Humanized Mouse Model Mimicking Pathology of Human Tuberculosis for in vivo Evaluation of Drug Regimens

Human immune system mice are highly valuable for dissection of human immune responses. Although they were employed for analyzing tuberculosis (TB) disease, there is little data on the spatial organization and cellular composition of human immune cells in TB granuloma pathology in this model. We demo...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in immunology Vol. 10; p. 89
Main Authors Arrey, Frida, Löwe, Delia, Kuhlmann, Stefanie, Kaiser, Peggy, Moura-Alves, Pedro, Krishnamoorthy, Gopinath, Lozza, Laura, Maertzdorf, Jeroen, Skrahina, Tatsiana, Skrahina, Alena, Gengenbacher, Martin, Nouailles, Geraldine, Kaufmann, Stefan H. E.
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 2019
Subjects
Animals
Antitubercular Agents - therapeutic use
Disease Models, Animal
Drug Therapy, Combination
Female
granuloma
Granuloma - drug therapy
Granuloma - pathology
Hematopoietic Stem Cell Transplantation
human immune system mice
humanized mouse models
Humans
Immunology
infection
lung
Lung - immunology
Lung - microbiology
Male
Mice
Mice, Inbred C57BL
Moxifloxacin - therapeutic use
Mycobacterium tuberculosis
Mycobacterium tuberculosis - physiology
Tuberculosis, Pulmonary - drug therapy
Tuberculosis, Pulmonary - pathology
lung
infection
humanized mouse models
pathology
Mycobacterium tuberculosis
granuloma
human immune system mice
antibiotics
Online AccessGet full text
ISSN1664-3224
1664-3224
DOI10.3389/fimmu.2019.00089

Cover

Abstract Human immune system mice are highly valuable for dissection of human immune responses. Although they were employed for analyzing tuberculosis (TB) disease, there is little data on the spatial organization and cellular composition of human immune cells in TB granuloma pathology in this model. We demonstrate that human immune system mice, generated by transplanted human fetal liver derived hematopoietic stem cells develop a continuum of pulmonary lesions upon aerosol infection. In particular, caseous necrotic granulomas, which contribute to prolonged TB treatment time, developed, and had cellular phenotypic spatial-organization similar to TB patients. By comparing two recommended drug regimens, we confirmed observations made in clinical settings: Adding Moxifloxacin to a classical chemotherapy regimen had no beneficial effects on bacterial eradication. We consider this model instrumental for deeper understanding of human specific features of TB pathogenesis and of particular value for the pre-clinical drug development pipeline.
AbstractList Human immune system mice are highly valuable for in vivo dissection of human immune responses. Although they were employed for analyzing tuberculosis (TB) disease, there is little data on the spatial organization and cellular composition of human immune cells in TB granuloma pathology in this model. We demonstrate that human immune system mice, generated by transplanted human fetal liver derived hematopoietic stem cells develop a continuum of pulmonary lesions upon Mycobacterium tuberculosis aerosol infection. In particular, caseous necrotic granulomas, which contribute to prolonged TB treatment time, developed, and had cellular phenotypic spatial-organization similar to TB patients. By comparing two recommended drug regimens, we confirmed observations made in clinical settings: Adding Moxifloxacin to a classical chemotherapy regimen had no beneficial effects on bacterial eradication. We consider this model instrumental for deeper understanding of human specific features of TB pathogenesis and of particular value for the pre-clinical drug development pipeline.
Human immune system mice are highly valuable for dissection of human immune responses. Although they were employed for analyzing tuberculosis (TB) disease, there is little data on the spatial organization and cellular composition of human immune cells in TB granuloma pathology in this model. We demonstrate that human immune system mice, generated by transplanted human fetal liver derived hematopoietic stem cells develop a continuum of pulmonary lesions upon aerosol infection. In particular, caseous necrotic granulomas, which contribute to prolonged TB treatment time, developed, and had cellular phenotypic spatial-organization similar to TB patients. By comparing two recommended drug regimens, we confirmed observations made in clinical settings: Adding Moxifloxacin to a classical chemotherapy regimen had no beneficial effects on bacterial eradication. We consider this model instrumental for deeper understanding of human specific features of TB pathogenesis and of particular value for the pre-clinical drug development pipeline.
Human immune system mice are highly valuable for in vivo dissection of human immune responses. Although they were employed for analyzing tuberculosis (TB) disease, there is little data on the spatial organization and cellular composition of human immune cells in TB granuloma pathology in this model. We demonstrate that human immune system mice, generated by transplanted human fetal liver derived hematopoietic stem cells develop a continuum of pulmonary lesions upon Mycobacterium tuberculosis aerosol infection. In particular, caseous necrotic granulomas, which contribute to prolonged TB treatment time, developed, and had cellular phenotypic spatial-organization similar to TB patients. By comparing two recommended drug regimens, we confirmed observations made in clinical settings: Adding Moxifloxacin to a classical chemotherapy regimen had no beneficial effects on bacterial eradication. We consider this model instrumental for deeper understanding of human specific features of TB pathogenesis and of particular value for the pre-clinical drug development pipeline.Human immune system mice are highly valuable for in vivo dissection of human immune responses. Although they were employed for analyzing tuberculosis (TB) disease, there is little data on the spatial organization and cellular composition of human immune cells in TB granuloma pathology in this model. We demonstrate that human immune system mice, generated by transplanted human fetal liver derived hematopoietic stem cells develop a continuum of pulmonary lesions upon Mycobacterium tuberculosis aerosol infection. In particular, caseous necrotic granulomas, which contribute to prolonged TB treatment time, developed, and had cellular phenotypic spatial-organization similar to TB patients. By comparing two recommended drug regimens, we confirmed observations made in clinical settings: Adding Moxifloxacin to a classical chemotherapy regimen had no beneficial effects on bacterial eradication. We consider this model instrumental for deeper understanding of human specific features of TB pathogenesis and of particular value for the pre-clinical drug development pipeline.
Author Lozza, Laura
Arrey, Frida
Kaiser, Peggy
Kuhlmann, Stefanie
Maertzdorf, Jeroen
Kaufmann, Stefan H. E.
Skrahina, Alena
Löwe, Delia
Krishnamoorthy, Gopinath
Nouailles, Geraldine
Skrahina, Tatsiana
Gengenbacher, Martin
Moura-Alves, Pedro
AuthorAffiliation 3 Republican Scientific and Practical Centre for Pulmonology and Tuberculosis , Minsk , Belarus
2 Department of Molecular Pharmacology and Cell Biology, Leibniz Forschungsinstitut für Molekulare Pharmakologie , Berlin , Germany
4 Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey , Newark, NJ , United States
1 Department of Immunology, Max Planck Institute for Infection Biology , Berlin , Germany
5 Division of Pulmonary Inflammation, Charité-Universitätsmedizin Berlin , Berlin , Germany
AuthorAffiliation_xml – name: 5 Division of Pulmonary Inflammation, Charité-Universitätsmedizin Berlin , Berlin , Germany
– name: 2 Department of Molecular Pharmacology and Cell Biology, Leibniz Forschungsinstitut für Molekulare Pharmakologie , Berlin , Germany
– name: 3 Republican Scientific and Practical Centre for Pulmonology and Tuberculosis , Minsk , Belarus
– name: 1 Department of Immunology, Max Planck Institute for Infection Biology , Berlin , Germany
– name: 4 Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey , Newark, NJ , United States
Author_xml – sequence: 1
  givenname: Frida
  surname: Arrey
  fullname: Arrey, Frida
– sequence: 2
  givenname: Delia
  surname: Löwe
  fullname: Löwe, Delia
– sequence: 3
  givenname: Stefanie
  surname: Kuhlmann
  fullname: Kuhlmann, Stefanie
– sequence: 4
  givenname: Peggy
  surname: Kaiser
  fullname: Kaiser, Peggy
– sequence: 5
  givenname: Pedro
  surname: Moura-Alves
  fullname: Moura-Alves, Pedro
– sequence: 6
  givenname: Gopinath
  surname: Krishnamoorthy
  fullname: Krishnamoorthy, Gopinath
– sequence: 7
  givenname: Laura
  surname: Lozza
  fullname: Lozza, Laura
– sequence: 8
  givenname: Jeroen
  surname: Maertzdorf
  fullname: Maertzdorf, Jeroen
– sequence: 9
  givenname: Tatsiana
  surname: Skrahina
  fullname: Skrahina, Tatsiana
– sequence: 10
  givenname: Alena
  surname: Skrahina
  fullname: Skrahina, Alena
– sequence: 11
  givenname: Martin
  surname: Gengenbacher
  fullname: Gengenbacher, Martin
– sequence: 12
  givenname: Geraldine
  surname: Nouailles
  fullname: Nouailles, Geraldine
– sequence: 13
  givenname: Stefan H. E.
  surname: Kaufmann
  fullname: Kaufmann, Stefan H. E.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30766535$$D View this record in MEDLINE/PubMed
BookMark eNqNkc1vFCEYxompsXXt3ZPh6GVXGBiGuZiYttombTSmngnLx5TKwArDmu1f35nZ2rQmJl6AwPM-7_Pyew0OQgwGgLcYrQjh7Qfr-r6sKoTbFUKIty_AEWaMLklV0YMn50NwnPPtKEG0JYTUr8AhQQ1jNamPQHdeehncndHwKpZsxlUbD69c79RPFzr4TQ430cduB6OFsxhel7VJqviYXYY2JugC3LpthGdb6YscXAyT-DSVDn43netNyG_ASyt9NscP-wL8-Hx2fXK-vPz65eLk0-VSUVYNS9WgMTFVpsG4QcxYjbTiiCBlLVvjppWM16rRTd2OEyPDdEu4VhUimDKrOVmAi72vjvJWbJLrZdqJKJ2YL2LqhEyDU94ILDGubK0RNzXF4-dg0_KGctSsucV28sJ7rxI2cvdbev9oiJGYGIiZgZgYiJnBWPNxX7Mp695oZcKQpH8W5PlLcDeii1vBCKspmQzePxik-KuYPIjeZWW8l8GMgESFOWEUkXHkBXj3tNdjkz90RwHaC1SKOSdj_yc_-6tEuWFGOqZ1_t-F96UEy1w
CitedBy_id crossref_primary_10_3389_fvets_2023_1264833
crossref_primary_10_3389_fimmu_2023_1223260
crossref_primary_10_1016_j_chom_2024_04_019
crossref_primary_10_3389_fimmu_2023_1193058
crossref_primary_10_3390_ijms25031656
crossref_primary_10_3390_vaccines8010036
crossref_primary_10_1177_0192623319886304
crossref_primary_10_1097_MCP_0000000000000708
crossref_primary_10_2147_IJN_S430019
crossref_primary_10_1128_iai_00430_22
crossref_primary_10_1111_imm_13606
crossref_primary_10_3389_fimmu_2020_617516
crossref_primary_10_3389_fcimb_2021_613149
crossref_primary_10_3390_ph16101475
crossref_primary_10_17721_fujcV12I1P164_179
crossref_primary_10_3389_fimmu_2021_663328
crossref_primary_10_1038_s42003_024_06006_x
crossref_primary_10_3390_microorganisms11102488
crossref_primary_10_1021_acsinfecdis_2c00075
crossref_primary_10_3390_v14091927
crossref_primary_10_1186_s13578_022_00750_5
Cites_doi 10.1016/j.humimm.2009.06.005
10.1371/journal.pone.0100984
10.1038/nature12988
10.1371/journal.ppat.1005271
10.1016/j.tube.2009.01.005
10.1016/j.tube.2005.08.008
10.1371/journal.pone.0063331
10.1179/joc.2004.16.4.334
10.1126/science.1129139
10.1242/dmm.019570
10.1002/eji.201343815
10.1073/pnas.1219985110
10.1084/jem.20081720
10.1128/AAC.00105-15
10.1128/IAI.00332-06
10.1056/NEJMoa1407426
10.1007/s00247-007-0496-z
10.1038/nrd.2017.162
10.1146/annurev-immunol-032713-120145
10.1016/j.cell.2016.08.072
10.1172/JCI72030
10.1073/pnas.1005566107
10.1056/NEJMoa1314210
10.1016/j.tpb.2015.06.004
10.1172/JCI67604
10.7861/clinmedicine.12-1-40
10.1164/rccm.201302-0249OC
10.1016/j.ijid.2014.11.028
10.1371/journal.pone.0127087
10.1002/iid3.124
10.1172/JCI42796
10.15252/emmm.201606330
10.1038/nm.3937
10.1038/srep33162
10.1002/path.4399
10.1128/IAI.00632-13
10.1371/journal.ppat.1005479
10.1073/pnas.1408839111
10.1073/pnas.150227197
10.1016/j.imbio.2012.05.011
10.4049/jimmunol.1201518
10.1128/IAI.71.10.6004-6011.2003
10.1242/dmm.020867
10.2353/ajpath.2010.100536
10.1002/eji.201344219
10.1128/IAI.00624-07
10.1111/imr.12252
10.1016/j.jim.2015.02.007
10.1038/s41598-017-09177-2
10.1073/pnas.1108776109
10.1111/cmi.12428
10.1186/1471-2172-14-53
10.1111/j.1574-6976.2012.00331.x
10.1038/nbt.2858
10.1016/j.jhep.2016.04.022
10.1371/journal.ppat.1004603
10.1084/jem.178.6.2249
10.1128/microbiolspec.TBTB2-0029-2016
10.1146/annurev-immunol-032712-095921
10.5935/MedicalExpress.2014.04.03
10.1073/pnas.1611776114
10.1111/cmi.12480
10.1016/j.it.2011.10.003
ContentType Journal Article
Copyright Copyright © 2019 Arrey, Löwe, Kuhlmann, Kaiser, Moura-Alves, Krishnamoorthy, Lozza, Maertzdorf, Skrahina, Skrahina, Gengenbacher, Nouailles and Kaufmann. 2019 Arrey, Löwe, Kuhlmann, Kaiser, Moura-Alves, Krishnamoorthy, Lozza, Maertzdorf, Skrahina, Skrahina, Gengenbacher, Nouailles and Kaufmann
Copyright_xml – notice: Copyright © 2019 Arrey, Löwe, Kuhlmann, Kaiser, Moura-Alves, Krishnamoorthy, Lozza, Maertzdorf, Skrahina, Skrahina, Gengenbacher, Nouailles and Kaufmann. 2019 Arrey, Löwe, Kuhlmann, Kaiser, Moura-Alves, Krishnamoorthy, Lozza, Maertzdorf, Skrahina, Skrahina, Gengenbacher, Nouailles and Kaufmann
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
ADTOC
UNPAY
DOA
DOI 10.3389/fimmu.2019.00089
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
Unpaywall for CDI: Periodical Content
Unpaywall
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList

MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: UNPAY
  name: Unpaywall
  url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1664-3224
ExternalDocumentID oai_doaj_org_article_1a112f5d08e5410491e9874807b8f1f8
10.3389/fimmu.2019.00089
PMC6365439
30766535
10_3389_fimmu_2019_00089
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: PreDiCT-TB
  grantid: 115337
GroupedDBID 53G
5VS
9T4
AAFWJ
AAKDD
AAYXX
ACGFO
ACGFS
ADBBV
ADRAZ
AENEX
AFPKN
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BCNDV
CITATION
DIK
EBS
EMOBN
GROUPED_DOAJ
GX1
HYE
KQ8
M48
M~E
OK1
PGMZT
RNS
RPM
ACXDI
CGR
CUY
CVF
ECM
EIF
IPNFZ
NPM
RIG
7X8
5PM
ADTOC
UNPAY
ID FETCH-LOGICAL-c462t-c702244ce711706efd0dc8030cff6b179a685c7d7590890e6d938dc203146fd83
IEDL.DBID DOA
ISSN 1664-3224
IngestDate Wed Aug 27 01:31:37 EDT 2025
Tue Aug 19 23:58:16 EDT 2025
Tue Sep 30 16:43:53 EDT 2025
Thu Sep 04 23:32:08 EDT 2025
Thu Apr 03 07:09:58 EDT 2025
Wed Oct 01 02:19:07 EDT 2025
Thu Apr 24 23:09:35 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords lung
infection
humanized mouse models
pathology
Mycobacterium tuberculosis
granuloma
human immune system mice
antibiotics
Language English
License This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
cc-by
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c462t-c702244ce711706efd0dc8030cff6b179a685c7d7590890e6d938dc203146fd83
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Edited by: Abhay Satoskar, The Ohio State University, United States
This article was submitted to Microbial Immunology, a section of the journal Frontiers in Immunology
These authors share co-last authorship
Present Address: Stefanie Kuhlmann, Bayer Pharmaceuticals, Berlin, Germany
Reviewed by: Shashank Gupta, Brown University, United States; Muazzam Jacobs, University of Cape Town, South Africa
Tatsiana Skrahina, Immutep, Berlin, Germany
OpenAccessLink https://doaj.org/article/1a112f5d08e5410491e9874807b8f1f8
PMID 30766535
PQID 2183640320
PQPubID 23479
ParticipantIDs doaj_primary_oai_doaj_org_article_1a112f5d08e5410491e9874807b8f1f8
unpaywall_primary_10_3389_fimmu_2019_00089
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6365439
proquest_miscellaneous_2183640320
pubmed_primary_30766535
crossref_primary_10_3389_fimmu_2019_00089
crossref_citationtrail_10_3389_fimmu_2019_00089
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2019-00-00
PublicationDateYYYYMMDD 2019-01-01
PublicationDate_xml – year: 2019
  text: 2019-00-00
PublicationDecade 2010
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
PublicationTitle Frontiers in immunology
PublicationTitleAlternate Front Immunol
PublicationYear 2019
Publisher Frontiers Media S.A
Publisher_xml – name: Frontiers Media S.A
References Galon (B64) 2006; 313
Evangelopoulos (B23) 2015; 32
Kaufmann (B66) 2018; 17
Gengenbacher (B62) 2017; 7
Patton (B29) 2015; 422
Hunter (B35) 2014; 44
Silva (B10) 2013; 218
Saeed (B9) 2012; 12
Pinho (B21) 2015; 104
Fox (B27) 2016; 12
Calderon (B56) 2013; 8
Gupta (B11) 2005; 85
Nouailles (B26) 2014; 124
Lenaerts (B4) 2015; 264
Lepus (B30) 2009; 70
Heitmann (B12) 2014; 234
Polena (B7) 2016; 6
Reece (B24) 2010; 120
Vuyyuru (B20) 2011; 108
Lu (B46) 2016; 167
Via (B31) 2013; 81
Zhou (B65) 2014; 506
Griffith-Richards (B58) 2007; 37
Irwin (B34) 2015; 8
Gorantla (B16) 2010; 177
B1
du Plessis (B45) 2013; 188
Fan (B49) 2015; 10
Leung (B53) 2013; 43
Zimmermann (B47) 2016; 8
Flynn (B51) 1993; 178
Lerner (B59) 2015; 17
Lee (B54) 2013; 14
Gengenbacher (B2) 2012; 36
Dorhoi (B3) 2016
Niazi (B40) 2015; 8
Rongvaux (B25) 2014; 32
Jindani (B36) 2014; 371
Jangalwe (B39) 2016; 4
Billerbeck (B17) 2016; 65
Basaraba (B5) 2017
Gideon (B28) 2015; 11
Kramnik (B14) 2000; 97
Strowig (B18) 2009; 206
Manabe (B33) 2003; 71
Billerbeck (B38) 2013; 191
Andersson (B50) 2007; 75
Gillespie (B22) 2014; 371
Libby (B19) 2010; 107
Griffith (B52) 2014; 32
Palanisamy (B32) 2009; 89
Dorhoi (B42) 2013; 123
Rongvaux (B15) 2013; 31
Dorhoi (B41) 2014; 44
Jones-López (B57) 2014; 9
Mattila (B43) 2015; 17
Lowe (B44) 2012; 33
Li (B61) 2015; 59
Tortoli (B60) 2004; 16
Silva (B37) 2014; 1
Osherov (B8) 2016; 12
Li (B48) 2017; 114
Prideaux (B63) 2015; 21
Basaraba (B6) 2006; 74
Heuts (B55) 2013; 110
Duque-Correa (B13) 2014; 111
References_xml – volume: 70
  start-page: 790
  year: 2009
  ident: B30
  article-title: Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/γc−/−, Balb/c-Rag1−/− γc−/−, and C
  publication-title: Hum Immunol.
  doi: 10.1016/j.humimm.2009.06.005
– volume: 9
  start-page: e100984
  year: 2014
  ident: B57
  article-title: Importance of cough and M. tuberculosis strain type as risks for increased transmission within households
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0100984
– volume: 506
  start-page: 52
  year: 2014
  ident: B65
  article-title: In vivo discovery of immunotherapy targets in the tumour microenvironment
  publication-title: Nature
  doi: 10.1038/nature12988
– volume: 12
  start-page: e1005271
  year: 2016
  ident: B27
  article-title: Tuberculosis in newborns: the lessons of the “Lübeck disaster”(1929–1933)
  publication-title: PLoS Pathogens
  doi: 10.1371/journal.ppat.1005271
– volume: 89
  start-page: 203
  year: 2009
  ident: B32
  article-title: Clinical strains of Mycobacterium tuberculosis display a wide range of virulence in guinea pigs
  publication-title: Tuberculosis
  doi: 10.1016/j.tube.2009.01.005
– volume: 85
  start-page: 277
  year: 2005
  ident: B11
  article-title: Animal models of tuberculosis
  publication-title: Tuberculosis
  doi: 10.1016/j.tube.2005.08.008
– volume: 8
  start-page: e63331
  year: 2013
  ident: B56
  article-title: A humanized mouse model of tuberculosis
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0063331
– volume: 16
  start-page: 334
  year: 2004
  ident: B60
  article-title: Evaluation of moxifloxacin activity in vitro against Mycobacterium tuberculosis, including resistant and multidrug-resistant strains
  publication-title: J Chemother.
  doi: 10.1179/joc.2004.16.4.334
– volume: 313
  start-page: 1960
  year: 2006
  ident: B64
  article-title: Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
  publication-title: Science
  doi: 10.1126/science.1129139
– volume: 8
  start-page: 591
  year: 2015
  ident: B34
  article-title: Multiple lesion types displaying vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with M. tuberculosis
  publication-title: Dis Model Mech.
  doi: 10.1242/dmm.019570
– volume: 43
  start-page: 2246
  year: 2013
  ident: B53
  article-title: Infectious diseases in humanized mice
  publication-title: Eur J Immunol.
  doi: 10.1002/eji.201343815
– volume: 110
  start-page: 6482
  year: 2013
  ident: B55
  article-title: CD4+ cell-dependent granuloma formation in humanized mice infected with mycobacteria
  publication-title: Proc Natl Acad Sci USA.
  doi: 10.1073/pnas.1219985110
– volume: 206
  start-page: 1423
  year: 2009
  ident: B18
  article-title: Priming of protective T cell responses against virus-induced tumors in mice with human immune system components
  publication-title: J Exp Med.
  doi: 10.1084/jem.20081720
– volume: 59
  start-page: 4026
  year: 2015
  ident: B61
  article-title: Evaluation of moxifloxacin-containing regimens in pathologically distinct murine tuberculosis models
  publication-title: Antimicrob Agents Chemother.
  doi: 10.1128/AAC.00105-15
– volume: 74
  start-page: 5397
  year: 2006
  ident: B6
  article-title: Pulmonary lymphatics are primary sites of Mycobacterium tuberculosis infection in guinea pigs infected by aerosol
  publication-title: Infect Immun.
  doi: 10.1128/IAI.00332-06
– volume: 371
  start-page: 1577
  year: 2014
  ident: B22
  article-title: Four-month moxifloxacin-based regimens for drug-sensitive tuberculosis
  publication-title: N Engl J Med.
  doi: 10.1056/NEJMoa1407426
– volume: 37
  start-page: 798
  year: 2007
  ident: B58
  article-title: Cavitating pulmonary tuberculosis in children: correlating radiology with pathogenesis
  publication-title: Pediatr Radiol.
  doi: 10.1007/s00247-007-0496-z
– volume: 17
  start-page: 35
  year: 2018
  ident: B66
  article-title: Host-directed therapies for bacterial and viral infections
  publication-title: Nat Rev Drug Discov.
  doi: 10.1038/nrd.2017.162
– volume: 32
  start-page: 659
  year: 2014
  ident: B52
  article-title: Chemokines and chemokine receptors: positioning cells for host defense and immunity
  publication-title: Annu Rev Immunol.
  doi: 10.1146/annurev-immunol-032713-120145
– volume: 167
  start-page: 433
  year: 2016
  ident: B46
  article-title: A functional role for antibodies in tuberculosis
  publication-title: Cell
  doi: 10.1016/j.cell.2016.08.072
– volume: 124
  start-page: 1268
  year: 2014
  ident: B26
  article-title: CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis
  publication-title: J Clin Invest.
  doi: 10.1172/JCI72030
– start-page: 153
  volume-title: Semin Immunopathology.
  year: 2016
  ident: B3
  article-title: Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis
– volume: 107
  start-page: 15589
  year: 2010
  ident: B19
  article-title: Humanized nonobese diabetic-scid IL2rγnull mice are susceptible to lethal Salmonella Typhi infection
  publication-title: Proc Natl Acad Sci USA.
  doi: 10.1073/pnas.1005566107
– volume: 371
  start-page: 1599
  year: 2014
  ident: B36
  article-title: High-dose rifapentine with moxifloxacin for pulmonary tuberculosis
  publication-title: N Engl J Med.
  doi: 10.1056/NEJMoa1314210
– volume: 104
  start-page: 68
  year: 2015
  ident: B21
  article-title: Impact of tuberculosis treatment length and adherence under different transmission intensities
  publication-title: Theor Popul Biol.
  doi: 10.1016/j.tpb.2015.06.004
– volume: 123
  start-page: 4836
  year: 2013
  ident: B42
  article-title: MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil recruitment
  publication-title: J Clin Invest.
  doi: 10.1172/JCI67604
– volume: 12
  start-page: 40
  year: 2012
  ident: B9
  article-title: Cavitating pulmonary tuberculosis: a global challenge
  publication-title: Clin Med.
  doi: 10.7861/clinmedicine.12-1-40
– volume: 188
  start-page: 724
  year: 2013
  ident: B45
  article-title: Increased frequency of myeloid-derived suppressor cells during active tuberculosis and after recent Mycobacterium tuberculosis infection suppresses T-cell function
  publication-title: Am J Respir Crit Care Med.
  doi: 10.1164/rccm.201302-0249OC
– volume: 32
  start-page: 76
  year: 2015
  ident: B23
  article-title: Understanding anti-tuberculosis drug efficacy: rethinking bacterial populations and how we model them
  publication-title: Int J Infect Dis.
  doi: 10.1016/j.ijid.2014.11.028
– volume: 10
  start-page: e0127087
  year: 2015
  ident: B49
  article-title: Impaired M. tuberculosis antigen-specific IFN-γ response without IL-17 enhancement in patients with severe cavitary pulmonary tuberculosis
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0127087
– volume: 4
  start-page: 427
  year: 2016
  ident: B39
  article-title: Improved B cell development in humanized NOD-scid IL2Rγnull mice transgenically expressing human stem cell factor, granulocyte-macrophage colony-stimulating factor and interleukin-3
  publication-title: Immun Inflamm Dis.
  doi: 10.1002/iid3.124
– volume: 120
  start-page: 3365
  year: 2010
  ident: B24
  article-title: Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice
  publication-title: J Clin Invest.
  doi: 10.1172/JCI42796
– volume: 8
  start-page: 1325
  year: 2016
  ident: B47
  article-title: Human isotype-dependent inhibitory antibody responses against Mycobacterium tuberculosis
  publication-title: EMBO Mol Med.
  doi: 10.15252/emmm.201606330
– volume: 21
  start-page: 1223
  year: 2015
  ident: B63
  article-title: The association between sterilizing activity and drug distribution into tuberculosis lesions
  publication-title: Nat Med.
  doi: 10.1038/nm.3937
– volume: 6
  start-page: 33162
  year: 2016
  ident: B7
  article-title: Mycobacterium tuberculosis exploits the formation of new blood vessels for its dissemination
  publication-title: Sci Rep.
  doi: 10.1038/srep33162
– volume: 234
  start-page: 338
  year: 2014
  ident: B12
  article-title: The IL-13/IL-4R α axis is involved in tuberculosis-associated pathology
  publication-title: J Pathol.
  doi: 10.1002/path.4399
– volume: 81
  start-page: 2909
  year: 2013
  ident: B31
  article-title: Differential virulence and disease progression following Mycobacterium tuberculosis complex infection of the common marmoset (Callithrix jacchus)
  publication-title: Infect Iimmun.
  doi: 10.1128/IAI.00632-13
– volume: 12
  start-page: e1005479
  year: 2016
  ident: B8
  article-title: Modulation of host angiogenesis as a microbial survival strategy and therapeutic target
  publication-title: PLoS Pathogens
  doi: 10.1371/journal.ppat.1005479
– volume: 111
  start-page: E4024
  year: 2014
  ident: B13
  article-title: Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas
  publication-title: Proc Natl Acad Sci USA.
  doi: 10.1073/pnas.1408839111
– volume: 97
  start-page: 8560
  year: 2000
  ident: B14
  article-title: Genetic control of resistance to experimental infection with virulent Mycobacterium tuberculosis
  publication-title: Proc Natl Acad Sci USA.
  doi: 10.1073/pnas.150227197
– volume: 218
  start-page: 325
  year: 2013
  ident: B10
  article-title: The in vivo extracellular life of facultative intracellular bacterial parasites: role in pathogenesis
  publication-title: Immunobiology
  doi: 10.1016/j.imbio.2012.05.011
– volume: 191
  start-page: 1753
  year: 2013
  ident: B38
  article-title: Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system mice
  publication-title: J Immunol.
  doi: 10.4049/jimmunol.1201518
– ident: B1
– volume: 71
  start-page: 6004
  year: 2003
  ident: B33
  article-title: Different strains of Mycobacterium tuberculosis cause various spectrums of disease in the rabbit model of tuberculosis
  publication-title: Infect Immun.
  doi: 10.1128/IAI.71.10.6004-6011.2003
– volume: 8
  start-page: 1141
  year: 2015
  ident: B40
  article-title: Lung necrosis and neutrophils reflect common pathways of susceptibility to Mycobacterium tuberculosis in genetically diverse, immune competent mice
  publication-title: Dis Model Mech.
  doi: 10.1242/dmm.020867
– volume: 177
  start-page: 2938
  year: 2010
  ident: B16
  article-title: Links between progressive HIV-1 infection of humanized mice and viral neuropathogenesis
  publication-title: Am J Pathol.
  doi: 10.2353/ajpath.2010.100536
– volume: 44
  start-page: 2380
  year: 2014
  ident: B41
  article-title: Type I IFN signaling triggers immunopathology in tuberculosis-susceptible mice by modulating lung phagocyte dynamics
  publication-title: Eur J Immunol.
  doi: 10.1002/eji.201344219
– volume: 75
  start-page: 5210
  year: 2007
  ident: B50
  article-title: Impaired expression of perforin and granulysin in CD8+ T cells at the site of infection in human chronic pulmonary tuberculosis
  publication-title: Infect Immun.
  doi: 10.1128/IAI.00624-07
– volume: 264
  start-page: 288
  year: 2015
  ident: B4
  article-title: Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses
  publication-title: Immunol Rev.
  doi: 10.1111/imr.12252
– volume: 422
  start-page: 13
  year: 2015
  ident: B29
  article-title: Evaluation of the efficiency of human immune system reconstitution in NSG mice and NSG mice containing a human HLA. A2 transgene using hematopoietic stem cells purified from different sources
  publication-title: J Immunol Methods
  doi: 10.1016/j.jim.2015.02.007
– volume: 7
  start-page: 8853
  year: 2017
  ident: B62
  article-title: NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans
  publication-title: Sci Rep.
  doi: 10.1038/s41598-017-09177-2
– volume: 108
  start-page: 20707
  year: 2011
  ident: B20
  article-title: Characteristics of Borrelia hermsii infection in human hematopoietic stem cell-engrafted mice mirror those of human relapsing fever
  publication-title: Proc Natl Acad Sci USA.
  doi: 10.1073/pnas.1108776109
– volume: 17
  start-page: 1085
  year: 2015
  ident: B43
  article-title: Granzyme B-expressing neutrophils correlate with bacterial load in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques
  publication-title: Cell Microbiol.
  doi: 10.1111/cmi.12428
– volume: 44
  start-page: 365
  year: 2014
  ident: B35
  article-title: Pathogenesis of post primary tuberculosis: immunity and hypersensitivity in the development of cavities
  publication-title: Ann Clin Lab Sci.
– volume: 14
  start-page: 53
  year: 2013
  ident: B54
  article-title: Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice
  publication-title: BMC Immunol.
  doi: 10.1186/1471-2172-14-53
– volume: 36
  start-page: 514
  year: 2012
  ident: B2
  article-title: Mycobacterium tuberculosis: success through dormancy
  publication-title: FEMS Microbiol Rev.
  doi: 10.1111/j.1574-6976.2012.00331.x
– volume: 32
  start-page: 364
  year: 2014
  ident: B25
  article-title: Development and function of human innate immune cells in a humanized mouse model
  publication-title: Nat Biotechnol.
  doi: 10.1038/nbt.2858
– volume: 65
  start-page: 334
  year: 2016
  ident: B17
  article-title: Humanized mice efficiently engrafted with fetal hepatoblasts and syngeneic immune cells develop human monocytes and NK cells
  publication-title: J Hepatol.
  doi: 10.1016/j.jhep.2016.04.022
– volume: 11
  start-page: e1004603
  year: 2015
  ident: B28
  article-title: Variability in tuberculosis granuloma T cell responses exists, but a balance of pro-and anti-inflammatory cytokines is associated with sterilization
  publication-title: PLoS Pathogens
  doi: 10.1371/journal.ppat.1004603
– volume: 178
  start-page: 2249
  year: 1993
  ident: B51
  article-title: An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection
  publication-title: J Exp Med.
  doi: 10.1084/jem.178.6.2249
– year: 2017
  ident: B5
  article-title: Pathology of tuberculosis: how the pathology of human tuberculosis informs and directs animal models
  publication-title: Microbiol Spectr.
  doi: 10.1128/microbiolspec.TBTB2-0029-2016
– volume: 31
  start-page: 635
  year: 2013
  ident: B15
  article-title: Human hemato-lymphoid system mice: current use and future potential for medicine
  publication-title: Annu Rev Immunol.
  doi: 10.1146/annurev-immunol-032712-095921
– volume: 1
  start-page: 174
  year: 2014
  ident: B37
  article-title: Immunophenotype of lung granulomas in HIV and non-HIV associated tuberculosis
  publication-title: MedicalExpress
  doi: 10.5935/MedicalExpress.2014.04.03
– volume: 114
  start-page: 5023
  year: 2017
  ident: B48
  article-title: Latently and uninfected healthcare workers exposed to TB make protective antibodies against Mycobacterium tuberculosis
  publication-title: Proc Natl Acad Sci USA.
  doi: 10.1073/pnas.1611776114
– volume: 17
  start-page: 1277
  year: 2015
  ident: B59
  article-title: The innate immune response in human tuberculosis
  publication-title: Cell Microbiol.
  doi: 10.1111/cmi.12480
– volume: 33
  start-page: 14
  year: 2012
  ident: B44
  article-title: Neutrophils in tuberculosis: friend or foe?
  publication-title: Trends Immunol.
  doi: 10.1016/j.it.2011.10.003
SSID ssj0000493335
Score 2.3153718
Snippet Human immune system mice are highly valuable for dissection of human immune responses. Although they were employed for analyzing tuberculosis (TB) disease,...
Human immune system mice are highly valuable for in vivo dissection of human immune responses. Although they were employed for analyzing tuberculosis (TB)...
SourceID doaj
unpaywall
pubmedcentral
proquest
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 89
SubjectTerms Animals
Antitubercular Agents - therapeutic use
Disease Models, Animal
Drug Therapy, Combination
Female
granuloma
Granuloma - drug therapy
Granuloma - pathology
Hematopoietic Stem Cell Transplantation
human immune system mice
humanized mouse models
Humans
Immunology
infection
lung
Lung - immunology
Lung - microbiology
Male
Mice
Mice, Inbred C57BL
Moxifloxacin - therapeutic use
Mycobacterium tuberculosis
Mycobacterium tuberculosis - physiology
Tuberculosis, Pulmonary - drug therapy
Tuberculosis, Pulmonary - pathology
SummonAdditionalLinks – databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1bb9MwGLXGJgQvCMYtMJCReAEpzE0c23mYJthFE1IRQqu0NyvxpQSlyUibQfn18-dkGdWq8cJr6jSX4y_f-Xw5B6G3qYM1VTD-xTkJKSdJmFvNQ6WItoRbE_sZ_PEXdjKhn8-Ss-vt0f0LnK8t7cBPatKUH37_XO67gN-DitPl211bzGYtrNIC6Uki0jtoy-WlCPr4uCf7PzouHMdx0s1Vrj1xJTd5Cf91vPPm8sl7bXWeLX9lZflXbjp-iB70pBJ_7HrBI7Rhqm10t7OZXD5GUz9SX_wxGo9doW8wGKCVeFzMCgUj5fhrtvAfwSWuLfaN8Wmbm0a1ZT0v5tgRW1xU-KK4qPHRIA8OjQ-bdoq_mSl4BMyfoMnx0enBSdgbLISKsmgRKg4ZnCrDwX-GGauJVsKFvbKW5S5UMyYSxTUHY_SUGKbTWGgVgeQ9s1rET9FmVVfmOcLK0EgRRy4MBbkcWNuvowj05hRjGVUB2r16tVL16uNgglFKV4UAGNKDIQEM6cEI0LvhjPNOeeOWtp8AraEdaGb7A3UzlX0IylHmuKVNNBEmoa4KTUcmFRy21OfCjqwI0JsrrKWLMZg4ySrjYJFAIxkFq_kAPeuwHy7lvpGMJXESIL7SK1buZfWXqvjudbxZDBt73c2_H_rPP5_0xf940pfoPvxjN5K0gzYXTWteOW61yF_7kLkEr_UieA
  priority: 102
  providerName: Scholars Portal
– databaseName: Unpaywall
  dbid: UNPAY
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZgK0QvvKHhJSNxASmtN3Fs51igVYW0VYW6UjlZiR9LRDapNknR9tfjcdKoCxWPY5KxYntm7PGM5xuE3qaOrakC_xfnJKScJGFuNQ-VItoSbk3sI_izY3Y0p5_PkrPB3wG5MNfi9-7wlO7ZYrns4AYWwEoSkd5GWwxCSRO0NT8-2f8K5ynGaOjkkvZRyBubbew6Hpz_Jovy94uRd7vqPFv_yMry2q5zeL-HQGo8WCFcNvm-27X5rrr8BcrxXwb0AN0bTE-838vKQ3TLVI_Qnb4Y5foxWnh_fnFpNJ7VXWMwlEkr8axYFgr86fgka_1Suca1xZ4Yn3a5WamurJuiwc78xUWFL4qLGh-MIOJA_GnVLfAXs4BKAs0TND88OP14FA5lGEJFWdSGisM-T5XhUKWGGauJVsItDspaljuFzphIFNccyqenxDCdxkKrCIDxmdUifoomVV2ZHYSVoZEizgQxFEB1IANARxGg0inGMqoCtHfFJqkGjHIolVFKd1aB6ZN--iRMn_TTF6B3Y4vzHp_jD7QfgPMjHSBr-xeOP3JQVDnNnAVqE02ESag7q6ZTkwoOife5sFMrAvTmSm6k00QIr2SVcWyRYGwyCgXpA_Ssl6PxV24lZSyJkwDxDQnb6Mvml6r45tG-WQzpv67z70dZ_OtIn_8P8Qu0DQ-9X-klmrSrzrxyllabvx6U7CcQhCRo
  priority: 102
  providerName: Unpaywall
Title Humanized Mouse Model Mimicking Pathology of Human Tuberculosis for in vivo Evaluation of Drug Regimens
URI https://www.ncbi.nlm.nih.gov/pubmed/30766535
https://www.proquest.com/docview/2183640320
https://pubmed.ncbi.nlm.nih.gov/PMC6365439
https://doi.org/10.3389/fimmu.2019.00089
https://doaj.org/article/1a112f5d08e5410491e9874807b8f1f8
UnpaywallVersion publishedVersion
Volume 10
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAFT
  databaseName: Open Access Digital Library
  customDbUrl:
  eissn: 1664-3224
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000493335
  issn: 1664-3224
  databaseCode: KQ8
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  providerName: Colorado Alliance of Research Libraries
– providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 1664-3224
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000493335
  issn: 1664-3224
  databaseCode: DOA
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVBFR
  databaseName: Free Medical Journals
  customDbUrl:
  eissn: 1664-3224
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000493335
  issn: 1664-3224
  databaseCode: DIK
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: http://www.freemedicaljournals.com
  providerName: Flying Publisher
– providerCode: PRVFQY
  databaseName: GFMER Free Medical Journals
  customDbUrl:
  eissn: 1664-3224
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000493335
  issn: 1664-3224
  databaseCode: GX1
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php
  providerName: Geneva Foundation for Medical Education and Research
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 1664-3224
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000493335
  issn: 1664-3224
  databaseCode: M~E
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVAQN
  databaseName: PubMed Central
  customDbUrl:
  eissn: 1664-3224
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0000493335
  issn: 1664-3224
  databaseCode: RPM
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/
  providerName: National Library of Medicine
– providerCode: PRVFZP
  databaseName: Scholars Portal Journals: Open Access
  customDbUrl:
  eissn: 1664-3224
  dateEnd: 20250131
  omitProxy: true
  ssIdentifier: ssj0000493335
  issn: 1664-3224
  databaseCode: M48
  dateStart: 20101001
  isFulltext: true
  titleUrlDefault: http://journals.scholarsportal.info
  providerName: Scholars Portal
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1bb9MwFLbQEIIXxJ0Am4zEC0hR3cSxk8eNbUxInSa0SuXJSnwpQWk6tc1Q-fU7x-6iViD2wkseEiex_R3b5_jyfYR8KADWQuP8l5Qs5pJlceWMjLVmxjHpbOpX8Efn4mzMv06yyZbUF-4JC_TAoeIGwxI8ApcZltuMQ-xQDC2EyXgQusrd0PljvjCMbQVTP4Pfm6ZpFtYlIQorBq6ezTrcyoX8lAxV3bfGIU_X_zcf88-tkg-79qpc_yqbZmscOn1CHm8cSHoYMv6U3LPtM_IgSEqun5Opn5Wvf1tDRxDUW4piZw0d1bNa46w4vShXvsNb07mjPjG97Cq70F0zX9ZLCk4srVt6XV_P6UlPBY6JjxfdlH6zU9QDWL4g49OTy89n8UZMIdZcJKtYSxytubYStWaEdYYZnUMT186JCpplKfJMSyNRBL1gVpgizY1OkN5eOJOnL8leO2_ta0K15Ylm4EhYjtQ4uI_fJAlyy2khSq4jMritWqU3TOMoeNEoiDgQDOXBUAiG8mBE5GP_xlVg2fhH2iNEq0-H_Nj-BliN2liNustqIvL-FmsF7QkXScrWAiwKXUbBUVY-Iq8C9v2voD8UIkuziMgdq9jJy-6Ttv7hObtFiod4IfOfevu5s6Rv_kdJ35JH-MUwa_SO7K0Wnd0HP2pVHfgmA9cvkyFcRzw_IPfH5xeH328AXZAdEg
linkProvider Directory of Open Access Journals
linkToUnpaywall http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZgK0QvvKHhJSNxASmtN3Fs51igVYW0VYW6UjlZiR9LRDapNknR9tfjcdKoCxWPY5KxYntm7PGM5xuE3qaOrakC_xfnJKScJGFuNQ-VItoSbk3sI_izY3Y0p5_PkrPB3wG5MNfi9-7wlO7ZYrns4AYWwEoSkd5GWwxCSRO0NT8-2f8K5ynGaOjkkvZRyBubbew6Hpz_Jovy94uRd7vqPFv_yMry2q5zeL-HQGo8WCFcNvm-27X5rrr8BcrxXwb0AN0bTE-838vKQ3TLVI_Qnb4Y5foxWnh_fnFpNJ7VXWMwlEkr8axYFgr86fgka_1Suca1xZ4Yn3a5WamurJuiwc78xUWFL4qLGh-MIOJA_GnVLfAXs4BKAs0TND88OP14FA5lGEJFWdSGisM-T5XhUKWGGauJVsItDspaljuFzphIFNccyqenxDCdxkKrCIDxmdUifoomVV2ZHYSVoZEizgQxFEB1IANARxGg0inGMqoCtHfFJqkGjHIolVFKd1aB6ZN--iRMn_TTF6B3Y4vzHp_jD7QfgPMjHSBr-xeOP3JQVDnNnAVqE02ESag7q6ZTkwoOife5sFMrAvTmSm6k00QIr2SVcWyRYGwyCgXpA_Ssl6PxV24lZSyJkwDxDQnb6Mvml6r45tG-WQzpv67z70dZ_OtIn_8P8Qu0DQ-9X-klmrSrzrxyllabvx6U7CcQhCRo
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Humanized+Mouse+Model+Mimicking+Pathology+of+Human+Tuberculosis+for+in+vivo+Evaluation+of+Drug+Regimens&rft.jtitle=Frontiers+in+immunology&rft.au=Frida+Arrey&rft.au=Delia+L%C3%B6we&rft.au=Stefanie+Kuhlmann&rft.au=Peggy+Kaiser&rft.date=2019&rft.pub=Frontiers+Media+S.A&rft.eissn=1664-3224&rft.volume=10&rft_id=info:doi/10.3389%2Ffimmu.2019.00089&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_1a112f5d08e5410491e9874807b8f1f8
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1664-3224&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1664-3224&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1664-3224&client=summon