Prognostic Significance and Biologic Associations of Senescence‐Associated Secretory Phenotype Biomarkers in Heart Failure

The role of cellular senescence in human heart failure (HF) remains unclear. The senescence-associated secretory phenotype (SASP) is composed of proteins released by senescent cells. We assessed the prognostic significance and biologic pathways associated with the SASP in human HF using a plasma pro...

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Published inJournal of the American Heart Association Vol. 13; no. 17; p. e033675
Main Authors Salman, Oday, Zamani, Payman, Zhao, Lei, Dib, Marie Joe, Gan, Sushrima, Azzo, Joe David, Pourmussa, Bianca, Richards, Arthur Mark, Javaheri, Ali, Mann, Douglas L., Rietzschel, Ernst, Zhao, Manyun, Wang, Zhaoqing, Ebert, Christina, Liu, Laura, Gunawardhana, Kushan L., Greenawalt, Danielle, Carayannopoulos, Leon, Chang, Ching‐Pin, van Empel, Vanessa, Gogain, Joseph, Schafer, Peter H., Gordon, David A., Ramirez‐Valle, Francisco, Cappola, Thomas P., Chirinos, Julio A.
Format Journal Article
LanguageEnglish
Published England John Wiley and Sons Inc 03.09.2024
Wiley
Subjects
Aged
aging
Biomarkers - blood
cell senescence
Cellular Senescence
Female
heart failure
Heart Failure - blood
Heart Failure - metabolism
Heart Failure - mortality
Heart Failure - physiopathology
Humans
Male
Middle Aged
Natriuretic Peptide, Brain
Original Research
pathways
Peptide Fragments
Prognosis
proteomics
Proteomics - methods
Senescence-Associated Secretory Phenotype
heart failure
pathways
aging
proteomics
cell senescence
Online AccessGet full text
ISSN2047-9980
2047-9980
DOI10.1161/JAHA.123.033675

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Abstract The role of cellular senescence in human heart failure (HF) remains unclear. The senescence-associated secretory phenotype (SASP) is composed of proteins released by senescent cells. We assessed the prognostic significance and biologic pathways associated with the SASP in human HF using a plasma proteomics approach. We measured 25 known SASP proteins among 2248 PHFS (Penn HF Study) participants using the SOMAScan V4 assay. We extracted the common variance in these proteins to generate SASP factor scores and assessed the relationship between these SASP factor scores and (1) all-cause death and (2) the composite of death or HF hospital admission. We also assessed the relationship of each SASP factor to 4746 other proteins, correcting for multiple comparisons, followed by pathway analyses. Two SASP factors were identified. Both factors were associated with older age, lower estimated glomerular filtration rate, and more advanced New York Heart Association class, among other clinical variables. Both SASP factors exhibited a significant positive association with the risk of death independent of the Meta-Analysis of Global-Group in Chronic HF score and NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels. The 2 identified SASP factors were associated with 1201 and 1554 proteins, respectively, belonging to various pathways including the coagulation system, complement system, acute phase response signaling, and retinoid X receptor-related pathways that regulate cell metabolism. Increased SASP components are independently associated with adverse outcomes in HF. Biologic pathways associated with SASP are predominantly related to coagulation, inflammation, and cell metabolism.
AbstractList The role of cellular senescence in human heart failure (HF) remains unclear. The senescence-associated secretory phenotype (SASP) is composed of proteins released by senescent cells. We assessed the prognostic significance and biologic pathways associated with the SASP in human HF using a plasma proteomics approach.BACKGROUNDThe role of cellular senescence in human heart failure (HF) remains unclear. The senescence-associated secretory phenotype (SASP) is composed of proteins released by senescent cells. We assessed the prognostic significance and biologic pathways associated with the SASP in human HF using a plasma proteomics approach.We measured 25 known SASP proteins among 2248 PHFS (Penn HF Study) participants using the SOMAScan V4 assay. We extracted the common variance in these proteins to generate SASP factor scores and assessed the relationship between these SASP factor scores and (1) all-cause death and (2) the composite of death or HF hospital admission. We also assessed the relationship of each SASP factor to 4746 other proteins, correcting for multiple comparisons, followed by pathway analyses. Two SASP factors were identified. Both factors were associated with older age, lower estimated glomerular filtration rate, and more advanced New York Heart Association class, among other clinical variables. Both SASP factors exhibited a significant positive association with the risk of death independent of the Meta-Analysis of Global-Group in Chronic HF score and NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels. The 2 identified SASP factors were associated with 1201 and 1554 proteins, respectively, belonging to various pathways including the coagulation system, complement system, acute phase response signaling, and retinoid X receptor-related pathways that regulate cell metabolism.METHODS AND RESULTSWe measured 25 known SASP proteins among 2248 PHFS (Penn HF Study) participants using the SOMAScan V4 assay. We extracted the common variance in these proteins to generate SASP factor scores and assessed the relationship between these SASP factor scores and (1) all-cause death and (2) the composite of death or HF hospital admission. We also assessed the relationship of each SASP factor to 4746 other proteins, correcting for multiple comparisons, followed by pathway analyses. Two SASP factors were identified. Both factors were associated with older age, lower estimated glomerular filtration rate, and more advanced New York Heart Association class, among other clinical variables. Both SASP factors exhibited a significant positive association with the risk of death independent of the Meta-Analysis of Global-Group in Chronic HF score and NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels. The 2 identified SASP factors were associated with 1201 and 1554 proteins, respectively, belonging to various pathways including the coagulation system, complement system, acute phase response signaling, and retinoid X receptor-related pathways that regulate cell metabolism.Increased SASP components are independently associated with adverse outcomes in HF. Biologic pathways associated with SASP are predominantly related to coagulation, inflammation, and cell metabolism.CONCLUSIONSIncreased SASP components are independently associated with adverse outcomes in HF. Biologic pathways associated with SASP are predominantly related to coagulation, inflammation, and cell metabolism.
Background The role of cellular senescence in human heart failure (HF) remains unclear. The senescence‐associated secretory phenotype (SASP) is composed of proteins released by senescent cells. We assessed the prognostic significance and biologic pathways associated with the SASP in human HF using a plasma proteomics approach. Methods and Results We measured 25 known SASP proteins among 2248 PHFS (Penn HF Study) participants using the SOMAScan V4 assay. We extracted the common variance in these proteins to generate SASP factor scores and assessed the relationship between these SASP factor scores and (1) all‐cause death and (2) the composite of death or HF hospital admission. We also assessed the relationship of each SASP factor to 4746 other proteins, correcting for multiple comparisons, followed by pathway analyses. Two SASP factors were identified. Both factors were associated with older age, lower estimated glomerular filtration rate, and more advanced New York Heart Association class, among other clinical variables. Both SASP factors exhibited a significant positive association with the risk of death independent of the Meta‐Analysis of Global‐Group in Chronic HF score and NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) levels. The 2 identified SASP factors were associated with 1201 and 1554 proteins, respectively, belonging to various pathways including the coagulation system, complement system, acute phase response signaling, and retinoid X receptor–related pathways that regulate cell metabolism. Conclusions Increased SASP components are independently associated with adverse outcomes in HF. Biologic pathways associated with SASP are predominantly related to coagulation, inflammation, and cell metabolism.
The role of cellular senescence in human heart failure (HF) remains unclear. The senescence-associated secretory phenotype (SASP) is composed of proteins released by senescent cells. We assessed the prognostic significance and biologic pathways associated with the SASP in human HF using a plasma proteomics approach. We measured 25 known SASP proteins among 2248 PHFS (Penn HF Study) participants using the SOMAScan V4 assay. We extracted the common variance in these proteins to generate SASP factor scores and assessed the relationship between these SASP factor scores and (1) all-cause death and (2) the composite of death or HF hospital admission. We also assessed the relationship of each SASP factor to 4746 other proteins, correcting for multiple comparisons, followed by pathway analyses. Two SASP factors were identified. Both factors were associated with older age, lower estimated glomerular filtration rate, and more advanced New York Heart Association class, among other clinical variables. Both SASP factors exhibited a significant positive association with the risk of death independent of the Meta-Analysis of Global-Group in Chronic HF score and NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels. The 2 identified SASP factors were associated with 1201 and 1554 proteins, respectively, belonging to various pathways including the coagulation system, complement system, acute phase response signaling, and retinoid X receptor-related pathways that regulate cell metabolism. Increased SASP components are independently associated with adverse outcomes in HF. Biologic pathways associated with SASP are predominantly related to coagulation, inflammation, and cell metabolism.
Author Greenawalt, Danielle
Ramirez‐Valle, Francisco
Mann, Douglas L.
Rietzschel, Ernst
van Empel, Vanessa
Gordon, David A.
Zamani, Payman
Zhao, Manyun
Carayannopoulos, Leon
Pourmussa, Bianca
Liu, Laura
Javaheri, Ali
Gunawardhana, Kushan L.
Salman, Oday
Gogain, Joseph
Cappola, Thomas P.
Ebert, Christina
Zhao, Lei
Richards, Arthur Mark
Wang, Zhaoqing
Azzo, Joe David
Gan, Sushrima
Chirinos, Julio A.
Dib, Marie Joe
Schafer, Peter H.
Chang, Ching‐Pin
AuthorAffiliation 8 Department of Cardiology Cardiovascular Research Institute Maastricht (CARIM) Maastricht Netherlands
9 SomaLogic, Inc. Boulder CO USA
1 Hospital of the University of Pennsylvania Philadelphia PA USA
4 Cardiovascular Research Institute, National University of Singapore Singapore City Singapore
7 Department of Cardiovascular Diseases Ghent University and Ghent University Hospital Ghent Belgium
6 Washington University School of Medicine St. Louis MO USA
2 University of Pennsylvania Perelman School of Medicine Philadelphia PA USA
3 Bristol Myers Squibb Company Princeton NJ USA
5 Christchurch Heart Institute, University of Otago Dunedin New Zealand
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Issue 17
Keywords heart failure
pathways
aging
proteomics
cell senescence
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This manuscript was sent to Sula Mazimba, MD, MPH, Associate Editor, for review by expert referees, editorial decision, and final disposition.
For Sources of Funding and Disclosures, see page 13.
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39392141 - J Am Heart Assoc. 2024 Oct 15;13(20):e034295. doi: 10.1161/JAHA.123.034295
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Snippet The role of cellular senescence in human heart failure (HF) remains unclear. The senescence-associated secretory phenotype (SASP) is composed of proteins...
Background The role of cellular senescence in human heart failure (HF) remains unclear. The senescence‐associated secretory phenotype (SASP) is composed of...
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SubjectTerms Aged
aging
Biomarkers - blood
cell senescence
Cellular Senescence
Female
heart failure
Heart Failure - blood
Heart Failure - metabolism
Heart Failure - mortality
Heart Failure - physiopathology
Humans
Male
Middle Aged
Natriuretic Peptide, Brain
Original Research
pathways
Peptide Fragments
Prognosis
proteomics
Proteomics - methods
Senescence-Associated Secretory Phenotype
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Title Prognostic Significance and Biologic Associations of Senescence‐Associated Secretory Phenotype Biomarkers in Heart Failure
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