A Molecular Diagnostic Algorithm to Guide Pollen Immunotherapy in Southern Europe: Towards Component-Resolved Management of Allergic Diseases

Correct identification of the culprit allergen is an essential part of diagnosis and treatment in immunoglobulin E (IgE)-mediated allergic diseases. In recent years, molecular biology has made important advances facilitating such identification and overcoming some of the drawbacks of natural allerge...

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Published inInternational archives of allergy and immunology Vol. 162; no. 2; pp. 163 - 172
Main Authors Douladiris, Nikolaos, Savvatianos, Savvas, Roumpedaki, Irene, Skevaki, Chrysanthi, Mitsias, Dimitrios, Papadopoulos, Nikolaos G.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.01.2013
Subjects
Algorithms
Allergens - administration & dosage
Allergens - immunology
Allergies
Antigens, Plant - administration & dosage
Antigens, Plant - immunology
Desensitization, Immunologic - methods
Disease
Europe
Humans
Immunoglobulin E - immunology
Immunotherapy
Molecular biology
Molecular Diagnostic Techniques - methods
Original Paper
Plant Proteins - administration & dosage
Plant Proteins - immunology
Pollen
Pollen - immunology
Rhinitis, Allergic, Seasonal - diagnosis
Rhinitis, Allergic, Seasonal - therapy
Europe
Pollen
Molecular diagnosis
Allergen-specific immunotherapy
Panallergens
Online AccessGet full text
ISSN1018-2438
1423-0097
1423-0097
DOI10.1159/000353113

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Abstract Correct identification of the culprit allergen is an essential part of diagnosis and treatment in immunoglobulin E (IgE)-mediated allergic diseases. In recent years, molecular biology has made important advances facilitating such identification and overcoming some of the drawbacks of natural allergen extracts, which consist of mixtures of various proteins that may be allergenic or not, specific for the allergen source or widely distributed (panallergens). New technologies offer the opportunity for a more accurate component-resolved diagnosis, of benefit especially to polysensitized allergic patients. The basic elements of molecular diagnostics with potential relevance to immunotherapy prescription are reviewed here, with a focus on Southern European sensitization patterns to pollen allergens. We propose a basic algorithm regarding component-resolved diagnostic work-up for pollen allergen-specific immunotherapy candidates in Southern Europe; this and similar algorithms can form the basis of improved patient management, conceptually a ‘Component-Resolved Allergy Management'.
AbstractList Correct identification of the culprit allergen is an essential part of diagnosis and treatment in immunoglobulin E (IgE)-mediated allergic diseases. In recent years, molecular biology has made important advances facilitating such identification and overcoming some of the drawbacks of natural allergen extracts, which consist of mixtures of various proteins that may be allergenic or not, specific for the allergen source or widely distributed (panallergens). New technologies offer the opportunity for a more accurate component-resolved diagnosis, of benefit especially to polysensitized allergic patients. The basic elements of molecular diagnostics with potential relevance to immunotherapy prescription are reviewed here, with a focus on Southern European sensitization patterns to pollen allergens. We propose a basic algorithm regarding component-resolved diagnostic work-up for pollen allergen-specific immunotherapy candidates in Southern Europe; this and similar algorithms can form the basis of improved patient management, conceptually a Component-Resolved Allergy Management'. Copyright [copy 2013 S. Karger AG, Basel
Correct identification of the culprit allergen is an essential part of diagnosis and treatment in immunoglobulin E (IgE)-mediated allergic diseases. In recent years, molecular biology has made important advances facilitating such identification and overcoming some of the drawbacks of natural allergen extracts, which consist of mixtures of various proteins that may be allergenic or not, specific for the allergen source or widely distributed (panallergens). New technologies offer the opportunity for a more accurate component-resolved diagnosis, of benefit especially to polysensitized allergic patients. The basic elements of molecular diagnostics with potential relevance to immunotherapy prescription are reviewed here, with a focus on Southern European sensitization patterns to pollen allergens. We propose a basic algorithm regarding component-resolved diagnostic work-up for pollen allergen-specific immunotherapy candidates in Southern Europe; this and similar algorithms can form the basis of improved patient management, conceptually a ‘Component-Resolved Allergy Management'.
Correct identification of the culprit allergen is an essential part of diagnosis and treatment in immunoglobulin E (IgE)-mediated allergic diseases. In recent years, molecular biology has made important advances facilitating such identification and overcoming some of the drawbacks of natural allergen extracts, which consist of mixtures of various proteins that may be allergenic or not, specific for the allergen source or widely distributed (panallergens). New technologies offer the opportunity for a more accurate component-resolved diagnosis, of benefit especially to polysensitized allergic patients. The basic elements of molecular diagnostics with potential relevance to immunotherapy prescription are reviewed here, with a focus on Southern European sensitization patterns to pollen allergens. We propose a basic algorithm regarding component-resolved diagnostic work-up for pollen allergen-specific immunotherapy candidates in Southern Europe; this and similar algorithms can form the basis of improved patient management, conceptually a 'Component-Resolved Allergy Management'. Copyright © 2013 S. Karger AG, Basel [PUBLICATION ABSTRACT]
Correct identification of the culprit allergen is an essential part of diagnosis and treatment in immunoglobulin E (IgE)-mediated allergic diseases. In recent years, molecular biology has made important advances facilitating such identification and overcoming some of the drawbacks of natural allergen extracts, which consist of mixtures of various proteins that may be allergenic or not, specific for the allergen source or widely distributed (panallergens). New technologies offer the opportunity for a more accurate component-resolved diagnosis, of benefit especially to polysensitized allergic patients. The basic elements of molecular diagnostics with potential relevance to immunotherapy prescription are reviewed here, with a focus on Southern European sensitization patterns to pollen allergens. We propose a basic algorithm regarding component-resolved diagnostic work-up for pollen allergen-specific immunotherapy candidates in Southern Europe; this and similar algorithms can form the basis of improved patient management, conceptually a 'Component-Resolved Allergy Management'.Correct identification of the culprit allergen is an essential part of diagnosis and treatment in immunoglobulin E (IgE)-mediated allergic diseases. In recent years, molecular biology has made important advances facilitating such identification and overcoming some of the drawbacks of natural allergen extracts, which consist of mixtures of various proteins that may be allergenic or not, specific for the allergen source or widely distributed (panallergens). New technologies offer the opportunity for a more accurate component-resolved diagnosis, of benefit especially to polysensitized allergic patients. The basic elements of molecular diagnostics with potential relevance to immunotherapy prescription are reviewed here, with a focus on Southern European sensitization patterns to pollen allergens. We propose a basic algorithm regarding component-resolved diagnostic work-up for pollen allergen-specific immunotherapy candidates in Southern Europe; this and similar algorithms can form the basis of improved patient management, conceptually a 'Component-Resolved Allergy Management'.
Author Douladiris, Nikolaos
Mitsias, Dimitrios
Skevaki, Chrysanthi
Roumpedaki, Irene
Papadopoulos, Nikolaos G.
Savvatianos, Savvas
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  surname: Douladiris
  fullname: Douladiris, Nikolaos
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  givenname: Savvas
  surname: Savvatianos
  fullname: Savvatianos, Savvas
  email: ss@allergy.gr
– sequence: 3
  givenname: Irene
  surname: Roumpedaki
  fullname: Roumpedaki, Irene
– sequence: 4
  givenname: Chrysanthi
  surname: Skevaki
  fullname: Skevaki, Chrysanthi
– sequence: 5
  givenname: Dimitrios
  surname: Mitsias
  fullname: Mitsias, Dimitrios
– sequence: 6
  givenname: Nikolaos G.
  surname: Papadopoulos
  fullname: Papadopoulos, Nikolaos G.
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Issue 2
Keywords Pollen
Molecular diagnosis
Allergen-specific immunotherapy
Panallergens
Language English
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Snippet Correct identification of the culprit allergen is an essential part of diagnosis and treatment in immunoglobulin E (IgE)-mediated allergic diseases. In recent...
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SubjectTerms Algorithms
Allergens - administration & dosage
Allergens - immunology
Allergies
Antigens, Plant - administration & dosage
Antigens, Plant - immunology
Desensitization, Immunologic - methods
Disease
Europe
Humans
Immunoglobulin E - immunology
Immunotherapy
Molecular biology
Molecular Diagnostic Techniques - methods
Original Paper
Plant Proteins - administration & dosage
Plant Proteins - immunology
Pollen
Pollen - immunology
Rhinitis, Allergic, Seasonal - diagnosis
Rhinitis, Allergic, Seasonal - therapy
Title A Molecular Diagnostic Algorithm to Guide Pollen Immunotherapy in Southern Europe: Towards Component-Resolved Management of Allergic Diseases
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