Association of Physical Activity With Telomere Length Among Elderly Adults - The Oulu Cohort 1945
Physical activity (PA) has been associated with telomere shortening. The association of PA intensity or volume with telomere length (TL) is nonetheless unclear. The aim of our study was to investigate the associations of exercise intensity and volume with TL in elderly adults from Northern Finland (...
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| Published in | Frontiers in physiology Vol. 10; p. 444 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
24.04.2019
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| Online Access | Get full text |
| ISSN | 1664-042X 1664-042X |
| DOI | 10.3389/fphys.2019.00444 |
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| Abstract | Physical activity (PA) has been associated with telomere shortening. The association of PA intensity or volume with telomere length (TL) is nonetheless unclear. The aim of our study was to investigate the associations of exercise intensity and volume with TL in elderly adults from Northern Finland (65° latitude North).
Seven hundred elderly subjects born in 1945 in the Oulu region were investigated. PA was measured during a 2-week period with a wrist-worn accelerometer. In addition, a questionnaire was used to assess sedentary time and to achieve a longitudinal PA history and intensity. Relative telomere lengths (RTL) were determined from frozen whole blood samples using a qPCR-based method.
Relative telomere lengths were significantly longer in women than men and negatively correlated with age in both genders (men
= -0.210,
= 0.000, women
= -0.174, and
= 0.000). During the 2-week study period, women took more steps than men (
= 0.001), but the association between steps and RTL was only seen in men (
= 0.05). Total steps taken (
= 0.202 and
= 0.04) and sedentary time (
= -0.247 and
= 0.007) significantly correlated with RTLs in 70-year old subjects. Moderate PA was associated with RTL in subjects with the highest quartile of moderate PA compared to the three lower quartiles (
-values: 0.023 between 4th and 1st, 0.04 between 4th and 2nd, and 0.027 between 4th and 3rd) in the 70-year old subjects.
Women had longer RTL and a higher step count compared to men. However, exercise volume and RTL correlated positively only in men. Surprisingly, age correlated negatively with RTL already within an age difference of 2 years. This suggests that telomere attrition rate may accelerate in older age. Moderate physical activity at the time of study was associated with RTL. |
|---|---|
| AbstractList | Introduction: Physical activity (PA) has been associated with telomere shortening. The association of PA intensity or volume with telomere length (TL) is nonetheless unclear. The aim of our study was to investigate the associations of exercise intensity and volume with TL in elderly adults from Northern Finland (65° latitude North).Methods: Seven hundred elderly subjects born in 1945 in the Oulu region were investigated. PA was measured during a 2-week period with a wrist-worn accelerometer. In addition, a questionnaire was used to assess sedentary time and to achieve a longitudinal PA history and intensity. Relative telomere lengths (RTL) were determined from frozen whole blood samples using a qPCR-based method.Results: Relative telomere lengths were significantly longer in women than men and negatively correlated with age in both genders (men r = -0.210, p = 0.000, women r = -0.174, and p = 0.000). During the 2-week study period, women took more steps than men (p = 0.001), but the association between steps and RTL was only seen in men (p = 0.05). Total steps taken (r = 0.202 and p = 0.04) and sedentary time (r = -0.247 and p = 0.007) significantly correlated with RTLs in 70-year old subjects. Moderate PA was associated with RTL in subjects with the highest quartile of moderate PA compared to the three lower quartiles (p-values: 0.023 between 4th and 1st, 0.04 between 4th and 2nd, and 0.027 between 4th and 3rd) in the 70-year old subjects.Conclusion: Women had longer RTL and a higher step count compared to men. However, exercise volume and RTL correlated positively only in men. Surprisingly, age correlated negatively with RTL already within an age difference of 2 years. This suggests that telomere attrition rate may accelerate in older age. Moderate physical activity at the time of study was associated with RTL. Introduction: Physical activity (PA) has been associated with telomere shortening. The association of PA intensity or volume with telomere length (TL) is nonetheless unclear. The aim of our study was to investigate the associations of exercise intensity and volume with TL in elderly adults from Northern Finland (65° latitude North). Methods: Seven hundred elderly subjects born in 1945 in the Oulu region were investigated. PA was measured during a 2-week period with a wrist-worn accelerometer. In addition, a questionnaire was used to assess sedentary time and to achieve a longitudinal PA history and intensity. Relative telomere lengths (RTL) were determined from frozen whole blood samples using a qPCR-based method. Results: Relative telomere lengths were significantly longer in women than men and negatively correlated with age in both genders (men r = -0.210, p = 0.000, women r = -0.174, and p = 0.000). During the 2-week study period, women took more steps than men ( p = 0.001), but the association between steps and RTL was only seen in men ( p = 0.05). Total steps taken ( r = 0.202 and p = 0.04) and sedentary time ( r = -0.247 and p = 0.007) significantly correlated with RTLs in 70-year old subjects. Moderate PA was associated with RTL in subjects with the highest quartile of moderate PA compared to the three lower quartiles ( p -values: 0.023 between 4th and 1st, 0.04 between 4th and 2nd, and 0.027 between 4th and 3rd) in the 70-year old subjects. Conclusion: Women had longer RTL and a higher step count compared to men. However, exercise volume and RTL correlated positively only in men. Surprisingly, age correlated negatively with RTL already within an age difference of 2 years. This suggests that telomere attrition rate may accelerate in older age. Moderate physical activity at the time of study was associated with RTL. Introduction: Physical activity (PA) has been associated with telomere shortening. The association of PA intensity or volume with telomere length (TL) is nonetheless unclear. The aim of our study was to investigate the associations of exercise intensity and volume with TL in elderly adults from Northern Finland (65° latitude North). Methods: Seven hundred elderly subjects born in 1945 in the Oulu region were investigated. PA was measured during a 2-week period with a wrist-worn accelerometer. In addition, a questionnaire was used to assess sedentary time and to achieve a longitudinal PA history and intensity. Relative telomere lengths (RTL) were determined from frozen whole blood samples using a qPCR-based method. Results: Relative telomere lengths were significantly longer in women than men and negatively correlated with age in both genders (men r = -0.210, p = 0.000, women r = -0.174, and p = 0.000). During the 2-week study period, women took more steps than men (p = 0.001), but the association between steps and RTL was only seen in men (p = 0.05). Total steps taken (r = 0.202 and p = 0.04) and sedentary time (r = -0.247 and p = 0.007) significantly correlated with RTLs in 70-year old subjects. Moderate PA was associated with RTL in subjects with the highest quartile of moderate PA compared to the three lower quartiles (p-values: 0.023 between 4th and 1st, 0.04 between 4th and 2nd, and 0.027 between 4th and 3rd) in the 70-year old subjects. Conclusion: Women had longer RTL and a higher step count compared to men. However, exercise volume and RTL correlated positively only in men. Surprisingly, age correlated negatively with RTL already within an age difference of 2 years. This suggests that telomere attrition rate may accelerate in older age. Moderate physical activity at the time of study was associated with RTL.Introduction: Physical activity (PA) has been associated with telomere shortening. The association of PA intensity or volume with telomere length (TL) is nonetheless unclear. The aim of our study was to investigate the associations of exercise intensity and volume with TL in elderly adults from Northern Finland (65° latitude North). Methods: Seven hundred elderly subjects born in 1945 in the Oulu region were investigated. PA was measured during a 2-week period with a wrist-worn accelerometer. In addition, a questionnaire was used to assess sedentary time and to achieve a longitudinal PA history and intensity. Relative telomere lengths (RTL) were determined from frozen whole blood samples using a qPCR-based method. Results: Relative telomere lengths were significantly longer in women than men and negatively correlated with age in both genders (men r = -0.210, p = 0.000, women r = -0.174, and p = 0.000). During the 2-week study period, women took more steps than men (p = 0.001), but the association between steps and RTL was only seen in men (p = 0.05). Total steps taken (r = 0.202 and p = 0.04) and sedentary time (r = -0.247 and p = 0.007) significantly correlated with RTLs in 70-year old subjects. Moderate PA was associated with RTL in subjects with the highest quartile of moderate PA compared to the three lower quartiles (p-values: 0.023 between 4th and 1st, 0.04 between 4th and 2nd, and 0.027 between 4th and 3rd) in the 70-year old subjects. Conclusion: Women had longer RTL and a higher step count compared to men. However, exercise volume and RTL correlated positively only in men. Surprisingly, age correlated negatively with RTL already within an age difference of 2 years. This suggests that telomere attrition rate may accelerate in older age. Moderate physical activity at the time of study was associated with RTL. Physical activity (PA) has been associated with telomere shortening. The association of PA intensity or volume with telomere length (TL) is nonetheless unclear. The aim of our study was to investigate the associations of exercise intensity and volume with TL in elderly adults from Northern Finland (65° latitude North). Seven hundred elderly subjects born in 1945 in the Oulu region were investigated. PA was measured during a 2-week period with a wrist-worn accelerometer. In addition, a questionnaire was used to assess sedentary time and to achieve a longitudinal PA history and intensity. Relative telomere lengths (RTL) were determined from frozen whole blood samples using a qPCR-based method. Relative telomere lengths were significantly longer in women than men and negatively correlated with age in both genders (men = -0.210, = 0.000, women = -0.174, and = 0.000). During the 2-week study period, women took more steps than men ( = 0.001), but the association between steps and RTL was only seen in men ( = 0.05). Total steps taken ( = 0.202 and = 0.04) and sedentary time ( = -0.247 and = 0.007) significantly correlated with RTLs in 70-year old subjects. Moderate PA was associated with RTL in subjects with the highest quartile of moderate PA compared to the three lower quartiles ( -values: 0.023 between 4th and 1st, 0.04 between 4th and 2nd, and 0.027 between 4th and 3rd) in the 70-year old subjects. Women had longer RTL and a higher step count compared to men. However, exercise volume and RTL correlated positively only in men. Surprisingly, age correlated negatively with RTL already within an age difference of 2 years. This suggests that telomere attrition rate may accelerate in older age. Moderate physical activity at the time of study was associated with RTL. |
| Author | Mutt, Shivaprakash Jagalur Gagnon, Dominique D. Jokelainen, Jari Stenbäck, Ville Leppäluoto, Juhani Herzig, Karl-Heinz Mäkelä, Kari A. Keinänen-Kiukaanniemi, Sirkka |
| AuthorAffiliation | 6 Unit of General Practice, Oulu University Hospital , Oulu , Finland 7 Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences , Poznań , Poland 5 Center for Life Course Health Research, Faculty of Medicine, University of Oulu , Oulu , Finland 1 Research Unit of Biomedicine, Department of Physiology and Biocenter of Oulu, University of Oulu , Oulu , Finland 3 Laboratory of Environmental Exercise Physiology, School of Human Kinetics, Laurentian University , Sudbury, ON , Canada 4 Centre for Research in Occupational Safety and Health, Laurentian University , Sudbury, ON , Canada 2 Medical Research Center, University of Oulu , Oulu , Finland |
| AuthorAffiliation_xml | – name: 2 Medical Research Center, University of Oulu , Oulu , Finland – name: 7 Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences , Poznań , Poland – name: 4 Centre for Research in Occupational Safety and Health, Laurentian University , Sudbury, ON , Canada – name: 1 Research Unit of Biomedicine, Department of Physiology and Biocenter of Oulu, University of Oulu , Oulu , Finland – name: 6 Unit of General Practice, Oulu University Hospital , Oulu , Finland – name: 5 Center for Life Course Health Research, Faculty of Medicine, University of Oulu , Oulu , Finland – name: 3 Laboratory of Environmental Exercise Physiology, School of Human Kinetics, Laurentian University , Sudbury, ON , Canada |
| Author_xml | – sequence: 1 givenname: Ville surname: Stenbäck fullname: Stenbäck, Ville – sequence: 2 givenname: Shivaprakash Jagalur surname: Mutt fullname: Mutt, Shivaprakash Jagalur – sequence: 3 givenname: Juhani surname: Leppäluoto fullname: Leppäluoto, Juhani – sequence: 4 givenname: Dominique D. surname: Gagnon fullname: Gagnon, Dominique D. – sequence: 5 givenname: Kari A. surname: Mäkelä fullname: Mäkelä, Kari A. – sequence: 6 givenname: Jari surname: Jokelainen fullname: Jokelainen, Jari – sequence: 7 givenname: Sirkka surname: Keinänen-Kiukaanniemi fullname: Keinänen-Kiukaanniemi, Sirkka – sequence: 8 givenname: Karl-Heinz surname: Herzig fullname: Herzig, Karl-Heinz |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31105579$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3390_nu11061229 crossref_primary_10_3390_medicina60050698 crossref_primary_10_1080_27697061_2024_2407942 crossref_primary_10_1615_CritRevPhysRehabilMed_2023047548 crossref_primary_10_3389_fphys_2019_01123 crossref_primary_10_1007_s11357_023_00873_8 crossref_primary_10_3390_jcm11010076 crossref_primary_10_3390_antiox12101847 crossref_primary_10_3390_jcm10040590 crossref_primary_10_1021_acschemneuro_1c00457 crossref_primary_10_3390_jcm10050994 crossref_primary_10_1007_s13668_024_00529_9 crossref_primary_10_1186_s40798_022_00503_1 crossref_primary_10_1016_j_exger_2021_111373 crossref_primary_10_1093_ageing_afaa186 crossref_primary_10_1186_s12967_024_04956_8 crossref_primary_10_3389_fphar_2022_973897 |
| Cites_doi | 10.1016/j.diabres.2008.02.002 10.1186/s12889-018-6359-8 10.18632/oncotarget.16726 10.3389/fphys.2016.00486 10.1093/aje/kww123 10.1016/j.exger.2017.05.019 10.1016/j.bbi.2012.08.014 10.3389/fphys.2018.01110 10.1080/02640414.2014.981848 10.1016/j.mad.2009.12.009 10.1249/MSS.0b013e31817c92aa 10.1038/s41598-018-25755-4 10.1371/journal.pone.0052769 10.1016/j.genm.2012.10.001 10.1126/science.1170633 10.1371/journal.pgen.1004191 10.1371/journal.pgen.1000375 10.1016/S0140-6736(05)67402-8 10.1196/annals.1297.047 10.1016/j.atherosclerosis.2009.09.070 10.2310/JIM.0b013e3182814cc2 10.1210/jc.2014-1851 10.1093/nar/gkn1027 10.1016/j.ypmed.2017.04.027 10.1093/aje/kww196 10.4162/nrp.2017.11.4.334 10.1249/mss.0b013e3181596695 10.1111/joim.12083 10.4061/2011/790378 10.1016/j.exger.2012.02.003 10.1093/epirev/mxs008 10.1016/j.genm.2008.05.003 10.1073/pnas.0407162101 10.1371/journal.pone.0010837 10.1007/s00421-010-1353-6 10.1073/pnas.0501724102 10.1016/j.mrfmmm.2011.11.002 10.1152/physrev.00026.2007 10.1186/s12906-018-2332-4 10.1093/nar/30.10.e47 |
| ContentType | Journal Article |
| Copyright | Copyright © 2019 Stenbäck, Mutt, Leppäluoto, Gagnon, Mäkelä, Jokelainen, Keinänen-Kiukaanniemi and Herzig. 2019 Stenbäck, Mutt, Leppäluoto, Gagnon, Mäkelä, Jokelainen, Keinänen-Kiukaanniemi and Herzig |
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| References | Adler (B1) 2013; 27 Aubert (B4) 2008; 88 Niemelä (B21) 2019; 19 Wang (B39) 2017; 11 Lee (B16) 2015; 33 Østhus (B24) 2012; 7 Undén (B38) 2008; 5 Alberti (B2) 2005; 366 Radimer (B27) 2004; 160 Seifarth (B34) 2012; 9 Nordfjäll (B22) 2005; 102 Shadyab (B35); 95 Epel (B9) 2004; 101 LaRocca (B15) 2010; 131 Podlevsky (B25) 2012; 730 Metsämarttila (B20) 2018; 8 He (B10) 2016; 7 Laine (B14) 2015; 14 Ludlow (B17) 2011; 2011 Tucker (B37) 2017; 100 Kawanishi (B13) 2004; 1019 Williams (B41) 2017; 185 Rojas (B30) 2018; 9 Mathur (B19) 2013; 61 Puterman (B26) 2010; 5 Salpea (B31) 2010; 209 Cawthon (B7) 2009; 37 Ludlow (B18) 2008; 40 Kadi (B12) 2008; 40 Nordfjäll (B23) 2009; 5 Rae (B28) 2010; 109 Weischer (B40) 2014; 10 Juuti (B11) 2008; 80 Cawthon (B6) 2002; 30 Shadyab (B36); 185 de Lange (B8) 2009; 326 Bojesen (B5) 2013; 274 Savela (B33) 2013; 48 Arsenis (B3) 2017; 8 Révész (B29) 2014; 99 Sanders (B32) 2013; 35 |
| References_xml | – volume: 14 start-page: 239 year: 2015 ident: B14 article-title: Effect of intensive exercise in early adult life on telomere length in later life in men. publication-title: J. Sports Sci. Med. – volume: 80 start-page: 477 year: 2008 ident: B11 article-title: Association of abnormal glucose tolerance with self-reported sleep apnea among a 57-year-old urban population in Northern Finland. publication-title: Diabetes Res. Clin. Pract. doi: 10.1016/j.diabres.2008.02.002 – volume: 19 year: 2019 ident: B21 article-title: Dose-response relation of self-reported and accelerometer-measured physical activity to perceived health in middle age - the northern finland birth cohort 1966 study. publication-title: BMC Public Health doi: 10.1186/s12889-018-6359-8 – volume: 8 start-page: 45008 year: 2017 ident: B3 article-title: Physical activity and telomere length: impact of aging and potential mechanisms of action. publication-title: Oncotarget doi: 10.18632/oncotarget.16726 – volume: 7 year: 2016 ident: B10 article-title: Redox mechanism of reactive oxygen species in exercise. publication-title: Front. Physiol. doi: 10.3389/fphys.2016.00486 – volume: 185 start-page: 529 year: 2017 ident: B41 article-title: Associations of leukocyte telomere length with aerobic and muscular fitness in young adults. publication-title: Am. J. Epidemiol. doi: 10.1093/aje/kww123 – volume: 95 start-page: 141 ident: B35 article-title: Leisure-time physical activity and leukocyte telomere length among older women. publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2017.05.019 – volume: 27 start-page: 15 year: 2013 ident: B1 article-title: Educational attainment and late life telomere length in the health, aging and body composition study. publication-title: Brain Behav. Immun. doi: 10.1016/j.bbi.2012.08.014 – volume: 9 year: 2018 ident: B30 article-title: Short telomere length is related to limitations in physical function in elderly european adults. publication-title: Front. Physiol. doi: 10.3389/fphys.2018.01110 – volume: 33 start-page: 991 year: 2015 ident: B16 article-title: Concurrent validation of the actigraph gt3x+, polar active accelerometer, omron HJ-720 and yamax digiwalker SW-701 pedometer step counts in lab-based and free-living settings. publication-title: J. Sports Sci. doi: 10.1080/02640414.2014.981848 – volume: 131 start-page: 165 year: 2010 ident: B15 article-title: Leukocyte telomere length is preserved with aging in endurance exercise-trained adults and related to maximal aerobic capacity. publication-title: Mech. Ageing Dev. doi: 10.1016/j.mad.2009.12.009 – volume: 40 start-page: 1764 year: 2008 ident: B18 article-title: Relationship between physical activity level, telomere length, and telomerase activity. publication-title: Med. Sci. Sports Exerc. doi: 10.1249/MSS.0b013e31817c92aa – volume: 8 year: 2018 ident: B20 article-title: Effect of physical activity on pulse wave velocity in elderly subjects with normal glucose, prediabetes or type 2 diabetes. publication-title: Sci. Rep. doi: 10.1038/s41598-018-25755-4 – volume: 7 year: 2012 ident: B24 article-title: Telomere length and long-term endurance exercise: does exercise training affect biological age? A pilot study. publication-title: PLoS One doi: 10.1371/journal.pone.0052769 – volume: 9 start-page: 390 year: 2012 ident: B34 article-title: Sex and life expectancy. publication-title: Gend. Med. doi: 10.1016/j.genm.2012.10.001 – volume: 326 start-page: 948 year: 2009 ident: B8 article-title: How telomeres solve the end-protection problem. publication-title: Science doi: 10.1126/science.1170633 – volume: 10 year: 2014 ident: B40 article-title: Telomere shortening unrelated to smoking, body weight, physical activity, and alcohol intake: 4,576 general population individuals with repeat measurements 10 years apart. publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1004191 – volume: 5 year: 2009 ident: B23 article-title: The individual blood cell telomere attrition rate is telomere length dependent. publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1000375 – volume: 366 start-page: 1059 year: 2005 ident: B2 article-title: The metabolic syndrome–a new worldwide definition. publication-title: Lancet doi: 10.1016/S0140-6736(05)67402-8 – volume: 1019 start-page: 278 year: 2004 ident: B13 article-title: Mechanism of telomere shortening by oxidative stress. publication-title: Ann. New York Acad. Sci. doi: 10.1196/annals.1297.047 – volume: 209 start-page: 42 year: 2010 ident: B31 article-title: Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation. publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2009.09.070 – volume: 61 start-page: 613 year: 2013 ident: B19 article-title: Telomere length and cardiorespiratory fitness in marathon runners. publication-title: J. Invest. Med. doi: 10.2310/JIM.0b013e3182814cc2 – volume: 99 start-page: 4607 year: 2014 ident: B29 article-title: Telomere length as a marker of cellular aging is associated with prevalence and progression of metabolic syndrome. publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2014-1851 – volume: 37 year: 2009 ident: B7 article-title: Telomere length measurement by a novel monochrome multiplex quantitative PCR method. publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkn1027 – volume: 100 start-page: 145 year: 2017 ident: B37 article-title: Physical activity and telomere length in U.S. men and women: an NHANES investigation. publication-title: Prev. Med. doi: 10.1016/j.ypmed.2017.04.027 – volume: 185 start-page: 172 ident: B36 article-title: Associations of accelerometer-measured and self-reported sedentary time with leukocyte telomere length in older women. publication-title: Am. J. Epidemiol. doi: 10.1093/aje/kww196 – volume: 11 start-page: 334 year: 2017 ident: B39 article-title: Associations of alcohol consumption and alcohol flush reaction with leukocyte telomere length in korean adults. publication-title: Nutr. Res. Pract. doi: 10.4162/nrp.2017.11.4.334 – volume: 40 start-page: 82 year: 2008 ident: B12 article-title: The effects of regular strength training on telomere length in human skeletal muscle. publication-title: Med. Sci. Sports Exerc. doi: 10.1249/mss.0b013e3181596695 – volume: 274 start-page: 399 year: 2013 ident: B5 article-title: Telomeres and human health. publication-title: J. Intern. Med. doi: 10.1111/joim.12083 – volume: 2011 year: 2011 ident: B17 article-title: Physical activity and telomere biology: exploring the link with aging-related disease prevention. publication-title: J. Aging Res. doi: 10.4061/2011/790378 – volume: 48 start-page: 81 year: 2013 ident: B33 article-title: Physical activity in midlife and telomere length measured in old age. publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2012.02.003 – volume: 35 start-page: 112 year: 2013 ident: B32 article-title: Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither? publication-title: Epidemiol. Rev. doi: 10.1093/epirev/mxs008 – volume: 5 start-page: 162 year: 2008 ident: B38 article-title: Gender differences in self-rated health, quality of life, quality of care, and metabolic control in patients with diabetes. publication-title: Gender Med. doi: 10.1016/j.genm.2008.05.003 – volume: 101 start-page: 17312 year: 2004 ident: B9 article-title: Accelerated telomere shortening in response to life stress. publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0407162101 – volume: 5 year: 2010 ident: B26 article-title: The power of exercise: buffering the effect of chronic stress on telomere length. publication-title: PLoS One doi: 10.1371/journal.pone.0010837 – volume: 109 start-page: 323 year: 2010 ident: B28 article-title: Skeletal muscle telomere length in healthy, experienced, endurance runners. publication-title: Eur. J. Appl. Physiol. doi: 10.1007/s00421-010-1353-6 – volume: 102 start-page: 16374 year: 2005 ident: B22 article-title: Telomere length and heredity: indications of paternal inheritance. publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0501724102 – volume: 730 start-page: 3 year: 2012 ident: B25 article-title: It all comes together at the ends: telomerase structure, function, and biogenesis. publication-title: Mutat. Res. doi: 10.1016/j.mrfmmm.2011.11.002 – volume: 88 start-page: 557 year: 2008 ident: B4 article-title: Telomeres and aging. publication-title: Physiol. Rev. doi: 10.1152/physrev.00026.2007 – volume: 160 start-page: 339 year: 2004 ident: B27 article-title: Dietary supplement use by US adults: data from the national health and nutrition examination survey, 1999-2000. publication-title: Am. J. Epidemiol. doi: 10.1186/s12906-018-2332-4 – volume: 30 year: 2002 ident: B6 article-title: Telomere measurement by quantitative PCR. publication-title: Nucleic Acids Res. doi: 10.1093/nar/30.10.e47 |
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| Snippet | Physical activity (PA) has been associated with telomere shortening. The association of PA intensity or volume with telomere length (TL) is nonetheless... Introduction: Physical activity (PA) has been associated with telomere shortening. The association of PA intensity or volume with telomere length (TL) is... Introduction: Physical activity (PA) has been associated with telomere shortening. The association of PA intensity or volume with telomere length (TL) is... |
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| Title | Association of Physical Activity With Telomere Length Among Elderly Adults - The Oulu Cohort 1945 |
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