Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide
Using a specific radioimmunoassay for human brain natriuretic peptide (hBNP) with a monoclonal antibody, we have investigated its synthesis, secretion, and clearance in comparison with those of atrial natriuretic peptide (ANP) in normal subjects and patients with congestive heart failure (CHF). Mean...
Saved in:
| Published in | The Journal of clinical investigation Vol. 87; no. 4; pp. 1402 - 1412 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Ann Arbor, MI
American Society for Clinical Investigation
01.04.1991
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-9738 |
| DOI | 10.1172/JCI115146 |
Cover
| Abstract | Using a specific radioimmunoassay for human brain natriuretic peptide (hBNP) with a monoclonal antibody, we have investigated its synthesis, secretion, and clearance in comparison with those of atrial natriuretic peptide (ANP) in normal subjects and patients with congestive heart failure (CHF). Mean BNP-like immunoreactivity (-LI) levels in normal atrium and ventricle were 250 and 18 pmol/g, respectively. The plasma BNP-LI level in normal subjects was 0.90 +/- 0.07 fmol/ml, which was 16% of the ANP-LI level. In contrast, the plasma BNP-LI level markedly increased in patients with CHF in proportion to its severity, and surpassed the ANP-LI level in severe cases. There was a significant step-up of the plasma BNP-LI level in the coronary sinus (CS) compared with that in the aortic root (Ao) and the difference between these BNP-LI levels, delta(CS-Ao)BNP, also increased with the severity of CHF. In addition, the step-up of the BNP-LI level in the anterior interventricular vein [delta(AIV-Ao)BNP] was comparable to delta(CS-Ao)BNP, indicating that BNP is secreted mainly from the ventricle. Predominant BNP synthesis in the ventricle was also confirmed by Northern blot analysis. Catheterization and pharmacokinetic studies revealed that hBNP is cleared from the circulation more slowly than alpha-hANP; this was in part attributed to lower (about 7%) binding affinity of hBNP to clearance receptors than that of alpha-hANP. A predominant molecular form of BNP-LI in the heart and plasma was a 3-kD form corresponding to hBNP. These results indicate that BNP is a novel cardiac hormone secreted predominantly from the ventricle, and that the synthesis, secretion and clearance of BNP differ from those of ANP, suggesting discrete physiological and pathophysiological roles of BNP in a dual natriuretic peptide system. |
|---|---|
| AbstractList | Using a specific radioimmunoassay for human brain natriuretic peptide (hBNP) with a monoclonal antibody, we have investigated its synthesis, secretion, and clearance in comparison with those of atrial natriuretic peptide (ANP) in normal subjects and patients with congestive heart failure (CHF). Mean BNP-like immunoreactivity (-LI) levels in normal atrium and ventricle were 250 and 18 pmol/g, respectively. The plasma BNP-LI level in normal subjects was 0.90 +/- 0.07 fmol/ml, which was 16% of the ANP-LI level. In contrast, the plasma BNP-LI level markedly increased in patients with CHF in proportion to its severity, and surpassed the ANP-LI level in severe cases. There was a significant step-up of the plasma BNP-LI level in the coronary sinus (CS) compared with that in the aortic root (Ao) and the difference between these BNP-LI levels, delta(CS-Ao)BNP, also increased with the severity of CHF. In addition, the step-up of the BNP-LI level in the anterior interventricular vein [delta(AIV-Ao)BNP] was comparable to delta(CS-Ao)BNP, indicating that BNP is secreted mainly from the ventricle. Predominant BNP synthesis in the ventricle was also confirmed by Northern blot analysis. Catheterization and pharmacokinetic studies revealed that hBNP is cleared from the circulation more slowly than alpha-hANP; this was in part attributed to lower (about 7%) binding affinity of hBNP to clearance receptors than that of alpha-hANP. A predominant molecular form of BNP-LI in the heart and plasma was a 3-kD form corresponding to hBNP. These results indicate that BNP is a novel cardiac hormone secreted predominantly from the ventricle, and that the synthesis, secretion and clearance of BNP differ from those of ANP, suggesting discrete physiological and pathophysiological roles of BNP in a dual natriuretic peptide system.Using a specific radioimmunoassay for human brain natriuretic peptide (hBNP) with a monoclonal antibody, we have investigated its synthesis, secretion, and clearance in comparison with those of atrial natriuretic peptide (ANP) in normal subjects and patients with congestive heart failure (CHF). Mean BNP-like immunoreactivity (-LI) levels in normal atrium and ventricle were 250 and 18 pmol/g, respectively. The plasma BNP-LI level in normal subjects was 0.90 +/- 0.07 fmol/ml, which was 16% of the ANP-LI level. In contrast, the plasma BNP-LI level markedly increased in patients with CHF in proportion to its severity, and surpassed the ANP-LI level in severe cases. There was a significant step-up of the plasma BNP-LI level in the coronary sinus (CS) compared with that in the aortic root (Ao) and the difference between these BNP-LI levels, delta(CS-Ao)BNP, also increased with the severity of CHF. In addition, the step-up of the BNP-LI level in the anterior interventricular vein [delta(AIV-Ao)BNP] was comparable to delta(CS-Ao)BNP, indicating that BNP is secreted mainly from the ventricle. Predominant BNP synthesis in the ventricle was also confirmed by Northern blot analysis. Catheterization and pharmacokinetic studies revealed that hBNP is cleared from the circulation more slowly than alpha-hANP; this was in part attributed to lower (about 7%) binding affinity of hBNP to clearance receptors than that of alpha-hANP. A predominant molecular form of BNP-LI in the heart and plasma was a 3-kD form corresponding to hBNP. These results indicate that BNP is a novel cardiac hormone secreted predominantly from the ventricle, and that the synthesis, secretion and clearance of BNP differ from those of ANP, suggesting discrete physiological and pathophysiological roles of BNP in a dual natriuretic peptide system. Using a specific radioimmunoassay for human brain natriuretic peptide (hBNP) with a monoclonal antibody, we have investigated its synthesis, secretion, and clearance in comparison with those of atrial natriuretic peptide (ANP) in normal subjects and patients with congestive heart failure (CHF). Mean BNP-like immunoreactivity (-LI) levels in normal atrium and ventricle were 250 and 18 pmol/g, respectively. The plasma BNP-LI level in normal subjects was 0.90 +/- 0.07 fmol/ml, which was 16% of the ANP-LI level. In contrast, the plasma BNP-LI level markedly increased in patients with CHF in proportion to its severity, and surpassed the ANP-LI level in severe cases. There was a significant step-up of the plasma BNP-LI level in the coronary sinus (CS) compared with that in the aortic root (Ao) and the difference between these BNP-LI levels, delta(CS-Ao)BNP, also increased with the severity of CHF. In addition, the step-up of the BNP-LI level in the anterior interventricular vein [delta(AIV-Ao)BNP] was comparable to delta(CS-Ao)BNP, indicating that BNP is secreted mainly from the ventricle. Predominant BNP synthesis in the ventricle was also confirmed by Northern blot analysis. Catheterization and pharmacokinetic studies revealed that hBNP is cleared from the circulation more slowly than alpha-hANP; this was in part attributed to lower (about 7%) binding affinity of hBNP to clearance receptors than that of alpha-hANP. A predominant molecular form of BNP-LI in the heart and plasma was a 3-kD form corresponding to hBNP. These results indicate that BNP is a novel cardiac hormone secreted predominantly from the ventricle, and that the synthesis, secretion and clearance of BNP differ from those of ANP, suggesting discrete physiological and pathophysiological roles of BNP in a dual natriuretic peptide system. |
| Author | Hosoda, K Shirakami, G Jougasaki, M Suga, S Yasue, H Nakao, K Obata, K Ogawa, Y Mukoyama, M Saito, Y |
| AuthorAffiliation | Department of Medicine, Kyoto University School of Medicine, Japan |
| AuthorAffiliation_xml | – name: Department of Medicine, Kyoto University School of Medicine, Japan |
| Author_xml | – sequence: 1 givenname: M surname: Mukoyama fullname: Mukoyama, M – sequence: 2 givenname: K surname: Nakao fullname: Nakao, K – sequence: 3 givenname: K surname: Hosoda fullname: Hosoda, K – sequence: 4 givenname: S surname: Suga fullname: Suga, S – sequence: 5 givenname: Y surname: Saito fullname: Saito, Y – sequence: 6 givenname: Y surname: Ogawa fullname: Ogawa, Y – sequence: 7 givenname: G surname: Shirakami fullname: Shirakami, G – sequence: 8 givenname: M surname: Jougasaki fullname: Jougasaki, M – sequence: 9 givenname: K surname: Obata fullname: Obata, K – sequence: 10 givenname: H surname: Yasue fullname: Yasue, H |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5411195$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/1849149$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1ksFu1DAQhn0oKm3hwAMg-YCQkLqtndhJfOAAqxZaVeoFztbYmbBGib21nRV9Ll4Qr7paQUtPc_i_f_7RzByTAx88EvKGszPO2-r8ennFueSiOSBHjFV8odq6e0mOU_rJGBdCikNyyDuhuFBH5PfnCM5TDzm6OWJ2lq5xnV2PFBIF6sMGR2oh9g4sXYU4lTRaHKt5Ap_O6MWmsN4iHUKk4Cn-uptdchlpP8P438bpPmWcTulWegYB31Pz3GSvyIsBxoSvd_WEfL-8-Lb8uri5_XK1_HSzsKIReaGMkqYBASg6hga62iCH2sqagYHBiAZsrbCSgrWmFWiFqUUjeyy6YID1Cfn40Hc9mwl7iz5HGPU6ugnivQ7g9L-Kdyv9I2x0pWRZcPG_3_ljuJsxZT25ZHEcwWOYk-6YUHXVbsG3fwftE3ZXKvq7nQ7JwjhE8NalPSYF51zJgp0_YDaGlCIO2roM2YXtdG7UnOnth-j9hxTHh0eOffQT9g80FMMy |
| CODEN | JCINAO |
| CitedBy_id | crossref_primary_10_1152_ajpheart_2000_278_1_H33 crossref_primary_10_1161_JAHA_116_003957 crossref_primary_10_1007_s00246_014_0872_z crossref_primary_10_1053_snep_2002_35666 crossref_primary_10_1097_00005344_200000006_00006 crossref_primary_10_1152_ajprenal_1998_274_1_F63 crossref_primary_10_1111_j_1527_5299_2001_00266_x crossref_primary_10_1016_j_clinthera_2007_02_004 crossref_primary_10_1016_j_peptides_2018_06_001 crossref_primary_10_2337_diacare_27_8_1929 crossref_primary_10_1373_clinchem_2013_210435 crossref_primary_10_2169_naika_98_2124 crossref_primary_10_1515_CCLM_2001_070 crossref_primary_10_1016_j_jacc_2004_07_016 crossref_primary_10_3317_jraas_2004_010 crossref_primary_10_1046_j_1440_1681_2002_03779_x crossref_primary_10_1016_j_ijcard_2005_01_043 crossref_primary_10_1016_j_ijcard_2007_12_017 crossref_primary_10_1016_j_peptides_2004_09_024 crossref_primary_10_1124_pr_118_017129 crossref_primary_10_1089_met_2019_0073 crossref_primary_10_1007_s10989_008_9126_3 crossref_primary_10_1080_13543784_2023_2290064 crossref_primary_10_1161_01_CIR_0000146904_13677_E4 crossref_primary_10_1016_S0735_1097_99_00522_7 crossref_primary_10_2217_fca_15_53 crossref_primary_10_1054_jcaf_2002_125368 crossref_primary_10_1111_j_1527_5299_2001_00231_x crossref_primary_10_2174_1573403X15666190326150550 crossref_primary_10_1007_s11259_021_09813_3 crossref_primary_10_1016_0888_7543_95_80225_B crossref_primary_10_1016_S0003_4975_97_00168_9 crossref_primary_10_1016_S0002_9343_99_80372_6 crossref_primary_10_1016_j_hfc_2007_10_003 crossref_primary_10_1016_j_peptides_2013_12_018 crossref_primary_10_1161_CIRCULATIONAHA_105_540039 crossref_primary_10_1536_ihj_47_401 crossref_primary_10_1097_01_mcg_0000190781_96021_20 crossref_primary_10_1253_circj_71_79 crossref_primary_10_1073_pnas_070371497 crossref_primary_10_3390_ijms24119642 crossref_primary_10_1164_rccm_200510_1545OC crossref_primary_10_1002_ejhf_3036 crossref_primary_10_1161_01_RES_78_4_606 crossref_primary_10_1586_14779072_2_6_803 crossref_primary_10_3390_s17092116 crossref_primary_10_1016_S0735_1097_97_00452_X crossref_primary_10_1161_01_CIR_0000147829_78357_C5 crossref_primary_10_1159_000509239 crossref_primary_10_1006_jmcc_1999_1030 crossref_primary_10_1253_jcj_61_657 crossref_primary_10_1007_s11695_013_0889_z crossref_primary_10_1016_j_clinbiochem_2007_10_015 crossref_primary_10_1186_s13036_017_0093_0 crossref_primary_10_1007_s00210_011_0670_6 crossref_primary_10_1371_journal_pone_0177327 crossref_primary_10_3390_bios10090107 crossref_primary_10_3389_fpsyg_2014_01040 crossref_primary_10_1242_jeb_165381 crossref_primary_10_1016_S0003_4975_02_03417_3 crossref_primary_10_1016_j_ijoa_2008_08_001 crossref_primary_10_1161_CIRCRESAHA_109_208314 crossref_primary_10_1373_clinchem_2013_220202 crossref_primary_10_31083_j_rcm2307238 crossref_primary_10_1007_BF01747496 crossref_primary_10_1515_CCLM_2000_076 crossref_primary_10_1159_000355746 crossref_primary_10_1016_S0003_4975_03_01322_5 crossref_primary_10_1007_s00392_005_0246_x crossref_primary_10_1007_s11010_010_0565_8 crossref_primary_10_1111_j_1540_8159_1994_tb01438_x crossref_primary_10_1016_j_archger_2012_09_005 crossref_primary_10_1016_j_peptides_2020_170352 crossref_primary_10_1007_BF02480654 crossref_primary_10_1016_S0378_3782_02_00038_5 crossref_primary_10_1016_S0954_6111_99_90094_X crossref_primary_10_4137_CMC_S7189 crossref_primary_10_1515_CCLM_2007_119 crossref_primary_10_3317_jraas_2003_020 crossref_primary_10_1111_j_1742_4658_2011_08081_x crossref_primary_10_1007_s00414_006_0102_1 crossref_primary_10_3389_fphys_2021_691407 crossref_primary_10_1016_j_jjcc_2011_06_010 crossref_primary_10_1021_ac102248d crossref_primary_10_1097_00005344_199901000_00014 crossref_primary_10_1097_01_HCR_0000311506_49398_6d crossref_primary_10_1002_hep_1840200425 crossref_primary_10_1291_hypres_31_1695 crossref_primary_10_2459_JCM_0b013e328341d061 crossref_primary_10_1371_journal_pone_0181206 crossref_primary_10_1161_01_RES_83_10_1035 crossref_primary_10_1006_exer_1997_0403 crossref_primary_10_1097_00000539_199710000_00035 crossref_primary_10_1212_WNL_0b013e31829d8773 crossref_primary_10_1161_01_HYP_27_3_833 crossref_primary_10_1161_CIRCULATIONAHA_105_552216 crossref_primary_10_1016_j_metabol_2015_09_019 crossref_primary_10_1016_S0002_8703_97_70225_4 crossref_primary_10_1097_MD_0000000000025931 crossref_primary_10_1007_s10157_018_1600_4 crossref_primary_10_1536_jhj_40_629 crossref_primary_10_1210_en_2004_0181 crossref_primary_10_1177_002215540104901012 crossref_primary_10_1253_circj_71_1446 crossref_primary_10_1016_j_omtm_2020_05_005 crossref_primary_10_1155_2012_962347 crossref_primary_10_1016_S1388_9842_00_00103_3 crossref_primary_10_1016_0167_5273_92_90020_4 crossref_primary_10_3109_08860229609052796 crossref_primary_10_1111_j_1527_5299_2007_05622_x crossref_primary_10_1124_jpet_102_042143 crossref_primary_10_1161_01_CIR_92_6_1558 crossref_primary_10_1046_j_1365_2869_1998_00109_x crossref_primary_10_1002_jemt_20152 crossref_primary_10_1253_jcj_62_658 crossref_primary_10_1016_j_amjcard_2005_01_079 crossref_primary_10_1073_pnas_96_18_10278 crossref_primary_10_1016_0002_8703_93_91042_D crossref_primary_10_1038_ki_1992_361 crossref_primary_10_1371_journal_pone_0108983 crossref_primary_10_1007_s00380_022_02216_7 crossref_primary_10_1016_j_peptides_2005_05_021 crossref_primary_10_1016_j_yjmcc_2011_01_017 crossref_primary_10_1016_j_ancard_2004_09_003 crossref_primary_10_1002_clc_4960230412 crossref_primary_10_1139_y11_054 crossref_primary_10_1002_dat_20218 crossref_primary_10_1161_JAHA_116_003557 crossref_primary_10_1111_j_0889_7204_2005_04696_x crossref_primary_10_1161_01_CIR_102_8_865 crossref_primary_10_1556_OH_2013_29541 crossref_primary_10_1016_S1155_1941_11_51206_5 crossref_primary_10_1097_CPM_0b013e3181acc359 crossref_primary_10_1016_j_peptides_2018_08_006 crossref_primary_10_1161_01_RES_81_5_694 crossref_primary_10_1139_y11_040 crossref_primary_10_1210_jcem_84_2_5489 crossref_primary_10_2217_fca_13_32 crossref_primary_10_1016_S0014_5793_96_01385_3 crossref_primary_10_25259_SNI_784_2020 crossref_primary_10_1007_s10787_998_0032_2 crossref_primary_10_1007_s12265_020_10042_3 crossref_primary_10_1097_01_PCC_0000224998_97784_A3 crossref_primary_10_1253_jcj_63_893 crossref_primary_10_1134_S1990747808030082 crossref_primary_10_1136_hrt_73_6_584_b crossref_primary_10_1016_j_ejheart_2004_04_018 crossref_primary_10_1097_01_CCM_0000229144_97624_90 crossref_primary_10_1016_S0147_9563_98_90063_2 crossref_primary_10_1038_ki_1993_44 crossref_primary_10_1016_0002_8703_94_90739_0 crossref_primary_10_2174_1567202619666220713110941 crossref_primary_10_1161_01_CIR_0000047280_15244_EB crossref_primary_10_26442_terarkh201890968_72 crossref_primary_10_1002_hep_1840220620 crossref_primary_10_1113_EP085091 crossref_primary_10_1016_S0735_1097_00_01095_0 crossref_primary_10_1016_j_abb_2006_03_028 crossref_primary_10_1016_j_ejheart_2004_04_012 crossref_primary_10_1093_eurheartj_sui009 crossref_primary_10_1017_S1047951110000089 crossref_primary_10_1073_pnas_95_5_2337 crossref_primary_10_1097_CCE_0000000000000392 crossref_primary_10_1002_ehf2_13595 crossref_primary_10_1253_circj_70_1058 crossref_primary_10_3390_cells11030588 crossref_primary_10_1016_S0167_4943_01_00098_X crossref_primary_10_1371_journal_pone_0263165 crossref_primary_10_1016_S0021_9258_18_53418_9 crossref_primary_10_1016_S0378_1119_02_00676_5 crossref_primary_10_1111_j_1440_1746_2005_03906_x crossref_primary_10_1007_s11255_009_9544_y crossref_primary_10_1016_j_repce_2016_12_001 crossref_primary_10_3390_ijms20112824 crossref_primary_10_2337_diacare_26_7_2081 crossref_primary_10_1507_endocrj_EJ12_0239 crossref_primary_10_1096_fj_03_1336fje crossref_primary_10_1111_j_1440_1681_1995_tb02873_x crossref_primary_10_1155_2013_235018 crossref_primary_10_1002_ccd_25985 crossref_primary_10_1097_00004872_200110000_00027 crossref_primary_10_1016_S0210_5691_04_70083_2 crossref_primary_10_1007_BF02389889 crossref_primary_10_1536_ihj_14_267 crossref_primary_10_1016_S0022_3565_24_37558_5 crossref_primary_10_1002_pdi_2183 crossref_primary_10_1016_S0167_5273_03_00047_0 crossref_primary_10_1016_j_ijcme_2014_07_007 crossref_primary_10_2139_ssrn_3974491 crossref_primary_10_3390_biology11071034 crossref_primary_10_3346_jkms_2020_35_e351 crossref_primary_10_1016_S0022_2143_99_90163_4 crossref_primary_10_4097_kjae_2011_61_1_1 crossref_primary_10_1007_s12265_013_9465_0 crossref_primary_10_1016_S0167_5273_02_00200_0 crossref_primary_10_1016_S1262_3636_08_70097_1 crossref_primary_10_1007_s00216_021_03490_6 crossref_primary_10_1016_j_cardfail_2005_04_025 crossref_primary_10_1152_ajpregu_2002_282_1_R156 crossref_primary_10_1161_CIRCULATIONAHA_107_742270 crossref_primary_10_1016_S0967_5868_03_00111_5 crossref_primary_10_1161_01_CIR_96_2_509 crossref_primary_10_1016_j_hfc_2005_01_002 crossref_primary_10_1161_hy0302_105214 crossref_primary_10_1253_circj_70_163 crossref_primary_10_1016_j_amjmed_2003_10_028 crossref_primary_10_1016_0167_5273_95_02468_9 crossref_primary_10_1016_j_cardfail_2005_04_019 crossref_primary_10_1016_S1071_9164_97_90028_2 crossref_primary_10_1016_0167_0115_96_00035_3 crossref_primary_10_1097_01_CCM_0000229675_78883_E9 crossref_primary_10_1152_ajpregu_00682_2004 crossref_primary_10_1164_rccm_2406003 crossref_primary_10_1007_s00018_017_2723_6 crossref_primary_10_1016_S0755_4982_06_74870_9 crossref_primary_10_1007_s00018_023_04894_6 crossref_primary_10_1161_01_CIR_103_1_72 crossref_primary_10_1074_jbc_272_37_23064 crossref_primary_10_1298_ptr_E10187 crossref_primary_10_1016_j_diabres_2014_02_009 crossref_primary_10_1016_j_cardfail_2019_07_546 crossref_primary_10_1159_000366470 crossref_primary_10_1007_s11897_006_0016_8 crossref_primary_10_1016_S0735_1097_02_02032_6 crossref_primary_10_1093_ejechocard_jer256 crossref_primary_10_7453_gahmj_2012_1_2_011 crossref_primary_10_1016_S0014_2999_98_00014_4 crossref_primary_10_1080_13547500903015784 crossref_primary_10_1210_endo_139_7_6093 crossref_primary_10_1097_00005344_199801000_00017 crossref_primary_10_1152_ajpheart_1998_275_4_H1200 crossref_primary_10_3390_biology11071017 crossref_primary_10_1007_s10741_008_9123_9 crossref_primary_10_3390_ijms20092281 crossref_primary_10_1007_s10557_009_6207_2 crossref_primary_10_1179_016164102101200474 crossref_primary_10_1097_00005344_199912000_00015 crossref_primary_10_1038_s41598_024_61888_5 crossref_primary_10_1161_01_HYP_27_4_906 crossref_primary_10_1006_phrs_2000_0758 crossref_primary_10_1177_147323000503300602 crossref_primary_10_1016_S0272_6386_03_00358_5 crossref_primary_10_1016_0735_1097_93_90468_G crossref_primary_10_1183_09031936_00173509 crossref_primary_10_2459_01_JCM_0000199778_85343_08 crossref_primary_10_1177_1074248413518971 crossref_primary_10_1161_JAHA_113_000150 crossref_primary_10_1152_ajprenal_00668_2013 crossref_primary_10_1517_13543776_18_1_61 crossref_primary_10_3390_biology11060911 crossref_primary_10_1016_j_amjms_2018_06_009 crossref_primary_10_1253_circj_69_277 crossref_primary_10_1007_s00109_009_0515_7 crossref_primary_10_1016_S0009_8981_97_00248_9 crossref_primary_10_2169_internalmedicine_50_5163 crossref_primary_10_1046_j_1365_2362_2002_01035_x crossref_primary_10_1136_hrt_86_1_27 crossref_primary_10_1007_s00228_007_0309_1 crossref_primary_10_1111_j_1530_0277_1995_tb01618_x crossref_primary_10_1016_S0923_2532_01_80047_8 crossref_primary_10_1016_0014_5793_95_00096_R crossref_primary_10_1053_j_ackd_2017_05_010 crossref_primary_10_1016_0735_1097_95_00338_X crossref_primary_10_1152_ajpregu_00444_2004 crossref_primary_10_1111_ped_12986 crossref_primary_10_1152_ajpheart_1997_273_5_H2372 crossref_primary_10_1016_S0828_282X_07_70758_4 crossref_primary_10_3892_etm_2019_8269 crossref_primary_10_1378_chest_123_2_338 crossref_primary_10_1161_HYPERTENSIONAHA_115_05610 crossref_primary_10_1016_j_rmed_2007_06_027 crossref_primary_10_1097_00004872_200018080_00018 crossref_primary_10_1507_endocrj_K10E_164 crossref_primary_10_1161_CIRCULATIONAHA_105_538520 crossref_primary_10_1007_s10741_007_9016_3 crossref_primary_10_1111_j_1440_1681_1993_tb01737_x crossref_primary_10_1111_j_1469_7793_1999_0359p_x crossref_primary_10_1291_hypres_31_89 crossref_primary_10_1253_jcj_64_965 crossref_primary_10_1177_003693309403900201 crossref_primary_10_1507_endocrj_K10E_150 crossref_primary_10_1016_j_jash_2008_02_001 crossref_primary_10_1016_S0735_1097_02_01814_4 crossref_primary_10_1210_er_2005_0014 crossref_primary_10_1016_j_jacc_2005_05_057 crossref_primary_10_1291_hypres_28_79 crossref_primary_10_1007_s10741_019_09883_1 crossref_primary_10_1152_ajprenal_00478_2006 crossref_primary_10_1177_0310057X0603400218 crossref_primary_10_1016_0026_0495_93_90023_H crossref_primary_10_1111_j_1523_1755_1998_00855_x crossref_primary_10_1007_s00508_016_0954_4 crossref_primary_10_1197_aemj_10_3_275 crossref_primary_10_3390_ijms23105680 crossref_primary_10_1111_j_1365_2362_2006_01594_x crossref_primary_10_1515_CCLM_2002_130 crossref_primary_10_1016_j_aanat_2017_07_003 crossref_primary_10_1016_j_ajhg_2018_06_007 crossref_primary_10_1126_scitranslmed_aav5464 crossref_primary_10_1007_s11427_013_4605_y crossref_primary_10_1093_eurheartj_ehi772 crossref_primary_10_1016_j_ijcard_2014_08_007 crossref_primary_10_21601_ortadogutipdergisi_466911 crossref_primary_10_4065_mcp_2010_0708 crossref_primary_10_1007_s10741_021_10137_2 crossref_primary_10_1292_jvms_61_523 crossref_primary_10_14341_2072_0351_6221 crossref_primary_10_1080_00015385_2019_1590958 crossref_primary_10_1080_10245330600774991 crossref_primary_10_1016_S0196_9781_97_00245_3 crossref_primary_10_3109_08037051_2014_923250 crossref_primary_10_1007_s10735_024_10214_4 crossref_primary_10_1016_j_hfc_2015_07_007 crossref_primary_10_1046_j_1365_2281_2001_00371_x crossref_primary_10_3109_07853890108995955 crossref_primary_10_1186_1758_5996_5_13 crossref_primary_10_1016_j_jacc_2008_11_032 crossref_primary_10_1016_S0002_8703_99_70414_X crossref_primary_10_1007_BF01829018 crossref_primary_10_1016_j_sintl_2021_100103 crossref_primary_10_1016_j_transci_2013_12_001 crossref_primary_10_1093_eurheartj_ehs229 crossref_primary_10_1016_j_tvjl_2009_06_008 crossref_primary_10_1016_j_jim_2011_06_005 crossref_primary_10_1097_CRD_0000000000000779 crossref_primary_10_3389_fphys_2016_00565 crossref_primary_10_1111_j_1472_8206_2005_00336_x crossref_primary_10_1016_j_ejim_2006_07_013 crossref_primary_10_1016_j_ijcard_2008_08_011 crossref_primary_10_1097_MD_0000000000003483 crossref_primary_10_1016_S0002_9149_00_00793_1 crossref_primary_10_1016_S1071_9164_96_80030_3 crossref_primary_10_1007_s00395_009_0070_y crossref_primary_10_1016_S1071_9164_98_90506_1 crossref_primary_10_1007_s00380_021_02011_w crossref_primary_10_1111_j_1540_8159_1994_tb01353_x crossref_primary_10_1111_j_1447_0594_2009_00514_x crossref_primary_10_1016_j_regpep_2008_06_006 crossref_primary_10_3904_kjm_2016_91_2_139 crossref_primary_10_1016_j_cjca_2019_12_004 crossref_primary_10_1016_S0021_9258_17_32511_5 crossref_primary_10_1016_j_cdev_2023_203878 crossref_primary_10_1152_ajpheart_2000_278_3_H731 crossref_primary_10_1007_s00380_007_1034_5 crossref_primary_10_3346_jkms_2015_30_4_442 crossref_primary_10_1016_j_jacc_2004_09_038 crossref_primary_10_1152_ajpheart_01127_2010 crossref_primary_10_1152_ajpheart_2001_280_1_H368 crossref_primary_10_1016_j_peptides_2020_170421 crossref_primary_10_1056_NEJM199308053290614 crossref_primary_10_1002_psc_2969 crossref_primary_10_1016_j_ejheart_2008_03_009 crossref_primary_10_1016_j_amjms_2016_08_001 crossref_primary_10_1253_circj_CJ_22_0531 crossref_primary_10_1097_TA_0b013e3182277b69 crossref_primary_10_1093_eurheartj_sum054 crossref_primary_10_1136_hrt_72_6_528 crossref_primary_10_1186_s41100_018_0177_4 crossref_primary_10_1016_j_trsl_2006_04_004 crossref_primary_10_1016_j_annemergmed_2005_01_027 crossref_primary_10_1016_j_jflm_2018_02_006 crossref_primary_10_1097_FJC_0000000000000724 crossref_primary_10_1111_echo_12048 crossref_primary_10_1080_10408347_2024_2427140 crossref_primary_10_1536_ihj_52_253 crossref_primary_10_1378_chest_110_5_1136 crossref_primary_10_2169_internalmedicine_43_1015 crossref_primary_10_1016_j_ejheart_2008_07_014 crossref_primary_10_1111_j_1525_139X_2005_17349_x crossref_primary_10_1161_CIRCULATIONAHA_118_035272 crossref_primary_10_1016_S0735_1097_00_00865_2 crossref_primary_10_1016_j_addr_2012_11_002 crossref_primary_10_1016_j_jjcc_2008_07_007 crossref_primary_10_1093_eurheartj_ehs262 crossref_primary_10_1016_j_cpcardiol_2003_09_001 crossref_primary_10_1124_jpet_115_229997 crossref_primary_10_1016_j_ijcard_2016_04_111 crossref_primary_10_1016_j_phrs_2006_06_011 crossref_primary_10_1007_s10157_010_0320_1 crossref_primary_10_1016_S0898_6568_01_00139_5 crossref_primary_10_1007_s00424_021_02596_1 crossref_primary_10_3109_00365519709084604 crossref_primary_10_3389_fnmol_2014_00075 crossref_primary_10_1378_chest_130_4_1220 crossref_primary_10_1016_S0014_5793_99_00081_2 crossref_primary_10_1097_01_HDX_0000074517_30102_64 crossref_primary_10_1016_j_tem_2004_03_005 crossref_primary_10_1007_s00216_014_7647_5 crossref_primary_10_1089_neu_2009_1022 crossref_primary_10_1111_j_1365_2362_2004_01301_x crossref_primary_10_1111_jce_15719 crossref_primary_10_1213_00000539_199602000_00003 crossref_primary_10_1152_ajplung_2001_281_4_L749 crossref_primary_10_1111_j_1527_5299_2004_03271_x crossref_primary_10_1016_j_peptides_2004_08_033 crossref_primary_10_1016_j_cll_2013_11_007 crossref_primary_10_1210_en_2010_0078 crossref_primary_10_1016_j_hfc_2006_08_006 crossref_primary_10_1186_1479_5876_12_51 crossref_primary_10_1016_S0002_9149_03_00170_X crossref_primary_10_1016_j_regpep_2004_12_025 crossref_primary_10_1097_00003246_199511000_00017 crossref_primary_10_1016_j_jjcc_2021_02_008 crossref_primary_10_1073_pnas_071389098 crossref_primary_10_1161_CIRCHEARTFAILURE_109_895581 crossref_primary_10_1016_0140_6736_93_93126_L crossref_primary_10_1002__SICI_1098_1128_199901_19_1_75__AID_MED4_3_0_CO_2_6 crossref_primary_10_1016_j_hfc_2009_04_002 crossref_primary_10_3934_genet_2017_1_1 crossref_primary_10_1111_j_1440_1681_1995_tb01918_x crossref_primary_10_1016_S0002_8703_96_90396_8 crossref_primary_10_1016_j_hfc_2009_04_005 crossref_primary_10_1517_13543784_8_7_1063 crossref_primary_10_1177_2045894019892801 crossref_primary_10_1016_j_peptides_2018_05_012 crossref_primary_10_1161_01_HYP_28_6_995 crossref_primary_10_1177_2048872612458580 crossref_primary_10_1186_1475_2840_11_22 crossref_primary_10_3390_cells13110931 crossref_primary_10_1016_j_ejogrb_2019_04_034 crossref_primary_10_14260_jemds_2020_474 crossref_primary_10_1111_j_1365_2796_2009_02135_x crossref_primary_10_3390_jcm10163622 crossref_primary_10_1016_j_clinbiochem_2013_03_014 crossref_primary_10_1161_01_CIR_96_10_3737 crossref_primary_10_1053_ajkd_2002_36329 crossref_primary_10_1002_clc_4960231016 crossref_primary_10_1016_j_echo_2007_06_006 crossref_primary_10_1016_S0021_9258_18_47183_9 crossref_primary_10_1161_01_CIR_94_12_3184 crossref_primary_10_1253_circj_CJ_19_0342 crossref_primary_10_3390_jcm8040559 crossref_primary_10_1021_bc0501000 crossref_primary_10_3389_fphys_2019_01215 crossref_primary_10_1016_S0002_9343_00_00364_8 crossref_primary_10_1016_0378_3782_96_01741_0 crossref_primary_10_3390_ijms20163946 crossref_primary_10_1007_s11274_011_0901_5 crossref_primary_10_1161_01_HYP_28_6_988 crossref_primary_10_1053_j_jvca_2012_01_018 crossref_primary_10_1253_circj_CJ_18_0824 crossref_primary_10_1161_01_HYP_25_5_1053 crossref_primary_10_1016_j_pharmthera_2021_107863 crossref_primary_10_1111_eci_12234 crossref_primary_10_1054_npep_1999_0770 crossref_primary_10_1253_circj_67_691 crossref_primary_10_1542_peds_2007_1856 crossref_primary_10_1016_S0003_4975_02_03654_8 crossref_primary_10_1253_circj_69_83 crossref_primary_10_1016_j_ijcard_2009_03_012 crossref_primary_10_1016_S0168_8278_05_80239_9 crossref_primary_10_1097_00004872_200203000_00025 crossref_primary_10_1096_fj_202000325RRR crossref_primary_10_1093_europace_eul060 crossref_primary_10_1161_CIRCULATIONAHA_107_759241 crossref_primary_10_17343_sdutfd_1332293 crossref_primary_10_1152_ajpheart_2002_282_1_H80 crossref_primary_10_1111_j_1476_5381_1993_tb13816_x crossref_primary_10_1016_S1388_9842_03_00035_7 crossref_primary_10_1016_j_ejheart_2005_09_001 crossref_primary_10_1016_j_cellsig_2019_03_022 crossref_primary_10_1016_j_hfc_2011_11_005 crossref_primary_10_1097_00005344_199902000_00008 crossref_primary_10_1586_14737175_2014_877841 crossref_primary_10_1111_j_1476_5381_2011_01339_x crossref_primary_10_1016_j_diabres_2010_03_012 crossref_primary_10_1016_j_ijcard_2003_04_021 crossref_primary_10_1016_j_cardfail_2025_03_005 crossref_primary_10_1016_j_trsl_2019_02_007 crossref_primary_10_1186_1475_2840_10_28 crossref_primary_10_3389_fcvm_2022_904881 crossref_primary_10_1016_j_cacc_2007_01_004 crossref_primary_10_1016_j_ijid_2013_06_012 crossref_primary_10_1016_S0735_1097_98_00045_X crossref_primary_10_1186_s12879_016_1929_9 crossref_primary_10_1253_circj_68_923 crossref_primary_10_1073_pnas_0538059100 crossref_primary_10_1517_13543784_10_5_935 crossref_primary_10_1253_jjcsc_4_2_213 crossref_primary_10_1016_j_ijcard_2006_10_003 crossref_primary_10_1074_jbc_272_33_20545 crossref_primary_10_1016_S0140_6736_97_06031_5 crossref_primary_10_1038_sj_jhh_1001792 crossref_primary_10_1161_01_CIR_93_11_1946 crossref_primary_10_1067_mje_2001_114911 crossref_primary_10_1161_01_HYP_27_3_552 crossref_primary_10_1097_01_tp_0000295851_24889_bf crossref_primary_10_1016_S0735_1097_98_00494_X crossref_primary_10_1291_hypres_30_651 crossref_primary_10_1016_j_ahj_2004_05_027 crossref_primary_10_1136_openhrt_2017_000666 crossref_primary_10_1515_CCLM_2007_274 crossref_primary_10_1016_j_yjmcc_2014_08_008 crossref_primary_10_1128_MCB_00154_10 crossref_primary_10_1253_circj_70_1557 crossref_primary_10_1177_0218492312450292 crossref_primary_10_1016_j_bcp_2010_06_015 crossref_primary_10_1111_j_1365_2125_1995_tb05803_x crossref_primary_10_1007_s00392_013_0554_5 crossref_primary_10_4070_kcj_2010_40_4_172 crossref_primary_10_1016_j_jss_2021_04_018 crossref_primary_10_1515_CCLM_2007_040 crossref_primary_10_1080_00365510500236077 crossref_primary_10_1111_j_1440_1681_1998_tb02171_x crossref_primary_10_1161_01_HYP_28_1_22 crossref_primary_10_1161_01_STR_29_8_1584 crossref_primary_10_1515_cclm_1992_30_12_837 crossref_primary_10_1542_peds_112_4_896 crossref_primary_10_1161_01_CIR_93_11_1963 crossref_primary_10_1536_ihj_46_1007 crossref_primary_10_1161_01_HYP_29_1_70 crossref_primary_10_1016_S0021_9258_17_32374_8 crossref_primary_10_1016_S0143_4004_99_80023_X crossref_primary_10_1111_dme_12856 crossref_primary_10_2169_internalmedicine_43_700 crossref_primary_10_1253_jcj_60_909 crossref_primary_10_1007_s00216_024_05223_x crossref_primary_10_1016_S1388_9842_01_00232_X crossref_primary_10_1016_j_jvs_2012_07_053 crossref_primary_10_1016_0735_1097_95_00504_8 crossref_primary_10_1016_j_carpath_2006_01_001 crossref_primary_10_3390_vetsci9020064 crossref_primary_10_1016_S1053_2498_01_00289_3 crossref_primary_10_1016_S1885_5857_07_60192_3 crossref_primary_10_1053_hl_1999_v28_a97762 crossref_primary_10_1186_s41100_019_0227_6 crossref_primary_10_1111_j_1540_8159_1999_tb00571_x crossref_primary_10_1681_ASN_2011100985 crossref_primary_10_1152_ajpheart_1998_274_5_H1684 crossref_primary_10_1046_j_1440_1681_2003_03914_x crossref_primary_10_1097_01_CCM_0000178351_03327_9F crossref_primary_10_1111_j_1540_8159_2006_00474_x crossref_primary_10_3390_ijms23115916 crossref_primary_10_1016_j_jjcc_2013_01_015 crossref_primary_10_1152_ajpheart_00668_2015 crossref_primary_10_1016_0002_8703_95_90054_3 crossref_primary_10_1016_j_pep_2015_03_011 crossref_primary_10_1097_MAJ_0b013e3180a6ecd2 crossref_primary_10_1164_rccm_201903_0488OC crossref_primary_10_1161_JAHA_119_013294 crossref_primary_10_1016_j_cca_2011_02_035 crossref_primary_10_1536_ihj_48_579 crossref_primary_10_1016_0014_5793_95_00780_D crossref_primary_10_1016_j_jcmg_2008_12_006 crossref_primary_10_1016_S0140_6736_94_92690_5 crossref_primary_10_1067_j_cpsurg_2009_12_003 crossref_primary_10_4097_kjae_2011_60_6_1 crossref_primary_10_1161_CIRCRESAHA_109_206037 crossref_primary_10_1016_j_jjcc_2009_08_005 crossref_primary_10_1111_j_1399_3046_2010_01421_x crossref_primary_10_1378_chest_128_4_2368 crossref_primary_10_4009_jsdt_51_135 crossref_primary_10_1111_j_1460_9592_2007_02243_x crossref_primary_10_3353_omp_14_1 crossref_primary_10_1253_jjcsc_5_1_25 crossref_primary_10_1097_01_mnm_0000084588_29433_2e crossref_primary_10_1038_s41598_018_23441_z crossref_primary_10_1016_S0025_7753_03_73711_7 crossref_primary_10_1111_j_1748_5827_2009_00802_x crossref_primary_10_1161_01_HYP_27_3_715 crossref_primary_10_1111_bph_14952 crossref_primary_10_1016_j_mam_2019_07_005 crossref_primary_10_1111_j_1527_5299_2002_00721_x crossref_primary_10_1177_0885066610387993 crossref_primary_10_1016_S0014_2999_99_00370_2 crossref_primary_10_4250_jcu_2013_21_1_1 crossref_primary_10_1002_ehf2_15042 crossref_primary_10_1016_0006_8993_93_91649_D crossref_primary_10_1111_j_1540_8159_1999_tb00440_x crossref_primary_10_3390_jcm14020626 crossref_primary_10_1016_j_mcna_2007_04_001 crossref_primary_10_1016_0026_0495_95_90174_4 crossref_primary_10_1016_j_ejheart_2005_02_002 crossref_primary_10_1161_01_HYP_0000015905_27598_E9 crossref_primary_10_1111_j_1460_9592_2008_02652_x crossref_primary_10_1016_j_hlc_2004_09_015 crossref_primary_10_1046_j_1460_9592_2003_t01_1_00171_x crossref_primary_10_1161_CIRCULATIONAHA_122_059960 crossref_primary_10_1038_hr_2014_70 crossref_primary_10_1111_j_1742_4658_2011_08082_x crossref_primary_10_1373_clinchem_2009_123778 crossref_primary_10_1161_CIRCULATIONAHA_109_873265 crossref_primary_10_1111_j_1742_4658_2011_08116_x crossref_primary_10_3389_fphys_2021_654356 crossref_primary_10_1016_S0025_7125_05_70575_7 crossref_primary_10_1161_CIRCEP_108_831586 crossref_primary_10_3390_diagnostics13172723 crossref_primary_10_1080_0886022X_2021_2003206 crossref_primary_10_2995_jacsurg_27_3 crossref_primary_10_1016_S0167_5273_02_00143_2 crossref_primary_10_1016_j_heliyon_2023_e13509 crossref_primary_10_1111_j_1600_0609_1999_tb01734_x crossref_primary_10_1007_s00134_008_1000_4 crossref_primary_10_1038_s41598_018_37053_0 crossref_primary_10_1016_j_ancard_2004_02_015 crossref_primary_10_1016_S0300_8932_02_76547_0 crossref_primary_10_4250_jcu_2010_18_4_139 crossref_primary_10_1007_BF03343766 crossref_primary_10_1007_s12257_010_0309_3 crossref_primary_10_1016_j_pcad_2007_05_002 crossref_primary_10_2183_pjab_95_037 crossref_primary_10_1038_srep03884 crossref_primary_10_1097_01_shk_0000226266_99960_d0 crossref_primary_10_1007_BF02483604 crossref_primary_10_1046_j_1365_2796_2002_00951_x crossref_primary_10_1097_00005344_200210000_00004 crossref_primary_10_2478_jim_2019_0025 crossref_primary_10_1016_S0002_9343_02_01121_X crossref_primary_10_2169_internalmedicine_49_4211 crossref_primary_10_4065_74_2_126 crossref_primary_10_1016_j_forsciint_2019_110079 crossref_primary_10_1016_j_peptides_2015_02_006 crossref_primary_10_1253_circj_70_447 crossref_primary_10_1093_clinchem_47_3_591 crossref_primary_10_1002_hep_1840160126 crossref_primary_10_1093_ndt_gfq408 crossref_primary_10_1507_endocrj_EJ19_0380 crossref_primary_10_2217_fca_10_87 crossref_primary_10_1111_j_1527_3466_1991_tb00417_x crossref_primary_10_1016_j_rec_2015_02_009 crossref_primary_10_1136_hrt_69_5_414 crossref_primary_10_1016_S0002_9149_01_01581_8 crossref_primary_10_1016_j_ijid_2016_10_014 crossref_primary_10_1038_labinvest_3700011 crossref_primary_10_1111_j_1365_2125_1992_tb04102_x crossref_primary_10_1016_j_atherosclerosis_2009_01_033 crossref_primary_10_1016_j_cardfail_2017_04_018 crossref_primary_10_1152_ajpheart_1997_273_5_H2406 crossref_primary_10_1016_S0300_8932_03_77013_4 crossref_primary_10_1016_S0735_1097_97_00482_8 crossref_primary_10_1152_ajpheart_01033_2008 crossref_primary_10_1210_en_2016_1095 crossref_primary_10_1097_CCM_0b013e318183f067 crossref_primary_10_1161_CIRCULATIONAHA_109_909937 crossref_primary_10_1007_s00414_011_0614_1 crossref_primary_10_1016_j_hrthm_2010_10_038 crossref_primary_10_3317_jraas_2000_059 crossref_primary_10_3390_toxins14110787 crossref_primary_10_1007_s10741_016_9544_9 crossref_primary_10_1002_mpo_1155 crossref_primary_10_1007_s00380_012_0278_x crossref_primary_10_1016_j_cca_2015_07_004 crossref_primary_10_1097_MCA_0b013e328056dd33 crossref_primary_10_1016_1050_1738_94_90052_3 crossref_primary_10_1111_j_1440_1681_1992_tb00438_x crossref_primary_10_1177_106002800303700217 crossref_primary_10_1016_j_atc_2006_04_001 crossref_primary_10_1515_JLM_2005_030 crossref_primary_10_1046_j_1365_201X_2001_00805_x crossref_primary_10_1016_j_immbio_2010_05_005 crossref_primary_10_1016_j_repce_2020_02_006 crossref_primary_10_1152_ajpregu_2001_280_6_R1727 crossref_primary_10_1111_j_1472_8206_2005_00379_x crossref_primary_10_3390_biology11081197 crossref_primary_10_1002_clc_4960160708 crossref_primary_10_1016_S0923_2532_02_01215_2 crossref_primary_10_1152_ajpheart_2000_278_5_H1500 crossref_primary_10_2169_internalmedicine_3780_19 crossref_primary_10_1016_j_neuint_2010_03_004 crossref_primary_10_1016_j_repc_2019_05_008 crossref_primary_10_1016_j_molmed_2008_04_003 crossref_primary_10_1016_S0002_8703_98_70252_2 crossref_primary_10_1016_S0041_0101_97_00176_1 crossref_primary_10_1016_j_resuscitation_2003_12_005 crossref_primary_10_1016_j_repc_2016_08_005 crossref_primary_10_1373_clinchem_2011_165696 crossref_primary_10_3109_10641969709084511 crossref_primary_10_1111_j_1553_2712_2003_tb02003_x crossref_primary_10_1016_j_amjmed_2005_08_041 crossref_primary_10_2310_6650_2005_53711 crossref_primary_10_1111_jog_13148 crossref_primary_10_1046_j_1365_2796_2000_00736_x crossref_primary_10_1016_j_bbadis_2012_12_014 crossref_primary_10_1186_s12933_019_0974_2 crossref_primary_10_3389_fphar_2024_1501407 crossref_primary_10_1291_hypres_31_1737 crossref_primary_10_1046_j_1523_1755_1999_00573_x crossref_primary_10_3390_ijms232214415 crossref_primary_10_1152_jappl_1998_84_5_1646 crossref_primary_10_1016_S0923_2532_02_01204_8 crossref_primary_10_1186_s12576_023_00882_4 crossref_primary_10_1136_hrt_70_5_397 crossref_primary_10_1007_s00508_011_0097_6 crossref_primary_10_1354_vp_40_5_501 crossref_primary_10_1253_jcj_64_537 crossref_primary_10_1007_s00125_006_0352_y crossref_primary_10_1111_j_1440_1681_1995_tb02874_x crossref_primary_10_1080_17482940802100261 crossref_primary_10_1517_13543784_8_1_79 crossref_primary_10_1161_01_HYP_0000021780_21830_DD crossref_primary_10_1016_0735_1097_94_00407_H crossref_primary_10_1253_circj_CJ_16_1282 crossref_primary_10_1016_0002_9378_95_90086_1 crossref_primary_10_1016_0002_8703_92_90413_P crossref_primary_10_1253_jcj_64_765 crossref_primary_10_1080_00365510050184895 crossref_primary_10_1016_j_ijcard_2025_133053 crossref_primary_10_1016_S0006_291X_05_81311_7 crossref_primary_10_1291_hypres_31_825 crossref_primary_10_1046_j_1365_2796_2003_01265_x crossref_primary_10_1016_S0735_1097_96_00277_X crossref_primary_10_1080_00365510500429763 crossref_primary_10_1371_journal_pone_0137464 crossref_primary_10_1016_S0002_9149_02_02507_9 crossref_primary_10_1016_S0168_8278_00_80393_1 crossref_primary_10_1016_j_lfs_2018_08_031 crossref_primary_10_1038_s41440_022_00938_9 crossref_primary_10_1097_CRD_0b013e3181815333 crossref_primary_10_1111_j_1600_0609_1998_tb01099_x crossref_primary_10_1139_y01_049 crossref_primary_10_1016_j_cjca_2010_12_038 crossref_primary_10_2353_ajpath_2010_091278 crossref_primary_10_1152_ajpheart_00414_2002 crossref_primary_10_1161_JAHA_122_025803 crossref_primary_10_1046_j_1523_1755_2001_0590041559_x crossref_primary_10_1507_endocrj_K10E_067 crossref_primary_10_1016_j_jacc_2006_08_066 crossref_primary_10_1097_00004872_200103000_00016 crossref_primary_10_1016_j_recesp_2015_02_009 crossref_primary_10_1016_j_ajpath_2012_09_015 crossref_primary_10_1536_jhj_44_713 crossref_primary_10_1016_S0735_1097_99_00593_8 crossref_primary_10_1016_j_amjcard_2011_11_047 crossref_primary_10_1067_mhj_2001_115435 crossref_primary_10_1203_01_pdr_0000196719_95046_19 crossref_primary_10_1016_S0167_0115_97_00019_0 crossref_primary_10_1067_mje_2003_56 crossref_primary_10_1016_S1071_9164_96_80068_6 crossref_primary_10_1111_jcmm_13183 crossref_primary_10_1016_0026_0495_92_90095_R crossref_primary_10_1139_y01_039 crossref_primary_10_1139_y01_032 crossref_primary_10_1161_hs0402_105657 crossref_primary_10_1002_clc_4960220211 crossref_primary_10_1073_pnas_0811851106 crossref_primary_10_1139_y01_031 crossref_primary_10_1161_CIRCULATIONAHA_109_857011 crossref_primary_10_32725_jnss_2012_002 crossref_primary_10_1161_CIRCULATIONAHA_107_701367 crossref_primary_10_1016_j_jacc_2003_09_051 crossref_primary_10_1038_s41440_022_00914_3 crossref_primary_10_1016_j_cca_2015_12_010 crossref_primary_10_1016_j_lfs_2004_11_010 crossref_primary_10_1292_jvms_23_0429 crossref_primary_10_3390_ijms20163874 crossref_primary_10_1016_j_bbadis_2014_10_016 crossref_primary_10_1016_j_amjcard_2004_03_013 crossref_primary_10_1507_endocrj_52_11 crossref_primary_10_1291_hypres_26_669 crossref_primary_10_1016_j_jacc_2003_09_048 crossref_primary_10_1016_S0022_3565_24_38225_4 crossref_primary_10_1210_jendso_bvac019 crossref_primary_10_1016_S0026_0495_96_90110_9 crossref_primary_10_1111_j_1440_1681_1995_tb01965_x crossref_primary_10_1016_S0014_5793_97_01050_8 crossref_primary_10_1212_WNL_0000000000001885 crossref_primary_10_1507_endocrj_EJ20241105 crossref_primary_10_1016_j_jjcc_2010_08_001 crossref_primary_10_1016_j_ijcard_2007_10_050 crossref_primary_10_1136_bmjopen_2018_024194 crossref_primary_10_1016_S0140_6736_02_07270_7 crossref_primary_10_1177_0192623316668276 crossref_primary_10_1016_S0140_6736_03_13976_1 crossref_primary_10_1097_00000539_199602000_00003 crossref_primary_10_1016_S0002_9149_98_00796_6 crossref_primary_10_1046_j_1365_201x_2000_00724_x crossref_primary_10_1016_S0002_8703_98_70316_3 crossref_primary_10_1161_HYPERTENSIONAHA_109_136804 crossref_primary_10_1016_j_explore_2011_12_002 crossref_primary_10_1093_omcr_omy110 crossref_primary_10_1016_0002_9149_92_90475_E crossref_primary_10_1054_jcaf_2003_39 crossref_primary_10_1016_j_jjcc_2011_01_002 crossref_primary_10_1016_S0883_9441_97_90003_4 crossref_primary_10_1002_pbc_20281 crossref_primary_10_1007_s00404_008_0728_y crossref_primary_10_1093_eurheartj_ehi891 crossref_primary_10_1016_j_jchf_2015_03_015 crossref_primary_10_1016_j_legalmed_2024_102479 crossref_primary_10_1074_jbc_273_19_11695 crossref_primary_10_1016_j_ejheart_2003_10_006 crossref_primary_10_1016_j_nut_2012_07_006 crossref_primary_10_20514_2226_6704_2018_8_5_333_345 crossref_primary_10_1161_CIRCINTERVENTIONS_109_910208 crossref_primary_10_1213_00000539_199710000_00035 crossref_primary_10_1038_nrcardio_2014_64 crossref_primary_10_1093_cvr_cvv017 crossref_primary_10_1038_s41598_017_10240_1 crossref_primary_10_1016_j_ijcard_2011_09_040 crossref_primary_10_1097_01_PCC_0000164634_58297_9A crossref_primary_10_1152_ajpheart_1999_276_3_H1049 crossref_primary_10_7580_KoreanJLegMed_2012_36_1_1 crossref_primary_10_1016_S1071_9164_96_80088_1 crossref_primary_10_1053_pcad_2002_24599 crossref_primary_10_1016_S0735_1097_02_01813_2 crossref_primary_10_1016_j_cpcardiol_2023_102345 crossref_primary_10_1254_jphs_09110FP crossref_primary_10_2108_zsj_24_577 crossref_primary_10_1016_S0002_9149_00_01147_4 crossref_primary_10_1161_01_RES_0000232322_06633_d3 crossref_primary_10_1152_ajpheart_2001_281_6_H2318 crossref_primary_10_1016_j_ijcard_2018_06_002 crossref_primary_10_1016_0735_1097_94_00525_U crossref_primary_10_1161_01_RES_78_1_8 crossref_primary_10_1016_S0002_9149_97_00023_4 crossref_primary_10_1016_S0923_2532_02_01174_2 crossref_primary_10_2165_00003495_200363010_00004 crossref_primary_10_1016_j_lpm_2006_09_013 crossref_primary_10_1016_S0272_6386_12_70269_X crossref_primary_10_1097_BOR_0b013e3282ec67d4 crossref_primary_10_1152_advan_00177_2016 crossref_primary_10_1378_chest_107_4_909 crossref_primary_10_1139_y01_052 crossref_primary_10_1016_j_ijcard_2016_11_197 crossref_primary_10_1038_sj_bmt_1702507 crossref_primary_10_1016_j_amjmed_2003_12_022 crossref_primary_10_1111_joic_12050 crossref_primary_10_1161_01_CIR_96_9_3053 crossref_primary_10_1016_S0140_6736_96_07424_7 crossref_primary_10_12677_ACM_2021_111028 crossref_primary_10_1111_j_1542_4758_2006_00136_x crossref_primary_10_1164_ajrccm_146_5_Pt_1_1198 crossref_primary_10_1016_j_jchf_2019_07_003 crossref_primary_10_3389_fphys_2021_650124 crossref_primary_10_1016_j_ejheart_2007_05_015 crossref_primary_10_3389_fphar_2023_1127123 crossref_primary_10_1161_01_HYP_27_3_811 crossref_primary_10_1007_BF00810519 crossref_primary_10_1016_S0167_5273_00_00462_9 crossref_primary_10_1373_jalm_2016_020230 crossref_primary_10_1253_jjcsc_5_2_247 crossref_primary_10_1016_j_jacc_2009_01_075 crossref_primary_10_1038_s42003_020_01408_z crossref_primary_10_1161_hy0102_099197 crossref_primary_10_1016_0735_1097_93_90208_I crossref_primary_10_1253_jjcsc_24_1_12 crossref_primary_10_1007_s00246_004_0812_4 crossref_primary_10_1093_eurheartj_suy025 crossref_primary_10_1016_j_ijcard_2008_04_045 crossref_primary_10_1016_j_placenta_2019_06_382 crossref_primary_10_1016_j_cca_2011_03_006 crossref_primary_10_1016_j_jacc_2003_07_047 crossref_primary_10_1016_S0002_9149_03_00741_0 crossref_primary_10_2169_internalmedicine_0471_17 crossref_primary_10_1177_0310057X0303100104 crossref_primary_10_1016_j_jpeds_2012_07_048 crossref_primary_10_1111_j_1749_6632_1997_tb52037_x crossref_primary_10_1016_j_ebiom_2017_02_026 crossref_primary_10_1007_s40292_017_0196_1 crossref_primary_10_1111_j_1527_3466_2000_tb00051_x crossref_primary_10_1161_01_CIR_0000153271_77341_9F crossref_primary_10_1016_0002_8703_94_90401_4 crossref_primary_10_1161_HYPERTENSIONAHA_106_069153 crossref_primary_10_1210_en_2007_1094 crossref_primary_10_1161_01_HYP_26_4_628 crossref_primary_10_1016_S0002_8703_98_70338_2 crossref_primary_10_1016_S0300_8932_07_75068_6 crossref_primary_10_1097_01_hjh_0000226200_73065_5d crossref_primary_10_1016_j_jacc_2015_01_033 crossref_primary_10_1378_chest_110_5_1220 crossref_primary_10_1007_s11897_020_00458_y crossref_primary_10_1016_j_ab_2006_07_032 crossref_primary_10_1016_0954_6111_95_90215_5 crossref_primary_10_1016_0735_1097_96_00067_8 crossref_primary_10_1152_jappl_2000_89_2_458 crossref_primary_10_1016_S0923_2532_00_80003_4 crossref_primary_10_1111_j_1440_1681_1997_tb02721_x crossref_primary_10_1016_S0009_8981_01_00388_6 crossref_primary_10_7134_phlebol_12_2_111_117 crossref_primary_10_1053_j_jvca_2017_08_016 crossref_primary_10_1046_j_1492_7535_2003_00042_x crossref_primary_10_1067_mhj_2001_114371 crossref_primary_10_1186_s40560_018_0308_6 crossref_primary_10_1038_s41598_020_64795_7 crossref_primary_10_1097_01_CCM_0000296266_74913_85 crossref_primary_10_1210_er_2003_0006 crossref_primary_10_1093_eurheartj_ehi260 crossref_primary_10_1152_ajpheart_00110_2005 crossref_primary_10_1016_j_acthis_2019_08_003 crossref_primary_10_17116_kardio201710123_25 crossref_primary_10_1016_j_jtcvs_2007_08_012 crossref_primary_10_1586_17446651_2_5_607 crossref_primary_10_1002_hep_510310207 crossref_primary_10_1080_07853890_1993_12088573 crossref_primary_10_24171_j_phrp_2017_8_4_02 crossref_primary_10_1093_ehjcvp_pvv031 crossref_primary_10_1054_jcaf_2002_0805288 crossref_primary_10_1530_JOE_14_0220 crossref_primary_10_1007_s11259_019_9745_5 crossref_primary_10_1016_S1388_9842_02_00004_1 crossref_primary_10_1016_j_cca_2011_04_012 crossref_primary_10_1016_j_ijrobp_2007_05_054 crossref_primary_10_1016_j_ejheart_2005_01_022 crossref_primary_10_1016_j_ijcard_2008_03_090 crossref_primary_10_1016_j_pmedr_2024_102600 crossref_primary_10_1152_ajpheart_2001_281_1_H146 crossref_primary_10_1016_S0143_4179_98_90054_3 crossref_primary_10_1164_rccm_200308_1142OC crossref_primary_10_1177_109980040000200103 crossref_primary_10_1080_08880010802435393 crossref_primary_10_1515_JPM_2005_023 crossref_primary_10_1016_S0002_8703_97_70196_0 crossref_primary_10_1038_s41598_017_02247_5 crossref_primary_10_1136_hrt_76_2_129 crossref_primary_10_1152_ajpheart_00029_2022 crossref_primary_10_1017_S1047951110000211 crossref_primary_10_1111_j_1365_2125_1994_tb04337_x crossref_primary_10_1016_j_peptides_2018_10_003 crossref_primary_10_1016_j_ijcha_2015_02_010 crossref_primary_10_1507_endocrj_K08E_145 crossref_primary_10_1046_j_1440_1681_1999_03034_x crossref_primary_10_1373_clinchem_2010_161125 crossref_primary_10_1016_j_ejim_2014_04_001 crossref_primary_10_1016_j_ygcen_2011_02_021 crossref_primary_10_1067_mhj_2001_119612 crossref_primary_10_1093_eurheartj_ehi033 crossref_primary_10_1177_0003319707312518 crossref_primary_10_1373_clinchem_2004_034272 crossref_primary_10_1016_0304_3940_93_90789_N crossref_primary_10_1016_j_ejheart_2003_12_015 crossref_primary_10_1373_clinchem_2011_169151 |
| ContentType | Journal Article |
| Copyright | 1992 INIST-CNRS |
| Copyright_xml | – notice: 1992 INIST-CNRS |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.1172/JCI115146 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EndPage | 1412 |
| ExternalDocumentID | PMC295184 1849149 5411195 10_1172_JCI115146 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- -~X .55 .GJ 29K 2WC 3O- 53G 5GY 5RE 8F7 AAWTL AAYXX ABOCM ACGFO ACIHN ACNCT ACPRK ADBBV AEAQA AENEX AFFNX AHMBA AI. ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL CITATION CS3 D-I DIK DU5 E3Z EBS EJD EMB F5P FRP GROUPED_DOAJ GX1 HYE H~9 IAO IEA IHR INH IOF IPO J5H KQ8 L7B M1P MVM N4W OK1 OVT P2P P6G RPM TEORI TR2 TVE VH1 VVN W2D WH7 WOQ WOW X7M YOC ZGI ZXP ZY1 .XZ 08G 08P 354 36B 5RS 7RV 7X7 88E 8AO 8FE 8FH 8FI 8FJ 8R4 8R5 AAKAS ABPMR ABUWG ADZCM AFCHL AFKRA ASPBG AVWKF AZFZN BBNVY BCR BCU BEC BENPR BHPHI BKEYQ BLC BPHCQ BVXVI CCPQU EBD EMOBN EX3 FEDTE FYUFA HCIFZ HMCUK HVGLF IHW IOV IQODW ISR ITC LK8 M5~ M7P NAPCQ OBH OCB ODZKP OFXIZ OGEVE OHH OHT OVD OVIDX PHGZM PHGZT PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO Q2X S0X SJFOW SV3 UHU UKHRP XSB YFH YHG YKV ~H1 CGR CUY CVF ECM EIF NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c464t-9b95b6a4ae480eba83be1a3c530abafb46ac39e25407b74ec4b3465de30a40ae3 |
| ISSN | 0021-9738 |
| IngestDate | Thu Aug 21 18:29:46 EDT 2025 Thu Sep 04 23:56:51 EDT 2025 Tue Aug 05 11:45:07 EDT 2025 Mon Jul 21 09:12:53 EDT 2025 Thu Apr 24 23:04:09 EDT 2025 Tue Jul 01 01:43:32 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | Heart Human Pharmacologic test Natriuretic hormone Immunological investigation Atrial natriuretic peptide Monoclonal antibody Experimental study Pharmacokinetics |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c464t-9b95b6a4ae480eba83be1a3c530abafb46ac39e25407b74ec4b3465de30a40ae3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | http://www.jci.org/articles/view/115146/files/pdf |
| PMID | 1849149 |
| PQID | 80493274 |
| PQPubID | 23479 |
| PageCount | 11 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_295184 proquest_miscellaneous_80493274 pubmed_primary_1849149 pascalfrancis_primary_5411195 crossref_citationtrail_10_1172_JCI115146 crossref_primary_10_1172_JCI115146 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 1900 |
| PublicationDate | 1991-04-01 |
| PublicationDateYYYYMMDD | 1991-04-01 |
| PublicationDate_xml | – month: 04 year: 1991 text: 1991-04-01 day: 01 |
| PublicationDecade | 1990 |
| PublicationPlace | Ann Arbor, MI |
| PublicationPlace_xml | – name: Ann Arbor, MI – name: United States |
| PublicationTitle | The Journal of clinical investigation |
| PublicationTitleAlternate | J Clin Invest |
| PublicationYear | 1991 |
| Publisher | American Society for Clinical Investigation |
| Publisher_xml | – name: American Society for Clinical Investigation |
| References | 2521343 - J Clin Invest. 1989 Jan;83(1):46-51 14278071 - Circulation. 1965 May;31:778-84 2971478 - Clin Chim Acta. 1988 Jun 30;175(1):11-7 2988929 - Endocr Rev. 1985 Spring;6(2):107-27 2521788 - Biochem Biophys Res Commun. 1989 Jan 31;158(2):360-8 2939312 - Life Sci. 1986 May 19;38(20):1827-33 2971636 - Histochemistry. 1988;89(5):411-3 2532010 - Biochem Biophys Res Commun. 1989 Dec 15;165(2):872-9 2428040 - Proc Natl Acad Sci U S A. 1986 Sep;83(18):6697-701 6542363 - Biochem Biophys Res Commun. 1984 Nov 14;124(3):815-21 6238598 - Biochem Biophys Res Commun. 1984 Oct 30;124(2):663-8 3421965 - Biochem Biophys Res Commun. 1988 Sep 15;155(2):726-32 3032934 - J Biol Chem. 1987 Apr 25;262(12):5510-4 3160345 - Biochem Biophys Res Commun. 1985 Jun 14;129(2):439-46 2961791 - J Clin Invest. 1988 Jan;81(1):82-6 2136732 - FEBS Lett. 1990 Jan 1;259(2):341-5 2525379 - Biochem Biophys Res Commun. 1989 Jun 15;161(2):732-9 6230082 - Biochem Biophys Res Commun. 1984 Jan 13;118(1):131-9 2318164 - Endocrinology. 1990 Apr;126(4):2225-7 2977170 - J Hypertens Suppl. 1988 Dec;6(4):S320-2 2533191 - Histochem J. 1989 Dec;21(12):715-20 2563900 - Nature. 1989 Mar 2;338(6210):78-83 2966015 - Circ Res. 1988 May;62(5):926-30 3156596 - Biochem Biophys Res Commun. 1985 Mar 15;127(2):413-9 2965582 - Biochem Biophys Res Commun. 1988 Mar 30;151(3):1277-84 2530003 - Circulation. 1989 Nov;80(5):1137-47 2989170 - Hypertension. 1985 Jul-Aug;7(4):469-82 2964562 - Nature. 1988 Mar 3;332(6159):78-81 2823385 - Science. 1987 Oct 30;238(4827):675-8 2945832 - J Clin Invest. 1986 Nov;78(5):1362-74 2837487 - J Biol Chem. 1988 Jul 5;263(19):9395-401 2969822 - Eur J Pharmacol. 1988 May 20;150(1-2):193-6 2570358 - Nature. 1989 Sep 7;341(6237):68-72 2956383 - J Hypertens Suppl. 1986 Dec;4(6):S492-6 2961427 - Can J Physiol Pharmacol. 1987 Aug;65(8):1756-61 2544622 - J Clin Invest. 1989 Jul;84(1):145-54 3226610 - Neurosci Lett. 1988 Dec 19;95(1-3):223-8 2946416 - Cell. 1986 Dec 5;47(5):695-702 2968368 - J Clin Invest. 1988 Jun;81(6):1962-70 2528349 - Biochem Biophys Res Commun. 1989 Aug 30;163(1):233-40 2935937 - Science. 1986 Mar 7;231(4742):1145-7 2570641 - Cell. 1989 Sep 22;58(6):1155-62 2522777 - Biochem Biophys Res Commun. 1989 Mar 31;159(3):1427-34 2521342 - J Clin Invest. 1989 Jan;83(1):298-305 2673236 - Biochem Biophys Res Commun. 1989 Aug 30;163(1):226-32 2971901 - Neurosci Lett. 1988 Aug 15;91(1):77-83 2938583 - Biochem Biophys Res Commun. 1986 Mar 28;135(3):728-34 2932797 - Science. 1985 Nov 15;230(4727):767-70 2936980 - Neuroscience. 1985 Nov;16(3):521-46 2858127 - Science. 1985 Mar 1;227(4690):1047-9 2954723 - Circulation. 1987 Jul;76(1):115-24 2946587 - Eur J Clin Pharmacol. 1986;31(1):101-3 |
| References_xml | – reference: 2961791 - J Clin Invest. 1988 Jan;81(1):82-6 – reference: 3226610 - Neurosci Lett. 1988 Dec 19;95(1-3):223-8 – reference: 2971478 - Clin Chim Acta. 1988 Jun 30;175(1):11-7 – reference: 2946587 - Eur J Clin Pharmacol. 1986;31(1):101-3 – reference: 2530003 - Circulation. 1989 Nov;80(5):1137-47 – reference: 14278071 - Circulation. 1965 May;31:778-84 – reference: 2521342 - J Clin Invest. 1989 Jan;83(1):298-305 – reference: 2977170 - J Hypertens Suppl. 1988 Dec;6(4):S320-2 – reference: 2525379 - Biochem Biophys Res Commun. 1989 Jun 15;161(2):732-9 – reference: 2318164 - Endocrinology. 1990 Apr;126(4):2225-7 – reference: 2956383 - J Hypertens Suppl. 1986 Dec;4(6):S492-6 – reference: 3421965 - Biochem Biophys Res Commun. 1988 Sep 15;155(2):726-32 – reference: 2971636 - Histochemistry. 1988;89(5):411-3 – reference: 2966015 - Circ Res. 1988 May;62(5):926-30 – reference: 2939312 - Life Sci. 1986 May 19;38(20):1827-33 – reference: 2932797 - Science. 1985 Nov 15;230(4727):767-70 – reference: 2935937 - Science. 1986 Mar 7;231(4742):1145-7 – reference: 2936980 - Neuroscience. 1985 Nov;16(3):521-46 – reference: 2971901 - Neurosci Lett. 1988 Aug 15;91(1):77-83 – reference: 3156596 - Biochem Biophys Res Commun. 1985 Mar 15;127(2):413-9 – reference: 2964562 - Nature. 1988 Mar 3;332(6159):78-81 – reference: 2570358 - Nature. 1989 Sep 7;341(6237):68-72 – reference: 2521343 - J Clin Invest. 1989 Jan;83(1):46-51 – reference: 2428040 - Proc Natl Acad Sci U S A. 1986 Sep;83(18):6697-701 – reference: 2544622 - J Clin Invest. 1989 Jul;84(1):145-54 – reference: 2968368 - J Clin Invest. 1988 Jun;81(6):1962-70 – reference: 2954723 - Circulation. 1987 Jul;76(1):115-24 – reference: 3160345 - Biochem Biophys Res Commun. 1985 Jun 14;129(2):439-46 – reference: 2961427 - Can J Physiol Pharmacol. 1987 Aug;65(8):1756-61 – reference: 2673236 - Biochem Biophys Res Commun. 1989 Aug 30;163(1):226-32 – reference: 2938583 - Biochem Biophys Res Commun. 1986 Mar 28;135(3):728-34 – reference: 6230082 - Biochem Biophys Res Commun. 1984 Jan 13;118(1):131-9 – reference: 6238598 - Biochem Biophys Res Commun. 1984 Oct 30;124(2):663-8 – reference: 2136732 - FEBS Lett. 1990 Jan 1;259(2):341-5 – reference: 2532010 - Biochem Biophys Res Commun. 1989 Dec 15;165(2):872-9 – reference: 2823385 - Science. 1987 Oct 30;238(4827):675-8 – reference: 2528349 - Biochem Biophys Res Commun. 1989 Aug 30;163(1):233-40 – reference: 2533191 - Histochem J. 1989 Dec;21(12):715-20 – reference: 2570641 - Cell. 1989 Sep 22;58(6):1155-62 – reference: 2988929 - Endocr Rev. 1985 Spring;6(2):107-27 – reference: 2522777 - Biochem Biophys Res Commun. 1989 Mar 31;159(3):1427-34 – reference: 2945832 - J Clin Invest. 1986 Nov;78(5):1362-74 – reference: 2989170 - Hypertension. 1985 Jul-Aug;7(4):469-82 – reference: 3032934 - J Biol Chem. 1987 Apr 25;262(12):5510-4 – reference: 2858127 - Science. 1985 Mar 1;227(4690):1047-9 – reference: 2563900 - Nature. 1989 Mar 2;338(6210):78-83 – reference: 2946416 - Cell. 1986 Dec 5;47(5):695-702 – reference: 2521788 - Biochem Biophys Res Commun. 1989 Jan 31;158(2):360-8 – reference: 2965582 - Biochem Biophys Res Commun. 1988 Mar 30;151(3):1277-84 – reference: 2969822 - Eur J Pharmacol. 1988 May 20;150(1-2):193-6 – reference: 2837487 - J Biol Chem. 1988 Jul 5;263(19):9395-401 – reference: 6542363 - Biochem Biophys Res Commun. 1984 Nov 14;124(3):815-21 |
| SSID | ssj0014454 |
| Score | 1.9803735 |
| Snippet | Using a specific radioimmunoassay for human brain natriuretic peptide (hBNP) with a monoclonal antibody, we have investigated its synthesis, secretion, and... |
| SourceID | pubmedcentral proquest pubmed pascalfrancis crossref |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 1402 |
| SubjectTerms | Antibodies, Monoclonal - immunology Atrial Natriuretic Factor - physiology Biological and medical sciences Blotting, Northern Cardiac Catheterization Fundamental and applied biological sciences. Psychology Heart Failure - metabolism Humans Myocardium - metabolism Natriuretic Peptide, Brain Nerve Tissue Proteins - genetics Nerve Tissue Proteins - immunology Nerve Tissue Proteins - pharmacokinetics Nerve Tissue Proteins - physiology Radioimmunoassay Receptors, Atrial Natriuretic Factor Receptors, Cell Surface - metabolism Vertebrates: cardiovascular system |
| Title | Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/1849149 https://www.proquest.com/docview/80493274 https://pubmed.ncbi.nlm.nih.gov/PMC295184 |
| Volume | 87 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbKkBASQtwmCgwsxANSCWsSJ054y6qhdlXbB1Zpe6psx9GKprTQFiF-F3-Mf8DxJbctE5eXKErc-ETf1_jYPuc7CL3xMk9Q7gN5ReY7RATCiaNMOFT0RZqlADpXO7qTaTick5Oz4KzT-VWLWtpt-XvxozWv5H9QhWuAq8qS_Qdky4fCBTgHfOEICMPxrzA-UvUderlS2d_pbMTeWgWppFJVj2G9fPVNXirtaeCA6F2Ad7oyGiG6MN9GrwZIW1XURlP25Pcvu6XaUe7pJK22ZxvxZx32aWp-tBqQg2d7k3l1j7jKTdNecZmpuawEQKpIgcl8PDtXmwL1ZdxpMk5mjRXbcTI5Ss6TT8NRNcIo-k9n8_PjqmVqs__cWoxMlV-gPny1kNZBYdjommFFwoLrxNSIyBQffTvKL-srGvoLDhNOr-YNuMREeV8faahSrv0sluBSF6uoDTXvK6NsGfsYEFfJ7N1Ctz0K7p7y40fjcuOLkMAKhxubrRgW9HZY9tVwoe6t2QZePjNlWNrmSVfDfWv-0-kDdN9CjBPD4oeoI_NH6M7EhnY8Rj81mXGNLdiyBbMNZliTGVsyY0tmDL8wZMYfcEFlDHBhluOSylhRufXJhsrvsCFye-d5ivlNpj1B84_Hp4OhY0uKOIKEZOvEPA54yAiTJOpLziKfS5f5IvD7jLOMk5AJP5aekqXklEhBuE_CIJVwn_SZ9PfRXg6v9xRhL6VpwCWhVLpEeDDthtaBcCOauj4P4y56W6C0EFZvX5V9uVzoeTf1FieDkQG0i16XTddGZKat0UED6rKlJVQXvSqgX8AQofb9WC5Xu80i6hOYpVHSRfuGCFUnEYldAqaGDYaU95X2fPNOvrzQGvQezMwi8uwPNj1Hd6t_8Qu0t_26kwfgxG_5S0373yOcAMs |
| linkProvider | Flying Publisher |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Brain+natriuretic+peptide+as+a+novel+cardiac+hormone+in+humans+%3A+evidence+for+an+exquisite+dual+natriuretic+peptide+system%2C+atrial+natriuretic+peptide+and+brain+natriuretic+peptide&rft.jtitle=The+Journal+of+clinical+investigation&rft.au=MUKOYAMA%2C+M&rft.au=NAKAO%2C+K&rft.au=KAMBAYASHI%2C+Y&rft.au=INOUYE%2C+K&rft.date=1991-04-01&rft.pub=American+Society+for+Clinical+Investigation&rft.issn=0021-9738&rft.volume=87&rft.issue=4&rft.spage=1402&rft.epage=1412&rft_id=info:doi/10.1172%2Fjci115146&rft.externalDBID=n%2Fa&rft.externalDocID=5411195 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9738&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9738&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9738&client=summon |