Effect of alginate supplementation on weight loss in obese subjects completing a 12-wk energy-restricted diet: a randomized controlled trial
Acute studies with alginate-based preloads suggested that these strong gelling fibers may induce increased feelings of satiety and reduce energy intakes. However, the long-term efficacy and safety of alginate supplementation on body weight regulation are lacking. The primary aim of the study was to...
Saved in:
| Published in | The American journal of clinical nutrition Vol. 96; no. 1; pp. 5 - 13 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Bethesda, MD
American Society for Nutrition
01.07.2012
American Society for Clinical Nutrition, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0002-9165 1938-3207 1938-3207 |
| DOI | 10.3945/ajcn.111.025312 |
Cover
| Abstract | Acute studies with alginate-based preloads suggested that these strong gelling fibers may induce increased feelings of satiety and reduce energy intakes. However, the long-term efficacy and safety of alginate supplementation on body weight regulation are lacking.
The primary aim of the study was to investigate the effects in subjects of alginate supplementation in conjunction with energy restriction (-300 kcal/d) on loss of body weight and fat and, second, on metabolic risk markers in comparison with in a placebo group.
In a parallel, double-blind, placebo-controlled study, we randomly assigned 96 obese subjects to either an energy-restricted diet plus a placebo preload supplement or an energy-restricted diet plus an alginate-based preload supplement (15 g fiber). The preload was administered as a beverage 3 times/d before main meals for a period of 12 wk.
No differences in loss of body weight and fat between groups were shown in the intension-to-treat (ITT) analysis (P > 0.1). However, in the completer analysis (n = 80), we showed a greater weight loss with alginate (6.78 ± 3.67 kg) than with the placebo (5.04 ± 3.40 kg) (P = 0.03), which was mainly attributed to a reduction in the percentage of body fat (P = 0.03). In the ITT analysis, a larger decrease in systolic and diastolic blood pressure was shown in the placebo group than in the alginate group (P < 0.05). Plasma concentrations of glucose, insulin, C-reactive protein, and ghrelin, HOMA-IR, and lipid metabolism did not differ between treatment groups in the ITT analysis (P > 0.1).
These results suggest that alginate supplementation as an adjunct to energy restriction may improve weight loss in obese subjects who complete a 12-wk dietary intervention. |
|---|---|
| AbstractList | Acute studies with alginate-based preloads suggested that these strong gelling fibers may induce increased feelings of satiety and reduce energy intakes. However, the long-term efficacy and safety of alginate supplementation on body weight regulation are lacking.BACKGROUNDAcute studies with alginate-based preloads suggested that these strong gelling fibers may induce increased feelings of satiety and reduce energy intakes. However, the long-term efficacy and safety of alginate supplementation on body weight regulation are lacking.The primary aim of the study was to investigate the effects in subjects of alginate supplementation in conjunction with energy restriction (-300 kcal/d) on loss of body weight and fat and, second, on metabolic risk markers in comparison with in a placebo group.OBJECTIVEThe primary aim of the study was to investigate the effects in subjects of alginate supplementation in conjunction with energy restriction (-300 kcal/d) on loss of body weight and fat and, second, on metabolic risk markers in comparison with in a placebo group.In a parallel, double-blind, placebo-controlled study, we randomly assigned 96 obese subjects to either an energy-restricted diet plus a placebo preload supplement or an energy-restricted diet plus an alginate-based preload supplement (15 g fiber). The preload was administered as a beverage 3 times/d before main meals for a period of 12 wk.DESIGNIn a parallel, double-blind, placebo-controlled study, we randomly assigned 96 obese subjects to either an energy-restricted diet plus a placebo preload supplement or an energy-restricted diet plus an alginate-based preload supplement (15 g fiber). The preload was administered as a beverage 3 times/d before main meals for a period of 12 wk.No differences in loss of body weight and fat between groups were shown in the intension-to-treat (ITT) analysis (P > 0.1). However, in the completer analysis (n = 80), we showed a greater weight loss with alginate (6.78 ± 3.67 kg) than with the placebo (5.04 ± 3.40 kg) (P = 0.03), which was mainly attributed to a reduction in the percentage of body fat (P = 0.03). In the ITT analysis, a larger decrease in systolic and diastolic blood pressure was shown in the placebo group than in the alginate group (P < 0.05). Plasma concentrations of glucose, insulin, C-reactive protein, and ghrelin, HOMA-IR, and lipid metabolism did not differ between treatment groups in the ITT analysis (P > 0.1).RESULTSNo differences in loss of body weight and fat between groups were shown in the intension-to-treat (ITT) analysis (P > 0.1). However, in the completer analysis (n = 80), we showed a greater weight loss with alginate (6.78 ± 3.67 kg) than with the placebo (5.04 ± 3.40 kg) (P = 0.03), which was mainly attributed to a reduction in the percentage of body fat (P = 0.03). In the ITT analysis, a larger decrease in systolic and diastolic blood pressure was shown in the placebo group than in the alginate group (P < 0.05). Plasma concentrations of glucose, insulin, C-reactive protein, and ghrelin, HOMA-IR, and lipid metabolism did not differ between treatment groups in the ITT analysis (P > 0.1).These results suggest that alginate supplementation as an adjunct to energy restriction may improve weight loss in obese subjects who complete a 12-wk dietary intervention.CONCLUSIONThese results suggest that alginate supplementation as an adjunct to energy restriction may improve weight loss in obese subjects who complete a 12-wk dietary intervention. Acute studies with alginate-based preloads suggested that these strong gelling fibers may induce increased feelings of satiety and reduce energy intakes. However, the long-term efficacy and safety of alginate supplementation on body weight regulation are lacking. The primary aim of the study was to investigate the effects in subjects of alginate supplementation in conjunction with energy restriction (-300 kcal/d) on loss of body weight and fat and, second, on metabolic risk markers in comparison with in a placebo group. In a parallel, double-blind, placebo-controlled study, we randomly assigned 96 obese subjects to either an energy-restricted diet plus a placebo preload supplement or an energy-restricted diet plus an alginate-based preload supplement (15 g fiber). The preload was administered as a beverage 3 times/d before main meals for a period of 12 wk. No differences in loss of body weight and fat between groups were shown in the intension-to-treat (ITT) analysis (P > 0.1). However, in the completer analysis (n = 80), we showed a greater weight loss with alginate (6.78 ± 3.67 kg) than with the placebo (5.04 ± 3.40 kg) (P = 0.03), which was mainly attributed to a reduction in the percentage of body fat (P = 0.03). In the ITT analysis, a larger decrease in systolic and diastolic blood pressure was shown in the placebo group than in the alginate group (P < 0.05). Plasma concentrations of glucose, insulin, C-reactive protein, and ghrelin, HOMA-IR, and lipid metabolism did not differ between treatment groups in the ITT analysis (P > 0.1). These results suggest that alginate supplementation as an adjunct to energy restriction may improve weight loss in obese subjects who complete a 12-wk dietary intervention. This trial was registered at clinicaltrials.gov as NCT01231178. Acute studies with alginate-based preloads suggested that these strong gelling fibers may induce increased feelings of satiety and reduce energy intakes. However, the long-term efficacy and safety of alginate supplementation on body weight regulation are lacking. The primary aim of the study was to investigate the effects in subjects of alginate supplementation in conjunction with energy restriction (-300 kcal/d) on loss of body weight and fat and, second, on metabolic risk markers in comparison with in a placebo group. In a parallel, double-blind, placebo-controlled study, we randomly assigned 96 obese subjects to either an energy-restricted diet plus a placebo preload supplement or an energy-restricted diet plus an alginate-based preload supplement (15 g fiber). The preload was administered as a beverage 3 times/d before main meals for a period of 12 wk. No differences in loss of body weight and fat between groups were shown in the intension-to-treat (ITT) analysis (P > 0.1). However, in the completer analysis (n = 80), we showed a greater weight loss with alginate (6.78 ± 3.67 kg) than with the placebo (5.04 ± 3.40 kg) (P = 0.03), which was mainly attributed to a reduction in the percentage of body fat (P = 0.03). In the ITT analysis, a larger decrease in systolic and diastolic blood pressure was shown in the placebo group than in the alginate group (P < 0.05). Plasma concentrations of glucose, insulin, C-reactive protein, and ghrelin, HOMA-IR, and lipid metabolism did not differ between treatment groups in the ITT analysis (P > 0.1). These results suggest that alginate supplementation as an adjunct to energy restriction may improve weight loss in obese subjects who complete a 12-wk dietary intervention. |
| Author | Georg Jensen, Morten Astrup, Arne Kristensen, Mette |
| Author_xml | – sequence: 1 givenname: Morten surname: Georg Jensen fullname: Georg Jensen, Morten – sequence: 2 givenname: Mette surname: Kristensen fullname: Kristensen, Mette – sequence: 3 givenname: Arne surname: Astrup fullname: Astrup, Arne |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26019906$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/22648709$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkVGLFSEYhiU22rNb192FEMHezFl11HG6W5bdCha6qevBcfTkydFJHQ6n39CPzmlOBQtBICifzyN-73cBznzwGoCXGG3rlrJruVd-izHeIsJqTJ6ADW5rUdUENWdggxAiVYs5OwcXKe0RwoQK_gycE8KpaFC7AT_ujNEqw2CgdDvrZdYwzdPk9Kh9ltkGD8s6aLv7kqELKUFbKr1OC9fvi5ugCmMRsvU7KCEm1eEr1F7H3bGKOuVoVdYDHKzOb8t9lH4Io_1eSir4HINz5Vgo6Z6Dp0a6pF-c9kvw-f7u0-376uHjuw-3Nw-VopzkiomeMoEN4k1rGKVaoB73vRlw2yLWU8kMF0iwwXCu0GAI5b1sUDEaZlgj60uA1ndnP8njQTrXTdGOMh47jLol2G4JtivBdmuwRblalSmGb3PpqhttUto56XWYU_EIbhtRk7qgrx-h-zBHXxpaKIKoYL-oVydq7kc9_PnA79EU4M0JkElJZ0puyqa_HEdLu7xw1yunYplO1OY_emGPDGXXUecorfun9xPJCL_7 |
| CODEN | AJCNAC |
| CitedBy_id | crossref_primary_10_1007_s40292_019_00309_5 crossref_primary_10_3390_md20090564 crossref_primary_10_3920_BM2014_0033 crossref_primary_10_3945_ajcn_117_163246 crossref_primary_10_1111_1541_4337_12558 crossref_primary_10_1007_s00125_018_4582_6 crossref_primary_10_3945_ajcn_113_074252 crossref_primary_10_3390_nu9111261 crossref_primary_10_1016_j_actbio_2020_05_033 crossref_primary_10_1007_s00394_020_02224_1 crossref_primary_10_1016_j_carbpol_2018_07_033 crossref_primary_10_1248_bpb_b18_00156 crossref_primary_10_1248_bpb_b18_00155 crossref_primary_10_3390_pharmaceutics13050631 crossref_primary_10_1016_j_fshw_2015_08_001 crossref_primary_10_1016_j_jnutbio_2024_109578 crossref_primary_10_3390_polym14081514 crossref_primary_10_3390_molecules22010182 crossref_primary_10_2478_rjdnmd_2018_0042 crossref_primary_10_1007_s11154_013_9254_8 crossref_primary_10_3390_molecules25040930 crossref_primary_10_3390_nu13020551 crossref_primary_10_1016_j_ejmech_2014_07_107 crossref_primary_10_3390_nu11092238 crossref_primary_10_1038_s41430_020_00739_8 crossref_primary_10_1038_s41366_021_00839_w crossref_primary_10_3109_09637486_2015_1034252 crossref_primary_10_21926_rpn_2304024 crossref_primary_10_1093_advances_nmac094 crossref_primary_10_1093_jn_nxac038 crossref_primary_10_1186_s40337_017_0143_5 crossref_primary_10_1016_j_jff_2023_105774 crossref_primary_10_1039_D1FO03099J crossref_primary_10_1093_nutrit_nuae151 crossref_primary_10_3109_09637486_2014_959898 crossref_primary_10_6116_kjh_2014_29_1_35 crossref_primary_10_3390_nu7042771 crossref_primary_10_2478_rjdnmd_2018_0031 crossref_primary_10_1016_j_fbio_2024_103995 crossref_primary_10_12677_AMS_2023_101005 crossref_primary_10_1016_j_carbpol_2016_04_037 crossref_primary_10_1063_5_0081695 crossref_primary_10_1080_09205063_2024_2394300 crossref_primary_10_18632_oncotarget_7249 crossref_primary_10_1016_j_tifs_2017_08_002 crossref_primary_10_1016_j_clnu_2020_10_032 crossref_primary_10_1111_nure_12091 crossref_primary_10_1016_j_actbio_2021_10_046 crossref_primary_10_1002_cbdv_202400116 crossref_primary_10_1097_HJH_0000000000000515 crossref_primary_10_1038_s41387_019_0088_7 crossref_primary_10_1039_D2FO02185D crossref_primary_10_4327_jsnfs_68_119 crossref_primary_10_1248_bpb_b15_00503 crossref_primary_10_1093_nutrit_nuae042 crossref_primary_10_1111_j_1467_789X_2012_01056_x crossref_primary_10_1002_oby_20539 crossref_primary_10_1016_j_jff_2015_12_006 crossref_primary_10_3390_obesities3020015 crossref_primary_10_1016_j_foodhyd_2021_106644 crossref_primary_10_1016_j_foodchem_2018_12_023 crossref_primary_10_3390_nu13061754 crossref_primary_10_1080_10408398_2023_2274453 crossref_primary_10_1155_2016_8635408 crossref_primary_10_1016_j_bcdf_2017_07_010 crossref_primary_10_1016_j_foodhyd_2015_02_019 crossref_primary_10_1016_j_physbeh_2017_10_009 crossref_primary_10_1002_btm2_10382 crossref_primary_10_1093_nutrit_nuab069 crossref_primary_10_3390_foods11050714 crossref_primary_10_1155_2016_2062360 crossref_primary_10_1248_bpb_b12_00899 crossref_primary_10_3390_nu14132627 crossref_primary_10_1016_j_taap_2018_11_008 crossref_primary_10_1016_j_numecd_2021_04_013 crossref_primary_10_3390_md19070352 crossref_primary_10_1248_bpb_b16_00127 crossref_primary_10_14710_jnc_v13i3_42821 |
| Cites_doi | 10.1093/ajcn/78.5.920 10.3390/md8072038 10.1111/j.1753-4887.2004.tb00001.x 10.1016/j.carbpol.2010.05.033 10.1016/j.appet.2008.06.013 10.1016/j.physbeh.2006.12.009 10.1038/oby.2011.232 10.1038/jhh.2008.144 10.3945/ajcn.2009.27465 10.1038/sj.ejcn.1602350 10.1038/sj.ijo.0801083 10.1016/j.appet.2010.11.147 10.7326/0003-4819-134-1-200101020-00007 10.3945/ajcn.2009.28095 10.1016/j.jada.2003.09.017 10.1016/j.appet.2011.05.030 10.1017/S0029665110000091 10.1016/S0899-9007(02)00750-5 10.14712/18059694.2019.126 10.1007/BF00280883 10.1093/jn/134.9.2293 10.1016/j.jnutbio.2010.05.009 10.1093/clinchem/18.6.499 10.1016/j.anaerobe.2011.08.003 10.1093/ajcn/86.5.1595 10.1016/0002-8223(94)90155-4 10.1038/nrendo.2011.77 10.1038/sj.ijo.0801568 10.1080/10408390500285673 10.1017/S0007114510003363 10.1093/jn/121.6.795 10.1093/ajcn/75.5.834 10.1093/jn/134.4.886 10.1001/jama.282.16.1539 10.1038/oby.2009.421 10.1056/NEJMoa012908 10.1016/j.appet.2011.07.004 10.1111/j.1467-789X.2009.00707.x 10.1038/oby.2011.63 10.1111/j.1753-4887.2001.tb07001.x 10.1001/archinte.164.2.210 10.1210/jcem.86.12.8111 |
| ContentType | Journal Article |
| Copyright | 2015 INIST-CNRS Copyright American Society for Clinical Nutrition, Inc. Jul 1, 2012 |
| Copyright_xml | – notice: 2015 INIST-CNRS – notice: Copyright American Society for Clinical Nutrition, Inc. Jul 1, 2012 |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7QP 7T7 7TS 8FD C1K FR3 K9. NAPCQ P64 7X8 ADTOC UNPAY |
| DOI | 10.3945/ajcn.111.025312 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Calcium & Calcified Tissue Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Physical Education Index Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium Biotechnology and BioEngineering Abstracts MEDLINE - Academic Unpaywall for CDI: Periodical Content Unpaywall |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Nursing & Allied Health Premium Technology Research Database ProQuest Health & Medical Complete (Alumni) Engineering Research Database Industrial and Applied Microbiology Abstracts (Microbiology A) Calcium & Calcified Tissue Abstracts Physical Education Index Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic Nursing & Allied Health Premium MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Diet & Clinical Nutrition |
| EISSN | 1938-3207 |
| EndPage | 13 |
| ExternalDocumentID | 10.3945/ajcn.111.025312 2695649011 22648709 26019906 10_3945_ajcn_111_025312 |
| Genre | Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- -ET -~X ..I .55 .GJ 0R~ 1HT 23M 2FS 2WC 3O- 4.4 48X 53G 5GY 5RE 5VS 6J9 85S 8R4 8R5 AABZA AACZT AAGQS AAHBH AAIKC AAJQQ AALRI AAMNW AAPGJ AAPQZ AAUQX AAUTI AAVAP AAWDT AAWTL AAXUO AAYWO AAYXX ABBTP ABDNZ ABDPE ABIME ABJNI ABLJU ABOCM ABPTD ABWST ACFRR ACGFO ACGFS ACGOD ACNCT ACPRK ACPVT ACUFI ACUTJ ACVFH ADBBV ADCNI ADGZP ADHUB ADMTO ADRTK ADUKH ADVEK ADVLN AEGXH AENEX AETBJ AEUPX AFFDN AFFNX AFFZL AFJKZ AFOFC AFPUW AFRAH AFXAL AGINJ AGKRT AGNAY AGQXC AGUTN AHMBA AI. AIAGR AIGII AITUG AJEEA AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANFBD APXCP AQDSO AQKUS BAWUL BAYMD BKOMP BTRTY C1A CDBKE CITATION DAKXR DIK E3Z EBS EFKBS EIHJH EJD ENERS EX3 F5P F9R FDB FECEO FLUFQ FOEOM FOTVD FQBLK FRP GAUVT GJXCC GX1 H13 HF~ HZ~ IH2 J5H KBUDW KOP KQ8 KSI KSN L7B LPU MBLQV MHKGH MV1 MVM N4W NEJ NHB NHCRO NOMLY NOYVH NU- NVLIB O9- ODMLO OHT OK1 OVD P2P P6G PCD PQQKQ PRG Q2X R0Z RHI RNS ROL SJN TCN TEORI TMA TNT TR2 TWZ UBH UHB UKR VH1 W2D W8F WH7 WHG WOQ WOW X7M XOL XSW YBU YHG YOJ YQJ YR5 YRY YSK YV5 YYQ YZZ ZCA ZCG ZGI ZUP ZXP ~KM AGCQF IQODW A8Z AAYOK ABSAR BCRHZ CGR CUY CVF ECM EIF NPM RHF ROX SV3 VXZ Z5M 7QP 7T7 7TS 8FD C1K FR3 K9. NAPCQ P64 7X8 ADTOC UNPAY |
| ID | FETCH-LOGICAL-c462t-58b4581f0679f544e80b1bbfd19905b4a5f68085df66c0df246ba7081f75f57a3 |
| IEDL.DBID | UNPAY |
| ISSN | 0002-9165 1938-3207 |
| IngestDate | Tue Aug 19 09:14:01 EDT 2025 Mon Sep 29 06:35:37 EDT 2025 Fri Jul 25 03:43:45 EDT 2025 Wed Feb 19 02:24:41 EST 2025 Mon Jul 21 09:15:20 EDT 2025 Wed Oct 01 04:43:06 EDT 2025 Thu Apr 24 23:09:33 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Human Obesity Energy Nutrition disorder Weight loss Alginates Supplementation Restricted diet Nutritional status Feeding |
| Language | English |
| License | CC BY 4.0 publisher-specific-oa |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c462t-58b4581f0679f544e80b1bbfd19905b4a5f68085df66c0df246ba7081f75f57a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 |
| OpenAccessLink | https://proxy.k.utb.cz/login?url=https://academic.oup.com/ajcn/article-pdf/96/1/5/23817046/5.pdf |
| PMID | 22648709 |
| PQID | 1022048523 |
| PQPubID | 41076 |
| PageCount | 9 |
| ParticipantIDs | unpaywall_primary_10_3945_ajcn_111_025312 proquest_miscellaneous_1021978323 proquest_journals_1022048523 pubmed_primary_22648709 pascalfrancis_primary_26019906 crossref_primary_10_3945_ajcn_111_025312 crossref_citationtrail_10_3945_ajcn_111_025312 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2012-07-01 |
| PublicationDateYYYYMMDD | 2012-07-01 |
| PublicationDate_xml | – month: 07 year: 2012 text: 2012-07-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Bethesda, MD |
| PublicationPlace_xml | – name: Bethesda, MD – name: United States – name: Bethesda |
| PublicationTitle | The American journal of clinical nutrition |
| PublicationTitleAlternate | Am J Clin Nutr |
| PublicationYear | 2012 |
| Publisher | American Society for Nutrition American Society for Clinical Nutrition, Inc |
| Publisher_xml | – name: American Society for Nutrition – name: American Society for Clinical Nutrition, Inc |
| References | Rigaud (10.3945/ajcn.111.025312_bib8) 1990; 14 Brownlee (10.3945/ajcn.111.025312_bib11) 2005; 45 Peters (10.3945/ajcn.111.025312_bib17) 2011; 19 Mueller-Cunningham (10.3945/ajcn.111.025312_bib7) 2003; 103 Delzenne (10.3945/ajcn.111.025312_bib36) 2010; 11 Miller (10.3945/ajcn.111.025312_bib4) 1994; 94 Cummings (10.3945/ajcn.111.025312_bib38) 2002; 346 Lyon (10.3945/ajcn.111.025312_bib30) 2010; 15 Jenkins (10.3945/ajcn.111.025312_bib45) 2002; 75 Terada (10.3945/ajcn.111.025312_bib42) 1995; 8 Williams (10.3945/ajcn.111.025312_bib47) 2004; 134 Liu (10.3945/ajcn.111.025312_bib2) 2003; 78 Odunsi (10.3945/ajcn.111.025312_bib15) 2010; 18 O’Sullivan (10.3945/ajcn.111.025312_bib43) 2010; 8 Parnell (10.3945/ajcn.111.025312_bib41) 2009; 89 Mattes (10.3945/ajcn.111.025312_bib14) 2007; 90 Stevens (10.3945/ajcn.111.025312_bib49) 2001; 134 He (10.3945/ajcn.111.025312_bib50) 2009; 23 Ramnani (10.3945/ajcn.111.025312_bib39) 2012; 18 Wanders (10.3945/ajcn.111.025312_bib18) 2011; 57 Barrera (10.3945/ajcn.111.025312_bib44) 2011; 7 Georg Jensen (10.3945/ajcn.111.025312_bib29) 2011; 57 Kromhout (10.3945/ajcn.111.025312_bib1) 2001; 25 Ford (10.3945/ajcn.111.025312_bib46) 2010; 69 Flint (10.3945/ajcn.111.025312_bib28) 2000; 24 Dewulf (10.3945/ajcn.111.025312_bib40) 2011; 22 Rolls (10.3945/ajcn.111.025312_bib9) 2004; 62 Birketvedt (10.3945/ajcn.111.025312_bib5) 2000; 43 Paxman (10.3945/ajcn.111.025312_bib19) 2008; 51 Cani (10.3945/ajcn.111.025312_bib21) 2006; 60 Matthews (10.3945/ajcn.111.025312_bib26) 1985; 28 Howarth (10.3945/ajcn.111.025312_bib10) 2001; 59 Cani (10.3945/ajcn.111.025312_bib22) 2009; 90 10.3945/ajcn.111.025312_bib25 10.3945/ajcn.111.025312_bib24 Friedewald (10.3945/ajcn.111.025312_bib27) 1972; 18 Ludwig (10.3945/ajcn.111.025312_bib3) 1999; 282 Wren (10.3945/ajcn.111.025312_bib37) 2001; 86 Birketvedt (10.3945/ajcn.111.025312_bib31) 2005; 11 Wolf (10.3945/ajcn.111.025312_bib48) 2002; 18 de Celis Alonso (10.3945/ajcn.111.025312_bib12) 2010; 82 Pelkman (10.3945/ajcn.111.025312_bib16) 2007; 86 Kristensen (10.3945/ajcn.111.025312_bib20) 2011; 56 Torsdottir (10.3945/ajcn.111.025312_bib32) 1991; 121 10.3945/ajcn.111.025312_bib33 Hoad (10.3945/ajcn.111.025312_bib13) 2004; 134 10.3945/ajcn.111.025312_bib35 10.3945/ajcn.111.025312_bib34 Hays (10.3945/ajcn.111.025312_bib6) 2004; 164 Roberfroid (10.3945/ajcn.111.025312_bib23) 2010; 104 |
| References_xml | – volume: 78 start-page: 920 year: 2003 ident: 10.3945/ajcn.111.025312_bib2 article-title: Relation between changes in intakes of dietary fiber and grain products and changes in weight and development of obesity among middle-aged women publication-title: Am J Clin Nutr doi: 10.1093/ajcn/78.5.920 – volume: 8 start-page: 2038 issue: 7 year: 2010 ident: 10.3945/ajcn.111.025312_bib43 article-title: Prebiotics from Marine Macroalgae for Human and Animal Health Applications publication-title: Mar Drugs doi: 10.3390/md8072038 – volume: 62 start-page: 1 year: 2004 ident: 10.3945/ajcn.111.025312_bib9 article-title: What can intervention studies tell us about the relationship between fruit and vegetable consumption and weight management? publication-title: Nutr Rev doi: 10.1111/j.1753-4887.2004.tb00001.x – volume: 15 start-page: 68 year: 2010 ident: 10.3945/ajcn.111.025312_bib30 article-title: The effect of a novel viscous polysaccharide along with lifestyle changes on short-term weight loss and associated risk factors in overweight and obese adults: an observational retrospective clinical program analysis publication-title: Altern Med Rev – volume: 82 start-page: 663 year: 2010 ident: 10.3945/ajcn.111.025312_bib12 article-title: NMR relaxometry and rheology of ionic and acid alginate gels publication-title: Carbohydrate Polymers doi: 10.1016/j.carbpol.2010.05.033 – volume: 51 start-page: 713 year: 2008 ident: 10.3945/ajcn.111.025312_bib19 article-title: Daily ingestion of alginate reduces energy intake in free-living subjects publication-title: Appetite doi: 10.1016/j.appet.2008.06.013 – ident: 10.3945/ajcn.111.025312_bib24 – volume: 90 start-page: 705 year: 2007 ident: 10.3945/ajcn.111.025312_bib14 article-title: Effects of a combination fiber system on appetite and energy intake in overweight humans publication-title: Physiol Behav doi: 10.1016/j.physbeh.2006.12.009 – ident: 10.3945/ajcn.111.025312_bib33 doi: 10.1038/oby.2011.232 – volume: 23 start-page: 363 year: 2009 ident: 10.3945/ajcn.111.025312_bib50 article-title: A comprehensive review on salt and health and current experience of worldwide salt reduction programmes publication-title: J Hum Hypertens doi: 10.1038/jhh.2008.144 – volume: 89 start-page: 1751 year: 2009 ident: 10.3945/ajcn.111.025312_bib41 article-title: Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults publication-title: Am J Clin Nutr doi: 10.3945/ajcn.2009.27465 – volume: 60 start-page: 567 year: 2006 ident: 10.3945/ajcn.111.025312_bib21 article-title: Oligofructose promotes satiety in healthy human: a pilot study publication-title: Eur J Clin Nutr doi: 10.1038/sj.ejcn.1602350 – volume: 24 start-page: 38 year: 2000 ident: 10.3945/ajcn.111.025312_bib28 article-title: Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies publication-title: Int J Obes Relat Metab Disord doi: 10.1038/sj.ijo.0801083 – volume: 56 start-page: 65 year: 2011 ident: 10.3945/ajcn.111.025312_bib20 article-title: Dietary fibres in the regulation of appetite and food intake. Importance of viscosity publication-title: Appetite doi: 10.1016/j.appet.2010.11.147 – volume: 134 start-page: 1 year: 2001 ident: 10.3945/ajcn.111.025312_bib49 article-title: Long-term weight loss and changes in blood pressure: results of the Trials of Hypertension Prevention, phase II publication-title: Ann Intern Med doi: 10.7326/0003-4819-134-1-200101020-00007 – volume: 8 start-page: 259 year: 1995 ident: 10.3945/ajcn.111.025312_bib42 article-title: Effect of dietary alginate on the faecal microbiota and faecal metabolic activity in humans publication-title: Microb Ecol Health Dis – volume: 90 start-page: 1236 year: 2009 ident: 10.3945/ajcn.111.025312_bib22 article-title: Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal publication-title: Am J Clin Nutr doi: 10.3945/ajcn.2009.28095 – volume: 103 start-page: 1600 year: 2003 ident: 10.3945/ajcn.111.025312_bib7 article-title: An ad libitum, very low-fat diet results in weight loss and changes in nutrient intakes in postmenopausal women publication-title: J Am Diet Assoc doi: 10.1016/j.jada.2003.09.017 – ident: 10.3945/ajcn.111.025312_bib35 – volume: 57 start-page: 544 year: 2011 ident: 10.3945/ajcn.111.025312_bib18 article-title: Effects of three dietary fiber on food in real life setting publication-title: Appetite doi: 10.1016/j.appet.2011.05.030 – volume: 69 start-page: 199 year: 2010 ident: 10.3945/ajcn.111.025312_bib46 article-title: Glycaemic index, appetite and body weight publication-title: Proc Nutr Soc doi: 10.1017/S0029665110000091 – ident: 10.3945/ajcn.111.025312_bib25 – volume: 18 start-page: 621 year: 2002 ident: 10.3945/ajcn.111.025312_bib48 article-title: Glycemic and insulinemic responses of nondiabetic healthy adult subjects to an experimental acid-induced viscosity complex incorporated into a glucose beverage publication-title: Nutrition doi: 10.1016/S0899-9007(02)00750-5 – volume: 43 start-page: 129 year: 2000 ident: 10.3945/ajcn.111.025312_bib5 article-title: Long-term effect of fibre supplement and reduced energy intake on body weight and blood lipids in overweight subjects publication-title: Acta Medica (Hradec Kralove) doi: 10.14712/18059694.2019.126 – volume: 28 start-page: 412 year: 1985 ident: 10.3945/ajcn.111.025312_bib26 article-title: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man publication-title: Diabetologia doi: 10.1007/BF00280883 – volume: 134 start-page: 2293 year: 2004 ident: 10.3945/ajcn.111.025312_bib13 article-title: In vivo imaging of intragastric gelation and its effect on satiety in humans publication-title: J Nutr doi: 10.1093/jn/134.9.2293 – volume: 22 start-page: 712 year: 2011 ident: 10.3945/ajcn.111.025312_bib40 article-title: Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARgamma-related adipogenesis in the white adipose tissue of high-fat diet-fed mice publication-title: J Nutr Biochem doi: 10.1016/j.jnutbio.2010.05.009 – volume: 18 start-page: 499 year: 1972 ident: 10.3945/ajcn.111.025312_bib27 article-title: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge publication-title: Clin Chem doi: 10.1093/clinchem/18.6.499 – volume: 18 start-page: 1 year: 2012 ident: 10.3945/ajcn.111.025312_bib39 article-title: In vitro fermentation and prebiotic potential of novel low molecular weight polysaccharides derived from agar and alginate seaweeds publication-title: Anaerob doi: 10.1016/j.anaerobe.2011.08.003 – volume: 86 start-page: 1595 year: 2007 ident: 10.3945/ajcn.111.025312_bib16 article-title: Novel calcium-gelled, alginate-pectin beverage reduced energy intake in nondieting overweight and obese women: interactions with dietary restraint status publication-title: Am J Clin Nutr doi: 10.1093/ajcn/86.5.1595 – volume: 94 start-page: 612 year: 1994 ident: 10.3945/ajcn.111.025312_bib4 article-title: Dietary fat, sugar, and fiber predict body fat content publication-title: J Am Diet Assoc doi: 10.1016/0002-8223(94)90155-4 – volume: 11 start-page: PI5 year: 2005 ident: 10.3945/ajcn.111.025312_bib31 article-title: Experiences with three different fiber supplements in weight reduction publication-title: Med Sci Monit – volume: 7 start-page: 507 year: 2011 ident: 10.3945/ajcn.111.025312_bib44 article-title: GLP-1 and energy balance: an integrated model of short-term and long-term control publication-title: Nat Rev Endocrinol doi: 10.1038/nrendo.2011.77 – volume: 25 start-page: 301 year: 2001 ident: 10.3945/ajcn.111.025312_bib1 article-title: Physical activity and dietary fiber determine population body fat levels: the Seven Countries Study publication-title: Int J Obes Relat Metab Disord doi: 10.1038/sj.ijo.0801568 – volume: 45 start-page: 497 year: 2005 ident: 10.3945/ajcn.111.025312_bib11 article-title: Alginate as a source of dietary fiber publication-title: Crit Rev Food Sci Nutr doi: 10.1080/10408390500285673 – volume: 104 start-page: S1 year: 2010 ident: 10.3945/ajcn.111.025312_bib23 article-title: Prebiotic effects: metabolic and health benefits publication-title: Br J Nutr doi: 10.1017/S0007114510003363 – volume: 121 start-page: 795 year: 1991 ident: 10.3945/ajcn.111.025312_bib32 article-title: A small dose of soluble alginate-fiber affects postprandial glycemia and gastric emptying in humans with diabetes publication-title: J Nutr doi: 10.1093/jn/121.6.795 – volume: 75 start-page: 834 year: 2002 ident: 10.3945/ajcn.111.025312_bib45 article-title: Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial publication-title: Am J Clin Nutr doi: 10.1093/ajcn/75.5.834 – volume: 134 start-page: 886 year: 2004 ident: 10.3945/ajcn.111.025312_bib47 article-title: Inclusion of guar gum and alginate into a crispy bar improves postprandial glycemia in humans publication-title: J Nutr doi: 10.1093/jn/134.4.886 – volume: 282 start-page: 1539 year: 1999 ident: 10.3945/ajcn.111.025312_bib3 article-title: Dietary fiber, weight gain, and cardiovascular disease risk factors in young adults publication-title: JAMA doi: 10.1001/jama.282.16.1539 – volume: 18 start-page: 1579 year: 2010 ident: 10.3945/ajcn.111.025312_bib15 article-title: Effect of alginate on satiation, appetite, gastric function, and selected gut satiety hormones in overweight and obesity publication-title: Obesity (Silver Spring) doi: 10.1038/oby.2009.421 – volume: 346 start-page: 1623 year: 2002 ident: 10.3945/ajcn.111.025312_bib38 article-title: Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery publication-title: N Engl J Med doi: 10.1056/NEJMoa012908 – volume: 57 start-page: 601 year: 2011 ident: 10.3945/ajcn.111.025312_bib29 article-title: Can alginate-based preloads increase weight loss beyond calorie restriction? A pilot study in obese individuals publication-title: Appetite doi: 10.1016/j.appet.2011.07.004 – volume: 14 start-page: 763 year: 1990 ident: 10.3945/ajcn.111.025312_bib8 article-title: Overweight treated with energy restriction and a dietary fibre supplement: a 6-month randomized, double-blind, placebo-controlled trial publication-title: Int J Obes – volume: 11 start-page: 234 year: 2010 ident: 10.3945/ajcn.111.025312_bib36 article-title: Gastrointestinal targets of appetite regulation in humans publication-title: Obes Rev doi: 10.1111/j.1467-789X.2009.00707.x – volume: 19 start-page: 1171 year: 2011 ident: 10.3945/ajcn.111.025312_bib17 article-title: Dose-dependent suppression of hunger by a specific alginate in a low-viscosity drink formulation publication-title: Obesity (Silver Spring) doi: 10.1038/oby.2011.63 – volume: 59 start-page: 129 year: 2001 ident: 10.3945/ajcn.111.025312_bib10 article-title: Dietary fiber and weight regulation publication-title: Nutr Rev doi: 10.1111/j.1753-4887.2001.tb07001.x – volume: 164 start-page: 210 year: 2004 ident: 10.3945/ajcn.111.025312_bib6 article-title: Effects of an ad libitum low-fat, high-carbohydrate diet on body weight, body composition, and fat distribution in older men and women: a randomized controlled trial publication-title: Arch Intern Med doi: 10.1001/archinte.164.2.210 – ident: 10.3945/ajcn.111.025312_bib34 doi: 10.1038/oby.2011.232 – volume: 86 start-page: 5992 year: 2001 ident: 10.3945/ajcn.111.025312_bib37 article-title: Ghrelin enhances appetite and increases food intake in humans publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.86.12.8111 |
| SSID | ssj0012486 |
| Score | 2.3782587 |
| Snippet | Acute studies with alginate-based preloads suggested that these strong gelling fibers may induce increased feelings of satiety and reduce energy intakes.... |
| SourceID | unpaywall proquest pubmed pascalfrancis crossref |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 5 |
| SubjectTerms | Adiposity Adult Alginates - adverse effects Alginates - therapeutic use Anti-Obesity Agents - adverse effects Anti-Obesity Agents - therapeutic use Beverages - adverse effects Beverages - analysis Biological and medical sciences Body Mass Index Carbohydrates Cardiovascular Diseases - epidemiology Denmark - epidemiology Diabetes Mellitus, Type 2 - epidemiology Diet, Reducing Dietary fiber Dietary Fiber - adverse effects Dietary Fiber - therapeutic use Dietary supplements Dietary Supplements - adverse effects Dietary Supplements - analysis Double-Blind Method Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Glucuronic Acid - adverse effects Glucuronic Acid - therapeutic use Hexuronic Acids - adverse effects Hexuronic Acids - therapeutic use Humans Insulin Resistance Intention to Treat Analysis Male Middle Aged Nutrition Obesity Obesity - blood Obesity - diet therapy Obesity - immunology Obesity - metabolism Obesity, Morbid - blood Obesity, Morbid - diet therapy Obesity, Morbid - immunology Obesity, Morbid - metabolism Patient Dropouts Risk Factors Vertebrates: anatomy and physiology, studies on body, several organs or systems Weight control Weight Loss |
| Title | Effect of alginate supplementation on weight loss in obese subjects completing a 12-wk energy-restricted diet: a randomized controlled trial |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/22648709 https://www.proquest.com/docview/1022048523 https://www.proquest.com/docview/1021978323 https://academic.oup.com/ajcn/article-pdf/96/1/5/23817046/5.pdf |
| UnpaywallVersion | publishedVersion |
| Volume | 96 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1938-3207 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0012486 issn: 0002-9165 databaseCode: KQ8 dateStart: 19990101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1938-3207 dateEnd: 20241002 omitProxy: true ssIdentifier: ssj0012486 issn: 0002-9165 databaseCode: DIK dateStart: 19990101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1938-3207 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0012486 issn: 0002-9165 databaseCode: GX1 dateStart: 0 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 1938-3207 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0012486 issn: 0002-9165 databaseCode: AKRWK dateStart: 19960101 isFulltext: true providerName: Library Specific Holdings |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1ti9QwEB50F3xBfDnfqucSQUQ_9D1pu35b1OPwuEXExfNTL2kTWK92F9vl8H6DP9qZNl09UUSEfijptDTpdOZJMvMMwBMuQq1Dk7laF4HLyzh2lU61S-7FJIiB05iSkw_nyf6CvzkSR7bOKeXCSBsV7g0pDfJTUft2FN11afxp4oe-8KOOWo4nvvCw9SKME9phGsF4MX87-ziAXgQ_ot9Xztw4CtKe3CeectE9mAyGh14_DqNzfunaWjY4RKavbfE78HkVLm_qtfx6KqvqJ4e0dwOOh670cSgn3qZVXnH2C8vjf_T1Jly3YJXNetlbcEHXO-C8WuqWPWWWUbRi84HQfwcuHdqt-tvwredFZivDZEXFH1rNGioh2oerkzzD47RbmmUVjglbYovSDckpWh5qWBfw3iVlM8moOMoJ012yokslRdCEI15mJb7PC7yOw1iuPi_PsMkG4Fd42pUluQOLvdfvX-67tvSDW_Akal2RKS6y0NAylxGc6yxQoVKmDNF7CsUlKlKGaLE0SVIEpYl4omSK8MakwohUxndhVK9qfR9YmBUlsZrx1OB9cSkRIgaZCVOdRAZthAPe8OHzwvKiU3mOKsf5EWlKTp-FZkp5rykOPNvesO4pQf4sOjmnSVt5InLDniQO7A6qlVvj0eQ0CUfDKqLYgcfby_jb016OrPVq08mEtGpHMvd6lfzxcIpaTIOpA8-3Ovq3N33wD7IP4QrCRhu0vAuj9stGP0Jo1qoJjGcH7z4cTOxv-B0Q0zWN |
| linkProvider | Unpaywall |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3da9RAEB_0Cn4gflSr0VpWELEP-d7d5HwrailCDx88qE9xN9mFs2nuMDmK_Rv8o51JNqcVRUTIQ9hMQnYzmfnt7sxvAJ5zERsT29w3pox8XqWpr01mfHIvViIGzlJKTj6eyaM5f3ciTlydU8qFUS4qPBhTGtTnsgndKPqryoZTGcahCJOeWo7LUATYehW2JO0wTWBrPnt_8HEEvQh-xLCvnPtpEmUDuU865aJ_MBmMAL1-GieX_NKtlWpxiOxQ2-J34PMmXF83K_X1XNX1Tw7p8A58GrsyxKGcButOB-XFLyyP_9HXu3DbgVV2MMjegyum2QbvzcJ07AVzjKI1m42E_ttw7dht1d-HbwMvMltapmoq_tAZ1lIJ0SFcneQZHuf90iyrcUzYAlu0aUlO0_JQy_qA9z4pmylGxVFOmemTFX0qKYImHPEyq_B9XuF1HMZqeba4wCYXgF_jaV-W5AHMD99-eH3ku9IPfsll0vki11zksaVlLis4N3mkY61tFaP3FJorVKQc0WJlpSyjyiZcapUhvLGZsCJT6Q5MmmVjHgGL87IiVjOeWbwvrRRCxCi3cWZkYtFGeBCMH74oHS86leeoC5wfkaYU9FloplQMmuLBy80Nq4ES5M-ie5c0aSNPRG7YE-nB7qhahTMebUGTcDSsIkk9eLa5jL897eWoxizXvUxMq3Yk83BQyR8Pp6jFLJp6sL_R0b-96eN_kH0CNxA2uqDlXZh0X9bmKUKzTu-53-87bF8z6g |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effect+of+alginate+supplementation+on+weight+loss+in+obese+subjects+completing+a+12-wk+energy-restricted+diet%3A+a+randomized+controlled+trial&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.au=Georg+Jensen%2C+Morten&rft.au=Kristensen%2C+Mette&rft.au=Astrup%2C+Arne&rft.date=2012-07-01&rft.issn=1938-3207&rft.eissn=1938-3207&rft.volume=96&rft.issue=1&rft.spage=5&rft_id=info:doi/10.3945%2Fajcn.111.025312&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0002-9165&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0002-9165&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0002-9165&client=summon |