Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy - Ullah, Irfan; Prévost, Jérémie; Ladinsky, Mark S.; Stone, Helen; Lu, Maolin; Anand, Sai Priya; Beaudoin-Bussières, Guillaume; Symmes, Kelly; Benlarbi, Mehdi; Ding, Shilei; Gasser, Romain; Fink, Corby; et al. (Immunity (Cambridge, Mass.), 2021)
Keywords: Angiotensin-Converting Enzyme 2 - genetics; Animals; Antibodies, Neutralizing - genetics; Antibodies, Neutralizing - metabolism; Antibodies, Viral - genetics; Antibodies, Viral - metabolism; bioluminescence imaging; Brain - pathology; Brain - virology; Cells, Cultured; COVID-19; COVID-19 - immunology; COVID-19 - therapy; Disease Models, Animal; Fc effector functions; human ACE2 transgenic mice; Humans; Immunoglobulin Fc Fragments - genetics; Luciferases - genetics; Luminescent Measurements; Lung - pathology; Lung - virology; Male; Mice; Mice, Transgenic; monocytes; nanoluciferase; natural killer cells; neutralizing antibodies; pathogenesis; SARS-CoV-2; SARS-CoV-2 - physiology; Testis - pathology; Testis - virology; COVID-19; monocytes; natural killer cells; pathogenesis; SARS-CoV-2; Fc effector functions; human ACE2 transgenic mice; bioluminescence imaging; neutralizing antibodies; nanoluciferase