Association between consumption of private well water contaminated by low levels of arsenic and dysglycemia in a rural region of Quebec, Canada
The association between arsenic (As) exposure and diabetes is not clearly defined for populations exposed to low or moderate levels of inorganic As (iAs) in drinking water (< 150µg/L). In the present study, the relationship between iAs concentration in drinking water (contaminated at a median lev...
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| Published in | Environmental research Vol. 159; pp. 232 - 238 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Inc
01.11.2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0013-9351 1096-0953 1096-0953 |
| DOI | 10.1016/j.envres.2017.07.049 |
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| Abstract | The association between arsenic (As) exposure and diabetes is not clearly defined for populations exposed to low or moderate levels of inorganic As (iAs) in drinking water (< 150µg/L). In the present study, the relationship between iAs concentration in drinking water (contaminated at a median level of 10.5µg/L) or As biomarkers (ie, urine and nails) and diabetes or prediabetes (defined as level of glycosylated hemoglobin - HbA1c – higher than 6%, self-reported diagnosis of diabetes by a physician, or the use of insulin or oral hypoglycemic drugs) was evaluated in 257 adults from Canada. For that we used logistic regression models and reported the odds ratio (OR) comparing participants in the 80th vs 20th percentile of iAs exposure indicators. The association between iAs exposure indicators and HbA1c was also explored for 234 adults and 35 children not taking insulin or oral hypoglycemic drugs using a linear regression analysis. All models were controlled for confounding variables (age, gender, first-degree family history of diabetes, obesity or overweight in adults’ model). We attempted to exclude adults with organic arsenic of marine origin in their urine by removing participants with detectable arsenobetaine or arsenocholine in urinary models. iAs biomarkers (toenail and urine) were not associated with diabetes or prediabetes in adults. iAs in well water was associated with a borderline significantly increased odds of diabetes or prediabetes (OR = 2.39; 95% CI: 0.99–5.72). Higher well water iAs concentrations were significantly associated with increased HbA1c in both children and adults (β: 0.002; p = 0.041 and β: 0.003; p < 0.0001 respectively). In children, HbA1c was also associated with toenail As concentration (β: 0.18; p = 0.016). These results suggest low-level iAs exposure is associated with a continuum of dysglycemia.
•Chronic inorganic arsenic exposure has been linked to an increased risk of diabetes.•This association is not sure for drinking water levels less than 150µg arsenic /L.•Few studies used water, urinary and toenail arsenic level as an exposure measurement.•This study applies a comprehensive exposure assessment.•It reveals an association between HbA1c with well water iAs in adults and children. |
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| AbstractList | The association between arsenic (As) exposure and diabetes is not clearly defined for populations exposed to low or moderate levels of inorganic As (iAs) in drinking water (< 150µg/L). In the present study, the relationship between iAs concentration in drinking water (contaminated at a median level of 10.5µg/L) or As biomarkers (ie, urine and nails) and diabetes or prediabetes (defined as level of glycosylated hemoglobin - HbA1c – higher than 6%, self-reported diagnosis of diabetes by a physician, or the use of insulin or oral hypoglycemic drugs) was evaluated in 257 adults from Canada. For that we used logistic regression models and reported the odds ratio (OR) comparing participants in the 80th vs 20th percentile of iAs exposure indicators. The association between iAs exposure indicators and HbA1c was also explored for 234 adults and 35 children not taking insulin or oral hypoglycemic drugs using a linear regression analysis. All models were controlled for confounding variables (age, gender, first-degree family history of diabetes, obesity or overweight in adults’ model). We attempted to exclude adults with organic arsenic of marine origin in their urine by removing participants with detectable arsenobetaine or arsenocholine in urinary models. iAs biomarkers (toenail and urine) were not associated with diabetes or prediabetes in adults. iAs in well water was associated with a borderline significantly increased odds of diabetes or prediabetes (OR = 2.39; 95% CI: 0.99–5.72). Higher well water iAs concentrations were significantly associated with increased HbA1c in both children and adults (β: 0.002; p = 0.041 and β: 0.003; p < 0.0001 respectively). In children, HbA1c was also associated with toenail As concentration (β: 0.18; p = 0.016). These results suggest low-level iAs exposure is associated with a continuum of dysglycemia. The association between arsenic (As) exposure and diabetes is not clearly defined for populations exposed to low or moderate levels of inorganic As (iAs) in drinking water (< 150µg/L). In the present study, the relationship between iAs concentration in drinking water (contaminated at a median level of 10.5µg/L) or As biomarkers (ie, urine and nails) and diabetes or prediabetes (defined as level of glycosylated hemoglobin - HbA1c – higher than 6%, self-reported diagnosis of diabetes by a physician, or the use of insulin or oral hypoglycemic drugs) was evaluated in 257 adults from Canada. For that we used logistic regression models and reported the odds ratio (OR) comparing participants in the 80th vs 20th percentile of iAs exposure indicators. The association between iAs exposure indicators and HbA1c was also explored for 234 adults and 35 children not taking insulin or oral hypoglycemic drugs using a linear regression analysis. All models were controlled for confounding variables (age, gender, first-degree family history of diabetes, obesity or overweight in adults’ model). We attempted to exclude adults with organic arsenic of marine origin in their urine by removing participants with detectable arsenobetaine or arsenocholine in urinary models. iAs biomarkers (toenail and urine) were not associated with diabetes or prediabetes in adults. iAs in well water was associated with a borderline significantly increased odds of diabetes or prediabetes (OR = 2.39; 95% CI: 0.99–5.72). Higher well water iAs concentrations were significantly associated with increased HbA1c in both children and adults (β: 0.002; p = 0.041 and β: 0.003; p < 0.0001 respectively). In children, HbA1c was also associated with toenail As concentration (β: 0.18; p = 0.016). These results suggest low-level iAs exposure is associated with a continuum of dysglycemia. •Chronic inorganic arsenic exposure has been linked to an increased risk of diabetes.•This association is not sure for drinking water levels less than 150µg arsenic /L.•Few studies used water, urinary and toenail arsenic level as an exposure measurement.•This study applies a comprehensive exposure assessment.•It reveals an association between HbA1c with well water iAs in adults and children. The association between arsenic (As) exposure and diabetes is not clearly defined for populations exposed to low or moderate levels of inorganic As (iAs) in drinking water (< 150µg/L). In the present study, the relationship between iAs concentration in drinking water (contaminated at a median level of 10.5µg/L) or As biomarkers (ie, urine and nails) and diabetes or prediabetes (defined as level of glycosylated hemoglobin - HbA1c - higher than 6%, self-reported diagnosis of diabetes by a physician, or the use of insulin or oral hypoglycemic drugs) was evaluated in 257 adults from Canada. For that we used logistic regression models and reported the odds ratio (OR) comparing participants in the 80th vs 20th percentile of iAs exposure indicators. The association between iAs exposure indicators and HbA1c was also explored for 234 adults and 35 children not taking insulin or oral hypoglycemic drugs using a linear regression analysis. All models were controlled for confounding variables (age, gender, first-degree family history of diabetes, obesity or overweight in adults' model). We attempted to exclude adults with organic arsenic of marine origin in their urine by removing participants with detectable arsenobetaine or arsenocholine in urinary models. iAs biomarkers (toenail and urine) were not associated with diabetes or prediabetes in adults. iAs in well water was associated with a borderline significantly increased odds of diabetes or prediabetes (OR = 2.39; 95% CI: 0.99-5.72). Higher well water iAs concentrations were significantly associated with increased HbA1c in both adults and children (β: 0.002; p = 0.041 and β: 0.003; p < 0.0001 respectively). In children, HbA1c was also associated with toenail As concentration (β: 0.18; p = 0.016). These results suggest low-level iAs exposure is associated with a continuum of dysglycemia. The association between arsenic (As) exposure and diabetes is not clearly defined for populations exposed to low or moderate levels of inorganic As (iAs) in drinking water (< 150µg/L). In the present study, the relationship between iAs concentration in drinking water (contaminated at a median level of 10.5µg/L) or As biomarkers (ie, urine and nails) and diabetes or prediabetes (defined as level of glycosylated hemoglobin - HbA1c - higher than 6%, self-reported diagnosis of diabetes by a physician, or the use of insulin or oral hypoglycemic drugs) was evaluated in 257 adults from Canada. For that we used logistic regression models and reported the odds ratio (OR) comparing participants in the 80th vs 20th percentile of iAs exposure indicators. The association between iAs exposure indicators and HbA1c was also explored for 234 adults and 35 children not taking insulin or oral hypoglycemic drugs using a linear regression analysis. All models were controlled for confounding variables (age, gender, first-degree family history of diabetes, obesity or overweight in adults' model). We attempted to exclude adults with organic arsenic of marine origin in their urine by removing participants with detectable arsenobetaine or arsenocholine in urinary models. iAs biomarkers (toenail and urine) were not associated with diabetes or prediabetes in adults. iAs in well water was associated with a borderline significantly increased odds of diabetes or prediabetes (OR = 2.39; 95% CI: 0.99-5.72). Higher well water iAs concentrations were significantly associated with increased HbA1c in both adults and children (β: 0.002; p = 0.041 and β: 0.003; p < 0.0001 respectively). In children, HbA1c was also associated with toenail As concentration (β: 0.18; p = 0.016). These results suggest low-level iAs exposure is associated with a continuum of dysglycemia.The association between arsenic (As) exposure and diabetes is not clearly defined for populations exposed to low or moderate levels of inorganic As (iAs) in drinking water (< 150µg/L). In the present study, the relationship between iAs concentration in drinking water (contaminated at a median level of 10.5µg/L) or As biomarkers (ie, urine and nails) and diabetes or prediabetes (defined as level of glycosylated hemoglobin - HbA1c - higher than 6%, self-reported diagnosis of diabetes by a physician, or the use of insulin or oral hypoglycemic drugs) was evaluated in 257 adults from Canada. For that we used logistic regression models and reported the odds ratio (OR) comparing participants in the 80th vs 20th percentile of iAs exposure indicators. The association between iAs exposure indicators and HbA1c was also explored for 234 adults and 35 children not taking insulin or oral hypoglycemic drugs using a linear regression analysis. All models were controlled for confounding variables (age, gender, first-degree family history of diabetes, obesity or overweight in adults' model). We attempted to exclude adults with organic arsenic of marine origin in their urine by removing participants with detectable arsenobetaine or arsenocholine in urinary models. iAs biomarkers (toenail and urine) were not associated with diabetes or prediabetes in adults. iAs in well water was associated with a borderline significantly increased odds of diabetes or prediabetes (OR = 2.39; 95% CI: 0.99-5.72). Higher well water iAs concentrations were significantly associated with increased HbA1c in both adults and children (β: 0.002; p = 0.041 and β: 0.003; p < 0.0001 respectively). In children, HbA1c was also associated with toenail As concentration (β: 0.18; p = 0.016). These results suggest low-level iAs exposure is associated with a continuum of dysglycemia. |
| Author | Langlois, Marie-France Gagnon, Fabien Lampron-Goulet, Éric |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28818805$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_envpol_2020_114968 crossref_primary_10_1515_ii_2017_0163 crossref_primary_10_1265_ehpm_24_00073 crossref_primary_10_1016_j_toxlet_2023_08_001 crossref_primary_10_3390_nu16223931 crossref_primary_10_1016_j_envres_2020_110286 crossref_primary_10_1016_j_scitotenv_2020_137575 crossref_primary_10_2903_j_efsa_2024_8488 crossref_primary_10_1289_EHP12785 crossref_primary_10_1016_j_rineng_2024_102054 crossref_primary_10_3390_cells12212537 crossref_primary_10_1016_j_apgeochem_2019_104500 crossref_primary_10_1177_09603271211045955 crossref_primary_10_1002_jcp_27318 crossref_primary_10_1186_s12889_024_20776_3 crossref_primary_10_3390_ijerph18073749 |
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| Title | Association between consumption of private well water contaminated by low levels of arsenic and dysglycemia in a rural region of Quebec, Canada |
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