A population-based study of mortality among patients with atrial fibrillation or flutter

• Published in: The American journal of medicine Vol. 113; no. 5; pp. 365 - 370
• Main Authors: Vidaillet, Humberto, Granada, Juan F, Chyou, P.o-Huang, Maassen, Karen, Ortiz, Mario, Pulido, Juan N, Sharma, Param, Smith, Peter N, Hayes, John
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.10.2002; Elsevier; Elsevier Sequoia S.A
• Subjects: Aged; Aged, 80 and over; Atrial fibrillation; Atrial Fibrillation - mortality; Atrial flutter; Atrial Flutter - mortality; Biological and medical sciences; Cardiac arrhythmia; Cardiac dysrhythmias; Cardiology. Vascular system; Female; Follow-Up Studies; Health risk assessment; Heart; Humans; Longitudinal Studies; Male; Medical sciences; Middle Aged; Mortality; Population-based; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Survival Rate; Time Factors; Wisconsin - epidemiology; United States; North America; America; Wisconsin; Population-based; Mortality; Atrial fibrillation; Atrial flutter; Human; Arrhythmia; Heart disease; Cardiovascular disease; Epidemiology; Excitability disorder
• ISSN: 0002-9343; 1555-7162
• DOI: 10.1016/S0002-9343(02)01253-6

To determine the mortality associated with atrial flutter and atrial fibrillation in the general population. Using the Marshfield Epidemiologic Study Area, a database that captures nearly all medical care and deaths among its 58,820 residents, we identified patients diagnosed with atrial flutter or atrial fibrillation from July 1, 1991, through June 30, 1995. Patients were followed prospectively and compared with a group of controls without these arrhythmias. A total of 4775 person-years of follow-up were completed in 577 patients and 577 controls. Compared with controls, mortality among patients with atrial fibrillation or flutter was nearly 7.8-fold higher at 6 months (95% confidence interval [CI]: 4.1 to 15) and 2.5-fold higher (95% CI: 2.0 to 3.1; P < 0.0001) at the last follow-up (mean [± SD] of 3.6 ± 2.3 years; range, 1 day to 7.3 years). At 6 months, mortality among patients with atrial flutter alone was somewhat greater than in controls and less than one third that of those with atrial fibrillation (with or without atrial flutter) (P = 0.02). At the last follow-up, however, mortality was greater among patients with atrial flutter (hazard ratio [HR] = 1.7; 95% CI: 1.2 to 2.6; P = 0.007), atrial fibrillation (HR = 2.4; 95% CI: 1.9 to 3.1; P < 0.0001), or both atrial arrhythmias (HR = 2.5; 95% CI: 1.9 to 3.3; P < 0.0001) when compared with controls in models that adjusted for cardiovascular risk factors. In the general population, both atrial flutter and atrial fibrillation are independent predictors of increased late mortality. The relatively benign course during the 6-month period after the initial diagnosis of atrial flutter suggests that early diagnosis and treatment of these patients may improve their long-term survival.