Cbl and Itch binding sites in ERBB4 CYT-1 and CYT-2 mediate K48- and K63-polyubiquitination, respectively - Meijer, Inez M.J.; van Rotterdam, Walter; van Zoelen, Everardus J.J.; van Leeuwen, Jeroen E.M. (Cellular signalling, 2013)
Keywords: Animals; Binding; Binding Sites; Cbl; Cell Line; chimerism; Control; Down-Regulation; endocytosis; Endosomes - metabolism; Epidermal Growth Factor - pharmacology; epidermal growth factor receptors; ERBB4; Humans; Itch; K48-polyubiquitination; K63-polyubiquitination; Lysine - chemistry; Lysosomes; mammals; Mice; Mutagenesis, Site-Directed; mutation; Mutations; NIH 3T3 Cells; phosphorylation; Phosphorylation - drug effects; Protein Binding; Protein Isoforms - genetics; Protein Isoforms - metabolism; Proto-Oncogene Proteins c-cbl - metabolism; Receptor, Epidermal Growth Factor - genetics; Receptor, Epidermal Growth Factor - metabolism; Receptor, ErbB-4; Receptors; Recombinant Fusion Proteins - biosynthesis; Recombinant Fusion Proteins - genetics; Recycling; Repressor Proteins - metabolism; sorting; Stimulation; Transfection; tyrosine; Ubiquitin-Protein Ligases - metabolism; ubiquitination; Ubiquitination - drug effects; Itch; K48-polyubiquitination; Cbl; ERBB4; K63-polyubiquitination