Effectiveness of enhancing cognitive reserve in children, adolescents and young adults at genetic risk for psychosis: Study protocol for a randomized controlled trial

Offspring of patients diagnosed with bipolar disorder and schizophrenia (Off-BDSZ) have a high genetic risk of developing a mental illness. The aim of this project is to develop and investigate the efficacy of an intervention aimed at this population, based on the concept of cognitive reserve. This...

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Published inRevista de psiquiatría y salud mental Vol. 16; no. 3; pp. 184 - 191
Main Authors de la Serna, Elena, Montejo, Laura, Solé, Brisa, Castro-Fornieles, Josefina, Camprodon-Boadas, Patricia, Sugranyes, Gisela, Rosa-Justicia, Mireia, Martinez-Aran, Anabel, Vieta, Eduard, Vicent-Gil, Muriel, Serra-Blasco, Maria, Cardoner, Narcís, Torrent, Carla
Format Journal Article
LanguageEnglish
Published Spain Elsevier España S.L.U 01.07.2023
Elsevier España, S.L.U
Subjects
Adolescent
Adult
Bipolar disorder
Bipolar Disorder - genetics
Child
Cognitive Reserve
Humans
Multicenter Studies as Topic
Offspring
Psychiatric/Mental Health
Psychotic Disorders - genetics
Randomized Controlled Trials as Topic
Schizophrenia
Schizophrenia - genetics
Treatment Outcome
Young Adult
SCQ
ADHD
DSM-V
PAS
CPT-II
CREATE
WCST
ROCF
Schizophrenia
CHTE
Bipolar disorder
SCWT
CAPE
SCID
CRASH
WMS-III
Core-A
WASH-U-KSADS
TOMAL
Off-BD
HDRS
BPSS-P
CC
Cognitive reserve
SLES
CGI
MAAS
CPRS-48
TMT-A
GAF
CR
fMRI
WAIS-IV
Offspring
TMT-B
CMRS
Off-BDSZ
WISC-IV
SMR
SOPS
FAST
K-SADS-PL
YMRS
Off-SZ
SPQ-B
questionnaire of habits and study techniques
attention-deficit hyperactivity disorder
Trail Making Test part-A
Trail Making Test part-B
Community Assessment of Psychic Experiences
Offspring of patients diagnosed with schizophrenia
Sexual Maturity Rating
Global Assessment Functioning
Conners’ Rating Scales 48 items
Stroop Color-Word Interference Test
Premorbid Adjustment Scale
Test of memory and learning
Cognitive Reserve EnhAncement ThErapy
Cognitive Reserve scale for Adolescents
Offspring of patients diagnosed with bipolar disorder and schizophrenia
Cognitive Reserve Assessment Scale in Health
structured clinical interview based on DSM-V
Bipolar Prodrome Symptom Interview and Scale-Prospective
functional magnetic resonance imaging
Wechsler Memory Scale third edition
Clinical Global Impressions
Kiddie Schedule for Affective Disorders and Schizophrenia-Present – Lifetime Version
community comparison group
Schizotypal Personality Questionnaire-Brief
Scale of Prodromal Symptoms
Offspring of patients diagnosed with bipolar disorder
Hamilton Depression Rating Scale for depressive symptomatology
Child Mania Rating Scale
Stressful Life Events Schedule
Wechsler Intelligence Scale for Children fourth edition
Cognitive Reserve
Wechsler Adult Intelligence Scale fourth edition
Continuous Performance Test second edition
Mindful Attention Awareness Scale
Functioning Assessment Short Test
Kiddie Schedule for Affective Disorders and Schizophrenia version of university of Washington
Rey-Osterrieth Complex Figure
Social Communication Questionnaire
Wisconsin Card Sorting Test
Young Mania Rating Scale
Diagnostic and Statistical Manual of Mental Disorders fifth edition
Online AccessGet full text
ISSN2950-2853
1888-9891
2950-2853
DOI10.1016/j.rpsm.2021.02.003

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Abstract Offspring of patients diagnosed with bipolar disorder and schizophrenia (Off-BDSZ) have a high genetic risk of developing a mental illness. The aim of this project is to develop and investigate the efficacy of an intervention aimed at this population, based on the concept of cognitive reserve. This is a multicenter randomized trial with an experimental test–retest design study with control group. Two groups will be included: a community comparison group (CC) and a Off-BDSZ group. A total of 108 Off-BDSZ and 65 CC aged between 6 and 25 years will be recruited. Off-BDSZ participants will be randomized to receive either Cognitive Reserve EnhAncement ThErapy (CREATE) (n=54), or a supportive approach (n=54). The CC group will be assessed at baseline. The duration of the intervention will be 3 months, with 12 weekly group sessions. The primary outcome will be the improvement in CR measured according to change in the Cognitive Reserve Assessment Scale in Health (CRASH) and Cognitive Reserve scale for Adolescents (CORE-A). All participants will be blindly evaluated using clinical, cognitive and neuroimaging measures at baseline, at three months (after the psychological intervention), and at twelve-month follow-up after treatment completion. The results will provide insight into whether the CREATE-Offspring version may enhance cognitive reserve (CR) in child, adolescent and young adult Off-BDSZ as well as advance knowledge about changes in clinical manifestations, neuropsychological performance and brain structure and function associated with improving CR. This novel and cost-effective intervention represents an advance in the framework of preventive interventions in mental health. Clinicaltrials.gov, NCT03722082. Registered on 26 October 2018.
AbstractList AbstractBackgroundOffspring of patients diagnosed with bipolar disorder and schizophrenia (Off-BDSZ) have a high genetic risk of developing a mental illness. The aim of this project is to develop and investigate the efficacy of an intervention aimed at this population, based on the concept of cognitive reserve. MethodsThis is a multicenter randomized trial with an experimental test–retest design study with control group. Two groups will be included: a community comparison group (CC) and a Off-BDSZ group. A total of 108 Off-BDSZ and 65 CC aged between 6 and 25 years will be recruited. Off-BDSZ participants will be randomized to receive either Cognitive Reserve EnhAncement ThErapy (CREATE) ( n= 54), or a supportive approach ( n= 54). The CC group will be assessed at baseline. The duration of the intervention will be 3 months, with 12 weekly group sessions. The primary outcome will be the improvement in CR measured according to change in the Cognitive Reserve Assessment Scale in Health (CRASH) and Cognitive Reserve scale for Adolescents (CORE-A). All participants will be blindly evaluated using clinical, cognitive and neuroimaging measures at baseline, at three months (after the psychological intervention), and at twelve-month follow-up after treatment completion. DiscussionThe results will provide insight into whether the CREATE-Offspring version may enhance cognitive reserve (CR) in child, adolescent and young adult Off-BDSZ as well as advance knowledge about changes in clinical manifestations, neuropsychological performance and brain structure and function associated with improving CR. This novel and cost-effective intervention represents an advance in the framework of preventive interventions in mental health. Trial registrationClinicaltrials.gov, NCT03722082. Registered on 26 October 2018.
Offspring of patients diagnosed with bipolar disorder and schizophrenia (Off-BDSZ) have a high genetic risk of developing a mental illness. The aim of this project is to develop and investigate the efficacy of an intervention aimed at this population, based on the concept of cognitive reserve. This is a multicenter randomized trial with an experimental test–retest design study with control group. Two groups will be included: a community comparison group (CC) and a Off-BDSZ group. A total of 108 Off-BDSZ and 65 CC aged between 6 and 25 years will be recruited. Off-BDSZ participants will be randomized to receive either Cognitive Reserve EnhAncement ThErapy (CREATE) (n=54), or a supportive approach (n=54). The CC group will be assessed at baseline. The duration of the intervention will be 3 months, with 12 weekly group sessions. The primary outcome will be the improvement in CR measured according to change in the Cognitive Reserve Assessment Scale in Health (CRASH) and Cognitive Reserve scale for Adolescents (CORE-A). All participants will be blindly evaluated using clinical, cognitive and neuroimaging measures at baseline, at three months (after the psychological intervention), and at twelve-month follow-up after treatment completion. The results will provide insight into whether the CREATE-Offspring version may enhance cognitive reserve (CR) in child, adolescent and young adult Off-BDSZ as well as advance knowledge about changes in clinical manifestations, neuropsychological performance and brain structure and function associated with improving CR. This novel and cost-effective intervention represents an advance in the framework of preventive interventions in mental health. Clinicaltrials.gov, NCT03722082. Registered on 26 October 2018.
Offspring of patients diagnosed with bipolar disorder and schizophrenia (Off-BDSZ) have a high genetic risk of developing a mental illness. The aim of this project is to develop and investigate the efficacy of an intervention aimed at this population, based on the concept of cognitive reserve.BACKGROUNDOffspring of patients diagnosed with bipolar disorder and schizophrenia (Off-BDSZ) have a high genetic risk of developing a mental illness. The aim of this project is to develop and investigate the efficacy of an intervention aimed at this population, based on the concept of cognitive reserve.This is a multicenter randomized trial with an experimental test-retest design study with control group. Two groups will be included: a community comparison group (CC) and a Off-BDSZ group. A total of 108 Off-BDSZ and 65 CC aged between 6 and 25 years will be recruited. Off-BDSZ participants will be randomized to receive either Cognitive Reserve EnhAncement ThErapy (CREATE) (n=54), or a supportive approach (n=54). The CC group will be assessed at baseline. The duration of the intervention will be 3 months, with 12 weekly group sessions. The primary outcome will be the improvement in CR measured according to change in the Cognitive Reserve Assessment Scale in Health (CRASH) and Cognitive Reserve scale for Adolescents (CORE-A). All participants will be blindly evaluated using clinical, cognitive and neuroimaging measures at baseline, at three months (after the psychological intervention), and at twelve-month follow-up after treatment completion.METHODSThis is a multicenter randomized trial with an experimental test-retest design study with control group. Two groups will be included: a community comparison group (CC) and a Off-BDSZ group. A total of 108 Off-BDSZ and 65 CC aged between 6 and 25 years will be recruited. Off-BDSZ participants will be randomized to receive either Cognitive Reserve EnhAncement ThErapy (CREATE) (n=54), or a supportive approach (n=54). The CC group will be assessed at baseline. The duration of the intervention will be 3 months, with 12 weekly group sessions. The primary outcome will be the improvement in CR measured according to change in the Cognitive Reserve Assessment Scale in Health (CRASH) and Cognitive Reserve scale for Adolescents (CORE-A). All participants will be blindly evaluated using clinical, cognitive and neuroimaging measures at baseline, at three months (after the psychological intervention), and at twelve-month follow-up after treatment completion.The results will provide insight into whether the CREATE-Offspring version may enhance cognitive reserve (CR) in child, adolescent and young adult Off-BDSZ as well as advance knowledge about changes in clinical manifestations, neuropsychological performance and brain structure and function associated with improving CR. This novel and cost-effective intervention represents an advance in the framework of preventive interventions in mental health.DISCUSSIONThe results will provide insight into whether the CREATE-Offspring version may enhance cognitive reserve (CR) in child, adolescent and young adult Off-BDSZ as well as advance knowledge about changes in clinical manifestations, neuropsychological performance and brain structure and function associated with improving CR. This novel and cost-effective intervention represents an advance in the framework of preventive interventions in mental health.Clinicaltrials.gov, NCT03722082. Registered on 26 October 2018.TRIAL REGISTRATIONClinicaltrials.gov, NCT03722082. Registered on 26 October 2018.
Author Martinez-Aran, Anabel
Solé, Brisa
Serra-Blasco, Maria
Castro-Fornieles, Josefina
Vicent-Gil, Muriel
Montejo, Laura
Vieta, Eduard
de la Serna, Elena
Cardoner, Narcís
Rosa-Justicia, Mireia
Torrent, Carla
Camprodon-Boadas, Patricia
Sugranyes, Gisela
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  givenname: Carla
  surname: Torrent
  fullname: Torrent, Carla
  organization: Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain
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Issue 3
Keywords SCQ
ADHD
DSM-V
PAS
CPT-II
CREATE
WCST
ROCF
Schizophrenia
CHTE
Bipolar disorder
SCWT
CAPE
SCID
CRASH
WMS-III
Core-A
WASH-U-KSADS
TOMAL
Off-BD
HDRS
BPSS-P
CC
Cognitive reserve
SLES
CGI
MAAS
CPRS-48
TMT-A
GAF
CR
fMRI
WAIS-IV
Offspring
TMT-B
CMRS
Off-BDSZ
WISC-IV
SMR
SOPS
FAST
K-SADS-PL
YMRS
Off-SZ
SPQ-B
questionnaire of habits and study techniques
attention-deficit hyperactivity disorder
Trail Making Test part-A
Trail Making Test part-B
Community Assessment of Psychic Experiences
Offspring of patients diagnosed with schizophrenia
Sexual Maturity Rating
Global Assessment Functioning
Conners’ Rating Scales 48 items
Stroop Color-Word Interference Test
Premorbid Adjustment Scale
Test of memory and learning
Cognitive Reserve EnhAncement ThErapy
Cognitive Reserve scale for Adolescents
Offspring of patients diagnosed with bipolar disorder and schizophrenia
Cognitive Reserve Assessment Scale in Health
structured clinical interview based on DSM-V
Bipolar Prodrome Symptom Interview and Scale-Prospective
functional magnetic resonance imaging
Wechsler Memory Scale third edition
Clinical Global Impressions
Kiddie Schedule for Affective Disorders and Schizophrenia-Present – Lifetime Version
community comparison group
Schizotypal Personality Questionnaire-Brief
Scale of Prodromal Symptoms
Offspring of patients diagnosed with bipolar disorder
Hamilton Depression Rating Scale for depressive symptomatology
Child Mania Rating Scale
Stressful Life Events Schedule
Wechsler Intelligence Scale for Children fourth edition
Cognitive Reserve
Wechsler Adult Intelligence Scale fourth edition
Continuous Performance Test second edition
Mindful Attention Awareness Scale
Functioning Assessment Short Test
Kiddie Schedule for Affective Disorders and Schizophrenia version of university of Washington
Rey-Osterrieth Complex Figure
Social Communication Questionnaire
Wisconsin Card Sorting Test
Young Mania Rating Scale
Diagnostic and Statistical Manual of Mental Disorders fifth edition
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PublicationTitle Revista de psiquiatría y salud mental
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Elsevier España, S.L.U
Publisher_xml – name: Elsevier España S.L.U
– name: Elsevier España, S.L.U
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Snippet Offspring of patients diagnosed with bipolar disorder and schizophrenia (Off-BDSZ) have a high genetic risk of developing a mental illness. The aim of this...
AbstractBackgroundOffspring of patients diagnosed with bipolar disorder and schizophrenia (Off-BDSZ) have a high genetic risk of developing a mental illness....
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SubjectTerms Adolescent
Adult
Bipolar disorder
Bipolar Disorder - genetics
Child
Cognitive Reserve
Humans
Multicenter Studies as Topic
Offspring
Psychiatric/Mental Health
Psychotic Disorders - genetics
Randomized Controlled Trials as Topic
Schizophrenia
Schizophrenia - genetics
Treatment Outcome
Young Adult
Title Effectiveness of enhancing cognitive reserve in children, adolescents and young adults at genetic risk for psychosis: Study protocol for a randomized controlled trial
URI https://www.clinicalkey.com/#!/content/1-s2.0-S188898912100029X
https://www.clinicalkey.es/playcontent/1-s2.0-S188898912100029X
https://dx.doi.org/10.1016/j.rpsm.2021.02.003
https://www.ncbi.nlm.nih.gov/pubmed/33631372
https://www.proquest.com/docview/2494295470
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