Non-Viral Vectors for Delivery of Nucleic Acid Therapies for Cancer

The research and development of non-viral gene therapy has been extensive over the past decade and has received a big push thanks to the recent successful approval of non-viral nucleic acid therapy products. Despite these developments, nucleic acid therapy applications in cancer have been limited. O...

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Published inBiotech (Basel) Vol. 11; no. 1; p. 6
Main Authors Kanvinde, Shrey, Kulkarni, Tanmay, Deodhar, Suyash, Bhattacharya, Deep, Dasgupta, Aneesha
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 07.03.2022
MDPI
Subjects
Acids
Cancer
Cancer therapies
Gene therapy
mRNA
Mutation
nanoparticles
non-viral vectors
nucleic acid delivery
Nucleic acids
polymers
Review
siRNA
Vectors (Biology)
Online AccessGet full text
ISSN2673-6284
2673-6284
DOI10.3390/biotech11010006

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Abstract The research and development of non-viral gene therapy has been extensive over the past decade and has received a big push thanks to the recent successful approval of non-viral nucleic acid therapy products. Despite these developments, nucleic acid therapy applications in cancer have been limited. One of the main causes of this has been the imbalance in development of delivery vectors as compared with sophisticated nucleic acid payloads, such as siRNA, mRNA, etc. This paper reviews non-viral vectors that can be used to deliver nucleic acids for cancer treatment. It discusses various types of vectors and highlights their current applications. Additionally, it discusses a perspective on the current regulatory landscape to facilitate the commercial translation of gene therapy.
AbstractList The research and development of non-viral gene therapy has been extensive over the past decade and has received a big push thanks to the recent successful approval of non-viral nucleic acid therapy products. Despite these developments, nucleic acid therapy applications in cancer have been limited. One of the main causes of this has been the imbalance in development of delivery vectors as compared with sophisticated nucleic acid payloads, such as siRNA, mRNA, etc. This paper reviews non-viral vectors that can be used to deliver nucleic acids for cancer treatment. It discusses various types of vectors and highlights their current applications. Additionally, it discusses a perspective on the current regulatory landscape to facilitate the commercial translation of gene therapy.
The research and development of non-viral gene therapy has been extensive over the past decade and has received a big push thanks to the recent successful approval of non-viral nucleic acid therapy products. Despite these developments, nucleic acid therapy applications in cancer have been limited. One of the main causes of this has been the imbalance in development of delivery vectors as compared with sophisticated nucleic acid payloads, such as siRNA, mRNA, etc. This paper reviews non-viral vectors that can be used to deliver nucleic acids for cancer treatment. It discusses various types of vectors and highlights their current applications. Additionally, it discusses a perspective on the current regulatory landscape to facilitate the commercial translation of gene therapy.The research and development of non-viral gene therapy has been extensive over the past decade and has received a big push thanks to the recent successful approval of non-viral nucleic acid therapy products. Despite these developments, nucleic acid therapy applications in cancer have been limited. One of the main causes of this has been the imbalance in development of delivery vectors as compared with sophisticated nucleic acid payloads, such as siRNA, mRNA, etc. This paper reviews non-viral vectors that can be used to deliver nucleic acids for cancer treatment. It discusses various types of vectors and highlights their current applications. Additionally, it discusses a perspective on the current regulatory landscape to facilitate the commercial translation of gene therapy.
Author Kulkarni, Tanmay
Dasgupta, Aneesha
Bhattacharya, Deep
Kanvinde, Shrey
Deodhar, Suyash
AuthorAffiliation 1 Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA; tkulkarni68@gmail.com (T.K.); deep.bhattacharya1991@gmail.com (D.B.)
3 Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA; dasgupta.aneesha@mayo.edu
2 Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA; suyashsanjay.deodhar@unmc.edu
AuthorAffiliation_xml – name: 3 Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA; dasgupta.aneesha@mayo.edu
– name: 2 Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA; suyashsanjay.deodhar@unmc.edu
– name: 1 Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA; tkulkarni68@gmail.com (T.K.); deep.bhattacharya1991@gmail.com (D.B.)
Author_xml – sequence: 1
  givenname: Shrey
  surname: Kanvinde
  fullname: Kanvinde, Shrey
– sequence: 2
  givenname: Tanmay
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– sequence: 3
  givenname: Suyash
  orcidid: 0000-0003-1536-6761
  surname: Deodhar
  fullname: Deodhar, Suyash
– sequence: 4
  givenname: Deep
  surname: Bhattacharya
  fullname: Bhattacharya, Deep
– sequence: 5
  givenname: Aneesha
  surname: Dasgupta
  fullname: Dasgupta, Aneesha
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Snippet The research and development of non-viral gene therapy has been extensive over the past decade and has received a big push thanks to the recent successful...
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SubjectTerms Acids
Cancer
Cancer therapies
Gene therapy
mRNA
Mutation
nanoparticles
non-viral vectors
nucleic acid delivery
Nucleic acids
polymers
Review
siRNA
Vectors (Biology)
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Title Non-Viral Vectors for Delivery of Nucleic Acid Therapies for Cancer
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