L312, a novel PPARγ ligand with potent anti-diabetic activity by selective regulation - Xie, Xinni; Zhou, Xinbo; Chen, Wei; Long, Long; Li, Wei; Yang, Xiuyan; Li, Song; Wang, Lili (Biochimica et biophysica acta, 2015)
Keywords: 3T3-L1 Cells; adipogenesis; Adipose Tissue, White - cytology; Adipose Tissue, White - drug effects; Adipose Tissue, White - metabolism; adverse effects; agonists; Animals; binding capacity; Binding, Competitive; blood glucose; blood lipids; Blotting, Western; Cyclin-Dependent Kinase 5 - metabolism; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - physiopathology; Diabetes Mellitus, Type 2 - prevention & control; epididymis; Female; gene expression; Gene Expression - drug effects; glycemic effect; HEK293 Cells; Humans; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - metabolism; Hypoglycemic Agents - pharmacology; insulin; Insulin Resistance; lead; Ligands; luciferase; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Molecular Docking Simulation; Molecular Structure; phosphorylation; Phosphorylation - drug effects; PPAR gamma - agonists; PPAR gamma - chemistry; PPAR gamma - metabolism; pSer273PPARγ; Reverse Transcriptase Polymerase Chain Reaction; Selective PPARγ modulator; Serine - metabolism; Thiazolidinediones - metabolism; Thiazolidinediones - pharmacology; weight gain; FFA; T2DM; Selective PPARγ modulator; ITT; sPPARγM; WAT; LBD; CBP; HOMA-IR; pSer273PPARγ; TZDs; TG; CDK5; PPAR; SPR; BAT; EC50; Insulin resistance; NCoR; OGTT