Alginate mediated functional aggregation of gold nanoclusters for systemic photothermal therapy and efficient renal clearance
•Contributed from polysarchride ligand of sodium alginate, Au NCs are sensitive to aggregate in tumor microenvironment.•The functional aggregation switches on photothermal conversion of AuNCs, endowing systemic photothermal therapy.•Sodium alginate delays renal clearance of AuNCs in blood circulatio...
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| Published in | Carbohydrate polymers Vol. 241; p. 116344 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.08.2020
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0144-8617 1879-1344 1879-1344 |
| DOI | 10.1016/j.carbpol.2020.116344 |
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| Abstract | •Contributed from polysarchride ligand of sodium alginate, Au NCs are sensitive to aggregate in tumor microenvironment.•The functional aggregation switches on photothermal conversion of AuNCs, endowing systemic photothermal therapy.•Sodium alginate delays renal clearance of AuNCs in blood circulation and prolongs the half-life to ∼9.3 h.
For renal clearable nanoagents, it is challenging to delay the renal clearance to acquire efficient tumor accumulation. Herein, we report sodium alginate (SA) stabilized gold (Au) NCs. The Au NCs are of high biocompatibility and renal clearable. Contributed from the ligands of SA, the half-life (t1/2) of Au NCs is prolonged to ∼9.3 h, enhancing the tumor accumulation rate to 10.4 %ID/g. In tumor microenvironment (TME), the Au NCs are stimulated to functionally aggregate, which switches on the photothermal effect. Animal experiments prove that Au NCs aggregates are efficient photothermal therapy (PTT) agents for both local treatment of single tumors and systemic treatment of double-tumor models without causing noticeable side effects, confirming the biosecurity of Au NCs and systemic PTT. The switchable strategy of PTT may signify the establishment of a new systemic therapeutic methodology. |
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| AbstractList | •Contributed from polysarchride ligand of sodium alginate, Au NCs are sensitive to aggregate in tumor microenvironment.•The functional aggregation switches on photothermal conversion of AuNCs, endowing systemic photothermal therapy.•Sodium alginate delays renal clearance of AuNCs in blood circulation and prolongs the half-life to ∼9.3 h.
For renal clearable nanoagents, it is challenging to delay the renal clearance to acquire efficient tumor accumulation. Herein, we report sodium alginate (SA) stabilized gold (Au) NCs. The Au NCs are of high biocompatibility and renal clearable. Contributed from the ligands of SA, the half-life (t1/2) of Au NCs is prolonged to ∼9.3 h, enhancing the tumor accumulation rate to 10.4 %ID/g. In tumor microenvironment (TME), the Au NCs are stimulated to functionally aggregate, which switches on the photothermal effect. Animal experiments prove that Au NCs aggregates are efficient photothermal therapy (PTT) agents for both local treatment of single tumors and systemic treatment of double-tumor models without causing noticeable side effects, confirming the biosecurity of Au NCs and systemic PTT. The switchable strategy of PTT may signify the establishment of a new systemic therapeutic methodology. For renal clearable nanoagents, it is challenging to delay the renal clearance to acquire efficient tumor accumulation. Herein, we report sodium alginate (SA) stabilized gold (Au) NCs. The Au NCs are of high biocompatibility and renal clearable. Contributed from the ligands of SA, the half-life (t1/2) of Au NCs is prolonged to ∼9.3 h, enhancing the tumor accumulation rate to 10.4 %ID/g. In tumor microenvironment (TME), the Au NCs are stimulated to functionally aggregate, which switches on the photothermal effect. Animal experiments prove that Au NCs aggregates are efficient photothermal therapy (PTT) agents for both local treatment of single tumors and systemic treatment of double-tumor models without causing noticeable side effects, confirming the biosecurity of Au NCs and systemic PTT. The switchable strategy of PTT may signify the establishment of a new systemic therapeutic methodology.For renal clearable nanoagents, it is challenging to delay the renal clearance to acquire efficient tumor accumulation. Herein, we report sodium alginate (SA) stabilized gold (Au) NCs. The Au NCs are of high biocompatibility and renal clearable. Contributed from the ligands of SA, the half-life (t1/2) of Au NCs is prolonged to ∼9.3 h, enhancing the tumor accumulation rate to 10.4 %ID/g. In tumor microenvironment (TME), the Au NCs are stimulated to functionally aggregate, which switches on the photothermal effect. Animal experiments prove that Au NCs aggregates are efficient photothermal therapy (PTT) agents for both local treatment of single tumors and systemic treatment of double-tumor models without causing noticeable side effects, confirming the biosecurity of Au NCs and systemic PTT. The switchable strategy of PTT may signify the establishment of a new systemic therapeutic methodology. For renal clearable nanoagents, it is challenging to delay the renal clearance to acquire efficient tumor accumulation. Herein, we report sodium alginate (SA) stabilized gold (Au) NCs. The Au NCs are of high biocompatibility and renal clearable. Contributed from the ligands of SA, the half-life (t₁/₂) of Au NCs is prolonged to ∼9.3 h, enhancing the tumor accumulation rate to 10.4 %ID/g. In tumor microenvironment (TME), the Au NCs are stimulated to functionally aggregate, which switches on the photothermal effect. Animal experiments prove that Au NCs aggregates are efficient photothermal therapy (PTT) agents for both local treatment of single tumors and systemic treatment of double-tumor models without causing noticeable side effects, confirming the biosecurity of Au NCs and systemic PTT. The switchable strategy of PTT may signify the establishment of a new systemic therapeutic methodology. For renal clearable nanoagents, it is challenging to delay the renal clearance to acquire efficient tumor accumulation. Herein, we report sodium alginate (SA) stabilized gold (Au) NCs. The Au NCs are of high biocompatibility and renal clearable. Contributed from the ligands of SA, the half-life (t ) of Au NCs is prolonged to ∼9.3 h, enhancing the tumor accumulation rate to 10.4 %ID/g. In tumor microenvironment (TME), the Au NCs are stimulated to functionally aggregate, which switches on the photothermal effect. Animal experiments prove that Au NCs aggregates are efficient photothermal therapy (PTT) agents for both local treatment of single tumors and systemic treatment of double-tumor models without causing noticeable side effects, confirming the biosecurity of Au NCs and systemic PTT. The switchable strategy of PTT may signify the establishment of a new systemic therapeutic methodology. |
| ArticleNumber | 116344 |
| Author | Liu, Guojian Lin, Min Wang, Lu Zhang, Hao Zhao, Pin Liu, Shuwei Cheng, Yanru Sui, Kunyan |
| Author_xml | – sequence: 1 givenname: Pin surname: Zhao fullname: Zhao, Pin organization: State Key Laboratory of Bio-Fibers and Eco-Textiles, Shandong Collaborative Innovation Center of Marine Biobased Fibers and Ecological Textiles, College of Materials Science and Engineering, Institute of Marine Biobased Materials, Qingdao University, Qingdao 266071, PR China – sequence: 2 givenname: Shuwei surname: Liu fullname: Liu, Shuwei organization: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China – sequence: 3 givenname: Lu surname: Wang fullname: Wang, Lu organization: Department of Oral Pathology, School and Hospital of Stomatology, Jilin University, Changchun 130021, PR China – sequence: 4 givenname: Guojian surname: Liu fullname: Liu, Guojian organization: State Key Laboratory of Bio-Fibers and Eco-Textiles, Shandong Collaborative Innovation Center of Marine Biobased Fibers and Ecological Textiles, College of Materials Science and Engineering, Institute of Marine Biobased Materials, Qingdao University, Qingdao 266071, PR China – sequence: 5 givenname: Yanru surname: Cheng fullname: Cheng, Yanru organization: State Key Laboratory of Bio-Fibers and Eco-Textiles, Shandong Collaborative Innovation Center of Marine Biobased Fibers and Ecological Textiles, College of Materials Science and Engineering, Institute of Marine Biobased Materials, Qingdao University, Qingdao 266071, PR China – sequence: 6 givenname: Min orcidid: 0000-0001-9161-9121 surname: Lin fullname: Lin, Min email: linmin900401@126.com organization: State Key Laboratory of Bio-Fibers and Eco-Textiles, Shandong Collaborative Innovation Center of Marine Biobased Fibers and Ecological Textiles, College of Materials Science and Engineering, Institute of Marine Biobased Materials, Qingdao University, Qingdao 266071, PR China – sequence: 7 givenname: Kunyan surname: Sui fullname: Sui, Kunyan email: sky@qdu.edu.cn organization: State Key Laboratory of Bio-Fibers and Eco-Textiles, Shandong Collaborative Innovation Center of Marine Biobased Fibers and Ecological Textiles, College of Materials Science and Engineering, Institute of Marine Biobased Materials, Qingdao University, Qingdao 266071, PR China – sequence: 8 givenname: Hao surname: Zhang fullname: Zhang, Hao email: hao_zhang@jlu.edu.cn organization: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, PR China |
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| Keywords | Systemic therapy Photothermal therapy Sodium alginate Biosecurity Renal clearance Nanoclusters |
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| Snippet | •Contributed from polysarchride ligand of sodium alginate, Au NCs are sensitive to aggregate in tumor microenvironment.•The functional aggregation switches on... For renal clearable nanoagents, it is challenging to delay the renal clearance to acquire efficient tumor accumulation. Herein, we report sodium alginate (SA)... |
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| StartPage | 116344 |
| SubjectTerms | adverse effects Alginates - chemistry animal experimentation Animals biocompatibility Biosecurity gold Gold - pharmacokinetics Gold - pharmacology half life HEK293 Cells Humans KB Cells ligands Metal Nanoparticles - therapeutic use Mice, Inbred BALB C Mice, Nude Nanoclusters nanogold neoplasms Neoplasms - therapy Photothermal Therapy photothermotherapy Renal clearance Sodium alginate Systemic therapy Tumor Microenvironment |
| Title | Alginate mediated functional aggregation of gold nanoclusters for systemic photothermal therapy and efficient renal clearance |
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