Uncovering the Mechanisms of Chinese Herbal Medicine (MaZiRenWan) for Functional Constipation by Focused Network Pharmacology Approach
MaZiRenWan (MZRW, also known as Hemp Seed Pill) is a Chinese Herbal Medicine which has been demonstrated to safely and effectively alleviate functional constipation (FC) in a randomized, placebo-controlled clinical study with 120 subjects. However, the underlying pharmacological actions of MZRW for...
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| Published in | Frontiers in pharmacology Vol. 9; p. 270 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
26.03.2018
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| Online Access | Get full text |
| ISSN | 1663-9812 1663-9812 |
| DOI | 10.3389/fphar.2018.00270 |
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| Abstract | MaZiRenWan (MZRW, also known as Hemp Seed Pill) is a Chinese Herbal Medicine which has been demonstrated to safely and effectively alleviate functional constipation (FC) in a randomized, placebo-controlled clinical study with 120 subjects. However, the underlying pharmacological actions of MZRW for FC, are still largely unknown. We systematically analyzed the bioactive compounds of MZRW and mechanism-of-action biological targets through a novel approach called "focused network pharmacology." Among the 97 compounds identified by UPLC-QTOF-MS/MS in MZRW extract, 34 were found in rat plasma, while 10 were found in rat feces. Hierarchical clustering analysis suggest that these compounds can be classified into component groups, in which compounds are highly similar to each other and most of them are from the same herb. Emodin, amygdalin, albiflorin, honokiol, and naringin were selected as representative compounds of corresponding component groups. All of them were shown to induce spontaneous contractions of rat colonic smooth muscle
. Network analysis revealed that biological targets in acetylcholine-, estrogen-, prostaglandin-, cannabinoid-, and purine signaling pathways are able to explain the prokinetic effects of representative compounds and corresponding component groups. In conclusion, MZRW active components enhance colonic motility, possibly by acting on multiple targets and pathways. |
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| AbstractList | MaZiRenWan (MZRW, also known as Hemp Seed Pill) is a Chinese Herbal Medicine which has been demonstrated to safely and effectively alleviate functional constipation (FC) in a randomized, placebo-controlled clinical study with 120 subjects. However, the underlying pharmacological actions of MZRW for FC, are still largely unknown. We systematically analyzed the bioactive compounds of MZRW and mechanism-of-action biological targets through a novel approach called “focused network pharmacology.” Among the 97 compounds identified by UPLC-QTOF-MS/MS in MZRW extract, 34 were found in rat plasma, while 10 were found in rat feces. Hierarchical clustering analysis suggest that these compounds can be classified into component groups, in which compounds are highly similar to each other and most of them are from the same herb. Emodin, amygdalin, albiflorin, honokiol, and naringin were selected as representative compounds of corresponding component groups. All of them were shown to induce spontaneous contractions of rat colonic smooth muscle in vitro. Network analysis revealed that biological targets in acetylcholine-, estrogen-, prostaglandin-, cannabinoid-, and purine signaling pathways are able to explain the prokinetic effects of representative compounds and corresponding component groups. In conclusion, MZRW active components enhance colonic motility, possibly by acting on multiple targets and pathways. MaZiRenWan (MZRW, also known as Hemp Seed Pill) is a Chinese Herbal Medicine which has been demonstrated to safely and effectively alleviate functional constipation (FC) in a randomized, placebo-controlled clinical study with 120 subjects. However, the underlying pharmacological actions of MZRW for FC, are still largely unknown. We systematically analyzed the bioactive compounds of MZRW and mechanism-of-action biological targets through a novel approach called "focused network pharmacology." Among the 97 compounds identified by UPLC-QTOF-MS/MS in MZRW extract, 34 were found in rat plasma, while 10 were found in rat feces. Hierarchical clustering analysis suggest that these compounds can be classified into component groups, in which compounds are highly similar to each other and most of them are from the same herb. Emodin, amygdalin, albiflorin, honokiol, and naringin were selected as representative compounds of corresponding component groups. All of them were shown to induce spontaneous contractions of rat colonic smooth muscle . Network analysis revealed that biological targets in acetylcholine-, estrogen-, prostaglandin-, cannabinoid-, and purine signaling pathways are able to explain the prokinetic effects of representative compounds and corresponding component groups. In conclusion, MZRW active components enhance colonic motility, possibly by acting on multiple targets and pathways. MaZiRenWan (MZRW, also known as Hemp Seed Pill) is a Chinese Herbal Medicine which has been demonstrated to safely and effectively alleviate functional constipation (FC) in a randomized, placebo-controlled clinical study with 120 subjects. However, the underlying pharmacological actions of MZRW for FC, are still largely unknown. We systematically analyzed the bioactive compounds of MZRW and mechanism-of-action biological targets through a novel approach called "focused network pharmacology." Among the 97 compounds identified by UPLC-QTOF-MS/MS in MZRW extract, 34 were found in rat plasma, while 10 were found in rat feces. Hierarchical clustering analysis suggest that these compounds can be classified into component groups, in which compounds are highly similar to each other and most of them are from the same herb. Emodin, amygdalin, albiflorin, honokiol, and naringin were selected as representative compounds of corresponding component groups. All of them were shown to induce spontaneous contractions of rat colonic smooth muscle in vitro. Network analysis revealed that biological targets in acetylcholine-, estrogen-, prostaglandin-, cannabinoid-, and purine signaling pathways are able to explain the prokinetic effects of representative compounds and corresponding component groups. In conclusion, MZRW active components enhance colonic motility, possibly by acting on multiple targets and pathways.MaZiRenWan (MZRW, also known as Hemp Seed Pill) is a Chinese Herbal Medicine which has been demonstrated to safely and effectively alleviate functional constipation (FC) in a randomized, placebo-controlled clinical study with 120 subjects. However, the underlying pharmacological actions of MZRW for FC, are still largely unknown. We systematically analyzed the bioactive compounds of MZRW and mechanism-of-action biological targets through a novel approach called "focused network pharmacology." Among the 97 compounds identified by UPLC-QTOF-MS/MS in MZRW extract, 34 were found in rat plasma, while 10 were found in rat feces. Hierarchical clustering analysis suggest that these compounds can be classified into component groups, in which compounds are highly similar to each other and most of them are from the same herb. Emodin, amygdalin, albiflorin, honokiol, and naringin were selected as representative compounds of corresponding component groups. All of them were shown to induce spontaneous contractions of rat colonic smooth muscle in vitro. Network analysis revealed that biological targets in acetylcholine-, estrogen-, prostaglandin-, cannabinoid-, and purine signaling pathways are able to explain the prokinetic effects of representative compounds and corresponding component groups. In conclusion, MZRW active components enhance colonic motility, possibly by acting on multiple targets and pathways. |
| Author | Lin, Chengyuan Hu, Dongdong Zhao, Ling Yang, Zhijun Zhang, Man Bian, Zhaoxiang Huang, Tao Ning, Ziwan Zhong, Linda L. D. Xu, Hongxi |
| AuthorAffiliation | 3 Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery , Shanghai , China 5 YMU-HKBU Joint Laboratory of Traditional Natural Medicine, Yunnan Minzu University , Kunming , China 2 School of Pharmacy, Shanghai University of Traditional Chinese Medicine , Shanghai , China 4 Guangzhou Research Institute of Snake Venom, Guangzhou Medical University , Guangzhou , China 1 Lab of Brain and Gut Research, School of Chinese Medicine, Hong Kong Baptist University , Kowloon Tong , Hong Kong 6 Hong Kong Chinese Medicine Clinical Study Centre, Hong Kong Baptist University , Kowloon Tong , Hong Kong |
| AuthorAffiliation_xml | – name: 3 Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery , Shanghai , China – name: 1 Lab of Brain and Gut Research, School of Chinese Medicine, Hong Kong Baptist University , Kowloon Tong , Hong Kong – name: 5 YMU-HKBU Joint Laboratory of Traditional Natural Medicine, Yunnan Minzu University , Kunming , China – name: 2 School of Pharmacy, Shanghai University of Traditional Chinese Medicine , Shanghai , China – name: 6 Hong Kong Chinese Medicine Clinical Study Centre, Hong Kong Baptist University , Kowloon Tong , Hong Kong – name: 4 Guangzhou Research Institute of Snake Venom, Guangzhou Medical University , Guangzhou , China |
| Author_xml | – sequence: 1 givenname: Tao surname: Huang fullname: Huang, Tao – sequence: 2 givenname: Ziwan surname: Ning fullname: Ning, Ziwan – sequence: 3 givenname: Dongdong surname: Hu fullname: Hu, Dongdong – sequence: 4 givenname: Man surname: Zhang fullname: Zhang, Man – sequence: 5 givenname: Ling surname: Zhao fullname: Zhao, Ling – sequence: 6 givenname: Chengyuan surname: Lin fullname: Lin, Chengyuan – sequence: 7 givenname: Linda L. D. surname: Zhong fullname: Zhong, Linda L. D. – sequence: 8 givenname: Zhijun surname: Yang fullname: Yang, Zhijun – sequence: 9 givenname: Hongxi surname: Xu fullname: Xu, Hongxi – sequence: 10 givenname: Zhaoxiang surname: Bian fullname: Bian, Zhaoxiang |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29632490$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright © 2018 Huang, Ning, Hu, Zhang, Zhao, Lin, Zhong, Yang, Xu and Bian. 2018 Huang, Ning, Hu, Zhang, Zhao, Lin, Zhong, Yang, Xu and Bian |
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| Keywords | functional constipation MaZiRenWan component group focused network pharmacology Chinese Herbal Medicine representative compound |
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