Can Dietary Intake of Vitamin C-Oriented Foods Reduce the Risk of Osteoporosis, Fracture, and BMD Loss? Systematic Review With Meta-Analyses of Recent Studies
Several epidemiological studies have been performed to evaluate the association of dietary intake of vitamin C-oriented foods (DIVCF) with risk of fracture and bone mineral density (BMD) loss, but the results remain controversial. Therefore, we conducted a systematic meta-analysis to assess this cor...
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| Published in | Frontiers in endocrinology (Lausanne) Vol. 10; p. 844 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Switzerland
Frontiers Media S.A
03.02.2020
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| ISSN | 1664-2392 1664-2392 |
| DOI | 10.3389/fendo.2019.00844 |
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| Abstract | Several epidemiological studies have been performed to evaluate the association of dietary intake of vitamin C-oriented foods (DIVCF) with risk of fracture and bone mineral density (BMD) loss, but the results remain controversial. Therefore, we conducted a systematic meta-analysis to assess this correlation.
We searched EmBase, PubMed, Web of Science, and the Chinese database CNKI for relevant articles published up to August 2019. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated using the random- or fixed-effects model. Discrepancies were resolved by consultation with a third expert.
A total of 13 eligible articles (including 17 studies) with 19,484 subjects were identified for the present meta-analysis. The pooled RR of hip fracture for the highest vs. lowest category was 0.66 (95% CI, 0.47-0.94) for DIVCF, i.e., people with a greater frequency of Vitamin C uptake had a 34% (95% CI, 6%-53%) lower prevalence of hip fracture. In subgroup analyses stratified by study design, gender, and age, the negative associations were statistically significant. Furthermore, the statistical analysis of the association between DIVCF and risk of osteoporosis (RR, 0.66; 95% CI, 0.48-0.92), BMD at the lumbar spine (pooled
, 0.15; 95% CI, 0.09-0.23), and BMD at the femoral neck (pooled
, 0.20; 95% CI, 0.11-0.34) showed beneficial effects of DIVCF.
Our meta-analysis indicates that DIVCF is negatively associated with the risk of hip fracture, osteoporosis, and BMD loss, suggesting that DIVCF decreases the risk of hip fracture, osteoporosis, and BMD loss. |
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| AbstractList | Several epidemiological studies have been performed to evaluate the association of dietary intake of vitamin C-oriented foods (DIVCF) with risk of fracture and bone mineral density (BMD) loss, but the results remain controversial. Therefore, we conducted a systematic meta-analysis to assess this correlation.
We searched EmBase, PubMed, Web of Science, and the Chinese database CNKI for relevant articles published up to August 2019. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated using the random- or fixed-effects model. Discrepancies were resolved by consultation with a third expert.
A total of 13 eligible articles (including 17 studies) with 19,484 subjects were identified for the present meta-analysis. The pooled RR of hip fracture for the highest vs. lowest category was 0.66 (95% CI, 0.47-0.94) for DIVCF, i.e., people with a greater frequency of Vitamin C uptake had a 34% (95% CI, 6%-53%) lower prevalence of hip fracture. In subgroup analyses stratified by study design, gender, and age, the negative associations were statistically significant. Furthermore, the statistical analysis of the association between DIVCF and risk of osteoporosis (RR, 0.66; 95% CI, 0.48-0.92), BMD at the lumbar spine (pooled
, 0.15; 95% CI, 0.09-0.23), and BMD at the femoral neck (pooled
, 0.20; 95% CI, 0.11-0.34) showed beneficial effects of DIVCF.
Our meta-analysis indicates that DIVCF is negatively associated with the risk of hip fracture, osteoporosis, and BMD loss, suggesting that DIVCF decreases the risk of hip fracture, osteoporosis, and BMD loss. Background: Several epidemiological studies have been performed to evaluate the association of dietary intake of vitamin C-oriented foods (DIVCF) with risk of fracture and bone mineral density (BMD) loss, but the results remain controversial. Therefore, we conducted a systematic meta-analysis to assess this correlation.Methods: We searched EmBase, PubMed, Web of Science, and the Chinese database CNKI for relevant articles published up to August 2019. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated using the random- or fixed-effects model. Discrepancies were resolved by consultation with a third expert.Results: A total of 13 eligible articles (including 17 studies) with 19,484 subjects were identified for the present meta-analysis. The pooled RR of hip fracture for the highest vs. lowest category was 0.66 (95% CI, 0.47–0.94) for DIVCF, i.e., people with a greater frequency of Vitamin C uptake had a 34% (95% CI, 6%−53%) lower prevalence of hip fracture. In subgroup analyses stratified by study design, gender, and age, the negative associations were statistically significant. Furthermore, the statistical analysis of the association between DIVCF and risk of osteoporosis (RR, 0.66; 95% CI, 0.48–0.92), BMD at the lumbar spine (pooled r, 0.15; 95% CI, 0.09–0.23), and BMD at the femoral neck (pooled r, 0.20; 95% CI, 0.11–0.34) showed beneficial effects of DIVCF.Conclusion: Our meta-analysis indicates that DIVCF is negatively associated with the risk of hip fracture, osteoporosis, and BMD loss, suggesting that DIVCF decreases the risk of hip fracture, osteoporosis, and BMD loss. Background: Several epidemiological studies have been performed to evaluate the association of dietary intake of vitamin C-oriented foods (DIVCF) with risk of fracture and bone mineral density (BMD) loss, but the results remain controversial. Therefore, we conducted a systematic meta-analysis to assess this correlation. Methods: We searched EmBase, PubMed, Web of Science, and the Chinese database CNKI for relevant articles published up to August 2019. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated using the random- or fixed-effects model. Discrepancies were resolved by consultation with a third expert. Results: A total of 13 eligible articles (including 17 studies) with 19,484 subjects were identified for the present meta-analysis. The pooled RR of hip fracture for the highest vs. lowest category was 0.66 (95% CI, 0.47-0.94) for DIVCF, i.e., people with a greater frequency of Vitamin C uptake had a 34% (95% CI, 6%-53%) lower prevalence of hip fracture. In subgroup analyses stratified by study design, gender, and age, the negative associations were statistically significant. Furthermore, the statistical analysis of the association between DIVCF and risk of osteoporosis (RR, 0.66; 95% CI, 0.48-0.92), BMD at the lumbar spine (pooled r, 0.15; 95% CI, 0.09-0.23), and BMD at the femoral neck (pooled r, 0.20; 95% CI, 0.11-0.34) showed beneficial effects of DIVCF. Conclusion: Our meta-analysis indicates that DIVCF is negatively associated with the risk of hip fracture, osteoporosis, and BMD loss, suggesting that DIVCF decreases the risk of hip fracture, osteoporosis, and BMD loss.Background: Several epidemiological studies have been performed to evaluate the association of dietary intake of vitamin C-oriented foods (DIVCF) with risk of fracture and bone mineral density (BMD) loss, but the results remain controversial. Therefore, we conducted a systematic meta-analysis to assess this correlation. Methods: We searched EmBase, PubMed, Web of Science, and the Chinese database CNKI for relevant articles published up to August 2019. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated using the random- or fixed-effects model. Discrepancies were resolved by consultation with a third expert. Results: A total of 13 eligible articles (including 17 studies) with 19,484 subjects were identified for the present meta-analysis. The pooled RR of hip fracture for the highest vs. lowest category was 0.66 (95% CI, 0.47-0.94) for DIVCF, i.e., people with a greater frequency of Vitamin C uptake had a 34% (95% CI, 6%-53%) lower prevalence of hip fracture. In subgroup analyses stratified by study design, gender, and age, the negative associations were statistically significant. Furthermore, the statistical analysis of the association between DIVCF and risk of osteoporosis (RR, 0.66; 95% CI, 0.48-0.92), BMD at the lumbar spine (pooled r, 0.15; 95% CI, 0.09-0.23), and BMD at the femoral neck (pooled r, 0.20; 95% CI, 0.11-0.34) showed beneficial effects of DIVCF. Conclusion: Our meta-analysis indicates that DIVCF is negatively associated with the risk of hip fracture, osteoporosis, and BMD loss, suggesting that DIVCF decreases the risk of hip fracture, osteoporosis, and BMD loss. |
| Author | Guo, Da Han, Yan-Hong Xiao, Xiao Liang, Wei-Xiong Chen, Hong-Yun Luo, Ming-Hui Li, Jia-Hui Huang, He-Tao Lin, Jiong-Tong Zhao, Jin-Long Yu, Jie Wu, Ming Liu, Jun Liang, Gui-Hong Guan, Zi-Tong Yang, Wei-Yi Zeng, Ling-Feng Hou, Sen-Rong Liu, Qiang Pan, Jian-Ke Li, Zi-Ping Wang, Qi Ou, Ai-Hua Zhao, Di Wei, Xu |
| AuthorAffiliation | 3 The Second Clinical College of Guangzhou University of Chinese Medicine , Guangzhou , China 5 World Federation of Chinese Medicine Societies , Beijing , China 1 The 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine) , Guangzhou , China 2 Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences , Guangzhou , China 4 Wangjing Hospital of China Academy of Chinese Medical Sciences , Beijing , China |
| AuthorAffiliation_xml | – name: 1 The 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine) , Guangzhou , China – name: 4 Wangjing Hospital of China Academy of Chinese Medical Sciences , Beijing , China – name: 2 Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences , Guangzhou , China – name: 3 The Second Clinical College of Guangzhou University of Chinese Medicine , Guangzhou , China – name: 5 World Federation of Chinese Medicine Societies , Beijing , China |
| Author_xml | – sequence: 1 givenname: Ling-Feng surname: Zeng fullname: Zeng, Ling-Feng – sequence: 2 givenname: Ming-Hui surname: Luo fullname: Luo, Ming-Hui – sequence: 3 givenname: Gui-Hong surname: Liang fullname: Liang, Gui-Hong – sequence: 4 givenname: Wei-Yi surname: Yang fullname: Yang, Wei-Yi – sequence: 5 givenname: Xiao surname: Xiao fullname: Xiao, Xiao – sequence: 6 givenname: Xu surname: Wei fullname: Wei, Xu – sequence: 7 givenname: Jie surname: Yu fullname: Yu, Jie – sequence: 8 givenname: Da surname: Guo fullname: Guo, Da – sequence: 9 givenname: Hong-Yun surname: Chen fullname: Chen, Hong-Yun – sequence: 10 givenname: Jian-Ke surname: Pan fullname: Pan, Jian-Ke – sequence: 11 givenname: He-Tao surname: Huang fullname: Huang, He-Tao – sequence: 12 givenname: Qiang surname: Liu fullname: Liu, Qiang – sequence: 13 givenname: Zi-Tong surname: Guan fullname: Guan, Zi-Tong – sequence: 14 givenname: Yan-Hong surname: Han fullname: Han, Yan-Hong – sequence: 15 givenname: Di surname: Zhao fullname: Zhao, Di – sequence: 16 givenname: Jin-Long surname: Zhao fullname: Zhao, Jin-Long – sequence: 17 givenname: Sen-Rong surname: Hou fullname: Hou, Sen-Rong – sequence: 18 givenname: Ming surname: Wu fullname: Wu, Ming – sequence: 19 givenname: Jiong-Tong surname: Lin fullname: Lin, Jiong-Tong – sequence: 20 givenname: Jia-Hui surname: Li fullname: Li, Jia-Hui – sequence: 21 givenname: Wei-Xiong surname: Liang fullname: Liang, Wei-Xiong – sequence: 22 givenname: Ai-Hua surname: Ou fullname: Ou, Ai-Hua – sequence: 23 givenname: Qi surname: Wang fullname: Wang, Qi – sequence: 24 givenname: Zi-Ping surname: Li fullname: Li, Zi-Ping – sequence: 25 givenname: Jun surname: Liu fullname: Liu, Jun |
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| Copyright | Copyright © 2020 Zeng, Luo, Liang, Yang, Xiao, Wei, Yu, Guo, Chen, Pan, Huang, Liu, Guan, Han, Zhao, Zhao, Hou, Wu, Lin, Li, Liang, Ou, Wang, Li and Liu. Copyright © 2020 Zeng, Luo, Liang, Yang, Xiao, Wei, Yu, Guo, Chen, Pan, Huang, Liu, Guan, Han, Zhao, Zhao, Hou, Wu, Lin, Li, Liang, Ou, Wang, Li and Liu. 2020 Zeng, Luo, Liang, Yang, Xiao, Wei, Yu, Guo, Chen, Pan, Huang, Liu, Guan, Han, Zhao, Zhao, Hou, Wu, Lin, Li, Liang, Ou, Wang, Li and Liu |
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| Keywords | meta-analysis risk reduction osteoporosis or fracture dietary intake BMD loss vitamin C-oriented foods |
| Language | English |
| License | Copyright © 2020 Zeng, Luo, Liang, Yang, Xiao, Wei, Yu, Guo, Chen, Pan, Huang, Liu, Guan, Han, Zhao, Zhao, Hou, Wu, Lin, Li, Liang, Ou, Wang, Li and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. cc-by |
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| SubjectTerms | BMD loss dietary intake Endocrinology meta-analysis osteoporosis or fracture risk reduction vitamin C-oriented foods |
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| Title | Can Dietary Intake of Vitamin C-Oriented Foods Reduce the Risk of Osteoporosis, Fracture, and BMD Loss? Systematic Review With Meta-Analyses of Recent Studies |
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