MRI-Visible Perivascular Spaces Associated With Cognitive Impairment in Military Veterans With Traumatic Brain Injury Mediated by CSF P-Tau
To investigate the association of MRI-visible perivascular spaces (PVS) with cognitive impairment in military veterans with traumatic brain injury (TBI), and whether cerebrospinal fluid (CSF) p-tau and Aβ mediate this effect. We included 55 Vietnam War veterans with a history of TBI and 52 non-TBI V...
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| Published in | Frontiers in psychiatry Vol. 13; p. 921203 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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Switzerland
Frontiers Media S.A
06.07.2022
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| Online Access | Get full text |
| ISSN | 1664-0640 1664-0640 |
| DOI | 10.3389/fpsyt.2022.921203 |
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| Abstract | To investigate the association of MRI-visible perivascular spaces (PVS) with cognitive impairment in military veterans with traumatic brain injury (TBI), and whether cerebrospinal fluid (CSF) p-tau and Aβ mediate this effect.
We included 55 Vietnam War veterans with a history of TBI and 52 non-TBI Vietnam War veterans from the Department of Defense Alzheimer's Disease Neuroimaging Initiative (ADNI) database. All the subjects had brain MRI, CSF p-tau, Aβ, and neuropsychological examinations. MRI-visible PVS number and grade were rated on MRI in the centrum semiovale (CSO-PVS) and basal ganglia (BG-PVS). Multiple linear regression was performed to assess the association between MRI-visible PVS and cognitive impairment and the interaction effect of TBI. Additionally, mediation effect of CSF biomarkers on the relationship between MRI-visible PVS and cognitive impairment was explored in TBI group.
Compared with military control, TBI group had higher CSO-PVS number (
= 0.001), CSF p-tau (
= 0.022) and poorer performance in verbal memory (
= 0.022). High CSO-PVS number was associated with poor verbal memory in TBI group (β = -0.039, 95% CI -0.062, -0.016), but not in military control group (β = 0.019, 95% CI -0.004, 0.043) (
-interaction = 0.003). Further mediation analysis revealed that CSF p-tau had a significant indirect effect (β = -0.009, 95% CI: -0.022 -0.001,
= 0.001) and mediated 18.75% effect for the relationship between CSO-PVS and verbal memory in TBI group.
MRI-visible CSO-PVS was more common in Vietnam War veterans with a history of TBI and was associated with poor verbal memory, mediated partially by CSF p-tau. |
|---|---|
| AbstractList | To investigate the association of MRI-visible perivascular spaces (PVS) with cognitive impairment in military veterans with traumatic brain injury (TBI), and whether cerebrospinal fluid (CSF) p-tau and Aβ mediate this effect.ObjectiveTo investigate the association of MRI-visible perivascular spaces (PVS) with cognitive impairment in military veterans with traumatic brain injury (TBI), and whether cerebrospinal fluid (CSF) p-tau and Aβ mediate this effect.We included 55 Vietnam War veterans with a history of TBI and 52 non-TBI Vietnam War veterans from the Department of Defense Alzheimer's Disease Neuroimaging Initiative (ADNI) database. All the subjects had brain MRI, CSF p-tau, Aβ, and neuropsychological examinations. MRI-visible PVS number and grade were rated on MRI in the centrum semiovale (CSO-PVS) and basal ganglia (BG-PVS). Multiple linear regression was performed to assess the association between MRI-visible PVS and cognitive impairment and the interaction effect of TBI. Additionally, mediation effect of CSF biomarkers on the relationship between MRI-visible PVS and cognitive impairment was explored in TBI group.Materials and MethodsWe included 55 Vietnam War veterans with a history of TBI and 52 non-TBI Vietnam War veterans from the Department of Defense Alzheimer's Disease Neuroimaging Initiative (ADNI) database. All the subjects had brain MRI, CSF p-tau, Aβ, and neuropsychological examinations. MRI-visible PVS number and grade were rated on MRI in the centrum semiovale (CSO-PVS) and basal ganglia (BG-PVS). Multiple linear regression was performed to assess the association between MRI-visible PVS and cognitive impairment and the interaction effect of TBI. Additionally, mediation effect of CSF biomarkers on the relationship between MRI-visible PVS and cognitive impairment was explored in TBI group.Compared with military control, TBI group had higher CSO-PVS number (p = 0.001), CSF p-tau (p = 0.022) and poorer performance in verbal memory (p = 0.022). High CSO-PVS number was associated with poor verbal memory in TBI group (β = -0.039, 95% CI -0.062, -0.016), but not in military control group (β = 0.019, 95% CI -0.004, 0.043) (p-interaction = 0.003). Further mediation analysis revealed that CSF p-tau had a significant indirect effect (β = -0.009, 95% CI: -0.022 -0.001, p = 0.001) and mediated 18.75% effect for the relationship between CSO-PVS and verbal memory in TBI group.ResultsCompared with military control, TBI group had higher CSO-PVS number (p = 0.001), CSF p-tau (p = 0.022) and poorer performance in verbal memory (p = 0.022). High CSO-PVS number was associated with poor verbal memory in TBI group (β = -0.039, 95% CI -0.062, -0.016), but not in military control group (β = 0.019, 95% CI -0.004, 0.043) (p-interaction = 0.003). Further mediation analysis revealed that CSF p-tau had a significant indirect effect (β = -0.009, 95% CI: -0.022 -0.001, p = 0.001) and mediated 18.75% effect for the relationship between CSO-PVS and verbal memory in TBI group.MRI-visible CSO-PVS was more common in Vietnam War veterans with a history of TBI and was associated with poor verbal memory, mediated partially by CSF p-tau.ConclusionMRI-visible CSO-PVS was more common in Vietnam War veterans with a history of TBI and was associated with poor verbal memory, mediated partially by CSF p-tau. ObjectiveTo investigate the association of MRI-visible perivascular spaces (PVS) with cognitive impairment in military veterans with traumatic brain injury (TBI), and whether cerebrospinal fluid (CSF) p-tau and Aβ mediate this effect.Materials and MethodsWe included 55 Vietnam War veterans with a history of TBI and 52 non-TBI Vietnam War veterans from the Department of Defense Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. All the subjects had brain MRI, CSF p-tau, Aβ, and neuropsychological examinations. MRI-visible PVS number and grade were rated on MRI in the centrum semiovale (CSO-PVS) and basal ganglia (BG-PVS). Multiple linear regression was performed to assess the association between MRI-visible PVS and cognitive impairment and the interaction effect of TBI. Additionally, mediation effect of CSF biomarkers on the relationship between MRI-visible PVS and cognitive impairment was explored in TBI group.ResultsCompared with military control, TBI group had higher CSO-PVS number (p = 0.001), CSF p-tau (p = 0.022) and poorer performance in verbal memory (p = 0.022). High CSO-PVS number was associated with poor verbal memory in TBI group (β = -0.039, 95% CI −0.062, −0.016), but not in military control group (β = 0.019, 95% CI −0.004, 0.043) (p-interaction = 0.003). Further mediation analysis revealed that CSF p-tau had a significant indirect effect (β = −0.009, 95% CI: −0.022 −0.001, p = 0.001) and mediated 18.75% effect for the relationship between CSO-PVS and verbal memory in TBI group.ConclusionMRI-visible CSO-PVS was more common in Vietnam War veterans with a history of TBI and was associated with poor verbal memory, mediated partially by CSF p-tau. To investigate the association of MRI-visible perivascular spaces (PVS) with cognitive impairment in military veterans with traumatic brain injury (TBI), and whether cerebrospinal fluid (CSF) p-tau and Aβ mediate this effect. We included 55 Vietnam War veterans with a history of TBI and 52 non-TBI Vietnam War veterans from the Department of Defense Alzheimer's Disease Neuroimaging Initiative (ADNI) database. All the subjects had brain MRI, CSF p-tau, Aβ, and neuropsychological examinations. MRI-visible PVS number and grade were rated on MRI in the centrum semiovale (CSO-PVS) and basal ganglia (BG-PVS). Multiple linear regression was performed to assess the association between MRI-visible PVS and cognitive impairment and the interaction effect of TBI. Additionally, mediation effect of CSF biomarkers on the relationship between MRI-visible PVS and cognitive impairment was explored in TBI group. Compared with military control, TBI group had higher CSO-PVS number ( = 0.001), CSF p-tau ( = 0.022) and poorer performance in verbal memory ( = 0.022). High CSO-PVS number was associated with poor verbal memory in TBI group (β = -0.039, 95% CI -0.062, -0.016), but not in military control group (β = 0.019, 95% CI -0.004, 0.043) ( -interaction = 0.003). Further mediation analysis revealed that CSF p-tau had a significant indirect effect (β = -0.009, 95% CI: -0.022 -0.001, = 0.001) and mediated 18.75% effect for the relationship between CSO-PVS and verbal memory in TBI group. MRI-visible CSO-PVS was more common in Vietnam War veterans with a history of TBI and was associated with poor verbal memory, mediated partially by CSF p-tau. |
| Author | Li, Wen-Bin Wang, Ming-Liang Li, Peng-Yang Yang, Dian-Xu Zou, Qiao-Qiao Wu, Xue Sun, Zheng Li, Yue-Hua |
| AuthorAffiliation | 3 Division of Cardiology, Pauley Heart Center, Virginia Commonwealth University , Richmond, VA , United States 1 Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital , Shanghai , China 2 Department of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital , Shanghai , China 4 Institute for Global Health Sciences, University of California, San Francisco , San Francisco, CA , United States |
| AuthorAffiliation_xml | – name: 2 Department of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital , Shanghai , China – name: 4 Institute for Global Health Sciences, University of California, San Francisco , San Francisco, CA , United States – name: 1 Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital , Shanghai , China – name: 3 Division of Cardiology, Pauley Heart Center, Virginia Commonwealth University , Richmond, VA , United States |
| Author_xml | – sequence: 1 givenname: Ming-Liang surname: Wang fullname: Wang, Ming-Liang – sequence: 2 givenname: Dian-Xu surname: Yang fullname: Yang, Dian-Xu – sequence: 3 givenname: Zheng surname: Sun fullname: Sun, Zheng – sequence: 4 givenname: Wen-Bin surname: Li fullname: Li, Wen-Bin – sequence: 5 givenname: Qiao-Qiao surname: Zou fullname: Zou, Qiao-Qiao – sequence: 6 givenname: Peng-Yang surname: Li fullname: Li, Peng-Yang – sequence: 7 givenname: Xue surname: Wu fullname: Wu, Xue – sequence: 8 givenname: Yue-Hua surname: Li fullname: Li, Yue-Hua |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35873253$$D View this record in MEDLINE/PubMed |
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| Keywords | traumatic brain injury Aβ tau MRI MRI-visible perivascular spaces CSF |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Liang Gong, Chengdu Second People’s Hospital, China; Jeiran Choupan, University of Southern California, United States; Giuseppe Barisano, University of Southern California, United States This article was submitted to Neuroimaging and Stimulation, a section of the journal Frontiers in Psychiatry Edited by: Thomas Nickl-Jockschat, The University of Iowa, United States These authors have contributed equally to this work and share first authorship |
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| SubjectTerms | CSF MRI MRI-visible perivascular spaces Psychiatry tau traumatic brain injury |
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| Title | MRI-Visible Perivascular Spaces Associated With Cognitive Impairment in Military Veterans With Traumatic Brain Injury Mediated by CSF P-Tau |
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