Ketolysis drives CD8+ T cell effector function through effects on histone acetylation - Luda, Katarzyna M.; Longo, Joseph; Kitchen-Goosen, Susan M.; Duimstra, Lauren R.; Ma, Eric H.; Watson, McLane J.; Oswald, Brandon M.; Fu, Zhen; Madaj, Zachary; Kupai, Ariana; Dickson, Bradley M.; DeCamp, Lisa M.; et al. (Immunity (Cambridge, Mass.), 2023)
Keywords: 3-Hydroxybutyric Acid - metabolism; 3-Hydroxybutyric Acid - pharmacology; acetyl-CoA; Acetylation; Animals; cancer immunology; CD8+ T cells; CD8-Positive T-Lymphocytes; effector function; epigenetics; Histones - metabolism; ketolysis; Ketone Bodies; metabolism; Mice; TCA cycle; CD8+ T cells; effector function; ketolysis; TCA cycle; cancer immunology; ketone bodies; metabolism; acetyl-CoA; epigenetics; CD8(+) T cells