Antimicrobial Susceptibility of Bacteria That Cause Bovine Respiratory Disease Complex in Alberta, Canada
Bovine respiratory disease (BRD) is the most important illness of feedlot cattle. Disease management targets the associated bacterial pathogens, , and . We conducted a cross-sectional study to measure the frequencies of antimicrobial-resistant BRD pathogens using a collaborative network of veterinar...
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| Published in | Frontiers in veterinary science Vol. 4; p. 207 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
04.12.2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 2297-1769 2297-1769 |
| DOI | 10.3389/fvets.2017.00207 |
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| Abstract | Bovine respiratory disease (BRD) is the most important illness of feedlot cattle. Disease management targets the associated bacterial pathogens,
, and
. We conducted a cross-sectional study to measure the frequencies of antimicrobial-resistant BRD pathogens using a collaborative network of veterinarians, industry, government, and a diagnostic laboratory. Seven private veterinary practices in southern Alberta collected samples from both living and dead BRD-affected animals at commercial feedlots. Susceptibility testing of 745 isolates showed that 100% of the
, and
isolates and 66.7% of the
isolates were resistant to at least one antimicrobial class. Resistance to macrolide antimicrobials (90.2% of all isolates) was notable for their importance to beef production and human medicine. Multidrug resistance (MDR) was high in all target pathogens with 47.2% of the isolates resistant to four or five antimicrobial classes and 24.0% resistance to six to nine classes. We compared the MDR profiles of isolates from two feedlots serviced by different veterinary practices. Differences in the average number of resistant classes were found for
(
< 0.001) and
(
= 0.002). Compared to previous studies, this study suggests an increasing trend of resistance in BRD pathogens against the antimicrobials used to manage the disease in Alberta. For the veterinary clinician, the results emphasize the importance of ongoing susceptibility testing of BRD pathogens to inform treatment protocols. Surveillance studies that collect additional epidemiological information and manage sampling bias will be necessary to develop strategies to limit the spread of resistance. |
|---|---|
| AbstractList | Bovine respiratory disease (BRD) is the most important illness of feedlot cattle. Disease management targets the associated bacterial pathogens, Mannheimia haemolytica, Mycoplasma bovis, Pasteurella multocida, Histophilus somni, and Trueperella pyogenes. We conducted a cross-sectional study to measure the frequencies of antimicrobial-resistant BRD pathogens using a collaborative network of veterinarians, industry, government, and a diagnostic laboratory. Seven private veterinary practices in southern Alberta collected samples from both living and dead BRD-affected animals at commercial feedlots. Susceptibility testing of 745 isolates showed that 100% of the M. haemolytica, M. bovis, P. multocida, and T. pyogenes isolates and 66.7% of the H. somni isolates were resistant to at least one antimicrobial class. Resistance to macrolide antimicrobials (90.2% of all isolates) was notable for their importance to beef production and human medicine. Multidrug resistance (MDR) was high in all target pathogens with 47.2% of the isolates resistant to four or five antimicrobial classes and 24.0% resistance to six to nine classes. We compared the MDR profiles of isolates from two feedlots serviced by different veterinary practices. Differences in the average number of resistant classes were found for M. haemolytica (p < 0.001) and P. multocida (p = 0.002). Compared to previous studies, this study suggests an increasing trend of resistance in BRD pathogens against the antimicrobials used to manage the disease in Alberta. For the veterinary clinician, the results emphasize the importance of ongoing susceptibility testing of BRD pathogens to inform treatment protocols. Surveillance studies that collect additional epidemiological information and manage sampling bias will be necessary to develop strategies to limit the spread of resistance.Bovine respiratory disease (BRD) is the most important illness of feedlot cattle. Disease management targets the associated bacterial pathogens, Mannheimia haemolytica, Mycoplasma bovis, Pasteurella multocida, Histophilus somni, and Trueperella pyogenes. We conducted a cross-sectional study to measure the frequencies of antimicrobial-resistant BRD pathogens using a collaborative network of veterinarians, industry, government, and a diagnostic laboratory. Seven private veterinary practices in southern Alberta collected samples from both living and dead BRD-affected animals at commercial feedlots. Susceptibility testing of 745 isolates showed that 100% of the M. haemolytica, M. bovis, P. multocida, and T. pyogenes isolates and 66.7% of the H. somni isolates were resistant to at least one antimicrobial class. Resistance to macrolide antimicrobials (90.2% of all isolates) was notable for their importance to beef production and human medicine. Multidrug resistance (MDR) was high in all target pathogens with 47.2% of the isolates resistant to four or five antimicrobial classes and 24.0% resistance to six to nine classes. We compared the MDR profiles of isolates from two feedlots serviced by different veterinary practices. Differences in the average number of resistant classes were found for M. haemolytica (p < 0.001) and P. multocida (p = 0.002). Compared to previous studies, this study suggests an increasing trend of resistance in BRD pathogens against the antimicrobials used to manage the disease in Alberta. For the veterinary clinician, the results emphasize the importance of ongoing susceptibility testing of BRD pathogens to inform treatment protocols. Surveillance studies that collect additional epidemiological information and manage sampling bias will be necessary to develop strategies to limit the spread of resistance. Bovine respiratory disease (BRD) is the most important illness of feedlot cattle. Disease management targets the associated bacterial pathogens, Mannheimia haemolytica, Mycoplasma bovis, Pasteurella multocida, Histophilus somni , and Trueperella pyogenes . We conducted a cross-sectional study to measure the frequencies of antimicrobial-resistant BRD pathogens using a collaborative network of veterinarians, industry, government, and a diagnostic laboratory. Seven private veterinary practices in southern Alberta collected samples from both living and dead BRD-affected animals at commercial feedlots. Susceptibility testing of 745 isolates showed that 100% of the M. haemolytica, M. bovis, P. multocida , and T. pyogenes isolates and 66.7% of the H. somni isolates were resistant to at least one antimicrobial class. Resistance to macrolide antimicrobials (90.2% of all isolates) was notable for their importance to beef production and human medicine. Multidrug resistance (MDR) was high in all target pathogens with 47.2% of the isolates resistant to four or five antimicrobial classes and 24.0% resistance to six to nine classes. We compared the MDR profiles of isolates from two feedlots serviced by different veterinary practices. Differences in the average number of resistant classes were found for M. haemolytica ( p < 0.001) and P. multocida ( p = 0.002). Compared to previous studies, this study suggests an increasing trend of resistance in BRD pathogens against the antimicrobials used to manage the disease in Alberta. For the veterinary clinician, the results emphasize the importance of ongoing susceptibility testing of BRD pathogens to inform treatment protocols. Surveillance studies that collect additional epidemiological information and manage sampling bias will be necessary to develop strategies to limit the spread of resistance. Bovine respiratory disease (BRD) is the most important illness of feedlot cattle. Disease management targets the associated bacterial pathogens, , and . We conducted a cross-sectional study to measure the frequencies of antimicrobial-resistant BRD pathogens using a collaborative network of veterinarians, industry, government, and a diagnostic laboratory. Seven private veterinary practices in southern Alberta collected samples from both living and dead BRD-affected animals at commercial feedlots. Susceptibility testing of 745 isolates showed that 100% of the , and isolates and 66.7% of the isolates were resistant to at least one antimicrobial class. Resistance to macrolide antimicrobials (90.2% of all isolates) was notable for their importance to beef production and human medicine. Multidrug resistance (MDR) was high in all target pathogens with 47.2% of the isolates resistant to four or five antimicrobial classes and 24.0% resistance to six to nine classes. We compared the MDR profiles of isolates from two feedlots serviced by different veterinary practices. Differences in the average number of resistant classes were found for ( < 0.001) and ( = 0.002). Compared to previous studies, this study suggests an increasing trend of resistance in BRD pathogens against the antimicrobials used to manage the disease in Alberta. For the veterinary clinician, the results emphasize the importance of ongoing susceptibility testing of BRD pathogens to inform treatment protocols. Surveillance studies that collect additional epidemiological information and manage sampling bias will be necessary to develop strategies to limit the spread of resistance. Bovine respiratory disease (BRD) is the most important illness of feedlot cattle. Disease management targets the associated bacterial pathogens, Mannheimia haemolytica, Mycoplasma bovis, Pasteurella multocida, Histophilus somni, and Trueperella pyogenes. We conducted a cross-sectional study to measure the frequencies of antimicrobial-resistant BRD pathogens using a collaborative network of veterinarians, industry, government, and a diagnostic laboratory. Seven private veterinary practices in southern Alberta collected samples from both living and dead BRD-affected animals at commercial feedlots. Susceptibility testing of 745 isolates showed that 100% of the M. haemolytica, M. bovis, P. multocida, and T. pyogenes isolates and 66.7% of the H. somni isolates were resistant to at least one antimicrobial class. Resistance to macrolide antimicrobials (90.2% of all isolates) was notable for their importance to beef production and human medicine. Multidrug resistance (MDR) was high in all target pathogens with 47.2% of the isolates resistant to four or five antimicrobial classes and 24.0% resistance to six to nine classes. We compared the MDR profiles of isolates from two feedlots serviced by different veterinary practices. Differences in the average number of resistant classes were found for M. haemolytica (p < 0.001) and P. multocida (p = 0.002). Compared to previous studies, this study suggests an increasing trend of resistance in BRD pathogens against the antimicrobials used to manage the disease in Alberta. For the veterinary clinician, the results emphasize the importance of ongoing susceptibility testing of BRD pathogens to inform treatment protocols. Surveillance studies that collect additional epidemiological information and manage sampling bias will be necessary to develop strategies to limit the spread of resistance. |
| Author | Ralston, Brenda Schmid, Karin Schatz, Crystal Matheson-Bird, Heather Olson, Merle Ajitkumar, Praseeda Klima, Cassidy Anholt, R. Michele Allan, Nick Peters, Delores McAllister, Tim Otto, Simon JG |
| AuthorAffiliation | 1 POV Inc. , Airdrie, AB , Canada 2 Agriculture and Agri-Food Canada , Lethbridge, AB , Canada 4 Bow Valley Research Inc. , Calgary, AB , Canada 7 School of Public Health, University of Alberta , Edmonton, AB , Canada 8 Alberta Beef Producers , Calgary, AB , Canada 3 Chinook Contract Research Inc. , Airdrie, AB , Canada 6 Alberta Ministry of Agriculture and Forestry , Airdrie, AB , Canada 9 Alberta Veterinary Laboratories Ltd , Calgary, AB , Canada 5 Institute for Applied Poultry Technologies , Airdrie, AB , Canada |
| AuthorAffiliation_xml | – name: 4 Bow Valley Research Inc. , Calgary, AB , Canada – name: 7 School of Public Health, University of Alberta , Edmonton, AB , Canada – name: 1 POV Inc. , Airdrie, AB , Canada – name: 2 Agriculture and Agri-Food Canada , Lethbridge, AB , Canada – name: 9 Alberta Veterinary Laboratories Ltd , Calgary, AB , Canada – name: 6 Alberta Ministry of Agriculture and Forestry , Airdrie, AB , Canada – name: 5 Institute for Applied Poultry Technologies , Airdrie, AB , Canada – name: 8 Alberta Beef Producers , Calgary, AB , Canada – name: 3 Chinook Contract Research Inc. , Airdrie, AB , Canada |
| Author_xml | – sequence: 1 givenname: R. Michele surname: Anholt fullname: Anholt, R. Michele – sequence: 2 givenname: Cassidy surname: Klima fullname: Klima, Cassidy – sequence: 3 givenname: Nick surname: Allan fullname: Allan, Nick – sequence: 4 givenname: Heather surname: Matheson-Bird fullname: Matheson-Bird, Heather – sequence: 5 givenname: Crystal surname: Schatz fullname: Schatz, Crystal – sequence: 6 givenname: Praseeda surname: Ajitkumar fullname: Ajitkumar, Praseeda – sequence: 7 givenname: Simon JG surname: Otto fullname: Otto, Simon JG – sequence: 8 givenname: Delores surname: Peters fullname: Peters, Delores – sequence: 9 givenname: Karin surname: Schmid fullname: Schmid, Karin – sequence: 10 givenname: Merle surname: Olson fullname: Olson, Merle – sequence: 11 givenname: Tim surname: McAllister fullname: McAllister, Tim – sequence: 12 givenname: Brenda surname: Ralston fullname: Ralston, Brenda |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29255716$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | Copyright © 2017 Anholt, Klima, Allan, Matheson-Bird, Schatz, Ajitkumar, Otto, Peters, Schmid, Olson, McAllister and Ralston. 2017 Anholt, Klima, Allan, Matheson-Bird, Schatz, Ajitkumar, Otto, Peters, Schmid, Olson, McAllister and Ralston |
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| Keywords | Haemophilus somnus antimicrobial resistance bovine respiratory disease complex Trueperella pyogenes Mannheimia haemolytica Mycoplasma bovis Pasteurella multocida |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Nour Eissa, University of Manitoba, Canada; Jean-Claude Desfontis, INRA UMR703 Ecole Nationale Vétérinaire, Agroalimentaire et de l’alimentation de Nantes-Atlantique, France; Gabriel Gutkind, Universidad de Buenos Aires, Argentina; Shankar Thangamani, Midwestern University, United States Edited by: Javiera Cornejo Kelly, Universidad de Chile, Chile Specialty section: This article was submitted to Veterinary Pharmacology and Toxicology, a section of the journal Frontiers in Veterinary Science |
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, and
. We... Bovine respiratory disease (BRD) is the most important illness of feedlot cattle. Disease management targets the associated bacterial pathogens, Mannheimia... Bovine respiratory disease (BRD) is the most important illness of feedlot cattle. Disease management targets the associated bacterial pathogens, Mannheimia... |
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| SubjectTerms | antimicrobial resistance bovine respiratory disease complex Haemophilus somnus Mannheimia haemolytica Mycoplasma bovis Pasteurella multocida Veterinary Science |
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| Title | Antimicrobial Susceptibility of Bacteria That Cause Bovine Respiratory Disease Complex in Alberta, Canada |
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