Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis Associated with Acetaminophen Use during Viral Infections
An association between drug treatment for viral infections and severe cutaneous adverse reactions has been noted. We investigated six patients diagnosed with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) after being prescribed acetaminophen for suspected viral illnesses. Multip...
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| Published in | Immune network Vol. 16; no. 4; pp. 256 - 260 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
대한면역학회
01.08.2016
The Korean Association of Immunologists |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1598-2629 2092-6685 2092-6685 |
| DOI | 10.4110/in.2016.16.4.256 |
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| Abstract | An association between drug treatment for viral infections and severe cutaneous adverse reactions has been noted. We investigated six patients diagnosed with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) after being prescribed acetaminophen for suspected viral illnesses. Multiplex analysis was performed to measure cytokine levels in sera before and after treatment. IL-2Rα levels significantly decreased during the convalescence phase. Although acetaminophen is relatively safe, the drug can trigger SJS/TEN in patients with suspected viral infections. T-cells and monocytes may be key components of the link between viral infection and acetaminophen-induced SJS/TEN. |
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| AbstractList | An association between drug treatment for viral infections and severe cutaneous adverse reactions has been noted. We investigated six patients diagnosed with Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) after being prescribed acetaminophen for suspected viral illnesses. Multiplex analysis was performed to measure cytokine levels in sera before and after treatment. IL-2Rα levels significantly decreased during the convalescence phase. Although acetaminophen is relatively safe, the drug can trigger SJS/TEN in patients with suspected viral infections. T-cells and monocytes may be key components of the link between viral infection and acetaminophen-induced SJS/TEN. An association between drug treatment for viral infections and severe cutaneous adverse reactions has been noted. We investigated six patients diagnosed with Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) after being prescribed acetaminophen for suspected viral illnesses. Multiplex analysis was performed to measure cytokine levels in sera before and after treatment. IL-2Ra levels significantly decreased during the convalescence phase. Although acetaminophen is relatively safe, the drug can trigger SJS/TEN in patients with suspected viral infections. T-cells and monocytes may be key components of the link between viral infection and acetaminophen-induced SJS/ TEN. KCI Citation Count: 4 |
| Author | Young-Min Ye Hye-Soo Yoo Seun-Joo Ahn Hae-Sim Park Ga-Young Ban |
| AuthorAffiliation | 1 Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon 16499, Korea 2 Ajou Regional Pharmacovigilance Center, Ajou University Hospital, Suwon 16499, Korea |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27574505$$D View this record in MEDLINE/PubMed https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002134522$$DAccess content in National Research Foundation of Korea (NRF) |
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| Cites_doi | 10.1007/s12016-007-8010-9 10.1067/mai.2000.110922 10.1586/eci.11.66 10.1186/1750-1172-5-39 10.1111/ijd.12423 10.1016/S1081-1206(10)61112-X 10.1016/j.jaad.2006.04.048 10.1080/00015550510038232 10.1016/S0091-6749(97)70042-3 10.1098/rspb.2008.0147 10.1111/j.1346-8138.2010.01170.x 10.1097/ACI.0b013e3283489bab 10.4168/aair.2015.7.3.304 10.5415/apallergy.2014.4.1.68 10.1016/j.jdermsci.2004.08.007 10.1046/j.1365-4362.1997.00043.x 10.1097/ACI.0b013e328355b865 10.1542/pir.29-1-12 |
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| Keywords | Acetaminophen Viral infection Severe cutaneous adverse reaction |
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| Title | Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis Associated with Acetaminophen Use during Viral Infections |
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