The important role of MHC in the pathogenesis of vitiligo and SLE has been confirmed in various populations. To map the most significant MHC variants associated with the risk of vitiligo and SLE, we conducted fine mapping analysis using 1117 vitiligo cases, 1046 SLE cases and 1693 healthy control su...

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Published inFrontiers in immunology Vol. 12; p. 758652
Main Authors Cao, Lu, Zhang, Ruixue, Wang, Yirui, Hu, Xia, Yong, Liang, Li, Bao, Ge, Huiyao, Chen, Weiwei, Zhen, Qi, Yu, Yafen, Mao, Yiwen, Li, Zhuo, Fan, Wencheng, Sun, Liangdan
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 10.01.2022
Subjects
Alleles
Asians - genetics
Case-Control Studies
Female
fine mapping
Genetic Predisposition to Disease - genetics
Histocompatibility Antigens - genetics
HLA-DP beta-Chains - genetics
HLA-DQ beta-Chains - genetics
Humans
Immunology
imputation
Lupus Erythematosus, Systemic - genetics
Male
MHC
Polymorphism, Single Nucleotide - genetics
systemic lupus erythematosus
vitiligo
Vitiligo - genetics
vitiligo
MHC
systemic lupus erythematosus
imputation
fine mapping
Online AccessGet full text
ISSN1664-3224
1664-3224
DOI10.3389/fimmu.2021.758652

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Abstract The important role of MHC in the pathogenesis of vitiligo and SLE has been confirmed in various populations. To map the most significant MHC variants associated with the risk of vitiligo and SLE, we conducted fine mapping analysis using 1117 vitiligo cases, 1046 SLE cases and 1693 healthy control subjects in the Han-MHC reference panel and 1000 Genomes Project phase 3. rs113465897 (P=1.03×10 -13 , OR=1.64, 95%CI =1.44–1.87) and rs3129898 (P=4.21×10 -17 , OR=1.93, 95%CI=1.66–2.25) were identified as being most strongly associated with vitiligo and SLE, respectively. Stepwise conditional analysis revealed additional independent signals at rs3130969(p=1.48×10 -7 , OR=0.69, 95%CI=0.60–0.79), HLA-DPB1*03:01 (p=1.07×10 -6 , OR=1.94, 95%CI=1.49–2.53) being linked to vitiligo and HLA-DQB1*0301 (P=4.53×10 -7 , OR=0.62, 95%CI=0.52-0.75) to SLE. Considering that epidemiological studies have confirmed comorbidities of vitiligo and SLE, we used the GCTA tool to analyse the genetic correlation between these two diseases in the HLA region, the correlation coefficient was 0.79 (P=5.99×10 -10 , SE=0.07), confirming their similar genetic backgrounds. Our findings highlight the value of the MHC region in vitiligo and SLE and provide a new perspective for comorbidities among autoimmune diseases.
AbstractList The important role of MHC in the pathogenesis of vitiligo and SLE has been confirmed in various populations. To map the most significant MHC variants associated with the risk of vitiligo and SLE, we conducted fine mapping analysis using 1117 vitiligo cases, 1046 SLE cases and 1693 healthy control subjects in the Han-MHC reference panel and 1000 Genomes Project phase 3. rs113465897 (P=1.03×10-13, OR=1.64, 95%CI =1.44-1.87) and rs3129898 (P=4.21×10-17, OR=1.93, 95%CI=1.66-2.25) were identified as being most strongly associated with vitiligo and SLE, respectively. Stepwise conditional analysis revealed additional independent signals at rs3130969(p=1.48×10-7, OR=0.69, 95%CI=0.60-0.79), HLA-DPB1*03:01 (p=1.07×10-6, OR=1.94, 95%CI=1.49-2.53) being linked to vitiligo and HLA-DQB1*0301 (P=4.53×10-7, OR=0.62, 95%CI=0.52-0.75) to SLE. Considering that epidemiological studies have confirmed comorbidities of vitiligo and SLE, we used the GCTA tool to analyse the genetic correlation between these two diseases in the HLA region, the correlation coefficient was 0.79 (P=5.99×10-10, SE=0.07), confirming their similar genetic backgrounds. Our findings highlight the value of the MHC region in vitiligo and SLE and provide a new perspective for comorbidities among autoimmune diseases.The important role of MHC in the pathogenesis of vitiligo and SLE has been confirmed in various populations. To map the most significant MHC variants associated with the risk of vitiligo and SLE, we conducted fine mapping analysis using 1117 vitiligo cases, 1046 SLE cases and 1693 healthy control subjects in the Han-MHC reference panel and 1000 Genomes Project phase 3. rs113465897 (P=1.03×10-13, OR=1.64, 95%CI =1.44-1.87) and rs3129898 (P=4.21×10-17, OR=1.93, 95%CI=1.66-2.25) were identified as being most strongly associated with vitiligo and SLE, respectively. Stepwise conditional analysis revealed additional independent signals at rs3130969(p=1.48×10-7, OR=0.69, 95%CI=0.60-0.79), HLA-DPB1*03:01 (p=1.07×10-6, OR=1.94, 95%CI=1.49-2.53) being linked to vitiligo and HLA-DQB1*0301 (P=4.53×10-7, OR=0.62, 95%CI=0.52-0.75) to SLE. Considering that epidemiological studies have confirmed comorbidities of vitiligo and SLE, we used the GCTA tool to analyse the genetic correlation between these two diseases in the HLA region, the correlation coefficient was 0.79 (P=5.99×10-10, SE=0.07), confirming their similar genetic backgrounds. Our findings highlight the value of the MHC region in vitiligo and SLE and provide a new perspective for comorbidities among autoimmune diseases.
The important role of MHC in the pathogenesis of vitiligo and SLE has been confirmed in various populations. To map the most significant MHC variants associated with the risk of vitiligo and SLE, we conducted fine mapping analysis using 1117 vitiligo cases, 1046 SLE cases and 1693 healthy control subjects in the Han-MHC reference panel and 1000 Genomes Project phase 3. rs113465897 (P=1.03×10-13, OR=1.64, 95%CI =1.44–1.87) and rs3129898 (P=4.21×10-17, OR=1.93, 95%CI=1.66–2.25) were identified as being most strongly associated with vitiligo and SLE, respectively. Stepwise conditional analysis revealed additional independent signals at rs3130969(p=1.48×10-7, OR=0.69, 95%CI=0.60–0.79), HLA-DPB1*03:01 (p=1.07×10-6, OR=1.94, 95%CI=1.49–2.53) being linked to vitiligo and HLA-DQB1*0301 (P=4.53×10-7, OR=0.62, 95%CI=0.52-0.75) to SLE. Considering that epidemiological studies have confirmed comorbidities of vitiligo and SLE, we used the GCTA tool to analyse the genetic correlation between these two diseases in the HLA region, the correlation coefficient was 0.79 (P=5.99×10-10, SE=0.07), confirming their similar genetic backgrounds. Our findings highlight the value of the MHC region in vitiligo and SLE and provide a new perspective for comorbidities among autoimmune diseases.
The important role of MHC in the pathogenesis of vitiligo and SLE has been confirmed in various populations. To map the most significant MHC variants associated with the risk of vitiligo and SLE, we conducted fine mapping analysis using 1117 vitiligo cases, 1046 SLE cases and 1693 healthy control subjects in the Han-MHC reference panel and 1000 Genomes Project phase 3. rs113465897 (P=1.03×10 -13 , OR=1.64, 95%CI =1.44–1.87) and rs3129898 (P=4.21×10 -17 , OR=1.93, 95%CI=1.66–2.25) were identified as being most strongly associated with vitiligo and SLE, respectively. Stepwise conditional analysis revealed additional independent signals at rs3130969(p=1.48×10 -7 , OR=0.69, 95%CI=0.60–0.79), HLA-DPB1*03:01 (p=1.07×10 -6 , OR=1.94, 95%CI=1.49–2.53) being linked to vitiligo and HLA-DQB1*0301 (P=4.53×10 -7 , OR=0.62, 95%CI=0.52-0.75) to SLE. Considering that epidemiological studies have confirmed comorbidities of vitiligo and SLE, we used the GCTA tool to analyse the genetic correlation between these two diseases in the HLA region, the correlation coefficient was 0.79 (P=5.99×10 -10 , SE=0.07), confirming their similar genetic backgrounds. Our findings highlight the value of the MHC region in vitiligo and SLE and provide a new perspective for comorbidities among autoimmune diseases.
The important role of MHC in the pathogenesis of vitiligo and SLE has been confirmed in various populations. To map the most significant MHC variants associated with the risk of vitiligo and SLE, we conducted fine mapping analysis using 1117 vitiligo cases, 1046 SLE cases and 1693 healthy control subjects in the Han-MHC reference panel and 1000 Genomes Project phase 3. rs113465897 (P=1.03×10 , OR=1.64, 95%CI =1.44-1.87) and rs3129898 (P=4.21×10 , OR=1.93, 95%CI=1.66-2.25) were identified as being most strongly associated with vitiligo and SLE, respectively. Stepwise conditional analysis revealed additional independent signals at rs3130969(p=1.48×10 , OR=0.69, 95%CI=0.60-0.79), HLA-DPB1*03:01 (p=1.07×10 , OR=1.94, 95%CI=1.49-2.53) being linked to vitiligo and HLA-DQB1*0301 (P=4.53×10 , OR=0.62, 95%CI=0.52-0.75) to SLE. Considering that epidemiological studies have confirmed comorbidities of vitiligo and SLE, we used the GCTA tool to analyse the genetic correlation between these two diseases in the HLA region, the correlation coefficient was 0.79 (P=5.99×10 , SE=0.07), confirming their similar genetic backgrounds. Our findings highlight the value of the MHC region in vitiligo and SLE and provide a new perspective for comorbidities among autoimmune diseases.
Author Yu, Yafen
Ge, Huiyao
Zhang, Ruixue
Fan, Wencheng
Hu, Xia
Wang, Yirui
Mao, Yiwen
Zhen, Qi
Yong, Liang
Li, Zhuo
Cao, Lu
Chen, Weiwei
Li, Bao
Sun, Liangdan
AuthorAffiliation 2 Institute of Dermatology, Anhui Medical University , Hefei , China
1 Department of Dermatology, The First Affiliated Hospital of Anhui Medical University , Hefei , China
5 Anhui Provincial Institute of Translational Medicine, Anhui Medical University , Hefei , China
6 The Comprehensive Lab, College of Basic Medicine, Anhui Medical University , Hefei , China
4 Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University , Hefei , China
3 Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education , Hefei , China
AuthorAffiliation_xml – name: 5 Anhui Provincial Institute of Translational Medicine, Anhui Medical University , Hefei , China
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– name: 6 The Comprehensive Lab, College of Basic Medicine, Anhui Medical University , Hefei , China
– name: 1 Department of Dermatology, The First Affiliated Hospital of Anhui Medical University , Hefei , China
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crossref_primary_10_1080_09546634_2025_2471451
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Cites_doi 10.1038/ng.603
10.1038/nrrheum.2016.137
10.1007/s00403-013-1368-z
10.1038/ng.81
10.1016/j.ajhg.2014.07.002
10.1016/j.jaad.2019.07.036
10.1159/000017954
10.1089/thy.2010.1643
10.1111/pcmr.12356
10.1038/jid.2012.501
10.1073/pnas.1523482113
10.1371/journal.pone.0064683
10.1038/ng.472
10.1111/jdv.12169
10.1111/ddg.13574
10.1681/ASN.2016121331
10.1073/pnas.1525001113
10.1155/2014/305436
10.1016/j.imlet.2011.05.001
10.1093/bioinformatics/bts474
10.1016/S0140-6736(14)60763-7
10.1038/ng.3576
10.1038/ng.3310
10.1111/j.1600-0749.2006.00355.x
10.1111/1346-8138.13846
10.1016/j.ajhg.2012.08.026
10.2332/allergolint.11-OA-0303
10.1038/ncomms8146
10.1038/jid.2011.240
10.1002/mgg3.403
10.1111/j.1468-3083.2010.03605.x
10.1016/j.jaut.2011.05.004
10.1038/jid.2012.320
10.1016/j.aller.2010.12.007
10.1016/j.ajhg.2009.01.005
10.1159/000354607
10.1016/j.jaad.2015.08.063
10.1111/jdv.12870
10.1016/j.gene.2018.01.053
10.1111/j.1744-313X.2012.01145.x
10.1111/ijcp.14024
10.1016/j.det.2016.11.013
10.1681/ASN.2013050446
10.1016/j.ajhg.2010.11.011
10.1111/j.1468-3083.2010.03971.x
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Keywords vitiligo
MHC
systemic lupus erythematosus
imputation
fine mapping
Language English
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Reviewed by: Juncheng Dai, Nanjing Medical University, China; Ting Gan, Peking University First Hospital, China
These authors have contributed equally to this work
This article was submitted to Autoimmune and Autoinflammatory Disorders, a section of the journal Frontiers in Immunology
Edited by: Xu-jie Zhou, Peking University First Hospital, China
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References Singh (B27) 2012; 132
Lee (B24) 2012; 28
Xu (B18) 2017; 28
Jia (B10) 2013; 8
Louthrenoo (B33) 2013; 40
Molineros (B35) 2014; 2014
Narita (B40) 2011; 60
Hadi (B43) 2020; 82
Okada (B12) 2015; 47
Zhou (B17) 2016; 48
Hayran (B29) 2021; 75
Yang (B25) 2011; 88
Morris (B37) 2012; 91
Akay (B42) 2010; 24
Cavalli (B14) 2016; 113
Gill (B4) 2016; 74
Taïeb (B21) 2007; 20
Yang (B16) 2018; 648
Browning (B23) 2009; 84
Chen (B5) 2015; 29
Sheth (B44) 2013; 227
Spritz (B6) 2017; 35
Liu (B45) 2018; 16
Mohd-Yusuf (B36) 2011; 139
Birlea (B9) 2013; 133
Bouayad (B28) 2013; 305
Poojary (B41) 2011; 39
Hayashi (B15) 2016; 113
Jin (B8) 2015; 28
Carter (B2) 2016; 12
Quan (B7) 2010; 42
Choi (B3) 2017; 44
Han (B22) 2009; 41
Cortes (B13) 2015; 6
Spritz (B38) 2010; 20
Okada (B11) 2014; 95
Harley (B34) 2008; 40
Hu (B26) 2011; 25
van Geel (B39) 2014; 28
Chung (B30) 2014; 25
Tang (B20) 2013; 133
Buc (B31) 1998; 8
Ezzedine (B1) 2015; 386
Fu (B19) 2011; 37
Sun (B32) 2018; 6
References_xml – volume: 42
  year: 2010
  ident: B7
  article-title: Genome-Wide Association Study for Vitiligo Identifies Susceptibility Loci at 6q27 and the MHC
  publication-title: Nat Genet
  doi: 10.1038/ng.603
– volume: 12
  year: 2016
  ident: B2
  article-title: The Global Burden of SLE: Prevalence, Health Disparities and Socioeconomic Impact
  publication-title: Nat Rev Rheumatol
  doi: 10.1038/nrrheum.2016.137
– volume: 305
  year: 2013
  ident: B28
  article-title: Association of HLA Alleles and Haplotypes With Vitiligo in Moroccan Patients: A Case-Control Study
  publication-title: Arch Dermatol Res
  doi: 10.1007/s00403-013-1368-z
– volume: 40
  year: 2008
  ident: B34
  article-title: Genome-Wide Association Scan in Women With Systemic Lupus Erythematosus Identifies Susceptibility Variants in ITGAM, PXK, KIAA1542 and Other Loci
  publication-title: Nat Genet
  doi: 10.1038/ng.81
– volume: 95
  year: 2014
  ident: B11
  article-title: Fine Mapping Major Histocompatibility Complex Associations in Psoriasis and its Clinical Subtypes
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2014.07.002
– volume: 82
  year: 2020
  ident: B43
  article-title: Comorbid Diseases of Vitiligo: A 10-Year Cross-Sectional Retrospective Study of an Urban US Population
  publication-title: J Am Acad Dermatol
  doi: 10.1016/j.jaad.2019.07.036
– volume: 8
  year: 1998
  ident: B31
  article-title: Occurrence Rates of HLA-DRB1, HLA-DQB1, and HLA-DPB1 Alleles in Patients Suffering From Vitiligo
  publication-title: Eur J Dermatol
  doi: 10.1159/000017954
– volume: 20
  year: 2010
  ident: B38
  article-title: Shared Genetic Relationships Underlying Generalized Vitiligo and Autoimmune Thyroid Disease
  publication-title: Thyroid
  doi: 10.1089/thy.2010.1643
– volume: 28
  year: 2015
  ident: B8
  article-title: Major Association of Vitiligo With HLA-A*02:01 in Japanese
  publication-title: Pigment Cell Melanoma Res
  doi: 10.1111/pcmr.12356
– volume: 133
  year: 2013
  ident: B9
  article-title: Association of Generalized Vitiligo With MHC Class II Loci in Patients From the Indian Subcontinent
  publication-title: J Invest Dermatol
  doi: 10.1038/jid.2012.501
– volume: 113
  year: 2016
  ident: B14
  article-title: MHC Class II Super-Enhancer Increases Surface Expression of HLA-DR and HLA-DQ and Affects Cytokine Production in Autoimmune Vitiligo
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1523482113
– volume: 8
  year: 2013
  ident: B10
  article-title: Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0064683
– volume: 41
  year: 2009
  ident: B22
  article-title: Genome-Wide Association Study in a Chinese Han Population Identifies Nine New Susceptibility Loci for Systemic Lupus Erythematosus
  publication-title: Nat Genet
  doi: 10.1038/ng.472
– volume: 28
  year: 2014
  ident: B39
  article-title: Clinical Profile of Generalized Vitiligo Patients With Associated Autoimmune/Autoinflammatory Diseases
  publication-title: J Eur Acad Dermatol Venereol
  doi: 10.1111/jdv.12169
– volume: 16
  year: 2018
  ident: B45
  article-title: Vitiligo and Autoantibodies: A Systematic Review and Meta-Analysis
  publication-title: J Dtsch Dermatol Ges
  doi: 10.1111/ddg.13574
– volume: 28
  year: 2017
  ident: B18
  article-title: Association Analysis of the MHC in Lupus Nephritis
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.2016121331
– volume: 113
  year: 2016
  ident: B15
  article-title: Autoimmune Vitiligo Is Associated With Gain-of-Function by a Transcriptional Regulator That Elevates Expression of HLA-A*02:01 In Vivo
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1525001113
– volume: 2014
  year: 2014
  ident: B35
  article-title: Evaluation of SLE Susceptibility Genes in Malaysians
  publication-title: Autoimmune Dis
  doi: 10.1155/2014/305436
– volume: 139
  start-page: 68
  year: 2011
  ident: B36
  article-title: HLA-A*11 and Novel Associations in Malays and Chinese With Systemic Lupus Erythematosus
  publication-title: Immunol Lett
  doi: 10.1016/j.imlet.2011.05.001
– volume: 28
  year: 2012
  ident: B24
  article-title: Estimation of Pleiotropy Between Complex Diseases Using Single-Nucleotide Polymorphism-Derived Genomic Relationships and Restricted Maximum Likelihood
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bts474
– volume: 386
  start-page: 74
  year: 2015
  ident: B1
  article-title: Vitiligo
  publication-title: Lancet
  doi: 10.1016/S0140-6736(14)60763-7
– volume: 48
  year: 2016
  ident: B17
  article-title: Deep Sequencing of the MHC Region in the Chinese Population Contributes to Studies of Complex Disease
  publication-title: Nat Genet
  doi: 10.1038/ng.3576
– volume: 47
  start-page: 798
  year: 2015
  ident: B12
  article-title: Construction of a Population-Specific HLA Imputation Reference Panel and its Application to Graves' Disease Risk in Japanese
  publication-title: Nat Genet
  doi: 10.1038/ng.3310
– volume: 20
  start-page: 27
  year: 2007
  ident: B21
  article-title: The Definition and Assessment of Vitiligo: A Consensus Report of the Vitiligo European Task Force
  publication-title: Pigment Cell Res
  doi: 10.1111/j.1600-0749.2006.00355.x
– volume: 44
  year: 2017
  ident: B3
  article-title: Increased Risk of Comorbid Rheumatic Disorders in Vitiligo Patients: A Nationwide Population-Based Study
  publication-title: J Dermatol
  doi: 10.1111/1346-8138.13846
– volume: 91
  year: 2012
  ident: B37
  article-title: Unraveling Multiple MHC Gene Associations With Systemic Lupus Erythematosus: Model Choice Indicates a Role for HLA Alleles and non-HLA Genes in Europeans
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2012.08.026
– volume: 60
  year: 2011
  ident: B40
  article-title: Generalized Vitiligo and Associated Autoimmune Diseases in Japanese Patients and Their Families
  publication-title: Allergol Int
  doi: 10.2332/allergolint.11-OA-0303
– volume: 6
  start-page: 7146
  year: 2015
  ident: B13
  article-title: Major Histocompatibility Complex Associations of Ankylosing Spondylitis Are Complex and Involve Further Epistasis With ERAP1
  publication-title: Nat Commun
  doi: 10.1038/ncomms8146
– volume: 132
  year: 2012
  ident: B27
  article-title: HLA Alleles and Amino-Acid Signatures of the Peptide-Binding Pockets of HLA Molecules in Vitiligo
  publication-title: J Invest Dermatol
  doi: 10.1038/jid.2011.240
– volume: 6
  year: 2018
  ident: B32
  article-title: HLA-DQβ1 Amino Acid Position 87 and DQB1*0301 are Associated With Chinese Han SLE
  publication-title: Mol Genet Genomic Med
  doi: 10.1002/mgg3.403
– volume: 24
  year: 2010
  ident: B42
  article-title: Epidemiology of Vitiligo, Associated Autoimmune Diseases and Audiological Abnormalities: Ankara Study of 80 Patients in Turkey
  publication-title: J Eur Acad Dermatol Venereol
  doi: 10.1111/j.1468-3083.2010.03605.x
– volume: 37
  year: 2011
  ident: B19
  article-title: Pathogenesis of Systemic Lupus Erythematosus Revisited 2011: End Organ Resistance to Damage, Autoantibody Initiation and Diversification, and HLA-Dr
  publication-title: J Autoimmun
  doi: 10.1016/j.jaut.2011.05.004
– volume: 133
  year: 2013
  ident: B20
  article-title: Association Analyses Identify Three Susceptibility Loci for Vitiligo in the Chinese Han Population
  publication-title: J Invest Dermatol
  doi: 10.1038/jid.2012.320
– volume: 39
  year: 2011
  ident: B41
  article-title: Vitiligo and Associated Autoimmune Disorders: A Retrospective Hospital-Based Study in Mumbai, India
  publication-title: Allergol Immunopathol (Madr)
  doi: 10.1016/j.aller.2010.12.007
– volume: 84
  year: 2009
  ident: B23
  article-title: A Unified Approach to Genotype Imputation and Haplotype-Phase Inference for Large Data Sets of Trios and Unrelated Individuals
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2009.01.005
– volume: 227
  year: 2013
  ident: B44
  article-title: Comorbidities Associated With Vitiligo: A Ten-Year Retrospective Study
  publication-title: Dermatology
  doi: 10.1159/000354607
– volume: 74
  start-page: 295
  year: 2016
  ident: B4
  article-title: Comorbid Autoimmune Diseases in Patients With Vitiligo: A Cross-Sectional Study
  publication-title: J Am Acad Dermatol
  doi: 10.1016/j.jaad.2015.08.063
– volume: 29
  year: 2015
  ident: B5
  article-title: Comorbidity Profiles in Association With Vitiligo: A Nationwide Population-Based Study in Taiwan
  publication-title: J Eur Acad Dermatol Venereol
  doi: 10.1111/jdv.12870
– volume: 648
  start-page: 76
  year: 2018
  ident: B16
  article-title: Fine-Mapping Analysis of the MHC Region for Vitiligo Based on a New Han-MHC Reference Panel
  publication-title: Gene
  doi: 10.1016/j.gene.2018.01.053
– volume: 40
  year: 2013
  ident: B33
  article-title: The Genetic Contribution of HLA-DRB5*01:01 to Systemic Lupus Erythematosus in Thailand
  publication-title: Int J Immunogenet
  doi: 10.1111/j.1744-313X.2012.01145.x
– volume: 75
  year: 2021
  ident: B29
  article-title: The Relationship Between non-Segmental Vitiligo, HLA Genotype and Oxidative Stress
  publication-title: Int J Clin Pract
  doi: 10.1111/ijcp.14024
– volume: 35
  year: 2017
  ident: B6
  article-title: Genetics of Vitiligo
  publication-title: Dermatol Clin
  doi: 10.1016/j.det.2016.11.013
– volume: 25
  year: 2014
  ident: B30
  article-title: Lupus Nephritis Susceptibility Loci in Women With Systemic Lupus Erythematosus
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.2013050446
– volume: 88
  start-page: 76
  year: 2011
  ident: B25
  article-title: GCTA: A Tool for Genome-Wide Complex Trait Analysis
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2010.11.011
– volume: 25
  year: 2011
  ident: B26
  article-title: Comparisons of Clinical Features of HLA-DRB1*07 Positive and Negative Vitiligo Patients in Chinese Han Population
  publication-title: J Eur Acad Dermatol Venereol
  doi: 10.1111/j.1468-3083.2010.03971.x
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Snippet The important role of MHC in the pathogenesis of vitiligo and SLE has been confirmed in various populations. To map the most significant MHC variants...
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StartPage 758652
SubjectTerms Alleles
Asians - genetics
Case-Control Studies
Female
fine mapping
Genetic Predisposition to Disease - genetics
Histocompatibility Antigens - genetics
HLA-DP beta-Chains - genetics
HLA-DQ beta-Chains - genetics
Humans
Immunology
imputation
Lupus Erythematosus, Systemic - genetics
Male
MHC
Polymorphism, Single Nucleotide - genetics
systemic lupus erythematosus
vitiligo
Vitiligo - genetics
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Title Fine Mapping Analysis of the MHC Region to Identify Variants Associated With Chinese Vitiligo and SLE and Association Across These Diseases
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