Imaging Cerebral Activity in Amyotrophic Lateral Sclerosis

Advances in neuroimaging, complementing histopathological insights, have established a multi-system involvement of cerebral networks beyond the traditional neuromuscular pathological view of amyotrophic lateral sclerosis (ALS). The development of effective disease-modifying therapy remains a priorit...

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Published inFrontiers in neurology Vol. 9; p. 1148
Main Authors Proudfoot, Malcolm, Bede, Peter, Turner, Martin R.
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 08.01.2019
Subjects
amyotrophic lateral sclerosis
biomarker
cortex
motor neurone disease
neuroimaging
Neurology
neurophysiology
cortex
biomarker
neurophysiology
amyotrophic lateral sclerosis
motor neurone disease
neuroimaging
Online AccessGet full text
ISSN1664-2295
1664-2295
DOI10.3389/fneur.2018.01148

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Abstract Advances in neuroimaging, complementing histopathological insights, have established a multi-system involvement of cerebral networks beyond the traditional neuromuscular pathological view of amyotrophic lateral sclerosis (ALS). The development of effective disease-modifying therapy remains a priority and this will be facilitated by improved biomarkers of motor system integrity against which to assess the efficacy of candidate drugs. Functional MRI (FMRI) is an established measure of both cerebral activity and connectivity, but there is an increasing recognition of neuronal oscillations in facilitating long-distance communication across the cortical surface. Such dynamic synchronization vastly expands the connectivity foundations defined by traditional neuronal architecture. This review considers the unique pathogenic insights afforded by the capture of cerebral disease activity in ALS using FMRI and encephalography.
AbstractList Advances in neuroimaging, complementing histopathological insights, have established a multi-system involvement of cerebral networks beyond the traditional neuromuscular pathological view of amyotrophic lateral sclerosis (ALS). The development of effective disease-modifying therapy remains a priority and this will be facilitated by improved biomarkers of motor system integrity against which to assess the efficacy of candidate drugs. Functional MRI (FMRI) is an established measure of both cerebral activity and connectivity, but there is an increasing recognition of neuronal oscillations in facilitating long-distance communication across the cortical surface. Such dynamic synchronization vastly expands the connectivity foundations defined by traditional neuronal architecture. This review considers the unique pathogenic insights afforded by the capture of cerebral disease activity in ALS using FMRI and encephalography.
Advances in neuroimaging, complementing histopathological insights, have established a multi-system involvement of cerebral networks beyond the traditional neuromuscular pathological view of amyotrophic lateral sclerosis (ALS). The development of effective disease-modifying therapy remains a priority and this will be facilitated by improved biomarkers of motor system integrity against which to assess the efficacy of candidate drugs. Functional MRI (FMRI) is an established measure of both cerebral activity and connectivity, but there is an increasing recognition of neuronal oscillations in facilitating long-distance communication across the cortical surface. Such dynamic synchronization vastly expands the connectivity foundations defined by traditional neuronal architecture. This review considers the unique pathogenic insights afforded by the capture of cerebral disease activity in ALS using FMRI and encephalography.Advances in neuroimaging, complementing histopathological insights, have established a multi-system involvement of cerebral networks beyond the traditional neuromuscular pathological view of amyotrophic lateral sclerosis (ALS). The development of effective disease-modifying therapy remains a priority and this will be facilitated by improved biomarkers of motor system integrity against which to assess the efficacy of candidate drugs. Functional MRI (FMRI) is an established measure of both cerebral activity and connectivity, but there is an increasing recognition of neuronal oscillations in facilitating long-distance communication across the cortical surface. Such dynamic synchronization vastly expands the connectivity foundations defined by traditional neuronal architecture. This review considers the unique pathogenic insights afforded by the capture of cerebral disease activity in ALS using FMRI and encephalography.
Author Bede, Peter
Turner, Martin R.
Proudfoot, Malcolm
AuthorAffiliation 3 Wellcome Centre for Integrative Neuroimaging, University of Oxford , Oxford , United Kingdom
2 Computational Neuroimaging Group, Academic Unit of Neurology, Trinity College Dublin , Dublin , Ireland
1 Nuffield Department of Clinical Neurosciences, University of Oxford , Oxford , United Kingdom
AuthorAffiliation_xml – name: 1 Nuffield Department of Clinical Neurosciences, University of Oxford , Oxford , United Kingdom
– name: 2 Computational Neuroimaging Group, Academic Unit of Neurology, Trinity College Dublin , Dublin , Ireland
– name: 3 Wellcome Centre for Integrative Neuroimaging, University of Oxford , Oxford , United Kingdom
Author_xml – sequence: 1
  givenname: Malcolm
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– sequence: 2
  givenname: Peter
  surname: Bede
  fullname: Bede, Peter
– sequence: 3
  givenname: Martin R.
  surname: Turner
  fullname: Turner, Martin R.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30671016$$D View this record in MEDLINE/PubMed
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Keywords cortex
biomarker
neurophysiology
amyotrophic lateral sclerosis
motor neurone disease
neuroimaging
Language English
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Reviewed by: Edoardo Gioele Spinelli, Vita-Salute San Raffaele University, Italy; Rodolfo Gabriel Gatto, University of Illinois at Chicago, United States
Edited by: Francesca Trojsi, Università Degli Studi Della Campania “Luigi Vanvitelli” Naples, Italy
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Snippet Advances in neuroimaging, complementing histopathological insights, have established a multi-system involvement of cerebral networks beyond the traditional...
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SubjectTerms amyotrophic lateral sclerosis
biomarker
cortex
motor neurone disease
neuroimaging
Neurology
neurophysiology
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Title Imaging Cerebral Activity in Amyotrophic Lateral Sclerosis
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