Amantadine in the early treatment of cocaine dependence: a double-blind, placebo-controlled trial
A 4-week, double-blind, placebo-controlled trial of amantadine was conducted in 61 cocaine dependent outpatients. Subjects received 100 mg of amantadine 3 times daily. A follow-up visit was conducted at week 8. There were no significant differences between groups in treatment retention, or in the nu...
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| Published in | Drug and alcohol dependence Vol. 41; no. 1; pp. 25 - 33 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Shannon
Elsevier Ireland Ltd
01.05.1996
Elsevier Science |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0376-8716 1879-0046 |
| DOI | 10.1016/0376-8716(96)01225-2 |
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| Abstract | A 4-week, double-blind, placebo-controlled trial of amantadine was conducted in 61 cocaine dependent outpatients. Subjects received 100 mg of amantadine 3 times daily. A follow-up visit was conducted at week 8. There were no significant differences between groups in treatment retention, or in the number of benzoylecgonine positive urine samples. Self-reported drug and alcohol use declined in both groups. At week 8 follow-up, self-reported drug use was significantly lower in the placebo group. Amantadine was not effective, and discontinuation of it may have been associated with an increase in cocaine use. |
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| AbstractList | A 4-week, double-blind, placebo-controlled trial of amantadine was conducted in 61 cocaine dependent outpatients. Subjects received 100 mg of amantadine 3 times daily. A follow-up visit was conducted at week 8. There were no significant differences between groups in treatment retention, or in the number of benzoylecgonine positive urine samples. Self-reported drug and alcohol use declined in both groups. At week 8 follow-up, self-reported drug use was significantly lower in the placebo group. Amantadine was not effective, and discontinuation of it may have been associated with an increase in cocaine use. Such a 4-week trial was conducted in 61 cocaine dependent outpatients. Subjects received 100mg of amantadine 3 times daily. A follow-up visit was conducted at week 8. There were no significant differences between groups. At week 8 follow-up, self-reported drug use was significantly lower in the placebo group. Amantadine was not effective, and discontinuation of it may have been associated with an increase in cocaine use. (Original abstract-amended) A 4-week, double-blind, placebo-controlled trial of amantadine was conducted in 61 cocaine dependent outpatients. Subjects received 100 mg of amantadine 3 times daily. A follow-up visit was conducted at week 8. There were no significant differences between groups in treatment retention, or in the number of benzoylecgonine positive urine samples. Self-reported drug and alcohol use declined in both groups. At week 8 follow-up, self-reported drug use was significantly lower in the placebo group. Amantadine was not effective, and discontinuation of it may have been associated with an increase in cocaine use.A 4-week, double-blind, placebo-controlled trial of amantadine was conducted in 61 cocaine dependent outpatients. Subjects received 100 mg of amantadine 3 times daily. A follow-up visit was conducted at week 8. There were no significant differences between groups in treatment retention, or in the number of benzoylecgonine positive urine samples. Self-reported drug and alcohol use declined in both groups. At week 8 follow-up, self-reported drug use was significantly lower in the placebo group. Amantadine was not effective, and discontinuation of it may have been associated with an increase in cocaine use. |
| Author | Weinrieb, Robert Epperson, Louise Sparkman, Thorne Volpicelli, Joseph R. Cornish, James O'Brien, Charles P. Kampman, Kyle Alterman, Arthur |
| Author_xml | – sequence: 1 givenname: Kyle surname: Kampman fullname: Kampman, Kyle – sequence: 2 givenname: Joseph R. surname: Volpicelli fullname: Volpicelli, Joseph R. – sequence: 3 givenname: Arthur surname: Alterman fullname: Alterman, Arthur – sequence: 4 givenname: James surname: Cornish fullname: Cornish, James – sequence: 5 givenname: Robert surname: Weinrieb fullname: Weinrieb, Robert – sequence: 6 givenname: Louise surname: Epperson fullname: Epperson, Louise – sequence: 7 givenname: Thorne surname: Sparkman fullname: Sparkman, Thorne – sequence: 8 givenname: Charles P. surname: O'Brien fullname: O'Brien, Charles P. |
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| Keywords | Cocaine Amantadine hydrochloride Double-blind outpatient Withdrawal Human Drug addiction Chemotherapy Poison withdrawal Treatment Dependence |
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| Snippet | A 4-week, double-blind, placebo-controlled trial of amantadine was conducted in 61 cocaine dependent outpatients. Subjects received 100 mg of amantadine 3... Such a 4-week trial was conducted in 61 cocaine dependent outpatients. Subjects received 100mg of amantadine 3 times daily. A follow-up visit was conducted at... |
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| SubjectTerms | Abusers Adult Alcoholism - diagnosis Alcoholism - psychology Alcoholism - rehabilitation Amantadine Amantadine - therapeutic use Amantadine hydrochloride Biological and medical sciences Cocaine Comorbidity Dopamine Agents - therapeutic use Dose-Response Relationship, Drug Double blind studies Double-Blind Method Double-blind outpatient Drug addictions Drug Administration Schedule Female Follow-Up Studies Humans Male Medical sciences Opioid-Related Disorders - diagnosis Opioid-Related Disorders - psychology Opioid-Related Disorders - rehabilitation Substance Abuse Detection Toxicology Treatment Treatment Outcome Withdrawal |
| Title | Amantadine in the early treatment of cocaine dependence: a double-blind, placebo-controlled trial |
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