18:1/18:1-Dioleoyl-phosphatidylglycerol prevents alveolar epithelial apoptosis and profibrotic stimulus in a neonatal piglet model of acute respiratory distress syndrome - Preuß, Stefanie; Scheiermann, Julia; Stadelmann, Sabrina; Omam, Friede D.; Winoto-Morbach, Supandi; Lex, Dennis; von Bismarck, Philipp; Adam-Klages, Sabine; Knerlich-Lukoschus, Friederike; Wesch, Daniela; Held-Feindt, Janka; Uhlig, Stefan; et al. (Pulmonary pharmacology & therapeutics, 2014)
Keywords: (Neonatal) acute respiratory distress syndrome; Airway epithelial cells; Animals; Animals, Newborn; Apoptosis - drug effects; Disease Models, Animal; Epithelial Cells - drug effects; Epithelial Cells - pathology; Epithelial-to-mesenchymal transition; Female; Fibrous lung repair; Macrophages, Alveolar - drug effects; Macrophages, Alveolar - metabolism; Male; Medical Education; Phosphatidylglycerols; Phosphatidylglycerols - pharmacology; Pulmonary Alveoli - cytology; Pulmonary Alveoli - drug effects; Pulmonary Alveoli - pathology; Pulmonary Edema - prevention & control; Pulmonary Fibrosis - pathology; Pulmonary Fibrosis - prevention & control; Pulmonary Surfactants - pharmacology; Pulmonary/Respiratory; Respiration, Artificial; Respiratory Distress Syndrome, Newborn - prevention & control; Secretory phospholipase A2; Swine; ITBVI; Secretory phospholipase A2; nARDS; sCrs; PEEP; Phosphatidylglycerols; rBAL; Rrs; TUNEL; Epithelial-to-mesenchymal transition; (Neonatal) acute respiratory distress syndrome; Peak; OI; Fibrous lung repair; PGs; DOPG; BALF; Airway epithelial cells; AECs; EMT; EVLWI; sPLA2; VEI; MAP; SVRI; VT; sC rs; mean airway pressure; V T; extra-vascular lung water index; resistance of the respiratory system; tidal volume; terminal deoxynucleotidyl transferase dUTP nick end labelling; intrathoracic blood volume index; broncho-alveolar lavage fluid; oxygenation index; 18:1/18:1-Dioleoyl-phosphatidylgycerol; positive end-expiratory pressure; repeated bronchoalveolar lavage; R rs; peak inspiratory pressure; systemic vascular resistance index; neonatal acute respiratory distress syndrome; specific (dynamic) compliance; ventilation efficiency index