Improved ex vivo expansion of adult hematopoietic stem cells by overcoming CUL4-mediated degradation of HOXB4 - Lee, Jennifer; Shieh, Jae-Hung; Zhang, Jianxuan; Liu, Liren; Zhang, Yue; Eom, Jae Yong; Morrone, Giovanni; Moore, Malcolm A.S.; Zhou, Pengbo (Blood, 2013)
Keywords: Adult; Adult Stem Cells - metabolism; Adult Stem Cells - physiology; Animals; Cell Culture Techniques - methods; Cell Proliferation; Cells, Cultured; Cullin Proteins - genetics; Cullin Proteins - metabolism; Cullin Proteins - physiology; Feasibility Studies; HeLa Cells; Hematopoiesis and Stem Cells; Hematopoietic Stem Cells - metabolism; Hematopoietic Stem Cells - physiology; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Homeodomain Proteins - physiology; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; Primary Cell Culture - methods; Protein Engineering; Proteolysis; Transcription Factors - genetics; Transcription Factors - metabolism; Transcription Factors - physiology