Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence - Sapey, Elizabeth; Greenwood, Hannah; Walton, Georgia; Mann, Elizabeth; Love, Alexander; Aaronson, Natasha; Insall, Robert H.; Stockley, Robert A.; Lord, Janet M. (Blood, 2014)
Keywords: Adult; Age Factors; Aged; Aged, 80 and over; Aging - immunology; Cell Degranulation - drug effects; Cell Degranulation - immunology; Chemotaxis, Leukocyte - drug effects; Chemotaxis, Leukocyte - immunology; Cross-Sectional Studies; Cytokines - metabolism; Cytokines - pharmacology; Enzyme Activation; Humans; Immune System Diseases - drug therapy; Immune System Diseases - immunology; Interleukin-8 - metabolism; Interleukin-8 - pharmacology; Leukocyte Disorders - drug therapy; Leukocyte Disorders - immunology; Middle Aged; Myeloblastin - metabolism; Neutrophils - drug effects; Neutrophils - immunology; Neutrophils - metabolism; Phagocytes, Granulocytes, and Myelopoiesis; Phosphatidylinositol 3-Kinases - metabolism; Phosphoinositide-3 Kinase Inhibitors; Receptors, Cytokine - metabolism; Signal Transduction; Young Adult