18:1/18:1-Dioleoyl-phosphatidylglycerol prevents alveolar epithelial apoptosis and profibrotic stimulus in a neonatal piglet model of acute respiratory distress syndrome
18:1/18:1-Dioleoyl-phosphatidylgycerol (DOPG) is a surfactant phospholipid that is nearly non-detectable in neonatal surfactant films. When alveolar macrophages are exposed to DOPG in vitro, secretory phospholipase A2 (sPLA2) production is blocked, resulting in suppressed macrophage activity and imp...
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| Published in | Pulmonary pharmacology & therapeutics Vol. 28; no. 1; pp. 25 - 34 |
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| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.06.2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1094-5539 1522-9629 1522-9629 |
| DOI | 10.1016/j.pupt.2013.10.002 |
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| Abstract | 18:1/18:1-Dioleoyl-phosphatidylgycerol (DOPG) is a surfactant phospholipid that is nearly non-detectable in neonatal surfactant films. When alveolar macrophages are exposed to DOPG in vitro, secretory phospholipase A2 (sPLA2) production is blocked, resulting in suppressed macrophage activity and improved surfactant function. We investigated whether the addition of DOPG to a commercially available surfactant preparation would improve lung function in a neonatal piglet model of acute respiratory distress syndrome.
Respiratory failure was achieved by triple-hit lung injury (repeated broncho-alveolar lavage, injurious ventilation, tracheal lipopolysaccharide instillation, each intervention 24 h apart) in twenty-four domestic piglets aged 2–6 days and subject to mechanical ventilation. Following each lung injury protocol the piglets were treated with surfactant alone or with surfactant + DOPG.
Within 72 h of mechanical ventilation, we observed significantly improved gas exchange (oxygenation and ventilation), lung mechanics (compliance and resistance of the respiratory system), and pulmonary oedema (extra-vascular lung water index) in the surfactant + DOPG group. This favourable clinical effect could be attributed to improved surfactant function, reduced sPLA2 secretion, inhibition of macrophage migration, reduced alveolar epithelial apoptosis, and suppression of amphiregulin and TGF-β1 expression in pulmonary tissues as a prerequisite for fibrous lung repair.
We conclude that surfactant fortified by DOPG preserves lung function, and prevents alveolar epithelial injury and fibrous stimulus by reduction of sPLA2 in a neonatal model of acute respiratory distress syndrome without any relevant discernable side effects. Hence, DOPG supplementation in a neonatal lung exerts important function protecting effects and seems to be justified in cases of overwhelming pulmonary inflammation. |
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| AbstractList | Abstract Background 18:1/18:1-Dioleoyl-phosphatidylgycerol (DOPG) is a surfactant phospholipid that is nearly non-detectable in neonatal surfactant films. When alveolar macrophages are exposed to DOPG in vitro , secretory phospholipase A2 (sPLA2) production is blocked, resulting in suppressed macrophage activity and improved surfactant function. We investigated whether the addition of DOPG to a commercially available surfactant preparation would improve lung function in a neonatal piglet model of acute respiratory distress syndrome. Materials and methods Respiratory failure was achieved by triple-hit lung injury (repeated broncho-alveolar lavage, injurious ventilation, tracheal lipopolysaccharide instillation, each intervention 24 h apart) in twenty-four domestic piglets aged 2–6 days and subject to mechanical ventilation. Following each lung injury protocol the piglets were treated with surfactant alone or with surfactant + DOPG. Results Within 72 h of mechanical ventilation, we observed significantly improved gas exchange (oxygenation and ventilation), lung mechanics (compliance and resistance of the respiratory system), and pulmonary oedema (extra-vascular lung water index) in the surfactant + DOPG group. This favourable clinical effect could be attributed to improved surfactant function, reduced sPLA2 secretion, inhibition of macrophage migration, reduced alveolar epithelial apoptosis, and suppression of amphiregulin and TGF-β1 expression in pulmonary tissues as a prerequisite for fibrous lung repair. Conclusions We conclude that surfactant fortified by DOPG preserves lung function, and prevents alveolar epithelial injury and fibrous stimulus by reduction of sPLA2 in a neonatal model of acute respiratory distress syndrome without any relevant discernable side effects. Hence, DOPG supplementation in a neonatal lung exerts important function protecting effects and seems to be justified in cases of overwhelming pulmonary inflammation. 18:1/18:1-Dioleoyl-phosphatidylgycerol (DOPG) is a surfactant phospholipid that is nearly non-detectable in neonatal surfactant films. When alveolar macrophages are exposed to DOPG in vitro, secretory phospholipase A2 (sPLA2) production is blocked, resulting in suppressed macrophage activity and improved surfactant function. We investigated whether the addition of DOPG to a commercially available surfactant preparation would improve lung function in a neonatal piglet model of acute respiratory distress syndrome. Respiratory failure was achieved by triple-hit lung injury (repeated broncho-alveolar lavage, injurious ventilation, tracheal lipopolysaccharide instillation, each intervention 24 h apart) in twenty-four domestic piglets aged 2–6 days and subject to mechanical ventilation. Following each lung injury protocol the piglets were treated with surfactant alone or with surfactant + DOPG. Within 72 h of mechanical ventilation, we observed significantly improved gas exchange (oxygenation and ventilation), lung mechanics (compliance and resistance of the respiratory system), and pulmonary oedema (extra-vascular lung water index) in the surfactant + DOPG group. This favourable clinical effect could be attributed to improved surfactant function, reduced sPLA2 secretion, inhibition of macrophage migration, reduced alveolar epithelial apoptosis, and suppression of amphiregulin and TGF-β1 expression in pulmonary tissues as a prerequisite for fibrous lung repair. We conclude that surfactant fortified by DOPG preserves lung function, and prevents alveolar epithelial injury and fibrous stimulus by reduction of sPLA2 in a neonatal model of acute respiratory distress syndrome without any relevant discernable side effects. Hence, DOPG supplementation in a neonatal lung exerts important function protecting effects and seems to be justified in cases of overwhelming pulmonary inflammation. 18:1/18:1-Dioleoyl-phosphatidylgycerol (DOPG) is a surfactant phospholipid that is nearly non-detectable in neonatal surfactant films. When alveolar macrophages are exposed to DOPG in vitro, secretory phospholipase A2 (sPLA2) production is blocked, resulting in suppressed macrophage activity and improved surfactant function. We investigated whether the addition of DOPG to a commercially available surfactant preparation would improve lung function in a neonatal piglet model of acute respiratory distress syndrome. Respiratory failure was achieved by triple-hit lung injury (repeated broncho-alveolar lavage, injurious ventilation, tracheal lipopolysaccharide instillation, each intervention 24 h apart) in twenty-four domestic piglets aged 2-6 days and subject to mechanical ventilation. Following each lung injury protocol the piglets were treated with surfactant alone or with surfactant + DOPG. Within 72 h of mechanical ventilation, we observed significantly improved gas exchange (oxygenation and ventilation), lung mechanics (compliance and resistance of the respiratory system), and pulmonary oedema (extra-vascular lung water index) in the surfactant + DOPG group. This favourable clinical effect could be attributed to improved surfactant function, reduced sPLA2 secretion, inhibition of macrophage migration, reduced alveolar epithelial apoptosis, and suppression of amphiregulin and TGF-β1 expression in pulmonary tissues as a prerequisite for fibrous lung repair. We conclude that surfactant fortified by DOPG preserves lung function, and prevents alveolar epithelial injury and fibrous stimulus by reduction of sPLA2 in a neonatal model of acute respiratory distress syndrome without any relevant discernable side effects. Hence, DOPG supplementation in a neonatal lung exerts important function protecting effects and seems to be justified in cases of overwhelming pulmonary inflammation. 18:1/18:1-Dioleoyl-phosphatidylgycerol (DOPG) is a surfactant phospholipid that is nearly non-detectable in neonatal surfactant films. When alveolar macrophages are exposed to DOPG in vitro, secretory phospholipase A2 (sPLA2) production is blocked, resulting in suppressed macrophage activity and improved surfactant function. We investigated whether the addition of DOPG to a commercially available surfactant preparation would improve lung function in a neonatal piglet model of acute respiratory distress syndrome.BACKGROUND18:1/18:1-Dioleoyl-phosphatidylgycerol (DOPG) is a surfactant phospholipid that is nearly non-detectable in neonatal surfactant films. When alveolar macrophages are exposed to DOPG in vitro, secretory phospholipase A2 (sPLA2) production is blocked, resulting in suppressed macrophage activity and improved surfactant function. We investigated whether the addition of DOPG to a commercially available surfactant preparation would improve lung function in a neonatal piglet model of acute respiratory distress syndrome.Respiratory failure was achieved by triple-hit lung injury (repeated broncho-alveolar lavage, injurious ventilation, tracheal lipopolysaccharide instillation, each intervention 24 h apart) in twenty-four domestic piglets aged 2-6 days and subject to mechanical ventilation. Following each lung injury protocol the piglets were treated with surfactant alone or with surfactant + DOPG.MATERIALS AND METHODSRespiratory failure was achieved by triple-hit lung injury (repeated broncho-alveolar lavage, injurious ventilation, tracheal lipopolysaccharide instillation, each intervention 24 h apart) in twenty-four domestic piglets aged 2-6 days and subject to mechanical ventilation. Following each lung injury protocol the piglets were treated with surfactant alone or with surfactant + DOPG.Within 72 h of mechanical ventilation, we observed significantly improved gas exchange (oxygenation and ventilation), lung mechanics (compliance and resistance of the respiratory system), and pulmonary oedema (extra-vascular lung water index) in the surfactant + DOPG group. This favourable clinical effect could be attributed to improved surfactant function, reduced sPLA2 secretion, inhibition of macrophage migration, reduced alveolar epithelial apoptosis, and suppression of amphiregulin and TGF-β1 expression in pulmonary tissues as a prerequisite for fibrous lung repair.RESULTSWithin 72 h of mechanical ventilation, we observed significantly improved gas exchange (oxygenation and ventilation), lung mechanics (compliance and resistance of the respiratory system), and pulmonary oedema (extra-vascular lung water index) in the surfactant + DOPG group. This favourable clinical effect could be attributed to improved surfactant function, reduced sPLA2 secretion, inhibition of macrophage migration, reduced alveolar epithelial apoptosis, and suppression of amphiregulin and TGF-β1 expression in pulmonary tissues as a prerequisite for fibrous lung repair.We conclude that surfactant fortified by DOPG preserves lung function, and prevents alveolar epithelial injury and fibrous stimulus by reduction of sPLA2 in a neonatal model of acute respiratory distress syndrome without any relevant discernable side effects. Hence, DOPG supplementation in a neonatal lung exerts important function protecting effects and seems to be justified in cases of overwhelming pulmonary inflammation.CONCLUSIONSWe conclude that surfactant fortified by DOPG preserves lung function, and prevents alveolar epithelial injury and fibrous stimulus by reduction of sPLA2 in a neonatal model of acute respiratory distress syndrome without any relevant discernable side effects. Hence, DOPG supplementation in a neonatal lung exerts important function protecting effects and seems to be justified in cases of overwhelming pulmonary inflammation. |
| Author | Scheiermann, Julia Lex, Dennis Adam-Klages, Sabine von Bismarck, Philipp Uhlig, Stefan Stadelmann, Sabrina Winoto-Morbach, Supandi Schütze, Stefan Krause, Martin F. Held-Feindt, Janka Knerlich-Lukoschus, Friederike Preuß, Stefanie Omam, Friede D. Wesch, Daniela |
| Author_xml | – sequence: 1 givenname: Stefanie surname: Preuß fullname: Preuß, Stefanie organization: Department of Paediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Schwanenweg 20, 24105 Kiel, Germany – sequence: 2 givenname: Julia surname: Scheiermann fullname: Scheiermann, Julia organization: Department of Paediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Schwanenweg 20, 24105 Kiel, Germany – sequence: 3 givenname: Sabrina surname: Stadelmann fullname: Stadelmann, Sabrina organization: Department of Paediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Schwanenweg 20, 24105 Kiel, Germany – sequence: 4 givenname: Friede D. surname: Omam fullname: Omam, Friede D. organization: Department of Paediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Schwanenweg 20, 24105 Kiel, Germany – sequence: 5 givenname: Supandi surname: Winoto-Morbach fullname: Winoto-Morbach, Supandi organization: Institute of Immunology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany – sequence: 6 givenname: Dennis surname: Lex fullname: Lex, Dennis organization: Institute of Pharmacology and Toxicology, University Hospital RWTH Aachen, Aachen, Germany – sequence: 7 givenname: Philipp surname: von Bismarck fullname: von Bismarck, Philipp organization: Department of Paediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Schwanenweg 20, 24105 Kiel, Germany – sequence: 8 givenname: Sabine surname: Adam-Klages fullname: Adam-Klages, Sabine organization: Institute of Immunology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany – sequence: 9 givenname: Friederike surname: Knerlich-Lukoschus fullname: Knerlich-Lukoschus, Friederike organization: Department of Neurosurgery, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany – sequence: 10 givenname: Daniela surname: Wesch fullname: Wesch, Daniela organization: Institute of Immunology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany – sequence: 11 givenname: Janka surname: Held-Feindt fullname: Held-Feindt, Janka organization: Department of Neurosurgery, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany – sequence: 12 givenname: Stefan surname: Uhlig fullname: Uhlig, Stefan organization: Institute of Pharmacology and Toxicology, University Hospital RWTH Aachen, Aachen, Germany – sequence: 13 givenname: Stefan surname: Schütze fullname: Schütze, Stefan organization: Institute of Immunology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany – sequence: 14 givenname: Martin F. surname: Krause fullname: Krause, Martin F. email: m.krause@pediatrics.uni-kiel.de organization: Department of Paediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Schwanenweg 20, 24105 Kiel, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24140177$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.2527/jas.2010-3270 10.1152/ajplung.00320.2007 10.1152/ajplung.00181.2001 10.1097/01.CCM.0000171540.54520.69 10.1152/ajplung.00251.2009 10.1097/PCC.0b013e3181d5063c 10.1084/jem.20080201 10.1001/jama.293.4.470 10.1074/jbc.M112.356824 10.1016/j.jconrel.2005.08.026 10.1021/la901250z 10.1097/CCM.0b013e31822f09d7 10.1203/01.PDR.0000075084.56255.E0 10.1165/rcmb.2003-0351OC 10.1165/rcmb.2002-0132OC 10.1016/j.bbamem.2009.12.010 10.1073/pnas.88.15.6642 10.1152/ajplung.2001.280.1.L58 10.1194/jlr.R800033-JLR200 10.1186/1465-9921-6-56 10.1152/physiolgenomics.00110.2005 10.1152/ajplung.00010.2008 10.1096/fj.11-186098 10.1016/S0022-3476(98)70482-2 10.1164/ajrccm.159.2.9805053 10.1097/MAJ.0b013e318239c96c 10.1183/09031936.93.06070971 10.1097/00003246-200104000-00004 10.1164/rccm.200304-467OC 10.1164/ajrccm.156.6.96-12081 10.1074/jbc.M109.040832 10.1016/S1095-6433(01)00306-3 10.1111/j.1651-2227.2000.tb00739.x 10.4049/jimmunol.175.6.4069 10.1016/j.bbadis.2009.06.007 10.1146/annurev-cellbio-092910-154036 10.1183/09031936.00074709 10.1203/01.PDR.0000103930.93849.B2 10.1002/smll.201300607 10.1165/rcmb.2006-0434OC 10.4049/jimmunol.159.1.391 10.1016/j.vetimm.2006.06.008 10.1097/CCM.0b013e3181922bd3 10.1177/1753425910368871 10.1073/pnas.0605669103 10.1164/rccm.201009-1424OC 10.1073/pnas.0909361107 10.1016/j.chemphyslip.2008.03.007 10.1016/0165-2427(93)90075-F 10.1164/rccm.200404-544OC 10.1097/PCC.0b013e3181dbe95e 10.4049/jimmunol.150.7.2885 10.1097/01.CCM.0000257325.88144.30 10.1183/09031936.03.00093002 10.1152/ajplung.1997.272.5.L925 |
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| Keywords | ITBVI Secretory phospholipase A2 nARDS sCrs PEEP Phosphatidylglycerols rBAL Rrs TUNEL Epithelial-to-mesenchymal transition (Neonatal) acute respiratory distress syndrome Peak OI Fibrous lung repair PGs DOPG BALF Airway epithelial cells AECs EMT EVLWI sPLA2 VEI MAP SVRI VT sC rs mean airway pressure V T extra-vascular lung water index resistance of the respiratory system tidal volume terminal deoxynucleotidyl transferase dUTP nick end labelling intrathoracic blood volume index broncho-alveolar lavage fluid oxygenation index 18:1/18:1-Dioleoyl-phosphatidylgycerol positive end-expiratory pressure repeated bronchoalveolar lavage R rs peak inspiratory pressure systemic vascular resistance index neonatal acute respiratory distress syndrome specific (dynamic) compliance ventilation efficiency index |
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| References | Arbibe, Vial, Rosinski-Chupin, Havet, Huerre, Vargaftig (bib28) 1997; 159 Zasadzinski, Stenger, Shieh, Dhar (bib8) 2010; 1798 Cabrera-Benítez, Parotto, Post, Han, Spieth, Cheng (bib50) 2012; 40 Seeds, Grier, Suckling, Safta, Long, Waite (bib4) 2012; 343 Seeger, Grube, Günther, Schmidt (bib3) 1993; 6 Wu, Medjane, Chapot, Kubrusly, Raw, Chignard (bib26) 2003; 168 Kasai, Allen, Mason, Kamimura, Zhang (bib49) 2005; 6 Henson, Tuder (bib23) 2008; 294 Bohlin, Merchak, Spence, Patterson, Hamvas (bib7) 2003; 54 Papazian, Doddoli, Chetaille, Gernez, Thirion, Roch (bib46) 2007; 35 Quesnel, Nardelli, Piednoir, Lecon, Marchal-Somme, Lasocki (bib20) 2010; 35 Furue, Mikawa, Nishina, Shiga, Ueno, Tomita (bib31) 2001; 29 del Riccio, van Tuyl, Post (bib44) 2004; 55 Bern, van der Loos, van Woensel, Bos (bib1) 2010; 11 Wang, Chang, Schwan, Notter (bib35) 2007; 37 Spragg, Taut, Lewis, Schenk, Ruppert, Dean (bib5) 2011; 183 Maus, Herold, Muth, Maus, Ermert, Weissmann (bib2) 2001; 280 Kazzi, Schürch, McLaughlin, Romero, Janisse (bib24) 2000; 89 Dolinay, Kaminski, Felgendreher, Kim, Reynolds, Watkins (bib51) 2006; 26 Flori, Glidden, Rutherford, Matthay (bib10) 2005; 171 Atochina-Vasserman, Beers, Gow (bib11) 2010; 16 Zelnickova, Kovaru, Pesak, Lojek, Matalova, Ondracek (bib36) 2006; 113 Mokres, Parai, Hilgendorff, Ertsey, Alvira, Rabinovitch (bib45) 2010; 298 Matute-Bello, Frevert, Martin (bib21) 2008; 295 Dyson, Singer (bib53) 2009; 37 Berger, Havet, Vial, Arbibe, Dumarey, Watson (bib13) 1999; 159 Nieto (bib47) 2011; 27 Saad, Policova, Acosta, Hair, Neumann (bib12) 2009; 25 Hasday, Dubin, Mongovin, Goldblum, Swoveland, Leturcq (bib38) 1997; 272 Wang, Nie, Wang, Li, Ge, Zhang (bib55) 2013 may 6 Tasaka, Ishizaka, Yamada, Shimizu, Koh, Hasegawa (bib39) 2003; 29 Matute-Bello, Liles, Radella, Steinberg, Ruzinski, Jonas (bib42) 1997; 156 Vahjen, Pieper, Zentek (bib22) 2011; 89 Broekelmann, Limper, Colby, McDonald (bib48) 1991; 88 Kuronuma, Mitsuzawa, Takeda, Nishitani, Chan, Kuroki (bib14) 2009; 284 Lotze, Mitchell, Bulas, Zola, Shalwitz, Gunkel (bib9) 1998; 132 de Luca, Minucci, Cogo, Capoluongo, Conti, Pietrini (bib29) 2011; 12 Attalah, Alaoui-El-Azher, Thouron, Koumanov, Wolf, Brochard (bib32) 2003; 21 Rau, Vieten, Haitsma, Freihorst, Poets, Ure (bib17) 2004; 30 Kitsiouli, Nakos, Lekka (bib18) 2009; 1792 Schneider, Wu, Le, Cho, Brenner, Blackburn (bib54) 2012; 26 Zeiher, Steingrub, Laterre, Dmitrienko, Fukiishi, Abraham (bib33) 2005; 33 Herold, Steinmueller, von Wulffen, Cakarova, Pinto, Pleschka (bib43) 2008; 205 Zhou, Lee, Lee, Cho, Kang, Koff (bib52) 2012; 287 Postle, Heeley, Wilton (bib16) 2001; 129 Kuo, Jan, Jeng, Chiu (bib27) 2005; 108 Wu, Singer, Thouron, Alaoui-el-azher, Touqui (bib30) 2002; 282 Burke, Dennis (bib34) 2009; 50 Kim, Kugler, Wolters, Robillard, Galvez, Brumwell (bib19) 2006; 103 Matute-Bello, Lee, Liles, Frevert, Mongovin, Wong (bib41) 2005; 175 Jacobsen, Aasted, Broe, Petersen (bib37) 1993; 39 Dentener, Bazil, von Asmuth, Ceska, Buurman (bib40) 1993; 7 Willson, Thomas, Markovitz, Bauman, DiCarlo, Pon (bib6) 2005; 293 Alley, Ces, Barahona, Templer (bib25) 2008; 154 Numata, Chu, Dakhama, Voelker (bib15) 2010; 107 del Riccio (10.1016/j.pupt.2013.10.002_bib44) 2004; 55 Lotze (10.1016/j.pupt.2013.10.002_bib9) 1998; 132 Postle (10.1016/j.pupt.2013.10.002_bib16) 2001; 129 Kasai (10.1016/j.pupt.2013.10.002_bib49) 2005; 6 Zhou (10.1016/j.pupt.2013.10.002_bib52) 2012; 287 Henson (10.1016/j.pupt.2013.10.002_bib23) 2008; 294 Mokres (10.1016/j.pupt.2013.10.002_bib45) 2010; 298 Spragg (10.1016/j.pupt.2013.10.002_bib5) 2011; 183 Kuronuma (10.1016/j.pupt.2013.10.002_bib14) 2009; 284 Alley (10.1016/j.pupt.2013.10.002_bib25) 2008; 154 Attalah (10.1016/j.pupt.2013.10.002_bib32) 2003; 21 Berger (10.1016/j.pupt.2013.10.002_bib13) 1999; 159 Kitsiouli (10.1016/j.pupt.2013.10.002_bib18) 2009; 1792 Seeger (10.1016/j.pupt.2013.10.002_bib3) 1993; 6 Atochina-Vasserman (10.1016/j.pupt.2013.10.002_bib11) 2010; 16 Wu (10.1016/j.pupt.2013.10.002_bib26) 2003; 168 Burke (10.1016/j.pupt.2013.10.002_bib34) 2009; 50 Kim (10.1016/j.pupt.2013.10.002_bib19) 2006; 103 Dolinay (10.1016/j.pupt.2013.10.002_bib51) 2006; 26 Herold (10.1016/j.pupt.2013.10.002_bib43) 2008; 205 Seeds (10.1016/j.pupt.2013.10.002_bib4) 2012; 343 Kuo (10.1016/j.pupt.2013.10.002_bib27) 2005; 108 Saad (10.1016/j.pupt.2013.10.002_bib12) 2009; 25 Dentener (10.1016/j.pupt.2013.10.002_bib40) 1993; 7 Arbibe (10.1016/j.pupt.2013.10.002_bib28) 1997; 159 Bohlin (10.1016/j.pupt.2013.10.002_bib7) 2003; 54 Tasaka (10.1016/j.pupt.2013.10.002_bib39) 2003; 29 Wang (10.1016/j.pupt.2013.10.002_bib55) 2013 Broekelmann (10.1016/j.pupt.2013.10.002_bib48) 1991; 88 Matute-Bello (10.1016/j.pupt.2013.10.002_bib42) 1997; 156 Hasday (10.1016/j.pupt.2013.10.002_bib38) 1997; 272 Schneider (10.1016/j.pupt.2013.10.002_bib54) 2012; 26 Kazzi (10.1016/j.pupt.2013.10.002_bib24) 2000; 89 Jacobsen (10.1016/j.pupt.2013.10.002_bib37) 1993; 39 Bern (10.1016/j.pupt.2013.10.002_bib1) 2010; 11 Zelnickova (10.1016/j.pupt.2013.10.002_bib36) 2006; 113 Nieto (10.1016/j.pupt.2013.10.002_bib47) 2011; 27 Numata (10.1016/j.pupt.2013.10.002_bib15) 2010; 107 Rau (10.1016/j.pupt.2013.10.002_bib17) 2004; 30 Wu (10.1016/j.pupt.2013.10.002_bib30) 2002; 282 Maus (10.1016/j.pupt.2013.10.002_bib2) 2001; 280 de Luca (10.1016/j.pupt.2013.10.002_bib29) 2011; 12 Matute-Bello (10.1016/j.pupt.2013.10.002_bib41) 2005; 175 Willson (10.1016/j.pupt.2013.10.002_bib6) 2005; 293 Papazian (10.1016/j.pupt.2013.10.002_bib46) 2007; 35 Flori (10.1016/j.pupt.2013.10.002_bib10) 2005; 171 Wang (10.1016/j.pupt.2013.10.002_bib35) 2007; 37 Cabrera-Benítez (10.1016/j.pupt.2013.10.002_bib50) 2012; 40 Zasadzinski (10.1016/j.pupt.2013.10.002_bib8) 2010; 1798 Matute-Bello (10.1016/j.pupt.2013.10.002_bib21) 2008; 295 Quesnel (10.1016/j.pupt.2013.10.002_bib20) 2010; 35 Vahjen (10.1016/j.pupt.2013.10.002_bib22) 2011; 89 Dyson (10.1016/j.pupt.2013.10.002_bib53) 2009; 37 Furue (10.1016/j.pupt.2013.10.002_bib31) 2001; 29 Zeiher (10.1016/j.pupt.2013.10.002_bib33) 2005; 33 |
| References_xml | – volume: 159 start-page: 613 year: 1999 end-page: 618 ident: bib13 article-title: Dioleylphosphatidylglycerol inhibits the expression of type II phospholipase A2 in macrophages publication-title: Am J Respir Crit Care Med – volume: 205 start-page: 3065 year: 2008 end-page: 3077 ident: bib43 article-title: Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand publication-title: J Exp Med – volume: 343 start-page: 446 year: 2012 end-page: 451 ident: bib4 article-title: Secretory phospholipase A2-mediated depletion of phosphatidylglycerol in early acute respiratory distress syndrome publication-title: Am J Med Sci – volume: 287 start-page: 41991 year: 2012 end-page: 42000 ident: bib52 article-title: Amphiregulin, an epidermal growth factor receptor (EGFR), plays an essential role in the pathogenesis of TGF-β1-induced pulmonary fibrosis publication-title: J Biol Chem – volume: 156 start-page: 1969 year: 1997 end-page: 1977 ident: bib42 article-title: Neutrophil apoptosis in the acute respiratory distress syndrome publication-title: Am J Respir Crit Care Med – volume: 298 start-page: L23 year: 2010 end-page: L35 ident: bib45 article-title: Prolonged mechanical ventilation with air induces apoptosis and causes failure of alveolar septation and angiogenesis in lungs of newborn mice publication-title: Am J Physiol Lung Cell Mol Physiol – volume: 55 start-page: 183 year: 2004 end-page: 189 ident: bib44 article-title: Apotosis in lung development and neonatal lung injury publication-title: Pediatr Res – volume: 295 start-page: L379 year: 2008 end-page: L399 ident: bib21 article-title: Animal models of acute lung injury publication-title: Am J Physiol Lung Cell Mol Physiol – volume: 89 start-page: 1218 year: 2000 end-page: 1225 ident: bib24 article-title: Surfactant phospholipids and surfactant activity among preterm infants with respiratory distress syndrome who develop bronchopulmonary dysplasia publication-title: Acta Paediatr – year: 2013 may 6 ident: bib55 article-title: Multiwall carbon nanotubules mediate macrophage activation and promote pulmonary fibrosis through TGF-β/Smad signaling pathway publication-title: Small – volume: 6 start-page: 56 year: 2005 ident: bib49 article-title: TGF-β1 induces human alveolar epithelial to mesenchymal transition (EMT) publication-title: Respir Res – volume: 280 start-page: L58 year: 2001 end-page: L68 ident: bib2 article-title: Monocytes recruited into the alveolar air space of mice show a monocytic phenotype but upregulate CD14 publication-title: Am J Physiol Lung Cell Mol Physiol – volume: 282 start-page: L743 year: 2002 end-page: L750 ident: bib30 article-title: Effect of surfactant on pulmonary expression of type IIA PLA2 in an animal model of acute lung injury publication-title: Am J Physiol Lung Cell Mol Physiol – volume: 35 start-page: 1312 year: 2010 end-page: 1321 ident: bib20 article-title: Alveolar fibroblasts in acute lung injury: biological behaviour and clinical relevance publication-title: Eur Respir J – volume: 11 start-page: 556 year: 2010 end-page: 560 ident: bib1 article-title: Cleaved caspase-3 in lung epithelium of children who died with acute respiratory distress syndrome publication-title: Pediatr Crit Care Med – volume: 37 start-page: S30 year: 2009 end-page: S37 ident: bib53 article-title: Animal models of sepsis: why does preclinical efficacy fail to translate to the clinical setting? publication-title: Crit Care Med – volume: 132 start-page: 40 year: 1998 end-page: 47 ident: bib9 article-title: Multicenter study of surfactant (beractant) use in the treatment of term infants with severe respiratory failure publication-title: J Pediatr – volume: 40 start-page: 510 year: 2012 end-page: 517 ident: bib50 article-title: Mechanical stress induces lung fibrosis by epithelial-mesenchymal transition publication-title: Crit Care Med – volume: 159 start-page: 391 year: 1997 end-page: 400 ident: bib28 article-title: Endotoxin induces expression of type II phospholipase A2 in macrophages during acute lung injury in guinea pigs publication-title: J Immunol – volume: 294 start-page: L601 year: 2008 end-page: L611 ident: bib23 article-title: Apoptosis in the lung: induction, clearance and detection publication-title: Am J Physiol Lung Cell Mol Physiol – volume: 183 start-page: 1055 year: 2011 end-page: 1061 ident: bib5 article-title: Recombinant surfactant protein C-based surfactant for patients with severe direct lung injury publication-title: Am J Respir Crit Care Med – volume: 16 start-page: 175 year: 2010 end-page: 182 ident: bib11 article-title: Chemical and structural modifications of pulmonary collectins and their functional consequences publication-title: Innate Immun – volume: 37 start-page: 387 year: 2007 end-page: 394 ident: bib35 article-title: Activity and inhibition resistance of a phospholipase-resistant synthetic surfactant in rat lungs publication-title: Am J Respir Cell Mol Biol – volume: 26 start-page: 68 year: 2006 end-page: 75 ident: bib51 article-title: Gene expression profiling of target genes in ventilator-induced lung injury publication-title: Physiol Genomics – volume: 171 start-page: 995 year: 2005 end-page: 1001 ident: bib10 article-title: Pediatric acute lung injury publication-title: Am J Respir Crit Care Med – volume: 175 start-page: 4069 year: 2005 end-page: 4075 ident: bib41 article-title: Fas-mediated acute lung injury requires Fas expression on nonmyeloid cells of the lung publication-title: J Immunol – volume: 89 start-page: 2430 year: 2011 end-page: 2439 ident: bib22 article-title: Increased dietary zinc oxide changes the bacterial core and enterobacterial composition in the ileum of piglets publication-title: J Anim Sci – volume: 103 start-page: 13180 year: 2006 end-page: 13185 ident: bib19 article-title: Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix publication-title: Proc Natl Acad Sci U S A – volume: 7 start-page: 2885 year: 1993 end-page: 2891 ident: bib40 article-title: Involvement of CD14 in lipopolysaccharide-induced tumor necrosis factor-α, IL-6 and IL-8 release by human monocytes and alveolar macrophages publication-title: J Immunol – volume: 272 start-page: L925 year: 1997 end-page: L933 ident: bib38 article-title: Bronchoalveolar macrophage CD14 expression: shift between membrane-associated and soluble pools publication-title: Am J Physiol Lung Cell Mol Physiol – volume: 27 start-page: 347 year: 2011 end-page: 376 ident: bib47 article-title: The ins and outs of the epithelial to mesenchymal transition in health and disease publication-title: Annu Rev Cell Dev Biol – volume: 88 start-page: 6642 year: 1991 end-page: 6646 ident: bib48 article-title: Transforming growth factor β1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis publication-title: Proc Natl Acad Sci U S A – volume: 25 start-page: 10907 year: 2009 end-page: 10912 ident: bib12 article-title: Mixed DPPC/DPPG monolayers at very high film compression publication-title: Langmuir – volume: 26 start-page: 503 year: 2012 end-page: 512 ident: bib54 article-title: Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-β production and epithelial to mesenchymal transition publication-title: FASEB J – volume: 284 start-page: 25488 year: 2009 end-page: 25500 ident: bib14 article-title: Anionic pulmonary surfactant phospholipids inhibit inflammatory responses from alveolar macrophages and U937 cells by binding the lipopolysaccharide-interacting proteins CD14 and MD-2 publication-title: J Biol Chem – volume: 30 start-page: 694 year: 2004 end-page: 701 ident: bib17 article-title: Surfactant in newborn compared with adolescent pigs publication-title: Am J Respir Cell Mol Biol – volume: 293 start-page: 470 year: 2005 end-page: 476 ident: bib6 article-title: Effect of exogenous surfactant (calfactant) in pediatric acute lung injury publication-title: JAMA – volume: 1798 start-page: 801 year: 2010 end-page: 828 ident: bib8 article-title: Overcoming rapid inactivation of lung surfactant: analogies between competitive adsorption and colloid stability publication-title: Biochim Biophys Acta – volume: 21 start-page: 1040 year: 2003 end-page: 1045 ident: bib32 article-title: Induction of type-IIA secretory phospholipase A2 in animal models of acute lung injury publication-title: Eur Respir J – volume: 29 start-page: 719 year: 2001 end-page: 729 ident: bib31 article-title: Therapeutic time-window of a group IIA phospholipase A2 inhibitor in rabbit acute lung injury: correlation with lung surfactant protection publication-title: Crit Care Med – volume: 1792 start-page: 941 year: 2009 end-page: 953 ident: bib18 article-title: Phospholipase A2 subclasses in acute respiratory distress syndrome publication-title: Biochim Biophys Acta – volume: 33 start-page: 1741 year: 2005 end-page: 1748 ident: bib33 article-title: LY315920NA/S-5920, a selective inhibitor of group IIA secretory phospholipase A2, fails to improve clinical outcome for patients with severe sepsis publication-title: Crit Care Med – volume: 50 start-page: S237 year: 2009 end-page: S242 ident: bib34 article-title: Phospholipase A2 structure/function, mechanism, and signaling publication-title: J Lipid Res – volume: 113 start-page: 383 year: 2006 end-page: 391 ident: bib36 article-title: Postnatal functional maturation in blood phagocytes in pig publication-title: Vet Immunol Immunopathol – volume: 29 start-page: 252 year: 2003 end-page: 258 ident: bib39 article-title: Effect of CD14 blockade on endotoxin-induced acute lung injury in mice publication-title: Am J Respir Cell Mol Biol – volume: 12 start-page: e20 year: 2011 end-page: e24 ident: bib29 article-title: Secretory phospholipase A publication-title: Pediatr Crit Care Med – volume: 6 start-page: 971 year: 1993 end-page: 977 ident: bib3 article-title: Surfactant inhibition by plasma proteins: differential sensitivity of various surfactant preparations publication-title: Eur Respir J – volume: 54 start-page: 185 year: 2003 end-page: 191 ident: bib7 article-title: Endogenous surfactant metabolism in newborn infants with and without respiratory failure publication-title: Pediatr Res – volume: 154 start-page: 64 year: 2008 end-page: 67 ident: bib25 article-title: X-ray diffraction measurement of the monolayer spontaneous curvature of dioleoylphosphatidylglycerol publication-title: Chem Phys Lipids – volume: 39 start-page: 461 year: 1993 end-page: 466 ident: bib37 article-title: Reactivities of 20 anti-human monoclonal antibodies with leukocytes from ten different animal species publication-title: Vet Immunol Immunopathol – volume: 168 start-page: 692 year: 2003 end-page: 699 ident: bib26 article-title: Surfactant protein-A and phosphatidylglycerol suppress type IIA phospholipase A2 synthesis via nuclear factor-κB publication-title: Am J Respir Crit Care Med – volume: 35 start-page: 755 year: 2007 end-page: 762 ident: bib46 article-title: A contributive result of open-lung biopsy improves survival in acute respiratory distress syndrome patients publication-title: Crit Care Med – volume: 107 start-page: 320 year: 2010 end-page: 325 ident: bib15 article-title: Pulmonary surfactant phosphatidylglycerol inhibits respiratory syncytial virus-induced inflammation and infection publication-title: Proc Natl Acad Sci U S A – volume: 129 start-page: 65 year: 2001 end-page: 73 ident: bib16 article-title: A comparison of the molecular species compositions of mammalian lung surfactant phospholipids publication-title: Comp Biochem Physiol Part A – volume: 108 start-page: 442 year: 2005 end-page: 452 ident: bib27 article-title: Induction of apoptosis in macrophages by air oxidation or dioleoylphosphatidylglycerol publication-title: J Control Release – volume: 89 start-page: 2430 year: 2011 ident: 10.1016/j.pupt.2013.10.002_bib22 article-title: Increased dietary zinc oxide changes the bacterial core and enterobacterial composition in the ileum of piglets publication-title: J Anim Sci doi: 10.2527/jas.2010-3270 – volume: 294 start-page: L601 year: 2008 ident: 10.1016/j.pupt.2013.10.002_bib23 article-title: Apoptosis in the lung: induction, clearance and detection publication-title: Am J Physiol Lung Cell Mol Physiol doi: 10.1152/ajplung.00320.2007 – volume: 282 start-page: L743 year: 2002 ident: 10.1016/j.pupt.2013.10.002_bib30 article-title: Effect of surfactant on pulmonary expression of type IIA PLA2 in an animal model of acute lung injury publication-title: Am J Physiol Lung Cell Mol Physiol doi: 10.1152/ajplung.00181.2001 – volume: 33 start-page: 1741 year: 2005 ident: 10.1016/j.pupt.2013.10.002_bib33 article-title: LY315920NA/S-5920, a selective inhibitor of group IIA secretory phospholipase A2, fails to improve clinical outcome for patients with severe sepsis publication-title: Crit Care Med doi: 10.1097/01.CCM.0000171540.54520.69 – volume: 298 start-page: L23 year: 2010 ident: 10.1016/j.pupt.2013.10.002_bib45 article-title: Prolonged mechanical ventilation with air induces apoptosis and causes failure of alveolar septation and angiogenesis in lungs of newborn mice publication-title: Am J Physiol Lung Cell Mol Physiol doi: 10.1152/ajplung.00251.2009 – volume: 11 start-page: 556 year: 2010 ident: 10.1016/j.pupt.2013.10.002_bib1 article-title: Cleaved caspase-3 in lung epithelium of children who died with acute respiratory distress syndrome publication-title: Pediatr Crit Care Med doi: 10.1097/PCC.0b013e3181d5063c – volume: 205 start-page: 3065 year: 2008 ident: 10.1016/j.pupt.2013.10.002_bib43 article-title: Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand publication-title: J Exp Med doi: 10.1084/jem.20080201 – volume: 293 start-page: 470 year: 2005 ident: 10.1016/j.pupt.2013.10.002_bib6 article-title: Effect of exogenous surfactant (calfactant) in pediatric acute lung injury publication-title: JAMA doi: 10.1001/jama.293.4.470 – volume: 287 start-page: 41991 year: 2012 ident: 10.1016/j.pupt.2013.10.002_bib52 article-title: Amphiregulin, an epidermal growth factor receptor (EGFR), plays an essential role in the pathogenesis of TGF-β1-induced pulmonary fibrosis publication-title: J Biol Chem doi: 10.1074/jbc.M112.356824 – volume: 108 start-page: 442 year: 2005 ident: 10.1016/j.pupt.2013.10.002_bib27 article-title: Induction of apoptosis in macrophages by air oxidation or dioleoylphosphatidylglycerol publication-title: J Control Release doi: 10.1016/j.jconrel.2005.08.026 – volume: 25 start-page: 10907 year: 2009 ident: 10.1016/j.pupt.2013.10.002_bib12 article-title: Mixed DPPC/DPPG monolayers at very high film compression publication-title: Langmuir doi: 10.1021/la901250z – volume: 40 start-page: 510 year: 2012 ident: 10.1016/j.pupt.2013.10.002_bib50 article-title: Mechanical stress induces lung fibrosis by epithelial-mesenchymal transition publication-title: Crit Care Med doi: 10.1097/CCM.0b013e31822f09d7 – volume: 54 start-page: 185 year: 2003 ident: 10.1016/j.pupt.2013.10.002_bib7 article-title: Endogenous surfactant metabolism in newborn infants with and without respiratory failure publication-title: Pediatr Res doi: 10.1203/01.PDR.0000075084.56255.E0 – volume: 30 start-page: 694 year: 2004 ident: 10.1016/j.pupt.2013.10.002_bib17 article-title: Surfactant in newborn compared with adolescent pigs publication-title: Am J Respir Cell Mol Biol doi: 10.1165/rcmb.2003-0351OC – volume: 29 start-page: 252 year: 2003 ident: 10.1016/j.pupt.2013.10.002_bib39 article-title: Effect of CD14 blockade on endotoxin-induced acute lung injury in mice publication-title: Am J Respir Cell Mol Biol doi: 10.1165/rcmb.2002-0132OC – volume: 1798 start-page: 801 year: 2010 ident: 10.1016/j.pupt.2013.10.002_bib8 article-title: Overcoming rapid inactivation of lung surfactant: analogies between competitive adsorption and colloid stability publication-title: Biochim Biophys Acta doi: 10.1016/j.bbamem.2009.12.010 – volume: 88 start-page: 6642 year: 1991 ident: 10.1016/j.pupt.2013.10.002_bib48 article-title: Transforming growth factor β1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.88.15.6642 – volume: 280 start-page: L58 year: 2001 ident: 10.1016/j.pupt.2013.10.002_bib2 article-title: Monocytes recruited into the alveolar air space of mice show a monocytic phenotype but upregulate CD14 publication-title: Am J Physiol Lung Cell Mol Physiol doi: 10.1152/ajplung.2001.280.1.L58 – volume: 50 start-page: S237 year: 2009 ident: 10.1016/j.pupt.2013.10.002_bib34 article-title: Phospholipase A2 structure/function, mechanism, and signaling publication-title: J Lipid Res doi: 10.1194/jlr.R800033-JLR200 – volume: 6 start-page: 56 year: 2005 ident: 10.1016/j.pupt.2013.10.002_bib49 article-title: TGF-β1 induces human alveolar epithelial to mesenchymal transition (EMT) publication-title: Respir Res doi: 10.1186/1465-9921-6-56 – volume: 26 start-page: 68 year: 2006 ident: 10.1016/j.pupt.2013.10.002_bib51 article-title: Gene expression profiling of target genes in ventilator-induced lung injury publication-title: Physiol Genomics doi: 10.1152/physiolgenomics.00110.2005 – volume: 295 start-page: L379 year: 2008 ident: 10.1016/j.pupt.2013.10.002_bib21 article-title: Animal models of acute lung injury publication-title: Am J Physiol Lung Cell Mol Physiol doi: 10.1152/ajplung.00010.2008 – volume: 26 start-page: 503 year: 2012 ident: 10.1016/j.pupt.2013.10.002_bib54 article-title: Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-β production and epithelial to mesenchymal transition publication-title: FASEB J doi: 10.1096/fj.11-186098 – volume: 132 start-page: 40 year: 1998 ident: 10.1016/j.pupt.2013.10.002_bib9 article-title: Multicenter study of surfactant (beractant) use in the treatment of term infants with severe respiratory failure publication-title: J Pediatr doi: 10.1016/S0022-3476(98)70482-2 – volume: 159 start-page: 613 year: 1999 ident: 10.1016/j.pupt.2013.10.002_bib13 article-title: Dioleylphosphatidylglycerol inhibits the expression of type II phospholipase A2 in macrophages publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.159.2.9805053 – volume: 343 start-page: 446 year: 2012 ident: 10.1016/j.pupt.2013.10.002_bib4 article-title: Secretory phospholipase A2-mediated depletion of phosphatidylglycerol in early acute respiratory distress syndrome publication-title: Am J Med Sci doi: 10.1097/MAJ.0b013e318239c96c – volume: 6 start-page: 971 year: 1993 ident: 10.1016/j.pupt.2013.10.002_bib3 article-title: Surfactant inhibition by plasma proteins: differential sensitivity of various surfactant preparations publication-title: Eur Respir J doi: 10.1183/09031936.93.06070971 – volume: 29 start-page: 719 year: 2001 ident: 10.1016/j.pupt.2013.10.002_bib31 article-title: Therapeutic time-window of a group IIA phospholipase A2 inhibitor in rabbit acute lung injury: correlation with lung surfactant protection publication-title: Crit Care Med doi: 10.1097/00003246-200104000-00004 – volume: 168 start-page: 692 year: 2003 ident: 10.1016/j.pupt.2013.10.002_bib26 article-title: Surfactant protein-A and phosphatidylglycerol suppress type IIA phospholipase A2 synthesis via nuclear factor-κB publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200304-467OC – volume: 156 start-page: 1969 year: 1997 ident: 10.1016/j.pupt.2013.10.002_bib42 article-title: Neutrophil apoptosis in the acute respiratory distress syndrome publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.156.6.96-12081 – volume: 284 start-page: 25488 year: 2009 ident: 10.1016/j.pupt.2013.10.002_bib14 article-title: Anionic pulmonary surfactant phospholipids inhibit inflammatory responses from alveolar macrophages and U937 cells by binding the lipopolysaccharide-interacting proteins CD14 and MD-2 publication-title: J Biol Chem doi: 10.1074/jbc.M109.040832 – volume: 129 start-page: 65 year: 2001 ident: 10.1016/j.pupt.2013.10.002_bib16 article-title: A comparison of the molecular species compositions of mammalian lung surfactant phospholipids publication-title: Comp Biochem Physiol Part A doi: 10.1016/S1095-6433(01)00306-3 – volume: 89 start-page: 1218 year: 2000 ident: 10.1016/j.pupt.2013.10.002_bib24 article-title: Surfactant phospholipids and surfactant activity among preterm infants with respiratory distress syndrome who develop bronchopulmonary dysplasia publication-title: Acta Paediatr doi: 10.1111/j.1651-2227.2000.tb00739.x – volume: 175 start-page: 4069 year: 2005 ident: 10.1016/j.pupt.2013.10.002_bib41 article-title: Fas-mediated acute lung injury requires Fas expression on nonmyeloid cells of the lung publication-title: J Immunol doi: 10.4049/jimmunol.175.6.4069 – volume: 1792 start-page: 941 year: 2009 ident: 10.1016/j.pupt.2013.10.002_bib18 article-title: Phospholipase A2 subclasses in acute respiratory distress syndrome publication-title: Biochim Biophys Acta doi: 10.1016/j.bbadis.2009.06.007 – volume: 27 start-page: 347 year: 2011 ident: 10.1016/j.pupt.2013.10.002_bib47 article-title: The ins and outs of the epithelial to mesenchymal transition in health and disease publication-title: Annu Rev Cell Dev Biol doi: 10.1146/annurev-cellbio-092910-154036 – volume: 35 start-page: 1312 year: 2010 ident: 10.1016/j.pupt.2013.10.002_bib20 article-title: Alveolar fibroblasts in acute lung injury: biological behaviour and clinical relevance publication-title: Eur Respir J doi: 10.1183/09031936.00074709 – volume: 55 start-page: 183 year: 2004 ident: 10.1016/j.pupt.2013.10.002_bib44 article-title: Apotosis in lung development and neonatal lung injury publication-title: Pediatr Res doi: 10.1203/01.PDR.0000103930.93849.B2 – year: 2013 ident: 10.1016/j.pupt.2013.10.002_bib55 article-title: Multiwall carbon nanotubules mediate macrophage activation and promote pulmonary fibrosis through TGF-β/Smad signaling pathway publication-title: Small doi: 10.1002/smll.201300607 – volume: 37 start-page: 387 year: 2007 ident: 10.1016/j.pupt.2013.10.002_bib35 article-title: Activity and inhibition resistance of a phospholipase-resistant synthetic surfactant in rat lungs publication-title: Am J Respir Cell Mol Biol doi: 10.1165/rcmb.2006-0434OC – volume: 159 start-page: 391 year: 1997 ident: 10.1016/j.pupt.2013.10.002_bib28 article-title: Endotoxin induces expression of type II phospholipase A2 in macrophages during acute lung injury in guinea pigs publication-title: J Immunol doi: 10.4049/jimmunol.159.1.391 – volume: 113 start-page: 383 year: 2006 ident: 10.1016/j.pupt.2013.10.002_bib36 article-title: Postnatal functional maturation in blood phagocytes in pig publication-title: Vet Immunol Immunopathol doi: 10.1016/j.vetimm.2006.06.008 – volume: 37 start-page: S30 year: 2009 ident: 10.1016/j.pupt.2013.10.002_bib53 article-title: Animal models of sepsis: why does preclinical efficacy fail to translate to the clinical setting? publication-title: Crit Care Med doi: 10.1097/CCM.0b013e3181922bd3 – volume: 16 start-page: 175 year: 2010 ident: 10.1016/j.pupt.2013.10.002_bib11 article-title: Chemical and structural modifications of pulmonary collectins and their functional consequences publication-title: Innate Immun doi: 10.1177/1753425910368871 – volume: 103 start-page: 13180 year: 2006 ident: 10.1016/j.pupt.2013.10.002_bib19 article-title: Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0605669103 – volume: 183 start-page: 1055 year: 2011 ident: 10.1016/j.pupt.2013.10.002_bib5 article-title: Recombinant surfactant protein C-based surfactant for patients with severe direct lung injury publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201009-1424OC – volume: 107 start-page: 320 year: 2010 ident: 10.1016/j.pupt.2013.10.002_bib15 article-title: Pulmonary surfactant phosphatidylglycerol inhibits respiratory syncytial virus-induced inflammation and infection publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0909361107 – volume: 154 start-page: 64 year: 2008 ident: 10.1016/j.pupt.2013.10.002_bib25 article-title: X-ray diffraction measurement of the monolayer spontaneous curvature of dioleoylphosphatidylglycerol publication-title: Chem Phys Lipids doi: 10.1016/j.chemphyslip.2008.03.007 – volume: 39 start-page: 461 year: 1993 ident: 10.1016/j.pupt.2013.10.002_bib37 article-title: Reactivities of 20 anti-human monoclonal antibodies with leukocytes from ten different animal species publication-title: Vet Immunol Immunopathol doi: 10.1016/0165-2427(93)90075-F – volume: 171 start-page: 995 year: 2005 ident: 10.1016/j.pupt.2013.10.002_bib10 article-title: Pediatric acute lung injury publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200404-544OC – volume: 12 start-page: e20 year: 2011 ident: 10.1016/j.pupt.2013.10.002_bib29 article-title: Secretory phospholipase A2 pathway during pediatric acute respiratory distress syndrome: a preliminary study publication-title: Pediatr Crit Care Med doi: 10.1097/PCC.0b013e3181dbe95e – volume: 7 start-page: 2885 year: 1993 ident: 10.1016/j.pupt.2013.10.002_bib40 article-title: Involvement of CD14 in lipopolysaccharide-induced tumor necrosis factor-α, IL-6 and IL-8 release by human monocytes and alveolar macrophages publication-title: J Immunol doi: 10.4049/jimmunol.150.7.2885 – volume: 35 start-page: 755 year: 2007 ident: 10.1016/j.pupt.2013.10.002_bib46 article-title: A contributive result of open-lung biopsy improves survival in acute respiratory distress syndrome patients publication-title: Crit Care Med doi: 10.1097/01.CCM.0000257325.88144.30 – volume: 21 start-page: 1040 year: 2003 ident: 10.1016/j.pupt.2013.10.002_bib32 article-title: Induction of type-IIA secretory phospholipase A2 in animal models of acute lung injury publication-title: Eur Respir J doi: 10.1183/09031936.03.00093002 – volume: 272 start-page: L925 year: 1997 ident: 10.1016/j.pupt.2013.10.002_bib38 article-title: Bronchoalveolar macrophage CD14 expression: shift between membrane-associated and soluble pools publication-title: Am J Physiol Lung Cell Mol Physiol doi: 10.1152/ajplung.1997.272.5.L925 |
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| Snippet | 18:1/18:1-Dioleoyl-phosphatidylgycerol (DOPG) is a surfactant phospholipid that is nearly non-detectable in neonatal surfactant films. When alveolar... Abstract Background 18:1/18:1-Dioleoyl-phosphatidylgycerol (DOPG) is a surfactant phospholipid that is nearly non-detectable in neonatal surfactant films. When... |
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| SubjectTerms | (Neonatal) acute respiratory distress syndrome Airway epithelial cells Animals Animals, Newborn Apoptosis - drug effects Disease Models, Animal Epithelial Cells - drug effects Epithelial Cells - pathology Epithelial-to-mesenchymal transition Female Fibrous lung repair Macrophages, Alveolar - drug effects Macrophages, Alveolar - metabolism Male Medical Education Phosphatidylglycerols Phosphatidylglycerols - pharmacology Pulmonary Alveoli - cytology Pulmonary Alveoli - drug effects Pulmonary Alveoli - pathology Pulmonary Edema - prevention & control Pulmonary Fibrosis - pathology Pulmonary Fibrosis - prevention & control Pulmonary Surfactants - pharmacology Pulmonary/Respiratory Respiration, Artificial Respiratory Distress Syndrome, Newborn - prevention & control Secretory phospholipase A2 Swine |
| Title | 18:1/18:1-Dioleoyl-phosphatidylglycerol prevents alveolar epithelial apoptosis and profibrotic stimulus in a neonatal piglet model of acute respiratory distress syndrome |
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