hs-CRP is strongly associated with coronary heart disease (CHD): A data mining approach using decision tree algorithm

• Published in: Computer methods and programs in biomedicine Vol. 141; pp. 105 - 109
• Main Authors: Tayefi, Maryam, Tajfard, Mohammad, Saffar, Sara, Hanachi, Parichehr, Amirabadizadeh, Ali Reza, Esmaeily, Habibollah, Taghipour, Ali, Ferns, Gordon A., Moohebati, Mohsen, Ghayour-Mobarhan, Majid
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.04.2017
• Subjects: Adult; Algorithms; C-Reactive Protein - metabolism; Case-Control Studies; Coronary artery disease; Coronary Disease - epidemiology; Coronary Disease - metabolism; Data Mining; Decision tree; Decision Trees; Female; hs-CRP; Humans; Internal Medicine; Male; Middle Aged; Other; Sensitivity and Specificity; LCX; ACCF/AHA; SOFM; LR; FBG; Data mining; Decision tree; AUC; MLP; DT; HDL; DBP; LDL; RBF; hs-CRP; CA; BMI; SBP; ROC; Coronary artery disease; LAD; TC; RCA; TG; SMO; CHD; CART; Sequential minimal optimization; Self-organizing feature maps; The American College of Cardiology Foundation and the American Heart Association; Total cholesterol; Systolic blood pressure; Fasting blood glucose; Left anterior descending; multi-layer perceptron; body mass index; Diastolic blood pressure; Classification and regression tree; Triglyceride; Low density lipoprotein; Logistic regression; receiver operating characteristics; Left circumflex artery; High density lipoprotein; Highly sensitive C-reactive protein; Area under the curve; Coronary heart disease; Radial basis function; Right coronary artery; Coronary angiography
• ISSN: 0169-2607; 1872-7565; 1872-7565
• DOI: 10.1016/j.cmpb.2017.02.001

•Associated risk factors of CAD using decision tree.•Sensitivity, specificity, accuracy of 96%, 87%, 94% and respectively.•Serum hs-CRP levels as most important variable associated with CAD.•Model is accurate, specific and sensitive for investigating risk factors of CAD. Coronary heart disease (CHD) is an important public health problem globally. Algorithms incorporating the assessment of clinical biomarkers together with several established traditional risk factors can help clinicians to predict CHD and support clinical decision making with respect to interventions. Decision tree (DT) is a data mining model for extracting hidden knowledge from large databases. We aimed to establish a predictive model for coronary heart disease using a decision tree algorithm. Here we used a dataset of 2346 individuals including 1159 healthy participants and 1187 participant who had undergone coronary angiography (405 participants with negative angiography and 782 participants with positive angiography). We entered 10 variables of a total 12 variables into the DT algorithm (including age, sex, FBG, TG, hs-CRP, TC, HDL, LDL, SBP and DBP). Our model could identify the associated risk factors of CHD with sensitivity, specificity, accuracy of 96%, 87%, 94% and respectively. Serum hs-CRP levels was at top of the tree in our model, following by FBG, gender and age. Our model appears to be an accurate, specific and sensitive model for identifying the presence of CHD, but will require validation in prospective studies.