Estimation of German KIR Allele Group Haplotype Frequencies
The impact of the highly polymorphic Killer-cell immunoglobulin-like receptor ( ) gene cluster on the outcome of hematopoietic stem cell transplantation (HCST) is subject of current research. To further understand the involvement of this gene family into Natural Killer (NK) cell-mediated graft-versu...
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| Published in | Frontiers in immunology Vol. 11; p. 429 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
12.03.2020
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1664-3224 1664-3224 |
| DOI | 10.3389/fimmu.2020.00429 |
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| Abstract | The impact of the highly polymorphic Killer-cell immunoglobulin-like receptor (
) gene cluster on the outcome of hematopoietic stem cell transplantation (HCST) is subject of current research. To further understand the involvement of this gene family into Natural Killer (NK) cell-mediated graft-versus-leukemia reactions, knowledge of haplotype structures, and allelic linkage is of importance. In this analysis, we estimate population-specific
haplotype frequencies at allele group resolution in a cohort of
= 458 German families. We addressed the polymorphism of the
gene complex and phasing ambiguities by a combined approach. Haplotype inference within first-degree family relations allowed us to limit the number of possible diplotypes. Structural restriction to a pattern set of 92 previously described
copy number haplotypes further reduced ambiguities.
haplotype frequency estimation was finally accomplished by means of an expectation-maximization algorithm. Applying a resolution threshold of ½
, we were able to identify a set of 551
allele group haplotypes, representing 21
copy number haplotypes. The haplotype frequencies allow studying linkage disequilibrium in two-locus as well as in multi-locus analyses. Our study reveals associations between
haplotype structures and allele group frequencies, thereby broadening our understanding of the
gene complex. |
|---|---|
| AbstractList | The impact of the highly polymorphic Killer-cell immunoglobulin-like receptor (KIR) gene cluster on the outcome of hematopoietic stem cell transplantation (HCST) is subject of current research. To further understand the involvement of this gene family into Natural Killer (NK) cell-mediated graft-versus-leukemia reactions, knowledge of haplotype structures, and allelic linkage is of importance. In this analysis, we estimate population-specific KIR haplotype frequencies at allele group resolution in a cohort of n = 458 German families. We addressed the polymorphism of the KIR gene complex and phasing ambiguities by a combined approach. Haplotype inference within first-degree family relations allowed us to limit the number of possible diplotypes. Structural restriction to a pattern set of 92 previously described KIR copy number haplotypes further reduced ambiguities. KIR haplotype frequency estimation was finally accomplished by means of an expectation-maximization algorithm. Applying a resolution threshold of ½ n, we were able to identify a set of 551 KIR allele group haplotypes, representing 21 KIR copy number haplotypes. The haplotype frequencies allow studying linkage disequilibrium in two-locus as well as in multi-locus analyses. Our study reveals associations between KIR haplotype structures and allele group frequencies, thereby broadening our understanding of the KIR gene complex. The impact of the highly polymorphic Killer-cell immunoglobulin-like receptor (KIR) gene cluster on the outcome of hematopoietic stem cell transplantation (HCST) is subject of current research. To further understand the involvement of this gene family into Natural Killer (NK) cell-mediated graft-versus-leukemia reactions, knowledge of haplotype structures, and allelic linkage is of importance. In this analysis, we estimate population-specific KIR haplotype frequencies at allele group resolution in a cohort of n = 458 German families. We addressed the polymorphism of the KIR gene complex and phasing ambiguities by a combined approach. Haplotype inference within first-degree family relations allowed us to limit the number of possible diplotypes. Structural restriction to a pattern set of 92 previously described KIR copy number haplotypes further reduced ambiguities. KIR haplotype frequency estimation was finally accomplished by means of an expectation-maximization algorithm. Applying a resolution threshold of ½ n, we were able to identify a set of 551 KIR allele group haplotypes, representing 21 KIR copy number haplotypes. The haplotype frequencies allow studying linkage disequilibrium in two-locus as well as in multi-locus analyses. Our study reveals associations between KIR haplotype structures and allele group frequencies, thereby broadening our understanding of the KIR gene complex.The impact of the highly polymorphic Killer-cell immunoglobulin-like receptor (KIR) gene cluster on the outcome of hematopoietic stem cell transplantation (HCST) is subject of current research. To further understand the involvement of this gene family into Natural Killer (NK) cell-mediated graft-versus-leukemia reactions, knowledge of haplotype structures, and allelic linkage is of importance. In this analysis, we estimate population-specific KIR haplotype frequencies at allele group resolution in a cohort of n = 458 German families. We addressed the polymorphism of the KIR gene complex and phasing ambiguities by a combined approach. Haplotype inference within first-degree family relations allowed us to limit the number of possible diplotypes. Structural restriction to a pattern set of 92 previously described KIR copy number haplotypes further reduced ambiguities. KIR haplotype frequency estimation was finally accomplished by means of an expectation-maximization algorithm. Applying a resolution threshold of ½ n, we were able to identify a set of 551 KIR allele group haplotypes, representing 21 KIR copy number haplotypes. The haplotype frequencies allow studying linkage disequilibrium in two-locus as well as in multi-locus analyses. Our study reveals associations between KIR haplotype structures and allele group frequencies, thereby broadening our understanding of the KIR gene complex. The impact of the highly polymorphic Killer-cell immunoglobulin-like receptor ( ) gene cluster on the outcome of hematopoietic stem cell transplantation (HCST) is subject of current research. To further understand the involvement of this gene family into Natural Killer (NK) cell-mediated graft-versus-leukemia reactions, knowledge of haplotype structures, and allelic linkage is of importance. In this analysis, we estimate population-specific haplotype frequencies at allele group resolution in a cohort of = 458 German families. We addressed the polymorphism of the gene complex and phasing ambiguities by a combined approach. Haplotype inference within first-degree family relations allowed us to limit the number of possible diplotypes. Structural restriction to a pattern set of 92 previously described copy number haplotypes further reduced ambiguities. haplotype frequency estimation was finally accomplished by means of an expectation-maximization algorithm. Applying a resolution threshold of ½ , we were able to identify a set of 551 allele group haplotypes, representing 21 copy number haplotypes. The haplotype frequencies allow studying linkage disequilibrium in two-locus as well as in multi-locus analyses. Our study reveals associations between haplotype structures and allele group frequencies, thereby broadening our understanding of the gene complex. |
| Author | Schäfer, Gesine Schefzyk, Daniel Massalski, Carolin Lange, Vinzenz Pruschke, Jens Solloch, Ute V. Sauter, Jürgen Kohler, Maja Heidl, Annett Schmidt, Alexander H. Schetelig, Johannes |
| AuthorAffiliation | 1 DKMS , Tübingen , Germany 3 University Hospital Carl Gustav Carus , Dresden , Germany 2 DKMS Life Science Lab , Dresden , Germany |
| AuthorAffiliation_xml | – name: 2 DKMS Life Science Lab , Dresden , Germany – name: 3 University Hospital Carl Gustav Carus , Dresden , Germany – name: 1 DKMS , Tübingen , Germany |
| Author_xml | – sequence: 1 givenname: Ute V. surname: Solloch fullname: Solloch, Ute V. – sequence: 2 givenname: Daniel surname: Schefzyk fullname: Schefzyk, Daniel – sequence: 3 givenname: Gesine surname: Schäfer fullname: Schäfer, Gesine – sequence: 4 givenname: Carolin surname: Massalski fullname: Massalski, Carolin – sequence: 5 givenname: Maja surname: Kohler fullname: Kohler, Maja – sequence: 6 givenname: Jens surname: Pruschke fullname: Pruschke, Jens – sequence: 7 givenname: Annett surname: Heidl fullname: Heidl, Annett – sequence: 8 givenname: Johannes surname: Schetelig fullname: Schetelig, Johannes – sequence: 9 givenname: Alexander H. surname: Schmidt fullname: Schmidt, Alexander H. – sequence: 10 givenname: Vinzenz surname: Lange fullname: Lange, Vinzenz – sequence: 11 givenname: Jürgen surname: Sauter fullname: Sauter, Jürgen |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32226430$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1182/blood-2003-01-0091 10.1186/1471-2164-15-63 10.1182/blood-2008-07-171926 10.1038/s41439-018-0030-x 10.4049/jimmunol.171.5.2192 10.1038/gene.2011.35 10.1038/nri3370 10.1093/genetics/49.1.49 10.1159/000070664 10.4049/jimmunol.1801586 10.1101/gr.137976.112 10.1073/pnas.080588597 10.1084/jem.20042558 10.1056/NEJMoa1200503 10.1371/journal.pone.0047491 10.1093/hmg/ddp538 10.1016/j.humimm.2017.10.001 10.1002/eji.200425493 10.1111/j.1365-2141.2005.05797.x 10.1371/journal.pone.0015115 10.1186/1471-2164-14-89 10.3389/fmed.2020.00032 10.1371/journal.pone.0086605 10.1038/bmt.2012.189 10.1007/s00251-006-0181-7 10.1007/s002510050453 10.1182/blood.2019001212 10.3389/fimmu.2017.00041 10.4049/jimmunol.168.5.2307 10.1038/gene.2011.52 10.1182/blood-2017-08-752170 10.4049/jimmunol.169.9.5118 10.1002/eji.200323741 10.1371/journal.pmed.0040008 10.1182/blood-2007-01-065383 10.1182/blood.2019002887 10.1007/s00251-002-0463-7 10.1186/s12864-017-3575-z 10.1126/science.1068440 10.1182/blood-2007-06-097386 10.3389/fimmu.2018.02843 10.1111/j.1365-2567.2009.03208.x 10.1182/blood-2014-05-576041 10.3389/fimmu.2019.00989 10.1101/gr.085738.108 10.1038/s41409-019-0559-4 10.1371/journal.pone.0163973 10.1182/blood.V94.1.333.413a31_333_339 10.1038/s41409-019-0520-6 10.4049/jimmunol.168.12.6208 10.3389/fimmu.2012.00258 10.1093/nar/gki032 10.1016/j.bbmt.2018.09.020 10.3389/fimmu.2018.02846 10.1016/S1074-7613(00)80394-5 10.3389/fimmu.2020.00314 10.1038/gene.2017.10 10.3389/fimmu.2012.00289 10.1186/s12864-016-2687-1 10.1200/JCO.2016.70.7059 10.1016/S0198-8859(03)00067-3 10.1038/nri3174 10.1371/journal.pone.0135960 10.3389/fimmu.2016.00144 10.1038/gene.2008.34 10.1111/tan.12817 |
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| Copyright | Copyright © 2020 Solloch, Schefzyk, Schäfer, Massalski, Kohler, Pruschke, Heidl, Schetelig, Schmidt, Lange and Sauter. Copyright © 2020 Solloch, Schefzyk, Schäfer, Massalski, Kohler, Pruschke, Heidl, Schetelig, Schmidt, Lange and Sauter. 2020 Solloch, Schefzyk, Schäfer, Massalski, Kohler, Pruschke, Heidl, Schetelig, Schmidt, Lange and Sauter |
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| Keywords | immunogenetics donor selection KIR HSCT haplotype frequency |
| Language | English |
| License | Copyright © 2020 Solloch, Schefzyk, Schäfer, Massalski, Kohler, Pruschke, Heidl, Schetelig, Schmidt, Lange and Sauter. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. cc-by |
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| References | Buhler (B43) 2019; 54 Shilling (B7) 1998; 48 Gomez-Lozano (B10) 2005; 35 Gómes-Lozano (B22) 2003; 33 Marsh (B1) 2003; 64 Ullah (B26) 2016; 7 Vierra-Green (B44) 2012; 7 Cisneros (B61) 2012; 3 Solloch (B58) 2017; 78 Parham (B17) 2013; 13 Ordonez (B60) 2008; 9 Rajagopalan (B21) 2012; 3 Cooley (B33) 2009; 113 Schöfl (B56) 2017; 18 Jiang (B4) 2012; 22 Urban (B38) 2020; 7 Nemat-Gorgani (B66) 2019; 202 Okada (B65) 2018; 5 Hollenbach (B67) 2015; 10 Augusto (B6) 2019; 10 Joris (B42) 2013; 48 Pyo (B50) 2013; 14 Traherne (B12) 2010; 19 Ruggeri (B28) 2002; 295 Shilling (B51) 2002; 168 Norman (B11) 2009; 19 Pidala (B24) 2014; 124 Lange (B55) 2014; 15 Boudreau (B35) 2017 Petersdorf (B41) 2007; 4 Abi-Rached (B9) 2005; 201 Schmidt (B54) 2019; 25 Bochtler (B39) 2016; 87 Lewontin (B63) 1964; 49 Wagner (B53) 2018; 9 Giebel (B29) 2003; 102 Robinson (B5) 2005; 33 Ordonez (B13) 2011; 12 Wilson (B2) 2000; 97 Faure (B20) 2002; 168 Uhrberg (B19) 1997; 7 Heidenreich (B32) 2017; 8 Klussmeier (B59) 2020; 11 Venstrom (B34) 2012; 367 Uhrberg (B47) 2002; 54 Dehn (B25) 2019; 134 Lang (B57) 2016; 17 Vierra-Green (B45) 2016; 11 Vivier (B16) 2012; 12 Martin (B8) 2003; 171 Giebel (B30) 2005; 131 Hsu (B46) 2002; 169 Middleton (B49) 2007; 59 Miller (B31) 2007; 109 Schmidt (B40) 2014; 9 Hou (B52) 2012; 13 Middleton (B3) 2010; 129 Cooley (B18) 2018; 131 Roe (B14) 2017; 18 Schetelig (B37) 2020 Bruijnesteijn (B15) 2018; 9 Lee (B23) 2007; 110 Schetelig (B36) 2019; 54 Ruggeri (B27) 1999; 94 Pyo (B48) 2010; 5 Nothnagel (B64) 2002; 54 Excoffier (B62) 1995; 12 |
| References_xml | – volume: 102 start-page: 814 year: 2003 ident: B29 article-title: Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors publication-title: Blood doi: 10.1182/blood-2003-01-0091 – volume: 15 start-page: 63 year: 2014 ident: B55 article-title: Cost-efficient high-throughput HLA typing by MiSeq amplicon sequencing publication-title: BMC Genomics doi: 10.1186/1471-2164-15-63 – volume: 113 start-page: 726 year: 2009 ident: B33 article-title: Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia publication-title: Blood doi: 10.1182/blood-2008-07-171926 – volume: 5 start-page: 29 year: 2018 ident: B65 article-title: eLD: Entropy-based linkage disequilibrium index between multiallelic sites publication-title: Hum Genome Var doi: 10.1038/s41439-018-0030-x – volume: 171 start-page: 2192 year: 2003 ident: B8 article-title: Cutting edge: expansion of the KIR locus by unequal crossing over publication-title: J Immunol doi: 10.4049/jimmunol.171.5.2192 – volume: 12 start-page: 544 year: 2011 ident: B13 article-title: Molecular characterisation of KIR2DS2*005, a fusion gene associated with a shortened KIR haplotype publication-title: Genes Immun doi: 10.1038/gene.2011.35 – volume: 13 start-page: 133 year: 2013 ident: B17 article-title: Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution publication-title: Nat Rev Immunol doi: 10.1038/nri3370 – volume: 49 start-page: 49 year: 1964 ident: B63 article-title: The interaction of selection and linkage. I general considerations; heterotic models publication-title: Genetics doi: 10.1093/genetics/49.1.49 – volume: 54 start-page: 186 year: 2002 ident: B64 article-title: Entropy as a measure for linkage disequilibrium over multilocus haplotype blocks publication-title: Hum Hered doi: 10.1159/000070664 – volume: 12 start-page: 921 year: 1995 ident: B62 article-title: Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population publication-title: Mol Biol Evol – volume: 202 start-page: 2636 year: 2019 ident: B66 article-title: Diversity of KIR, HLA class I, and their interactions in seven populations of Sub-Saharan Africans publication-title: J Immunol doi: 10.4049/jimmunol.1801586 – volume: 22 start-page: 1845 year: 2012 ident: B4 article-title: Copy number variation leads to considerable diversity for B but not A haplotypes of the human KIR genes encoding NK cell receptors publication-title: Genome Res doi: 10.1101/gr.137976.112 – volume: 97 start-page: 4778 year: 2000 ident: B2 article-title: Plasticity in the organization and sequences of human KIR/ILT gene families publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.080588597 – volume: 201 start-page: 1319 year: 2005 ident: B9 article-title: Natural selection drives recurrent formation of activating killer cell immunoglobulin-like receptor and Ly49 from inhibitory homologues publication-title: J Exp Med doi: 10.1084/jem.20042558 – volume: 367 start-page: 805 year: 2012 ident: B34 article-title: HLA-C-dependent prevention of leukemia relapse by donor activating KIR2DS1 publication-title: N Engl J Med doi: 10.1056/NEJMoa1200503 – volume: 7 start-page: e47491 year: 2012 ident: B44 article-title: Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals publication-title: PLoS ONE. doi: 10.1371/journal.pone.0047491 – volume: 19 start-page: 737 year: 2010 ident: B12 article-title: Mechanisms of copy number variation and hybrid gene formation in the KIR immune gene complex publication-title: Hum Mol Genet doi: 10.1093/hmg/ddp538 – volume: 78 start-page: 710 year: 2017 ident: B58 article-title: Frequencies of gene variant CCR5-Δ32 in 87 countries based on next-generation sequencing of 1.3 million individuals sampled from 3 national DKMS donor centers publication-title: Hum Immunol. doi: 10.1016/j.humimm.2017.10.001 – volume: 35 start-page: 16 year: 2005 ident: B10 article-title: The silent KIR3DP1 gene (CD158c) is transcribed and might encode a secreted receptor in a minority of humans, in whom the KIR3DP1, KIR2DL4 and KIR3DL1/KIR3DS1 genes are duplicated publication-title: Eur J Immunol doi: 10.1002/eji.200425493 – volume: 131 start-page: 483 year: 2005 ident: B30 article-title: Homozygosity for human leucocyte antigen-C ligands of KIR2DL1 is associated with increased risk of relapse after human leucocyte antigen-C-matched unrelated donor haematopoietic stem cell transplantation publication-title: Br J Haematol doi: 10.1111/j.1365-2141.2005.05797.x – volume: 5 start-page: e15115 year: 2010 ident: B48 article-title: Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus publication-title: PLoS ONE. doi: 10.1371/journal.pone.0015115 – volume: 14 start-page: 89 year: 2013 ident: B50 article-title: Recombinant structures expand and contract inter and intragenic diversification at the KIR locus publication-title: BMC Genomics doi: 10.1186/1471-2164-14-89 – volume: 7 start-page: 32 year: 2020 ident: B38 article-title: Hap-E Search 2.0: improving the performance of a probabilistic donor-recipient matching algorithm based on haplotype frequencies publication-title: Front Med. doi: 10.3389/fmed.2020.00032 – volume: 9 start-page: e86605 year: 2014 ident: B40 article-title: Toward an optimal global stem cell donor recruitment strategy publication-title: PLoS ONE doi: 10.1371/journal.pone.0086605 – volume: 48 start-page: 483 year: 2013 ident: B42 article-title: The impact of frequent HLA haplotypes in high linkage disequilibrium on donor search and clinical outcome after unrelated haematopoietic SCT publication-title: Bone Marrow Transplant. doi: 10.1038/bmt.2012.189 – volume: 59 start-page: 145 year: 2007 ident: B49 article-title: KIR haplotype content at the allele level in 77 Northern Irish families publication-title: Immunogenetics doi: 10.1007/s00251-006-0181-7 – volume: 48 start-page: 413 year: 1998 ident: B7 article-title: Evidence for recombination as a mechanism for KIR diversification publication-title: Immunogenetics doi: 10.1007/s002510050453 – volume: 134 start-page: 924 year: 2019 ident: B25 article-title: Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from NMDP/CIBMTR publication-title: Blood doi: 10.1182/blood.2019001212 – volume: 8 start-page: 41 year: 2017 ident: B32 article-title: Reduction of relapse after unrelated donor stem cell transplantation by KIR-based graft selection publication-title: Front Immunol doi: 10.3389/fimmu.2017.00041 – volume: 168 start-page: 2307 year: 2002 ident: B51 article-title: Allelic polymorphism synergizes with variable gene content to individualize human KIR genotype publication-title: J Immunol doi: 10.4049/jimmunol.168.5.2307 – volume: 13 start-page: 47 year: 2012 ident: B52 article-title: Conserved KIR allele-level haplotypes are altered by microvariation in individuals with European ancestry publication-title: Genes Immun doi: 10.1038/gene.2011.52 – volume: 131 start-page: 1053 year: 2018 ident: B18 article-title: Strategies to activate NK cells to prevent relapse and induce remission following hematopoietic stem cell transplantation publication-title: Blood doi: 10.1182/blood-2017-08-752170 – volume: 169 start-page: 5118 year: 2002 ident: B46 article-title: Killer Ig-Like receptor haplotype analysis by gene content: evidence for genomic diversity with a minimum of six basic framework haplotypes, each with multiple subsets publication-title: J Immunol doi: 10.4049/jimmunol.169.9.5118 – volume: 33 start-page: 639 year: 2003 ident: B22 article-title: Recognition of HLA-G by the NK cell receptor KIR2DL4 is not essential for human reproduction publication-title: Eur J Immunol doi: 10.1002/eji.200323741 – volume: 4 start-page: e8 year: 2007 ident: B41 article-title: MHC haplotype matching for unrelated hematopoietic cell transplantation publication-title: PLoS Med doi: 10.1371/journal.pmed.0040008 – volume: 109 start-page: 5058 year: 2007 ident: B31 article-title: Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCT publication-title: Blood doi: 10.1182/blood-2007-01-065383 – year: 2020 ident: B37 article-title: External validation of models for KIR2DS1/KIR3DL1-informed Selection of hematopoietic cell donors fails publication-title: Blood doi: 10.1182/blood.2019002887 – volume: 54 start-page: 221 year: 2002 ident: B47 article-title: Definition of gene content for nine common group B haplotypes of the caucasoid population: KIR haplotypes contain between seven and eleven KIR genes publication-title: Immunogenetics doi: 10.1007/s00251-002-0463-7 – volume: 18 start-page: 161 year: 2017 ident: B56 article-title: 2.7 million samples genotyped for HLA by next generation sequencing: lessons learned publication-title: BMC Genomics doi: 10.1186/s12864-017-3575-z – volume: 295 start-page: 2097 year: 2002 ident: B28 article-title: Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants publication-title: Science doi: 10.1126/science.1068440 – volume: 110 start-page: 4576 year: 2007 ident: B23 article-title: High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation publication-title: Blood doi: 10.1182/blood-2007-06-097386 – volume: 9 start-page: 2843 year: 2018 ident: B53 article-title: Allele-level KIR genotyping of more than a million samples: workflow, algorithm, and observations publication-title: Front Immunol doi: 10.3389/fimmu.2018.02843 – volume: 129 start-page: 8 year: 2010 ident: B3 article-title: The extensive polymorphism of KIR genes publication-title: Immunology doi: 10.1111/j.1365-2567.2009.03208.x – volume: 124 start-page: 2596 year: 2014 ident: B24 article-title: Nonpermissive HLA-DPB1 mismatch increases mortality after myeloablative unrelated allogeneic hematopoietic cell transplantation publication-title: Blood doi: 10.1182/blood-2014-05-576041 – volume: 10 start-page: 989 year: 2019 ident: B6 article-title: Fluctuating and geographically specific selection characterize rapid evolution of the human KIR region publication-title: Front Immunol doi: 10.3389/fimmu.2019.00989 – volume: 19 start-page: 757 year: 2009 ident: B11 article-title: Meiotic recombination generates rich diversity in NK cell receptor genes, alleles, and haplotypes publication-title: Genome Res doi: 10.1101/gr.085738.108 – volume: 54 start-page: 561 year: 2019 ident: B36 article-title: Does donor KIR-genotype impact outcome after unrelated hematopoietic stem cell transplantation for myelodysplastic syndromes or secondary acute myeloid leukemia? publication-title: Bone Marrow Transplant doi: 10.1038/s41409-019-0559-4 – volume: 11 start-page: e0163973 year: 2016 ident: B45 article-title: Estimating KIR haplotype frequencies on a cohort of 10,000 individuals: a comprehensive study on population variations, typing resolutions, and reference haplotypes publication-title: PLoS ONE. doi: 10.1371/journal.pone.0163973 – volume: 94 start-page: 333 year: 1999 ident: B27 article-title: Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation publication-title: Blood doi: 10.1182/blood.V94.1.333.413a31_333_339 – volume: 54 start-page: 1701 year: 2019 ident: B43 article-title: High-resolution HLA phased haplotype frequencies to predict the success of unrelated donor searches and clinical outcome following hematopoietic stem cell transplantation publication-title: Bone Marrow Transplant doi: 10.1038/s41409-019-0520-6 – volume: 168 start-page: 6208 year: 2002 ident: B20 article-title: KIR2DL4 (CD158d), an NK cell-activating receptor with inhibitory potential publication-title: J Immunol doi: 10.4049/jimmunol.168.12.6208 – volume: 3 start-page: 258 year: 2012 ident: B21 article-title: KIR2DL4 (CD158d): An activation receptor for HLA-G publication-title: Front Immunol doi: 10.3389/fimmu.2012.00258 – volume: 33 start-page: D523 year: 2005 ident: B5 article-title: IPD–the immuno polymorphism database publication-title: Nucleic Acids Res doi: 10.1093/nar/gki032 – volume: 25 start-page: e39 year: 2019 ident: B54 article-title: KIR genotyping data of more than 3 million individuals are available for global unrelated stem cell donor searches. (comment to: Weisdorf D, Cooley S, Wang T, et al. KIR donor selection: feasibility in identifying better donors) publication-title: Biol Blood Marrow Transplant doi: 10.1016/j.bbmt.2018.09.020 – volume: 9 start-page: 2846 year: 2018 ident: B15 article-title: Extensive alternative splicing of KIR transcripts publication-title: Front Immunol doi: 10.3389/fimmu.2018.02846 – volume: 7 start-page: 753 year: 1997 ident: B19 article-title: Human diversity in killer cell inhibitory receptor genes publication-title: Immunity doi: 10.1016/S1074-7613(00)80394-5 – volume: 11 start-page: 314 year: 2020 ident: B59 article-title: High-throughput MICA/B genotyping of over two million samples: workflow and allele frequencies publication-title: Front Immunol. doi: 10.3389/fimmu.2020.00314 – volume: 18 start-page: 127 year: 2017 ident: B14 article-title: Revealing complete complex KIR haplotypes phased by long-read sequencing technology publication-title: Genes Immun doi: 10.1038/gene.2017.10 – volume: 3 start-page: 289 year: 2012 ident: B61 article-title: KIR2DL5: an orphan inhibitory receptor displaying complex patterns of polymorphism and expression publication-title: Front Immunol doi: 10.3389/fimmu.2012.00289 – volume: 17 start-page: 374 year: 2016 ident: B57 article-title: ABO allele-level frequency estimation based on population-scale genotyping by next generation sequencing publication-title: BMC Genomics doi: 10.1186/s12864-016-2687-1 – year: 2017 ident: B35 article-title: KIR3DL1/HLA-B subtypes govern acute myelogenous leukemia relapse after hematopoietic cell transplantation publication-title: J Clin Oncol doi: 10.1200/JCO.2016.70.7059 – volume: 64 start-page: 648 year: 2003 ident: B1 article-title: Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002 publication-title: Hum Immunol doi: 10.1016/S0198-8859(03)00067-3 – volume: 12 start-page: 239 year: 2012 ident: B16 article-title: Targeting natural killer cells and natural killer T cells in cancer publication-title: Nat Rev Immunol doi: 10.1038/nri3174 – volume: 10 start-page: e0135960 year: 2015 ident: B67 article-title: Race, ethnicity and ancestry in unrelated transplant matching for the national marrow donor program: a comparison of multiple forms of self-identification with genetics publication-title: PLoS ONE. doi: 10.1371/journal.pone.0135960 – volume: 7 start-page: 144 year: 2016 ident: B26 article-title: Functional Reconstitution of natural killer cells in allogeneic hematopoietic stem cell transplantation publication-title: Front Immunol doi: 10.3389/fimmu.2016.00144 – volume: 9 start-page: 431 year: 2008 ident: B60 article-title: Duplication, mutation and recombination of the human orphan gene KIR2DS3 contribute to the diversity of KIR haplotypes publication-title: Genes Immun doi: 10.1038/gene.2008.34 – volume: 87 start-page: 439 year: 2016 ident: B39 article-title: A comparative reference study for the validation of HLA-matching algorithms in the search for allogeneic hematopoietic stem cell donors and cord blood units publication-title: HLA doi: 10.1111/tan.12817 |
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| SubjectTerms | Alleles Cohort Studies donor selection European Continental Ancestry Group - genetics Gene Frequency Germany haplotype frequency Haplotypes HSCT Humans immunogenetics Immunology KIR Receptors, KIR - genetics |
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| Title | Estimation of German KIR Allele Group Haplotype Frequencies |
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