Effects of Lycium barbarum Polysaccharide on Endoplasmic Reticulum Stress and Oxidative Stress in Obese Mice
The incidence of obesity-associated decline in male fertility has increased over the years. polysaccharide (LBP), a natural plant polysaccharide extracted from the Chinese herb has shown promising therapeutic effects in overcoming the same. This study aimed to investigate the protective effect of LB...
Saved in:
| Published in | Frontiers in pharmacology Vol. 11; p. 742 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
26.05.2020
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1663-9812 1663-9812 |
| DOI | 10.3389/fphar.2020.00742 |
Cover
| Abstract | The incidence of obesity-associated decline in male fertility has increased over the years.
polysaccharide (LBP), a natural plant polysaccharide extracted from the Chinese herb
has shown promising therapeutic effects in overcoming the same.
This study aimed to investigate the protective effect of LBP on the testes of obese mice.
Following administration of LBP to high-fat diet-induced obese mice for 35 days, serum, sperm, and testis samples were obtained for subsequent experiments. Biochemical analysis and sex hormone content determination were performed to observe changes in glycolipid metabolism and testosterone levels, respectively, in the blood. Hematoxylin and eosin staining were carried out to assess the pathological changes in the testicular tissue. Oxidative stress levels were detected using enzyme-linked immunosorbent assay and expression levels of endoplasmic reticulum stress markers were determined using western blot in the testicular tissue.
Our results suggested that LBP reduced glucose levels and insulin resistance, increased testosterone levels and insulin sensitivity, and decreased testicular oxidative stress and pathological damage in obese mice. In addition, LBP down-regulated the expression of p-eIF2α, GRP78, and CHOP in the testicular tissues of obese mice.
Our results show that LBP is a potential novel drug for preventing male infertility caused by obesity. |
|---|---|
| AbstractList | The incidence of obesity-associated decline in male fertility has increased over the years.
polysaccharide (LBP), a natural plant polysaccharide extracted from the Chinese herb
has shown promising therapeutic effects in overcoming the same.
This study aimed to investigate the protective effect of LBP on the testes of obese mice.
Following administration of LBP to high-fat diet-induced obese mice for 35 days, serum, sperm, and testis samples were obtained for subsequent experiments. Biochemical analysis and sex hormone content determination were performed to observe changes in glycolipid metabolism and testosterone levels, respectively, in the blood. Hematoxylin and eosin staining were carried out to assess the pathological changes in the testicular tissue. Oxidative stress levels were detected using enzyme-linked immunosorbent assay and expression levels of endoplasmic reticulum stress markers were determined using western blot in the testicular tissue.
Our results suggested that LBP reduced glucose levels and insulin resistance, increased testosterone levels and insulin sensitivity, and decreased testicular oxidative stress and pathological damage in obese mice. In addition, LBP down-regulated the expression of p-eIF2α, GRP78, and CHOP in the testicular tissues of obese mice.
Our results show that LBP is a potential novel drug for preventing male infertility caused by obesity. BackgroundThe incidence of obesity-associated decline in male fertility has increased over the years. Lycium barbarum polysaccharide (LBP), a natural plant polysaccharide extracted from the Chinese herb L. barbarum has shown promising therapeutic effects in overcoming the same.AimThis study aimed to investigate the protective effect of LBP on the testes of obese mice.MethodsFollowing administration of LBP to high-fat diet-induced obese mice for 35 days, serum, sperm, and testis samples were obtained for subsequent experiments. Biochemical analysis and sex hormone content determination were performed to observe changes in glycolipid metabolism and testosterone levels, respectively, in the blood. Hematoxylin and eosin staining were carried out to assess the pathological changes in the testicular tissue. Oxidative stress levels were detected using enzyme-linked immunosorbent assay and expression levels of endoplasmic reticulum stress markers were determined using western blot in the testicular tissue.ResultsOur results suggested that LBP reduced glucose levels and insulin resistance, increased testosterone levels and insulin sensitivity, and decreased testicular oxidative stress and pathological damage in obese mice. In addition, LBP down-regulated the expression of p-eIF2α, GRP78, and CHOP in the testicular tissues of obese mice.ConclusionOur results show that LBP is a potential novel drug for preventing male infertility caused by obesity. The incidence of obesity-associated decline in male fertility has increased over the years. Lycium barbarum polysaccharide (LBP), a natural plant polysaccharide extracted from the Chinese herb L. barbarum has shown promising therapeutic effects in overcoming the same.BACKGROUNDThe incidence of obesity-associated decline in male fertility has increased over the years. Lycium barbarum polysaccharide (LBP), a natural plant polysaccharide extracted from the Chinese herb L. barbarum has shown promising therapeutic effects in overcoming the same.This study aimed to investigate the protective effect of LBP on the testes of obese mice.AIMThis study aimed to investigate the protective effect of LBP on the testes of obese mice.Following administration of LBP to high-fat diet-induced obese mice for 35 days, serum, sperm, and testis samples were obtained for subsequent experiments. Biochemical analysis and sex hormone content determination were performed to observe changes in glycolipid metabolism and testosterone levels, respectively, in the blood. Hematoxylin and eosin staining were carried out to assess the pathological changes in the testicular tissue. Oxidative stress levels were detected using enzyme-linked immunosorbent assay and expression levels of endoplasmic reticulum stress markers were determined using western blot in the testicular tissue.METHODSFollowing administration of LBP to high-fat diet-induced obese mice for 35 days, serum, sperm, and testis samples were obtained for subsequent experiments. Biochemical analysis and sex hormone content determination were performed to observe changes in glycolipid metabolism and testosterone levels, respectively, in the blood. Hematoxylin and eosin staining were carried out to assess the pathological changes in the testicular tissue. Oxidative stress levels were detected using enzyme-linked immunosorbent assay and expression levels of endoplasmic reticulum stress markers were determined using western blot in the testicular tissue.Our results suggested that LBP reduced glucose levels and insulin resistance, increased testosterone levels and insulin sensitivity, and decreased testicular oxidative stress and pathological damage in obese mice. In addition, LBP down-regulated the expression of p-eIF2α, GRP78, and CHOP in the testicular tissues of obese mice.RESULTSOur results suggested that LBP reduced glucose levels and insulin resistance, increased testosterone levels and insulin sensitivity, and decreased testicular oxidative stress and pathological damage in obese mice. In addition, LBP down-regulated the expression of p-eIF2α, GRP78, and CHOP in the testicular tissues of obese mice.Our results show that LBP is a potential novel drug for preventing male infertility caused by obesity.CONCLUSIONOur results show that LBP is a potential novel drug for preventing male infertility caused by obesity. |
| Author | Wei, Gui-Jiang Qin, Hai-Mei Pang, Xiao-Xia Liao, Bi-Yun Yang, Feng-Lian Wei, Yu-Xia Wang, Jun-Li |
| AuthorAffiliation | 2 Reproductive Center, Affiliated Hospital of Youjiang Medical College for Nationalities , Baise , China 1 Youjiang Medical College for Nationalities , Baise , China |
| AuthorAffiliation_xml | – name: 2 Reproductive Center, Affiliated Hospital of Youjiang Medical College for Nationalities , Baise , China – name: 1 Youjiang Medical College for Nationalities , Baise , China |
| Author_xml | – sequence: 1 givenname: Feng-Lian surname: Yang fullname: Yang, Feng-Lian – sequence: 2 givenname: Yu-Xia surname: Wei fullname: Wei, Yu-Xia – sequence: 3 givenname: Bi-Yun surname: Liao fullname: Liao, Bi-Yun – sequence: 4 givenname: Gui-Jiang surname: Wei fullname: Wei, Gui-Jiang – sequence: 5 givenname: Hai-Mei surname: Qin fullname: Qin, Hai-Mei – sequence: 6 givenname: Xiao-Xia surname: Pang fullname: Pang, Xiao-Xia – sequence: 7 givenname: Jun-Li surname: Wang fullname: Wang, Jun-Li |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32528287$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1UktrGzEQXkpK82juPRUde7Gj12qlS6EEtw24uPRxFtqRlChoV660DvG_r2wnISlUCDSMvsfAfKfN0ZhG1zTvCJ4zJtWFX9-YPKeY4jnGHaevmhMiBJspSejRs_q4OS_lFtfDlGKCv2mOGW2ppLI7aeLCewdTQcmj5RbCZkC9yfXW4nuK22IAqk2wDqURLUab1tGUIQD64aYAm1hxP6fsSkFmtGh1H6yZwp17bIYRrXpXHPoWwL1tXnsTizt_eM-a358Xvy6_zparL1eXn5Yz4IJOM9IxbKHz0nhiaO-It2Akp7bzFLAA2nIMRLXCc6DWtkII3CuqWt5hIy2ws-bqoGuTudXrHAaTtzqZoPeNlK-1yXX66DSv7JZ2iraVLq01ivUEQBrXtk54VrU-HrTWm35wFtw4ZRNfiL78GcONvk53uqOCE0KrwIcHgZz-bFyZ9BAKuBjN6NKmaMoJVbKVQlbo--deTyaP66oAfABATqVk558gBOtdKPQ-FHoXCr0PRaWIfygQprqitJs2xP8T_wIoaL3m |
| CitedBy_id | crossref_primary_10_1016_j_foodres_2022_111408 crossref_primary_10_3724_abbs_2024046 crossref_primary_10_3390_foods11223571 crossref_primary_10_1016_j_ijbiomac_2022_10_176 crossref_primary_10_1038_s41366_023_01411_4 crossref_primary_10_3390_antiox13020136 crossref_primary_10_3390_ijms25042130 crossref_primary_10_3390_separations9080197 crossref_primary_10_1016_j_ijbiomac_2024_137241 crossref_primary_10_3390_antiox12111959 crossref_primary_10_1155_2021_3617498 crossref_primary_10_3389_fmicb_2021_819993 crossref_primary_10_3390_nu15204437 crossref_primary_10_4103_1673_5374_293156 crossref_primary_10_1080_10942912_2022_2057529 crossref_primary_10_1016_j_aqrep_2023_101605 crossref_primary_10_1016_j_fsi_2025_110229 crossref_primary_10_1186_s13765_021_00642_1 crossref_primary_10_1002_ptr_8400 crossref_primary_10_3390_ph16020215 crossref_primary_10_1016_j_fbio_2023_102502 |
| Cites_doi | 10.1186/1477-7827-12-34 10.2147/DDDT.S176316 10.2174/1389450116666150427155342 10.1016/j.fertnstert.2017.02.115 10.1016/j.jogoh.2018.06.008 10.1089/ars.2007.1782 10.1002/jat.3720 10.22074/cellj.2019.6339 10.1371/journal.pone.0211837 10.1007/s10815-015-0506-2 10.1111/obr.12827 10.1016/j.chemosphere.2015.02.058 10.1159/000486165 10.1042/CS20180179 10.1186/s12944-020-01210-0 10.1186/s12906-019-2736-9 10.3389/fendo.2018.00769 10.3390/ijms20225785 10.1016/j.jes.2014.11.004 10.1089/ars.2014.6122 10.1016/j.pathophys.2019.02.001 10.1186/s12894-018-0360-5 10.26355/eurrev_201904_17595 10.1016/j.ejcb.2016.02.002 10.3390/ijms17030327 10.1039/C6FO01575A 10.1016/j.pneurobio.2017.08.001 10.1016/j.jacc.2017.05.043 10.1016/j.jff.2019.03.006 10.1038/srep05587 10.1210/en.2018-00569 10.1097/MOU.0000000000000417 10.1186/s12935-019-0805-2 10.1038/ijo.2017.203 10.1111/andr.12606 10.7717/peerj.3518 10.1507/endocrj.EJ16-0430 10.1530/REP-17-0161 10.20463/jenb.2019.0005 10.1039/C4FO01153H |
| ContentType | Journal Article |
| Copyright | Copyright © 2020 Yang, Wei, Liao, Wei, Qin, Pang and Wang. Copyright © 2020 Yang, Wei, Liao, Wei, Qin, Pang and Wang 2020 Yang, Wei, Liao, Wei, Qin, Pang and Wang |
| Copyright_xml | – notice: Copyright © 2020 Yang, Wei, Liao, Wei, Qin, Pang and Wang. – notice: Copyright © 2020 Yang, Wei, Liao, Wei, Qin, Pang and Wang 2020 Yang, Wei, Liao, Wei, Qin, Pang and Wang |
| DBID | AAYXX CITATION NPM 7X8 5PM DOA |
| DOI | 10.3389/fphar.2020.00742 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1663-9812 |
| ExternalDocumentID | oai_doaj_org_article_45665279259548dda93b1cc8ae55e6f3 PMC7264112 32528287 10_3389_fphar_2020_00742 |
| Genre | Journal Article |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAKDD AAYXX ACGFO ACGFS ACXDI ADBBV ADRAZ AENEX AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK EMOBN GROUPED_DOAJ GX1 HYE KQ8 M48 M~E O5R O5S OK1 P2P PGMZT RNS RPM IPNFZ NPM RIG 7X8 5PM |
| ID | FETCH-LOGICAL-c462t-1730dc7f8af1a2be1fdca842d7f2c06c2540c1956f4c2dd56660b9295470a8dc3 |
| IEDL.DBID | M48 |
| ISSN | 1663-9812 |
| IngestDate | Wed Aug 27 01:25:36 EDT 2025 Thu Aug 21 18:33:59 EDT 2025 Thu Sep 04 22:29:45 EDT 2025 Mon Jul 21 05:15:26 EDT 2025 Tue Jul 01 03:27:36 EDT 2025 Thu Apr 24 23:13:12 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | endoplasmic stress infertility Lycium barbarum polysaccharide obesity oxidative stress |
| Language | English |
| License | Copyright © 2020 Yang, Wei, Liao, Wei, Qin, Pang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c462t-1730dc7f8af1a2be1fdca842d7f2c06c2540c1956f4c2dd56660b9295470a8dc3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology Edited by: Cheorl-Ho Kim, Sungkyunkwan University, South Korea Reviewed by: Yasuhiro Kosuge, Nihon University, Japan; Taeshin Kim, Vivere Health, United States |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.3389/fphar.2020.00742 |
| PMID | 32528287 |
| PQID | 2412985868 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_45665279259548dda93b1cc8ae55e6f3 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7264112 proquest_miscellaneous_2412985868 pubmed_primary_32528287 crossref_primary_10_3389_fphar_2020_00742 crossref_citationtrail_10_3389_fphar_2020_00742 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2020-05-26 |
| PublicationDateYYYYMMDD | 2020-05-26 |
| PublicationDate_xml | – month: 05 year: 2020 text: 2020-05-26 day: 26 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland |
| PublicationTitle | Frontiers in pharmacology |
| PublicationTitleAlternate | Front Pharmacol |
| PublicationYear | 2020 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Raad (B31) 2019; 14 Karna (B15) 2019; 19 Leisegang (B19) 2014; 12 Koo (B16) 2019; 23 Guo (B11) 2015; 132 Shi (B34) 2017; 64 Malhotra (B25) 2007; 9 Martin-Jiménez (B26) 2017; 158 Mu (B28) 2018; 132 Ferigolo (B10) 2019; 7 Li (B22) 2015; 6 Yang (B40) 2015; 30 Yan (B38) 2015; 32 Xiao (B36) 2014; 4 Abdel-Fadeil (B2) 2019; 26 Yan-Fei (B39) 2018; 18 Di Vincenzo (B9) 2018; 9 Li (B21) 2014; 2014 Niemann (B29) 2017; 70 Cui (B7) 2017; 44 Deshpande (B8) 2019; 160 Liu (B24) 2015; 16 Wang (B35) 2020; 19 An (B3) 2017; 5 Xu (B37) 2015; 23 Craig (B5) 2017; 107 Karna (B14) 2019; 19 Crean (B6) 2019; 20 Kumar (B18) 2018; 47 Park (B30) 2017; 42 Škurla (B32) 2018; 83 Zeeshan (B42) 2016; 17 Abbasihormozi (B1) 2019; 21 Yang (B41) 2018; 12 Cannarella (B4) 2019; 23 Liu (B23) 2017; 154 Shi (B33) 2017; 8 Kahn (B12) 2017; 27 Mo (B27) 2019; 56 Karna (B13) 2019; 20 Kratochvílová (B17) 2016; 95 Leite (B20) 2019; 39 |
| References_xml | – volume: 12 start-page: 34 year: 2014 ident: B19 article-title: Obesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled male cohort publication-title: J. Urol. doi: 10.1186/1477-7827-12-34 – volume: 12 start-page: 3211 year: 2018 ident: B41 article-title: Lycium barbarum polysaccharide prevents cisplatin-induced MLTC-1 cell apoptosis and autophagy via regulating endoplasmic reticulum stress pathway publication-title: Drug Design Dev. Ther. doi: 10.2147/DDDT.S176316 – volume: 16 start-page: 1301 year: 2015 ident: B24 article-title: Antioxidant mechanisms in nonalcoholic fatty liver disease publication-title: Curr. Drug Targets doi: 10.2174/1389450116666150427155342 – volume: 107 start-page: 848 year: 2017 ident: B5 article-title: Obesity, male infertility, and the sperm epigenome publication-title: Fertility Sterility doi: 10.1016/j.fertnstert.2017.02.115 – volume: 47 start-page: 565 year: 2018 ident: B18 article-title: Reactive Oxygen Species in Seminal Plasma as a Cause of Male Infertility publication-title: J. Gynecol. Obstet. Hum. Reprod. doi: 10.1016/j.jogoh.2018.06.008 – volume: 9 start-page: 2277 year: 2007 ident: B25 article-title: Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Cycle or a Double-Edged Sword publication-title: Antioxid. Redox Signaling doi: 10.1089/ars.2007.1782 – volume: 39 start-page: 305 year: 2019 ident: B20 article-title: Ascorbic acid supplementation ameliorates testicular hormonal signaling, sperm production and oxidative stress in male rats exposed to rosuvastatin during pre-puberty publication-title: J. Appl. Toxicol. doi: 10.1002/jat.3720 – volume: 21 start-page: 307 year: 2019 ident: B1 article-title: Stress Hormone and Oxidative Stress Biomarkers Link Obesity and Diabetes with Reduced Fertility Potential publication-title: Cell J. doi: 10.22074/cellj.2019.6339 – volume: 14 year: 2019 ident: B31 article-title: Adverse effects of paternal obesity on the motile spermatozoa quality publication-title: PloS One doi: 10.1371/journal.pone.0211837 – volume: 32 start-page: 1097 year: 2015 ident: B38 article-title: Protective effects of metformin on reproductive function in obese male rats induced by high-fat diet publication-title: J. Assisted Reprod. Genet. doi: 10.1007/s10815-015-0506-2 – volume: 20 start-page: 921 year: 2019 ident: B6 article-title: High-fat diets reduce male reproductive success in animal models: A systematic review and meta-analysis publication-title: Obes. Rev doi: 10.1111/obr.12827 – volume: 132 start-page: 70 year: 2015 ident: B11 article-title: Role of Endoplasmic reticulum apoptotic pathway in testicular Sertoli cells injury induced by Carbon disulfide publication-title: Chemosphere doi: 10.1016/j.chemosphere.2015.02.058 – volume: 44 start-page: 2407 year: 2017 ident: B7 article-title: Melatonin Relieves Busulfan-Induced Spermatogonial Stem Cell Apoptosis of Mouse Testis by Inhibiting Endoplasmic Reticulum Stress publication-title: Cell. Physiol. Biochem doi: 10.1159/000486165 – volume: 132 start-page: 883 year: 2018 ident: B28 article-title: CTRP3 attenuates high-fat diet-induced male reproductive dysfunction in mice publication-title: Clin. Sci (Lond) doi: 10.1042/CS20180179 – volume: 19 start-page: 72 year: 2020 ident: B35 article-title: Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease publication-title: Lipids Health Dis. doi: 10.1186/s12944-020-01210-0 – volume: 19 start-page: 333 year: 2019 ident: B14 article-title: The ameliorative effect of monotropein, astragalin, and spiraeoside on oxidative stress, endoplasmic reticulum stress, and mitochondrial signaling pathway in varicocelized rats publication-title: BMC Complement Altern. Med. doi: 10.1186/s12906-019-2736-9 – volume: 9 year: 2018 ident: B9 article-title: Obesity, Male Reproductive Function and Bariatric Surgery publication-title: Front. Endocrinol. (Lausanne). doi: 10.3389/fendo.2018.00769 – volume: 20 year: 2019 ident: B13 article-title: The Effect of Schisandra chinensis Baillon on Cross-Talk between Oxidative Stress, Endoplasmic Reticulum Stress, and Mitochondrial Signaling Pathway in Testes of Varicocele-Induced SD Rat publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms20225785 – volume: 30 start-page: 81 year: 2015 ident: B40 article-title: Sodium fluoride induces apoptosis through reactive oxygen species-mediated endoplasmic reticulum stress pathway in Sertoli cells publication-title: J. Environ. Sci. (China) doi: 10.1016/j.jes.2014.11.004 – volume: 23 start-page: 695 year: 2015 ident: B37 article-title: Critical Role of Endoplasmic Reticulum Stress in Chronic Intermittent Hypoxia-Induced Deficits in Synaptic Plasticity and Long-Term Memory publication-title: Antioxid. Redox Signaling doi: 10.1089/ars.2014.6122 – volume: 26 start-page: 181 year: 2019 ident: B2 article-title: Experimental obesity and diabetes reduce male fertility: Potential involvement of hypothalamic Kiss-1, pituitary nitric oxide, serum vaspin and visfatin publication-title: Pathophysiology doi: 10.1016/j.pathophys.2019.02.001 – volume: 18 start-page: 42 year: 2018 ident: B39 article-title: Obesity impairs male fertility through long-term effects on spermatogenesis publication-title: BMC Urol. doi: 10.1186/s12894-018-0360-5 – volume: 23 start-page: 3112 year: 2019 ident: B4 article-title: Non-hormonal treatment for male infertility: the potential role of Serenoa repens, selenium and lycopene publication-title: Eur. Rev. Med. Pharmacol. Sci. doi: 10.26355/eurrev_201904_17595 – volume: 95 start-page: 115 year: 2016 ident: B17 article-title: The role of the endoplasmic reticulum stress in stemness, pluripotency and development publication-title: Eur. J. Cell Biol. doi: 10.1016/j.ejcb.2016.02.002 – volume: 17 year: 2016 ident: B42 article-title: Endoplasmic reticulum stress and associated ROS publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms17030327 – volume: 8 start-page: 1215 year: 2017 ident: B33 article-title: Beneficial effects of Lycium barbarum polysaccharide on spermatogenesis by improving antioxidant activity and inhibiting apoptosis in streptozotocin-induced diabetic male mice publication-title: Food Funct. doi: 10.1039/C6FO01575A – volume: 158 start-page: 45 year: 2017 ident: B26 article-title: Astrocytes and endoplasmic reticulum stress: A bridge between obesity and neurodegenerative diseases publication-title: Prog. Neurobiol doi: 10.1016/j.pneurobio.2017.08.001 – volume: 70 start-page: 230 year: 2017 ident: B29 article-title: Oxidative Stress and Cardiovascular Risk: Obesity, Diabetes, Smoking, and Pollution: Part 3 of a 3-Part Series publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2017.05.043 – volume: 83 start-page: 212 year: 2018 ident: B32 article-title: Obesity and reduced fertility of men publication-title: Ceska Gynekol. – volume: 2014 start-page: 1 year: 2014 ident: B21 article-title: Crude Extracts from Lycium barbarum Suppress SREBP-1c Expression and Prevent Diet-Induced Fatty Liver through AMPK Activation publication-title: BioMed. Res. Int. – volume: 56 start-page: 57 year: 2019 ident: B27 article-title: Protective mechanism of punicalagin against endoplasmic reticulum stress in the liver of mice with type 2 diabetes mellitus publication-title: J. Funct. Foods doi: 10.1016/j.jff.2019.03.006 – volume: 4 start-page: 5587 year: 2014 ident: B36 article-title: Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model publication-title: Sci. Rep. doi: 10.1038/srep05587 – volume: 160 start-page: 220 year: 2019 ident: B8 article-title: Genetically Inherited Obesity and High-Fat Diet-Induced Obesity Differentially Alter Spermatogenesis in Adult Male Rats publication-title: Endocrinology doi: 10.1210/en.2018-00569 – volume: 27 start-page: 441 year: 2017 ident: B12 article-title: Obesity and male infertility publication-title: Curr. Opin. Urol. doi: 10.1097/MOU.0000000000000417 – volume: 19 start-page: 85 year: 2019 ident: B15 article-title: Cross-talk between ER stress and mitochondrial pathway mediated adriamycin-induced testicular toxicity and DA-9401 modulate adriamycin-induced apoptosis in Sprague-Dawley rats publication-title: Cancer Cell Int. doi: 10.1186/s12935-019-0805-2 – volume: 42 start-page: 244 year: 2017 ident: B30 article-title: Diet-induced obesity leads to metabolic dysregulation in offspring via endoplasmic reticulum stress in a sex-specific manner publication-title: Int. J. Obesity (Lond) doi: 10.1038/ijo.2017.203 – volume: 7 start-page: 341 year: 2019 ident: B10 article-title: Sperm functional aspects and enriched proteomic pathways of seminal plasma of adult men with obesity publication-title: Andrology doi: 10.1111/andr.12606 – volume: 5 year: 2017 ident: B3 article-title: The difference in expression of long noncoding RNAs in rat semen induced by high-fat diet was associated with metabolic pathways publication-title: Peerj doi: 10.7717/peerj.3518 – volume: 64 start-page: 907 year: 2017 ident: B34 article-title: Protective effects of Lycium barbarum polysaccharide on male sexual dysfunction and fertility impairments by activating hypothalamic pituitary gonadal axis in streptozotocin-induced type-1 diabetic male mice publication-title: Endocrine J. doi: 10.1507/endocrj.EJ16-0430 – volume: 154 start-page: R123 year: 2017 ident: B23 article-title: Obesity, a serious etiologic factor for male subfertility in modern society publication-title: Reproduction doi: 10.1530/REP-17-0161 – volume: 23 start-page: 28 year: 2019 ident: B16 article-title: Effects of treadmill exercise on the regulatory mechanisms of mitochondrial dynamics and oxidative stress in the brains of high-fat diet fed rats publication-title: J. Exerc. Nutr. Biochem. doi: 10.20463/jenb.2019.0005 – volume: 6 start-page: 1547 year: 2015 ident: B22 article-title: Fucosylated chondroitin sulphate from Cusumaria frondosa mitigates hepatic endoplasmic reticulum stress and inflammation in insulin resistant mice publication-title: Food Funct. doi: 10.1039/C4FO01153H |
| SSID | ssj0000399364 |
| Score | 2.3721623 |
| Snippet | The incidence of obesity-associated decline in male fertility has increased over the years.
polysaccharide (LBP), a natural plant polysaccharide extracted from... The incidence of obesity-associated decline in male fertility has increased over the years. Lycium barbarum polysaccharide (LBP), a natural plant... BackgroundThe incidence of obesity-associated decline in male fertility has increased over the years. Lycium barbarum polysaccharide (LBP), a natural plant... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 742 |
| SubjectTerms | endoplasmic stress infertility Lycium barbarum polysaccharide obesity oxidative stress Pharmacology |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3da9swEBejT3sZ-573hQajMKiJLcuS_LiVllLaLWwt9M3IJ4kaUjssCTT_fe_kJE1G2V72YowsY6E76X7n0_2Osc-5EyFzVZNmQctUGihSE1CXGy98CAEhdEmJwuff1cmlPL0qr7ZKfdGZsIEeeJi4ERp4VRLLXUnUZM7ZqmhyAGN9WXoVIs8nmrEtZyruwWR3lRzikuiFVaMwvbbE_ynoKJeWYscORbr-hzDmn0clt2zP8VP2ZAUa-ddhsM_YI989Z_vjgXV6ecAv7pOoZgd8n4_v-aiXL9hkYCie8T7wsyW0ixvexCgD3oz7yXJmgXKvWud53_GjzvVThNQ3LfCffj78HuS_YkoJt53jP25bF9nC141tx6m8gOfnuOm8ZJfHRxeHJ-mqyEIKUol5muMSd6CDsSG3ovF5cGCNFE4HAZkCdCAzoKTCIEE4h9JQWVNRdFBn1jgoXrG9ru_8G8YtwQtQyipAtzEHY7zUhS7xCvgJmbDResprWDGQUyGMSY2eCAmpjkKqSUh1FFLCvmzemA7sG3_p-42kuOlHvNmxAbWpXmlT_S9tStintQ7UuM4oeGI73y9mNSIdUZnSKJOw14NObD5ViJI8V50wvaMtO2PZfdK115HLWyMgRcj79n8M_h17TNNBZxuEes_25r8X_gNCpnnzMa6OO1bnFno priority: 102 providerName: Directory of Open Access Journals |
| Title | Effects of Lycium barbarum Polysaccharide on Endoplasmic Reticulum Stress and Oxidative Stress in Obese Mice |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/32528287 https://www.proquest.com/docview/2412985868 https://pubmed.ncbi.nlm.nih.gov/PMC7264112 https://doaj.org/article/45665279259548dda93b1cc8ae55e6f3 |
| Volume | 11 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1663-9812 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000399364 issn: 1663-9812 databaseCode: KQ8 dateStart: 20100101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1663-9812 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000399364 issn: 1663-9812 databaseCode: DOA dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1663-9812 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000399364 issn: 1663-9812 databaseCode: DIK dateStart: 20100101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1663-9812 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000399364 issn: 1663-9812 databaseCode: GX1 dateStart: 0 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1663-9812 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000399364 issn: 1663-9812 databaseCode: M~E dateStart: 20100101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 1663-9812 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000399364 issn: 1663-9812 databaseCode: RPM dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVFZP databaseName: Scholars Portal Journals: Open Access customDbUrl: eissn: 1663-9812 dateEnd: 20250131 omitProxy: true ssIdentifier: ssj0000399364 issn: 1663-9812 databaseCode: M48 dateStart: 20101201 isFulltext: true titleUrlDefault: http://journals.scholarsportal.info providerName: Scholars Portal |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3di9QwEA96vvgifltPjwhyIFy9Nm3T7IOIyh2HuLroLdxbSSfJXWGv3dsPuP73zqTdXVcWwZfSpmnTZiaZ3ySZXxh7GxvhIjMow8jlaZgqSELlUJdLK6xzDiF0RoHCw-_ybJx-vcguNuHRfQXOd7p2tJ_UeDZ5f3vTfsQG_4E8TrS3x256pYnaU9AqLXT17rJ7aJcE6fiwB_u-XyZb7PmkYjSz4QBNWzdvufMlW3bK0_nvwqB_L6X8wzadPmQPelDJP3Va8IjdsfVjdjjqWKnbI36-CbKaH_FDPtrwVbdP2KRjMJ7zxvFvLVTLa176WQg8GTWTdq6BYrMqY3lT85PaNFOE3NcV8J920Q0f8l8-5ITr2vAft5XxbOKrxKrmtP2A5UPslJ6y8enJ-ZezsN-EIYRUikUYYxdgIHdKu1iL0sbOgFapMLkTEElABzMCCjp0KQhjEB3KqBzQ7GEeaWUgecb26qa2LxjXBD9ASi0B3coYlLJpnuQZHgGLSAN2vKryAnqGctooY1Kgp0JCKryQChJS4YUUsHfrJ6YdO8c_8n4mKa7zEa-2T2hml0XfTAuEkzIjTsWMiPCM0YOkjAGUtllmpUsC9malAwW2Q5pc0bVtlvPCa5zKlFQBe97pxLqoRGTk2eYBy7e0Zetbtu_U1ZXn-s4RsCIkfvkfP7rP7tMFLXEQ8hXbW8yW9jUip0V54EccDnyz-A1mlBjp |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effects+of+Lycium+barbarum+Polysaccharide+on+Endoplasmic+Reticulum+Stress+and+Oxidative+Stress+in+Obese+Mice&rft.jtitle=Frontiers+in+pharmacology&rft.au=Yang%2C+Feng-Lian&rft.au=Wei%2C+Yu-Xia&rft.au=Liao%2C+Bi-Yun&rft.au=Wei%2C+Gui-Jiang&rft.date=2020-05-26&rft.issn=1663-9812&rft.eissn=1663-9812&rft.volume=11&rft_id=info:doi/10.3389%2Ffphar.2020.00742&rft.externalDBID=n%2Fa&rft.externalDocID=10_3389_fphar_2020_00742 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1663-9812&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1663-9812&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1663-9812&client=summon |