Uterus transplantation: From animal models through the first heart beating pregnancy to the first human live birth
Absolute uterine factor infertility affects 3–5% of the general population, and unfortunately this condition is untreatable. There are some available options, including surrogacy or adoption, but neither of these suits each and every woman who desires to have her own genetic child. With recent advan...
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          | Published in | Women's health (London, England) Vol. 12; no. 4; pp. 442 - 449 | 
|---|---|
| Main Authors | , , , , , , | 
| Format | Journal Article | 
| Language | English | 
| Published | 
        London, England
          SAGE Publications
    
        01.07.2016
     Sage Publications Ltd  | 
| Subjects | |
| Online Access | Get full text | 
| ISSN | 1745-5065 1745-5057 1745-5065  | 
| DOI | 10.1177/1745505716653849 | 
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| Abstract | Absolute uterine factor infertility affects 3–5% of the general population, and unfortunately this condition is untreatable. There are some available options, including surrogacy or adoption, but neither of these suits each and every woman who desires to have her own genetic child. With recent advances in surgery and transplant immunology, uterus transplantation may be a source of hope for these women with uterine infertility. In the last decade, a number of animal species including rats, mice, rabbits, pigs, sheep, and primates have been used as experimental models, and pregnancies were achieved in some of these. Human data consist of 11 subjects yielding positive pregnancy results with no live births in the second trial from Turkey and, more fortunately, live births from the latest trial from Sweden. In the light of all these studies, uterus transplantation has been proven to be a viable option for women with uterine factor infertility. | 
    
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| AbstractList | Absolute uterine factor infertility affects 3-5% of the general population, and unfortunately this condition is untreatable. There are some available options, including surrogacy or adoption, but neither of these suits each and every woman who desires to have her own genetic child. With recent advances in surgery and transplant immunology, uterus transplantation may be a source of hope for these women with uterine infertility. In the last decade, a number of animal species including rats, mice, rabbits, pigs, sheep, and primates have been used as experimental models, and pregnancies were achieved in some of these. Human data consist of 11 subjects yielding positive pregnancy results with no live births in the second trial from Turkey and, more fortunately, live births from the latest trial from Sweden. In the light of all these studies, uterus transplantation has been proven to be a viable option for women with uterine factor infertility. | 
    
| Author | Mendilcioglu, Inanc Dogan, Selen Ozkan, Omer Simsek, Mehmet Ozkan, Ozlenen Aydinuraz, Batu Dogan, Nasuh Utku  | 
    
| AuthorAffiliation | 2 Department of Obstetrics and Gynecology, Akdeniz University, Antalya, Turkey 3 IVF Center, Private Memorial Hospital, Antalya, Turkey 1 Department of Plastic, Reconstructive and Aesthetic Surgery, Akdeniz University, Antalya, Turkey  | 
    
| AuthorAffiliation_xml | – name: 2 Department of Obstetrics and Gynecology, Akdeniz University, Antalya, Turkey – name: 3 IVF Center, Private Memorial Hospital, Antalya, Turkey – name: 1 Department of Plastic, Reconstructive and Aesthetic Surgery, Akdeniz University, Antalya, Turkey  | 
    
| Author_xml | – sequence: 1 givenname: Omer surname: Ozkan fullname: Ozkan, Omer – sequence: 2 givenname: Nasuh Utku surname: Dogan fullname: Dogan, Nasuh Utku email: nasuhutkudogan@yahoo.com – sequence: 3 givenname: Ozlenen surname: Ozkan fullname: Ozkan, Ozlenen – sequence: 4 givenname: Inanc surname: Mendilcioglu fullname: Mendilcioglu, Inanc – sequence: 5 givenname: Selen surname: Dogan fullname: Dogan, Selen email: nasuhutkudogan@yahoo.com – sequence: 6 givenname: Batu surname: Aydinuraz fullname: Aydinuraz, Batu – sequence: 7 givenname: Mehmet surname: Simsek fullname: Simsek, Mehmet  | 
    
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| Snippet | Absolute uterine factor infertility affects 3–5% of the general population, and unfortunately this condition is untreatable. There are some available options,... Absolute uterine factor infertility affects 3-5% of the general population, and unfortunately this condition is untreatable. There are some available options,...  | 
    
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| SubjectTerms | Animals Evidence-Based Medicine Female Humans Infertility, Female - etiology Infertility, Female - therapy Pregnancy Pregnancy Outcome Review Tissue Survival Treatment Outcome Uterus - transplantation  | 
    
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| Title | Uterus transplantation: From animal models through the first heart beating pregnancy to the first human live birth | 
    
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