Nonsense-Mediated mRNA Decay in Yeast Does Not Require PAB1 or a Poly(A) Tail
Eukaryotic mRNAs harboring premature translation termination codons are recognized and rapidly degraded by the nonsense-mediated mRNA decay (NMD) pathway. The mechanism for discriminating between mRNAs that terminate translation prematurely and those subject to termination at natural stop codons rem...
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| Published in | Molecular cell Vol. 29; no. 1; pp. 134 - 140 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
18.01.2008
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1097-2765 1097-4164 |
| DOI | 10.1016/j.molcel.2007.10.031 |
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| Abstract | Eukaryotic mRNAs harboring premature translation termination codons are recognized and rapidly degraded by the nonsense-mediated mRNA decay (NMD) pathway. The mechanism for discriminating between mRNAs that terminate translation prematurely and those subject to termination at natural stop codons remains unclear. Studies in multiple organisms indicate that proximity of the termination codon to the 3′ poly(A) tail and the poly(A) RNA-binding protein, PAB1, constitute the critical determinant in NMD substrate recognition. We demonstrate that mRNA in yeast lacking a poly(A) tail can be destabilized by introduction of a premature termination codon and, importantly, that this mRNA is a substrate of the NMD machinery. We further show that, in cells lacking Pab1p, mRNA substrate recognition and destabilization by NMD are intact. These results establish that neither the poly(A) tail nor PAB1 is required in yeast for discrimination of nonsense codon-containing mRNA from normal by NMD. |
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| AbstractList | Eukaryotic mRNAs harboring premature translation termination codons are recognized and rapidly degraded by the nonsense-mediated mRNA decay (NMD) pathway. The mechanism for discriminating between mRNAs that terminate translation prematurely and those subject to termination at natural stop codons remains unclear. Studies in multiple organisms indicate that proximity of the termination codon to the 3′ poly(A) tail and the poly(A) RNA-binding protein, PAB1, constitute the critical determinant in NMD substrate recognition. We demonstrate that mRNA in yeast lacking a poly(A) tail can be destabilized by introduction of a premature termination codon and, importantly, that this mRNA is a substrate of the NMD machinery. We further show that, in cells lacking Pab1p, mRNA substrate recognition and destabilization by NMD are intact. These results establish that neither the poly(A) tail nor PAB1 is required in yeast for discrimination of nonsense codon-containing mRNA from normal by NMD. Eukaryotic mRNAs harboring premature translation termination codons are recognized and rapidly degraded by the nonsense-mediated mRNA decay (NMD) pathway. The mechanism for discriminating between mRNAs that terminate translation prematurely and those subject to termination at natural stop codons remains unclear. Studies in multiple organisms indicate that proximity of the termination codon to the 3' poly(A) tail and the poly(A) RNA-binding protein, PAB1, constitute the critical determinant in NMD substrate recognition. We demonstrate that mRNA in yeast lacking a poly(A) tail can be destabilized by introduction of a premature termination codon and, importantly, that this mRNA is a substrate of the NMD machinery. We further show that, in cells lacking Pab1p, mRNA substrate recognition and destabilization by NMD are intact. These results establish that neither the poly(A) tail nor PAB1 is required in yeast for discrimination of nonsense-codon-containing mRNA from normal by NMD.Eukaryotic mRNAs harboring premature translation termination codons are recognized and rapidly degraded by the nonsense-mediated mRNA decay (NMD) pathway. The mechanism for discriminating between mRNAs that terminate translation prematurely and those subject to termination at natural stop codons remains unclear. Studies in multiple organisms indicate that proximity of the termination codon to the 3' poly(A) tail and the poly(A) RNA-binding protein, PAB1, constitute the critical determinant in NMD substrate recognition. We demonstrate that mRNA in yeast lacking a poly(A) tail can be destabilized by introduction of a premature termination codon and, importantly, that this mRNA is a substrate of the NMD machinery. We further show that, in cells lacking Pab1p, mRNA substrate recognition and destabilization by NMD are intact. These results establish that neither the poly(A) tail nor PAB1 is required in yeast for discrimination of nonsense-codon-containing mRNA from normal by NMD. Eukaryotic mRNAs harboring premature translation termination codons are recognized and rapidly degraded by the nonsense-mediated mRNA decay (NMD) pathway. The mechanism for discriminating between mRNAs that terminate translation prematurely and those subject to termination at natural stop codons remains unclear. Studies in multiple organisms indicate that proximity of the termination codon to the 3′ poly(A) tail and the poly(A) RNA binding protein, PAB1, constitute the critical determinant in NMD substrate recognition. We demonstrate that mRNA in yeast lacking a poly(A) tail can be destabilized by introduction of a premature termination codon and importantly, this mRNA is a substrate of the NMD machinery. We further show that in cells lacking Pab1p, mRNA substrate recognition and destabilization by NMD is intact. These results establish that neither the poly(A) tail, nor PAB1, is required in yeast for discrimination of nonsense codon-containing mRNA from normal by NMD. |
| Author | van Hoof, Ambro Meaux, Stacie Baker, Kristian E. |
| AuthorAffiliation | 2 Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH 44106 1 Department of Microbiology and Molecular Genetics, University of Texas Health Science Center-Houston, Houston, TX 77030 |
| AuthorAffiliation_xml | – name: 2 Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH 44106 – name: 1 Department of Microbiology and Molecular Genetics, University of Texas Health Science Center-Houston, Houston, TX 77030 |
| Author_xml | – sequence: 1 givenname: Stacie surname: Meaux fullname: Meaux, Stacie organization: Department of Microbiology and Molecular Genetics, University of Texas Health Science Center-Houston, Houston, TX 77030, USA – sequence: 2 givenname: Ambro surname: van Hoof fullname: van Hoof, Ambro email: ambro.van.hoof@uth.tmc.edu organization: Department of Microbiology and Molecular Genetics, University of Texas Health Science Center-Houston, Houston, TX 77030, USA – sequence: 3 givenname: Kristian E. surname: Baker fullname: Baker, Kristian E. email: kristian.baker@case.edu organization: Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH 44106, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18206975$$D View this record in MEDLINE/PubMed |
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| Snippet | Eukaryotic mRNAs harboring premature translation termination codons are recognized and rapidly degraded by the nonsense-mediated mRNA decay (NMD) pathway. The... |
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| SubjectTerms | Codon, Nonsense DNA Galactokinase - genetics Genes, Reporter Genes, Synthetic Green Fluorescent Proteins - genetics Open Reading Frames - genetics Poly(A)-Binding Proteins - physiology Recombinant Fusion Proteins - genetics RNA Stability - physiology RNA, Catalytic - genetics RNA, Messenger - physiology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - physiology |
| Title | Nonsense-Mediated mRNA Decay in Yeast Does Not Require PAB1 or a Poly(A) Tail |
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