Uterus transplantation: From animal models through the first heart beating pregnancy to the first human live birth

Absolute uterine factor infertility affects 3–5% of the general population, and unfortunately this condition is untreatable. There are some available options, including surrogacy or adoption, but neither of these suits each and every woman who desires to have her own genetic child. With recent advan...

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Published inWomen's health (London, England) Vol. 12; no. 4; pp. 442 - 449
Main Authors Ozkan, Omer, Dogan, Nasuh Utku, Ozkan, Ozlenen, Mendilcioglu, Inanc, Dogan, Selen, Aydinuraz, Batu, Simsek, Mehmet
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.07.2016
Sage Publications Ltd
Subjects
Online AccessGet full text
ISSN1745-5065
1745-5057
1745-5065
DOI10.1177/1745505716653849

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Abstract Absolute uterine factor infertility affects 3–5% of the general population, and unfortunately this condition is untreatable. There are some available options, including surrogacy or adoption, but neither of these suits each and every woman who desires to have her own genetic child. With recent advances in surgery and transplant immunology, uterus transplantation may be a source of hope for these women with uterine infertility. In the last decade, a number of animal species including rats, mice, rabbits, pigs, sheep, and primates have been used as experimental models, and pregnancies were achieved in some of these. Human data consist of 11 subjects yielding positive pregnancy results with no live births in the second trial from Turkey and, more fortunately, live births from the latest trial from Sweden. In the light of all these studies, uterus transplantation has been proven to be a viable option for women with uterine factor infertility.
AbstractList Absolute uterine factor infertility affects 3-5% of the general population, and unfortunately this condition is untreatable. There are some available options, including surrogacy or adoption, but neither of these suits each and every woman who desires to have her own genetic child. With recent advances in surgery and transplant immunology, uterus transplantation may be a source of hope for these women with uterine infertility. In the last decade, a number of animal species including rats, mice, rabbits, pigs, sheep, and primates have been used as experimental models, and pregnancies were achieved in some of these. Human data consist of 11 subjects yielding positive pregnancy results with no live births in the second trial from Turkey and, more fortunately, live births from the latest trial from Sweden. In the light of all these studies, uterus transplantation has been proven to be a viable option for women with uterine factor infertility.
Author Mendilcioglu, Inanc
Dogan, Selen
Ozkan, Omer
Simsek, Mehmet
Ozkan, Ozlenen
Aydinuraz, Batu
Dogan, Nasuh Utku
AuthorAffiliation 2 Department of Obstetrics and Gynecology, Akdeniz University, Antalya, Turkey
3 IVF Center, Private Memorial Hospital, Antalya, Turkey
1 Department of Plastic, Reconstructive and Aesthetic Surgery, Akdeniz University, Antalya, Turkey
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Issue 4
Keywords Absolute uterine factor infertility
deceased donor
infertility
uterus transplantation
Language English
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Snippet Absolute uterine factor infertility affects 3–5% of the general population, and unfortunately this condition is untreatable. There are some available options,...
Absolute uterine factor infertility affects 3-5% of the general population, and unfortunately this condition is untreatable. There are some available options,...
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SubjectTerms Animals
Evidence-Based Medicine
Female
Humans
Infertility, Female - etiology
Infertility, Female - therapy
Pregnancy
Pregnancy Outcome
Review
Tissue Survival
Treatment Outcome
Uterus - transplantation
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Title Uterus transplantation: From animal models through the first heart beating pregnancy to the first human live birth
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