Dust mite-derived Der f 3 activates a pro-inflammatory program in airway epithelial cells via PAR-1 and PAR-2 - Li, Bizhou; Zou, Zehong; Meng, Fanmei; Raz, Eyal; Huang, Yuye; Tao, Ailin; Ai, Yuncan (Molecular immunology, 2019)
Keywords: A549 Cells; Airway epithelial cell; allergens; Allergens - immunology; Allergens - pharmacology; Animals; Arthropod Proteins - immunology; Arthropod Proteins - pharmacology; calcium signaling; Calcium Signaling - drug effects; Calcium Signaling - genetics; Calcium Signaling - immunology; Cytokines - genetics; Cytokines - immunology; Der f 3; Dermatophagoides farinae; dust; dust mites; enzyme activity; enzyme-linked immunosorbent assay; epithelial cells; Epithelial Cells - immunology; Epithelial Cells - pathology; epithelium; Extracellular Signal-Regulated MAP Kinases - genetics; Extracellular Signal-Regulated MAP Kinases - immunology; Gene Expression Regulation - drug effects; Gene Expression Regulation - immunology; Gene Knockdown Techniques; gene silencing; genes; granulocyte-macrophage colony-stimulating factor; House dust mite (HDM); human cell lines; Humans; Inflammation; Inflammation - chemically induced; Inflammation - genetics; Inflammation - immunology; Inflammation - pathology; Inflammation Mediators - immunology; interleukin-6; interleukin-8; MAP Kinase Signaling System - drug effects; MAP Kinase Signaling System - genetics; MAP Kinase Signaling System - immunology; mitogen-activated protein kinase; NF-kappa B - genetics; NF-kappa B - immunology; pathogenesis; Protease; Protease-activated receptor (PAR); Pyroglyphidae - immunology; quantitative polymerase chain reaction; Receptor, PAR-1 - genetics; Receptor, PAR-1 - immunology; Receptor, PAR-2 - genetics; Receptor, PAR-2 - immunology; Respiratory Mucosa - immunology; reverse transcriptase polymerase chain reaction; sequence analysis; Serine Endopeptidases - immunology; Serine Endopeptidases - pharmacology; serine proteinases; small interfering RNA; Th17 Cells - immunology; Th17 Cells - pathology; Th2 Cells - immunology; Th2 Cells - pathology; transcription factor NF-kappa B; Airway epithelial cell; House dust mite (HDM); Inflammation; Protease-activated receptor (PAR); Protease; Der f 3