Advocacy of Precision Allergy Molecular Diagnosis in Decision Making for the Eligibility of Customized Allergen Immunotherapy
Allergen immunotherapy (AIT) with aeroallergens is the only disease-modifying treatment for patients with different allergic conditions. Despite the effectiveness of AIT having been proven in both randomized controlled trials and real-world studies, it remains underused in less than 10% of subjects...
Saved in:
| Published in | Current Issues in Molecular Biology Vol. 45; no. 12; pp. 9976 - 9984 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
MDPI AG
01.12.2023
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1467-3045 1467-3037 1467-3045 |
| DOI | 10.3390/cimb45120623 |
Cover
| Abstract | Allergen immunotherapy (AIT) with aeroallergens is the only disease-modifying treatment for patients with different allergic conditions. Despite the effectiveness of AIT having been proven in both randomized controlled trials and real-world studies, it remains underused in less than 10% of subjects with allergic rhinitis (AR) and/or asthma (A). We aimed to determine the current eligibility for house dust mite (HDM) AIT by means of a precision allergy molecular diagnosis (PAMD@) model in a selected cohort of youngsters with different allergic phenotypes according to the available evidence. A complex response to both HDM and storage mite allergens was depicted regardless of the subjects’ basal atopic condition. No solely specific IgE-binding responses to Der p 1, Der p 2, and/or Der p 23 were found in the studied cohort. Despite the patients with A and atopic dermatitis showing significantly higher serum titers to six mite allergens than subjects with AR, no specific molecular profile was regarded as disease specific. Given the increasing complexity of specific IgE responses to the local prevailing aeroallergens, the identification and presence of such molecules are needed in commercially available AIT in the era of precision medicine. |
|---|---|
| AbstractList | Allergen immunotherapy (AIT) with aeroallergens is the only disease-modifying treatment for patients with different allergic conditions. Despite the effectiveness of AIT having been proven in both randomized controlled trials and real-world studies, it remains underused in less than 10% of subjects with allergic rhinitis (AR) and/or asthma (A). We aimed to determine the current eligibility for house dust mite (HDM) AIT by means of a precision allergy molecular diagnosis (PAMD@) model in a selected cohort of youngsters with different allergic phenotypes according to the available evidence. A complex response to both HDM and storage mite allergens was depicted regardless of the subjects’ basal atopic condition. No solely specific IgE-binding responses to Der p 1, Der p 2, and/or Der p 23 were found in the studied cohort. Despite the patients with A and atopic dermatitis showing significantly higher serum titers to six mite allergens than subjects with AR, no specific molecular profile was regarded as disease specific. Given the increasing complexity of specific IgE responses to the local prevailing aeroallergens, the identification and presence of such molecules are needed in commercially available AIT in the era of precision medicine. Allergen immunotherapy (AIT) with aeroallergens is the only disease-modifying treatment for patients with different allergic conditions. Despite the effectiveness of AIT having been proven in both randomized controlled trials and real-world studies, it remains underused in less than 10% of subjects with allergic rhinitis (AR) and/or asthma (A). We aimed to determine the current eligibility for house dust mite (HDM) AIT by means of a precision allergy molecular diagnosis (PAMD@) model in a selected cohort of youngsters with different allergic phenotypes according to the available evidence. A complex response to both HDM and storage mite allergens was depicted regardless of the subjects' basal atopic condition. No solely specific IgE-binding responses to Der p 1, Der p 2, and/or Der p 23 were found in the studied cohort. Despite the patients with A and atopic dermatitis showing significantly higher serum titers to six mite allergens than subjects with AR, no specific molecular profile was regarded as disease specific. Given the increasing complexity of specific IgE responses to the local prevailing aeroallergens, the identification and presence of such molecules are needed in commercially available AIT in the era of precision medicine.Allergen immunotherapy (AIT) with aeroallergens is the only disease-modifying treatment for patients with different allergic conditions. Despite the effectiveness of AIT having been proven in both randomized controlled trials and real-world studies, it remains underused in less than 10% of subjects with allergic rhinitis (AR) and/or asthma (A). We aimed to determine the current eligibility for house dust mite (HDM) AIT by means of a precision allergy molecular diagnosis (PAMD@) model in a selected cohort of youngsters with different allergic phenotypes according to the available evidence. A complex response to both HDM and storage mite allergens was depicted regardless of the subjects' basal atopic condition. No solely specific IgE-binding responses to Der p 1, Der p 2, and/or Der p 23 were found in the studied cohort. Despite the patients with A and atopic dermatitis showing significantly higher serum titers to six mite allergens than subjects with AR, no specific molecular profile was regarded as disease specific. Given the increasing complexity of specific IgE responses to the local prevailing aeroallergens, the identification and presence of such molecules are needed in commercially available AIT in the era of precision medicine. |
| Audience | Academic |
| Author | Pineda, Fernando Sánchez-Machín, Inmaculada Poza-Guedes, Paloma González-Pérez, Ruperto |
| Author_xml | – sequence: 1 givenname: Ruperto orcidid: 0000-0002-6664-0276 surname: González-Pérez fullname: González-Pérez, Ruperto – sequence: 2 givenname: Paloma orcidid: 0000-0001-8516-6648 surname: Poza-Guedes fullname: Poza-Guedes, Paloma – sequence: 3 givenname: Fernando orcidid: 0000-0001-8366-9145 surname: Pineda fullname: Pineda, Fernando – sequence: 4 givenname: Inmaculada surname: Sánchez-Machín fullname: Sánchez-Machín, Inmaculada |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38132469$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkklvFDEQhVsoiCxw44wsceHABC_tXo6jSYCREsEBzq3y0k0Ftz3Y3UGDxH_Hk0migCIhH2yVvnp-dr3j4sAHb4viJaOnQrT0ncZRlZJxWnHxpDhiZVUvBC3lwYPzYXGc0hWlsm5q9qw4FA0TvKzao-L30lwHDXpLQk8-R6sxYfBk6ZyNw5ZcBmf17CCSM4TBh4SJoCdnd9wlfEc_kD5EMn2z5NzhgAodTjd6qzlNYcRf1twKWk_W4zj7kOEIm-3z4mkPLtkXt_tJ8fX9-ZfVx8XFpw_r1fJiocuKTwsp-h6Y5koyIbUCLQznrTKlYZyLRvYCKsusrqqqNa2gSnFJlWgE0NpQZcVJsd7rmgBX3SbiCHHbBcDuphDi0EGcUDvbNZLplpWUMt3nb5UKRAtSG6EraPM1WWux15r9BrY_wbl7QUa73Ui6hyPJ_Js9v4nhx2zT1I2YtHUOvA1z6nhLpWRNXdOMvt6jA2Qn6PswRdA7vFvWdV22DWM7wdNHqLyMHVHncPSY6381vLp1MKvRmnu7dynIwNs9oGNIKdr-fy_i_-AaJ5hyHrIRdI83_QG4a9Mm |
| CitedBy_id | crossref_primary_10_3389_falgy_2024_1298816 crossref_primary_10_1111_cea_14486 crossref_primary_10_3390_ijms25189959 crossref_primary_10_3390_cimb46110759 crossref_primary_10_3390_ijms26010284 crossref_primary_10_3390_ph17111510 |
| Cites_doi | 10.1016/j.jaci.2020.03.029 10.1111/all.13266 10.1038/s41577-022-00786-1 10.1074/jbc.M110.128306 10.1186/s40413-015-0079-7 10.3389/fimmu.2021.651500 10.1016/j.jaci.2015.03.041 10.3389/fimmu.2021.687294 10.1016/j.jaci.2019.06.049 10.4049/jimmunol.1202288 10.1111/j.1398-9995.2012.02817.x 10.1016/j.jaci.2012.05.053 10.1159/000135696 10.1111/j.1398-9995.2008.01647.x 10.3389/fimmu.2021.786738 10.1111/all.14749 10.1007/s12016-018-8693-0 10.1186/s13601-020-00327-w 10.20944/preprints202305.0039.v1 10.1111/pai.13986 10.1111/pai.13854 10.1016/j.jaci.2017.01.009 10.1038/nature07548 10.1016/j.waojou.2020.100118 10.1016/j.jaci.2015.03.024 10.3390/cimb45070347 10.1111/pai.13189 10.1111/cea.12680 10.1186/2045-7022-3-3 10.3390/jpm13081206 10.1007/s11882-005-0012-1 10.3389/fimmu.2020.01815 10.1016/j.jaci.2018.10.048 10.1002/alr.23090 10.3390/cells12030383 10.1111/pai.12807 10.1016/j.jaci.2014.01.042 10.1016/j.aller.2017.09.002 10.1111/all.13776 10.1186/s13223-015-0109-6 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2023 MDPI AG |
| Copyright_xml | – notice: COPYRIGHT 2023 MDPI AG |
| DBID | AAYXX CITATION NPM 7X8 ADTOC UNPAY DOA |
| DOI | 10.3390/cimb45120623 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic Unpaywall for CDI: Periodical Content Unpaywall DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | CrossRef PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1467-3045 |
| EndPage | 9984 |
| ExternalDocumentID | oai_doaj_org_article_851c914001cf4515ba39a5cd3c6a9a6e 10.3390/cimb45120623 A777498113 38132469 10_3390_cimb45120623 |
| Genre | Journal Article |
| GeographicLocations | Spain |
| GeographicLocations_xml | – name: Spain |
| GrantInformation_xml | – fundername: Fundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC), Servicio Canario de Salud. grantid: OA17/042. |
| GroupedDBID | --- 36B 53G 5GY AAYXX AENEX AFZYC ALMA_UNASSIGNED_HOLDINGS CITATION DIK E3Z EMB F5P FRP GROUPED_DOAJ GX1 IAO IGS IHR INH ITC MODMG OK1 PGMZT RNS RPM TR2 NPM M~E 7X8 0VX A8Z ADBBV ADTOC BAWUL C1A EMOBN ESTFP MM. SV3 UNPAY |
| ID | FETCH-LOGICAL-c462t-53ffa1c2b5135cbac3d229bd4d122385f3a6e1ec6669d930bb250b383a07d0be3 |
| IEDL.DBID | UNPAY |
| ISSN | 1467-3045 1467-3037 |
| IngestDate | Fri Oct 03 12:52:08 EDT 2025 Sun Oct 26 04:10:43 EDT 2025 Wed Oct 01 13:53:28 EDT 2025 Fri Feb 23 00:23:04 EST 2024 Tue Jan 02 04:47:15 EST 2024 Thu Apr 03 07:04:30 EDT 2025 Thu Oct 16 04:48:56 EDT 2025 Thu Apr 24 22:58:20 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 12 |
| Keywords | allergic phenotype molecular allergology allergen immunotherapy mites allergens |
| Language | English |
| License | cc-by |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c462t-53ffa1c2b5135cbac3d229bd4d122385f3a6e1ec6669d930bb250b383a07d0be3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0001-8366-9145 0000-0002-6664-0276 0000-0001-8516-6648 |
| OpenAccessLink | https://proxy.k.utb.cz/login?url=https://www.mdpi.com/1467-3045/45/12/623/pdf?version=1702389558 |
| PMID | 38132469 |
| PQID | 2905518770 |
| PQPubID | 23479 |
| PageCount | 9 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_851c914001cf4515ba39a5cd3c6a9a6e unpaywall_primary_10_3390_cimb45120623 proquest_miscellaneous_2905518770 gale_infotracmisc_A777498113 gale_infotracacademiconefile_A777498113 pubmed_primary_38132469 crossref_primary_10_3390_cimb45120623 crossref_citationtrail_10_3390_cimb45120623 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-12-01 |
| PublicationDateYYYYMMDD | 2023-12-01 |
| PublicationDate_xml | – month: 12 year: 2023 text: 2023-12-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland |
| PublicationTitle | Current Issues in Molecular Biology |
| PublicationTitleAlternate | Curr Issues Mol Biol |
| PublicationYear | 2023 |
| Publisher | MDPI AG |
| Publisher_xml | – name: MDPI AG |
| References | Silar (ref_32) 2012; 67 ref_36 Lis (ref_13) 2023; 45 Stringari (ref_38) 2014; 134 ref_12 Dramburg (ref_2) 2023; 34 Durham (ref_1) 2023; 23 Curin (ref_25) 2021; 12 Weghofer (ref_22) 2013; 190 Hatzler (ref_15) 2012; 130 Bonertz (ref_4) 2018; 73 Mueller (ref_24) 2016; 46 Yang (ref_30) 2022; 12 Mahler (ref_3) 2020; 10 Thomas (ref_19) 2005; 5 Trompette (ref_18) 2009; 457 ref_37 Weghofer (ref_17) 2008; 63 Bousquet (ref_8) 2020; 145 Muddaluru (ref_26) 2021; 76 Akdis (ref_6) 2020; 31 Zimmer (ref_42) 2017; 45 Resch (ref_21) 2015; 136 Wise (ref_34) 2023; 13 Caraballo (ref_39) 2021; 12 Heinzerling (ref_11) 2013; 3 Custovic (ref_14) 2015; 136 Chen (ref_29) 2018; 143 Weghofer (ref_16) 2008; 147 Eichenfield (ref_10) 2017; 139 Eberlein (ref_33) 2020; 11 Caraballo (ref_31) 2020; 13 Miller (ref_40) 2019; 57 Celi (ref_23) 2019; 74 ref_9 Pineda (ref_41) 2023; 34 Canonica (ref_5) 2015; 8 Berings (ref_28) 2020; 146 Mueller (ref_20) 2010; 285 Demoly (ref_27) 2016; 12 ref_7 Halken (ref_35) 2017; 28 |
| References_xml | – volume: 146 start-page: 1097 year: 2020 ident: ref_28 article-title: Molecular profiling of allergen-specific antibody responses may enhance success of specific immunotherapy publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2020.03.029 – ident: ref_9 – volume: 73 start-page: 64 year: 2018 ident: ref_4 article-title: Challenges in the implementation of EAACI guidelines on allergen immunotherapy: A global perspective on the regulation of allergen products publication-title: Allergy doi: 10.1111/all.13266 – volume: 23 start-page: 317 year: 2023 ident: ref_1 article-title: Allergen immunotherapy: Past, present and future publication-title: Nat. Rev. Immunol. doi: 10.1038/s41577-022-00786-1 – volume: 285 start-page: 25394 year: 2010 ident: ref_20 article-title: Der p 5 Crystal Structure Provides Insight into the Group 5 Dust Mite Allergens publication-title: J. Biol. Chem. doi: 10.1074/jbc.M110.128306 – volume: 8 start-page: 31 year: 2015 ident: ref_5 article-title: Allergen Immunotherapy (AIT): A prototype of Precision Medicine publication-title: World Allergy Organ. J. doi: 10.1186/s40413-015-0079-7 – volume: 12 start-page: 651500 year: 2021 ident: ref_39 article-title: Are the Terms Major and Minor Allergens Useful for Precision Allergology? publication-title: Front. Immunol. doi: 10.3389/fimmu.2021.651500 – volume: 136 start-page: 1645 year: 2015 ident: ref_14 article-title: Evolution pathways of IgE responses to grass and mite allergens throughout childhood publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2015.03.041 – volume: 12 start-page: 687294 year: 2021 ident: ref_25 article-title: IgE Epitopes of the House Dust Mite Allergen Der p 7 Are Mainly Discontinuous and Conformational publication-title: Front. Immunol. doi: 10.3389/fimmu.2021.687294 – volume: 145 start-page: 70 year: 2020 ident: ref_8 article-title: Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2019.06.049 – volume: 190 start-page: 3059 year: 2013 ident: ref_22 article-title: Identification of Der p 23, a Peritrophin-like Protein, as a New Major Dermatophagoides pteronyssinus Allergen Associated with the Peritrophic Matrix of Mite Fecal Pellets publication-title: J. Immunol. doi: 10.4049/jimmunol.1202288 – volume: 67 start-page: 822 year: 2012 ident: ref_32 article-title: Basophil response and the induction of a tolerance in venom immunotherapy: A long-term sting challenge study publication-title: Allergy doi: 10.1111/j.1398-9995.2012.02817.x – volume: 130 start-page: 894 year: 2012 ident: ref_15 article-title: Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2012.05.053 – volume: 147 start-page: 101 year: 2008 ident: ref_16 article-title: Characterization of folded recombinant Der p 5, a potential diagnostic marker allergen for house dust mite allergy publication-title: Int. Arch. Allergy Immunol. doi: 10.1159/000135696 – volume: 63 start-page: 758 year: 2008 ident: ref_17 article-title: Characterization of Der p 21, a new important allergen derived from the gut of house dust mites publication-title: Allergy doi: 10.1111/j.1398-9995.2008.01647.x – volume: 12 start-page: 786738 year: 2022 ident: ref_30 article-title: Specific IgE and IgG4 Profiles of House Dust Mite Components in Allergen-Specific Immunotherapy publication-title: Front. Immunol. doi: 10.3389/fimmu.2021.786738 – volume: 76 start-page: 2177 year: 2021 ident: ref_26 article-title: Comparison of house dust mite sensitization profiles in allergic adults from Canada, Europe, South Africa and USA publication-title: Allergy doi: 10.1111/all.14749 – volume: 57 start-page: 312 year: 2019 ident: ref_40 article-title: The Role of Dust Mites in Allergy publication-title: Clin. Rev. Allergy Immunol. doi: 10.1007/s12016-018-8693-0 – volume: 10 start-page: 28 year: 2020 ident: ref_3 article-title: Allergen Immunotherapy (AIT) in children: A vulnerable population with its own rights and legislation—Summary of EMA-initiated multi-stakeholder meeting on Allergen Immunotherapy (AIT) for children, held at Paul-Ehrlich-Institut, Langen, Germany, 16.1.2019 publication-title: Clin. Transl. Allergy doi: 10.1186/s13601-020-00327-w – ident: ref_7 doi: 10.20944/preprints202305.0039.v1 – volume: 34 start-page: e13986 year: 2023 ident: ref_41 article-title: Comment on Platts-Mills et al publication-title: Pediatr. Allergy Immunol. doi: 10.1111/pai.13986 – volume: 34 start-page: e13854 year: 2023 ident: ref_2 article-title: EAACI Molecular Allergology User’s Guide 2.0 publication-title: Pediatr. Allergy Immunol. doi: 10.1111/pai.13854 – volume: 139 start-page: S49 year: 2017 ident: ref_10 article-title: Current guidelines for the evaluation and management of atopic dermatitis: A comparison of the Joint Task Force Practice Parameter and American Academy of Dermatology guidelines publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2017.01.009 – volume: 457 start-page: 585 year: 2009 ident: ref_18 article-title: Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein publication-title: Nature doi: 10.1038/nature07548 – volume: 13 start-page: 100118 year: 2020 ident: ref_31 article-title: The allergenic activity and clinical impact of individual IgE-antibody binding molecules from indoor allergen sources publication-title: World Allergy Organ. J. doi: 10.1016/j.waojou.2020.100118 – ident: ref_12 – volume: 136 start-page: 1083 year: 2015 ident: ref_21 article-title: Different IgE recognition of mite allergen components in asthmatic and nonasthmatic children publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2015.03.024 – volume: 45 start-page: 5481 year: 2023 ident: ref_13 article-title: Selected Technical Aspects of Molecular Allergy Diagnostics publication-title: Curr. Issues Mol. Biol. doi: 10.3390/cimb45070347 – volume: 31 start-page: 1 year: 2020 ident: ref_6 article-title: EAACI Allergen Immunotherapy User’s Guide publication-title: Pediatr. Allergy Immunol. doi: 10.1111/pai.13189 – volume: 46 start-page: 365 year: 2016 ident: ref_24 article-title: Serological, genomic and structural analyses of the major mite allergen Der p 23 publication-title: Clin. Exp. Allergy doi: 10.1111/cea.12680 – volume: 3 start-page: 3 year: 2013 ident: ref_11 article-title: The skin prick test—European standards publication-title: Clin. Transl. Allergy doi: 10.1186/2045-7022-3-3 – ident: ref_36 doi: 10.3390/jpm13081206 – volume: 5 start-page: 388 year: 2005 ident: ref_19 article-title: Structural biology of allergens publication-title: Curr. Allergy Asthma Rep. doi: 10.1007/s11882-005-0012-1 – volume: 11 start-page: 1815 year: 2020 ident: ref_33 article-title: Basophil Activation as Marker of Clinically Relevant Allergy and Therapy Outcome publication-title: Front Immunol. doi: 10.3389/fimmu.2020.01815 – volume: 143 start-page: 1248 year: 2018 ident: ref_29 article-title: Selection of house dust mite–allergic patients by molecular diagnosis may enhance success of specific immunotherapy publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2018.10.048 – volume: 13 start-page: 293 year: 2023 ident: ref_34 article-title: International consensus statement on allergy and rhinology: Allergic rhinitis—2023 publication-title: Int. Forum Allergy Rhinol. doi: 10.1002/alr.23090 – ident: ref_37 doi: 10.3390/cells12030383 – volume: 28 start-page: 728 year: 2017 ident: ref_35 article-title: EAACI guidelines on allergen immunotherapy: Prevention of allergy publication-title: Pediatr. Allergy Immunol. doi: 10.1111/pai.12807 – volume: 134 start-page: 75 year: 2014 ident: ref_38 article-title: Italian Pediatric Allergy Network (I-PAN). The effect of component-resolved diagnosis on specific immunotherapy prescription in children with hay fever publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2014.01.042 – volume: 45 start-page: 4 year: 2017 ident: ref_42 article-title: Quality requirements for allergen extracts and allergoids for allergen immunotherapy publication-title: Allergol. Immunopathol. doi: 10.1016/j.aller.2017.09.002 – volume: 74 start-page: 1787 year: 2019 ident: ref_23 article-title: House dust mite allergy in Italy—Diagnostic and clinical relevance of Der p 23 (and of minor allergens): A real-life, multicenter study publication-title: Allergy doi: 10.1111/all.13776 – volume: 12 start-page: 2 year: 2016 ident: ref_27 article-title: Management of the polyallergic patient with allergy immunotherapy: A practice-based approach publication-title: Allergy Asthma Clin. Immunol. doi: 10.1186/s13223-015-0109-6 |
| SSID | ssj0057871 ssib044733985 |
| Score | 2.3758204 |
| Snippet | Allergen immunotherapy (AIT) with aeroallergens is the only disease-modifying treatment for patients with different allergic conditions. Despite the... |
| SourceID | doaj unpaywall proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 9976 |
| SubjectTerms | allergen immunotherapy Allergens allergic phenotype Atopic dermatitis Care and treatment Decision-making Ethylenediaminetetraacetic acid Immunoglobulin E Immunotherapy Medical research Medicine, Experimental mites molecular allergology |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Li9RAEG5kQfQivs3uKi34OEjYfqQ76eO4D1ZhxIMLewv9igzMZpbdGZcI_ner0pkxg6gXr-lKJ9VV1fUV1IOQVxAjWB-8zaOyIgd8q3KrbZObyjaFkj6IgIHi9JM-PSs-nqvz0agvzAlL7YHTwR0AIvAGogDGPbzMlbPSWOWD9NoaqyPevqwyo2AKNKkoSinNLyCMaslTnRGYFJNlSoEHGnbgZxcONhZMC7nlnPoe_r_f1CNXdWfVXtruxs7nI590cp_cG8AknSQmHpBbsX1Ibqfxkt0j8mMSvoGr8h1dNPTz1TBNh06w-u9rR6frybj0KOXbza7prKVHa7ppP6iKAqqlgBLpMeYu96m0_X6HK4CNF7PvMQwbxpZ-wGKToaSre0zOTo6_HJ7mw7iF3BdaLHMlm8ZyL5ziUnlnvQxCGBeKwAFDVKqRcNw8egh4TDCSOQfwyUGEa1kZmIvyCdlpF218RmhpsLOebnijTWEiXBJeVxZCO2VBNIxn5N36nGs_9CLHkRjzGmISlEo9lkpGXm-oL1MPjj_QvUeRbWiwc3b_APSpHvSp_pc-ZeQtCrxG-4ZfAiGlMgVgDDtl1ZMSALOpOIfP7W9Rgl36reWXa5WpcQmT2dq4WF3XwjDsg1eWLCNPky5t_hkAFEBcbTLyZqNcf2V6938wvUfuCgBvKU1nn-wsr1bxOYCtpXvR29VPJo8ikA priority: 102 providerName: Directory of Open Access Journals |
| Title | Advocacy of Precision Allergy Molecular Diagnosis in Decision Making for the Eligibility of Customized Allergen Immunotherapy |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/38132469 https://www.proquest.com/docview/2905518770 https://www.mdpi.com/1467-3045/45/12/623/pdf?version=1702389558 https://doaj.org/article/851c914001cf4515ba39a5cd3c6a9a6e |
| UnpaywallVersion | publishedVersion |
| Volume | 45 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1467-3045 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0057871 issn: 1467-3045 databaseCode: DOA dateStart: 19990101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1467-3045 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0057871 issn: 1467-3045 databaseCode: DIK dateStart: 19990101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1467-3045 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0057871 issn: 1467-3045 databaseCode: GX1 dateStart: 19990101 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1467-3045 dateEnd: 99991231 omitProxy: true ssIdentifier: ssib044733985 issn: 1467-3037 databaseCode: M~E dateStart: 19990101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 1467-3045 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0057871 issn: 1467-3045 databaseCode: RPM dateStart: 20210101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELegE4KX8c0CozISHw8oaxzHTvyEytZpIHXaA5XGU_BXpoourdpmqJPgb-ecuFELAiEhVXloLm5OPvt-5979DqGXECNIbbQMLZNxCPiWhZLLIhSZLBJGtYmNCxSHp_xklHw8Z-e-z-nCp1VCKD6uN-l6Fbu_8nrwIXEPXHVvZop3V_4oiaTO4wjGsptohzMA4x20Mzo9639uaorcwzVrZjtQk_pOIdDv6fGlSsDdRTymW06p5u7_fYfecFG3q3ImV9_kZLLhi47voi9rLZoUlK8H1VId6OtfCB7_Q817aNfjVNxvDOs-umHLB-hW07ly9RB975sr8IJ6hacFPpv7Rj247woLL1Z4uG66i4-aVL7xAo9LfLSWG9Y9sDAAZgwAFA9cWnSdpVuPd1gBIr0cX1vjB7Ql_uDqWHy12OoRGh0PPh2ehL6TQ6gTHi9DRotCEh0rRijTSmpq4lgokxgC8CRjBZXcEqshlhJG0EgpQGYKgmcZpSZSlj5GnXJa2j2EU-FI-3hBCi4SYWH_0TyTEDUymSRpRAL0dj2VufY0567bxiSHcMdNfL458QF61UrPGnqPP8i9d1bRyjhS7vqL6fwi92s8B_CqBQSsEdFg54QpSYVk2lDNpQAFA_TG2VTutg54JZikpgICFHMkXHk_BSwuMkLg5_a3JGHJ663bL9ZWmbtbLk-utNNqkccichR7aRoF6Eljru07AzYD9MxFgF639vtXpZ_-q-AzdCcGE22yfPZRZzmv7HPAakvVrc844Dr8MejWR2ldv0J_AqtXOI8 |
| linkProvider | Unpaywall |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bi9QwFA46i-iL90t1lQheHqQ7TdOkzZOMe2EVZtkHB9anmluX4mxnmJmudMH_7kmbKTOKIgh9ak_THnKS833tuSD0CjiC1EbL0DIZh4BvWSi5LEKRySJhVJvYOKI4PuHHk-TTGTvzfU6XPqwSqHjZbtLtKna_8oZwkHgIrno4N8X7S_8piaTO4wjGsutohzMA4wO0Mzk5HX3pcorczW3VzH6gLvSdAtEf6vJCJeDuIh7TLafU1u7_fYfecFE362oum-9yOt3wRUd30Ne1Fl0Iyre9eqX29NUvBR7_Q8276LbHqXjUGdY9dM1W99GNrnNl8wD9GJlL8IK6wbMCny58ox48comF5w0er5vu4oMulK9c4rLCB2u5cdsDCwNgxgBA8aELi26jdNvx9mtApBfllTV-QFvhjy6PxWeLNQ_R5Ojw8_5x6Ds5hDrh8SpktCgk0bFihDKtpKYmjoUyiSEATzJWUMktsRq4lDCCRkoBMlNAnmWUmkhZ-ggNqlllnyCcCle0jxek4CIRFvYfzTMJrJHJJEkjEqB366nMtS9z7rptTHOgO27i882JD9DrXnrelff4g9wHZxW9jCvK3Z6YLc5zv8ZzAK9aAGGNiAY7J0xJKiTThmouBSgYoLfOpnK3dcArwSR1GRCgmCvClY9SwOIiIwQet7slCUteb11-ubbK3F1ycXKVndXLPBaRK7GXplGAHnfm2r8zYDNAz1wE6E1vv39V-um_Cj5Dt2Iw0S7KZxcNVovaPgestlIv_Hr8CdTxNVk |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Advocacy+of+Precision+Allergy+Molecular+Diagnosis+in+Decision+Making+for+the+Eligibility+of+Customized+Allergen+Immunotherapy&rft.jtitle=Current+issues+in+molecular+biology&rft.au=Gonz%C3%A1lez-P%C3%A9rez%2C+Ruperto&rft.au=Poza-Guedes%2C+Paloma&rft.au=Pineda%2C+Fernando&rft.au=S%C3%A1nchez-Mach%C3%ADn%2C+Inmaculada&rft.date=2023-12-01&rft.issn=1467-3045&rft.eissn=1467-3045&rft.volume=45&rft.issue=12&rft.spage=9976&rft_id=info:doi/10.3390%2Fcimb45120623&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1467-3045&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1467-3045&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1467-3045&client=summon |