miR-6089 may prevent the inflammatory events leading to cardiovascular disorders in RA patients
Cardiovascular disease (CVD) is the most important comorbid condition in rheumatoid arthritis (RA) patients. Dysregulated expression of non-coding RNA families has a critical role in RA-associated inflammatory events, including cardiovascular manifestations. The long non-coding RNA (lncRNA)- HIX0032...
Saved in:
| Published in | Heliyon Vol. 10; no. 17; p. e36763 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
15.09.2024
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2405-8440 2405-8440 |
| DOI | 10.1016/j.heliyon.2024.e36763 |
Cover
| Abstract | Cardiovascular disease (CVD) is the most important comorbid condition in rheumatoid arthritis (RA) patients. Dysregulated expression of non-coding RNA families has a critical role in RA-associated inflammatory events, including cardiovascular manifestations. The long non-coding RNA (lncRNA)- HIX003209 has a role in RA associated inflammation. In the current study, we investigated the association of HIX003209 and its downstream microRNA, miR-6089, with various cardiovascular and inflammatory biomarkers in RA patients.
60 RA patients, including 30 newly diagnosed and 30 on-treatment patients were recruited in this study, and 30 healthy people were selected as a control group. The gene expression of HIX003209, miR-6089, and CXCR3 were measured using Real-time PCR. The CVD risk was measured using Systematic Coronary Risk Evaluation (SCORE) and Framingham Risk Score (FRS).
The gene expression of LncRNA-HIX003209 was elevated significantly in newly-diagnosed compared to under-treatment and control groups (p < 0.05). The miR-6089 gene expression was elevated significantly in under-treatment RA patients group compared to control group (p < 0.001). There was a significant positive correlation between LncRNA-HIX003209 with CXCR3 gene expression (p < 0.01, r = 0.341). There was a significantly negative correlation between the gene expression of miR-6089 with DAS-28 (p < 0.05, r = −0.309), NT-proBNP plasma level (p = 0.039, r = −0.268), and CXCL9 plasma level (p < 0.001, r = −0.421).
Regarding its anti-inflammatory effects, miR-6089 may play an important role in preventing the pathological events of cardiovascular disorders in RA patients, through its inhibitory effects on inflammatory chemokines, such as CXCL9, and NT-ProBNP. Higher expression of LncRNA-HIX003209 may disrupt the anti-inflammatory effect of miR-6089 in RA patients. |
|---|---|
| AbstractList | Background: Cardiovascular disease (CVD) is the most important comorbid condition in rheumatoid arthritis (RA) patients. Dysregulated expression of non-coding RNA families has a critical role in RA-associated inflammatory events, including cardiovascular manifestations. The long non-coding RNA (lncRNA)- HIX003209 has a role in RA associated inflammation. In the current study, we investigated the association of HIX003209 and its downstream microRNA, miR-6089, with various cardiovascular and inflammatory biomarkers in RA patients. Material and methods: 60 RA patients, including 30 newly diagnosed and 30 on-treatment patients were recruited in this study, and 30 healthy people were selected as a control group. The gene expression of HIX003209, miR-6089, and CXCR3 were measured using Real-time PCR. The CVD risk was measured using Systematic Coronary Risk Evaluation (SCORE) and Framingham Risk Score (FRS). Results: The gene expression of LncRNA-HIX003209 was elevated significantly in newly-diagnosed compared to under-treatment and control groups (p < 0.05). The miR-6089 gene expression was elevated significantly in under-treatment RA patients group compared to control group (p < 0.001). There was a significant positive correlation between LncRNA-HIX003209 with CXCR3 gene expression (p < 0.01, r = 0.341). There was a significantly negative correlation between the gene expression of miR-6089 with DAS-28 (p < 0.05, r = −0.309), NT-proBNP plasma level (p = 0.039, r = −0.268), and CXCL9 plasma level (p < 0.001, r = −0.421). Conclusion: Regarding its anti-inflammatory effects, miR-6089 may play an important role in preventing the pathological events of cardiovascular disorders in RA patients, through its inhibitory effects on inflammatory chemokines, such as CXCL9, and NT-ProBNP. Higher expression of LncRNA-HIX003209 may disrupt the anti-inflammatory effect of miR-6089 in RA patients. Cardiovascular disease (CVD) is the most important comorbid condition in rheumatoid arthritis (RA) patients. Dysregulated expression of non-coding RNA families has a critical role in RA-associated inflammatory events, including cardiovascular manifestations. The long non-coding RNA (lncRNA)- HIX003209 has a role in RA associated inflammation. In the current study, we investigated the association of HIX003209 and its downstream microRNA, miR-6089, with various cardiovascular and inflammatory biomarkers in RA patients. 60 RA patients, including 30 newly diagnosed and 30 on-treatment patients were recruited in this study, and 30 healthy people were selected as a control group. The gene expression of HIX003209, miR-6089, and CXCR3 were measured using Real-time PCR. The CVD risk was measured using Systematic Coronary Risk Evaluation (SCORE) and Framingham Risk Score (FRS). The gene expression of LncRNA-HIX003209 was elevated significantly in newly-diagnosed compared to under-treatment and control groups (p < 0.05). The miR-6089 gene expression was elevated significantly in under-treatment RA patients group compared to control group (p < 0.001). There was a significant positive correlation between LncRNA-HIX003209 with CXCR3 gene expression (p < 0.01, r = 0.341). There was a significantly negative correlation between the gene expression of miR-6089 with DAS-28 (p < 0.05, r = −0.309), NT-proBNP plasma level (p = 0.039, r = −0.268), and CXCL9 plasma level (p < 0.001, r = −0.421). Regarding its anti-inflammatory effects, miR-6089 may play an important role in preventing the pathological events of cardiovascular disorders in RA patients, through its inhibitory effects on inflammatory chemokines, such as CXCL9, and NT-ProBNP. Higher expression of LncRNA-HIX003209 may disrupt the anti-inflammatory effect of miR-6089 in RA patients. Cardiovascular disease (CVD) is the most important comorbid condition in rheumatoid arthritis (RA) patients. Dysregulated expression of non-coding RNA families has a critical role in RA-associated inflammatory events, including cardiovascular manifestations. The long non-coding RNA (lncRNA)- HIX003209 has a role in RA associated inflammation. In the current study, we investigated the association of HIX003209 and its downstream microRNA, miR-6089, with various cardiovascular and inflammatory biomarkers in RA patients. 60 RA patients, including 30 newly diagnosed and 30 on-treatment patients were recruited in this study, and 30 healthy people were selected as a control group. The gene expression of HIX003209, miR-6089, and CXCR3 were measured using Real-time PCR. The CVD risk was measured using Systematic Coronary Risk Evaluation (SCORE) and Framingham Risk Score (FRS). The gene expression of LncRNA-HIX003209 was elevated significantly in newly-diagnosed compared to under-treatment and control groups (p < 0.05). The miR-6089 gene expression was elevated significantly in under-treatment RA patients group compared to control group (p < 0.001). There was a significant positive correlation between LncRNA-HIX003209 with CXCR3 gene expression (p < 0.01, r = 0.341). There was a significantly negative correlation between the gene expression of miR-6089 with DAS-28 (p < 0.05, r = −0.309), NT-proBNP plasma level (p = 0.039, r = −0.268), and CXCL9 plasma level (p < 0.001, r = −0.421). Regarding its anti-inflammatory effects, miR-6089 may play an important role in preventing the pathological events of cardiovascular disorders in RA patients, through its inhibitory effects on inflammatory chemokines, such as CXCL9, and NT-ProBNP. Higher expression of LncRNA-HIX003209 may disrupt the anti-inflammatory effect of miR-6089 in RA patients. Cardiovascular disease (CVD) is the most important comorbid condition in rheumatoid arthritis (RA) patients. Dysregulated expression of non-coding RNA families has a critical role in RA-associated inflammatory events, including cardiovascular manifestations. The long non-coding RNA (lncRNA)- HIX003209 has a role in RA associated inflammation. In the current study, we investigated the association of HIX003209 and its downstream microRNA, miR-6089, with various cardiovascular and inflammatory biomarkers in RA patients. 60 RA patients, including 30 newly diagnosed and 30 on-treatment patients were recruited in this study, and 30 healthy people were selected as a control group. The gene expression of HIX003209, miR-6089, and CXCR3 were measured using Real-time PCR. The CVD risk was measured using Systematic Coronary Risk Evaluation (SCORE) and Framingham Risk Score (FRS). The gene expression of LncRNA-HIX003209 was elevated significantly in newly-diagnosed compared to under-treatment and control groups (p < 0.05). The miR-6089 gene expression was elevated significantly in under-treatment RA patients group compared to control group (p < 0.001). There was a significant positive correlation between LncRNA-HIX003209 with CXCR3 gene expression (p < 0.01, r = 0.341). There was a significantly negative correlation between the gene expression of miR-6089 with DAS-28 (p < 0.05, r = -0.309), NT-proBNP plasma level (p = 0.039, r = -0.268), and CXCL9 plasma level (p < 0.001, r = -0.421). Regarding its anti-inflammatory effects, miR-6089 may play an important role in preventing the pathological events of cardiovascular disorders in RA patients, through its inhibitory effects on inflammatory chemokines, such as CXCL9, and NT-ProBNP. Higher expression of LncRNA-HIX003209 may disrupt the anti-inflammatory effect of miR-6089 in RA patients. Cardiovascular disease (CVD) is the most important comorbid condition in rheumatoid arthritis (RA) patients. Dysregulated expression of non-coding RNA families has a critical role in RA-associated inflammatory events, including cardiovascular manifestations. The long non-coding RNA (lncRNA)- HIX003209 has a role in RA associated inflammation. In the current study, we investigated the association of HIX003209 and its downstream microRNA, miR-6089, with various cardiovascular and inflammatory biomarkers in RA patients.BackgroundCardiovascular disease (CVD) is the most important comorbid condition in rheumatoid arthritis (RA) patients. Dysregulated expression of non-coding RNA families has a critical role in RA-associated inflammatory events, including cardiovascular manifestations. The long non-coding RNA (lncRNA)- HIX003209 has a role in RA associated inflammation. In the current study, we investigated the association of HIX003209 and its downstream microRNA, miR-6089, with various cardiovascular and inflammatory biomarkers in RA patients.60 RA patients, including 30 newly diagnosed and 30 on-treatment patients were recruited in this study, and 30 healthy people were selected as a control group. The gene expression of HIX003209, miR-6089, and CXCR3 were measured using Real-time PCR. The CVD risk was measured using Systematic Coronary Risk Evaluation (SCORE) and Framingham Risk Score (FRS).Material and methods60 RA patients, including 30 newly diagnosed and 30 on-treatment patients were recruited in this study, and 30 healthy people were selected as a control group. The gene expression of HIX003209, miR-6089, and CXCR3 were measured using Real-time PCR. The CVD risk was measured using Systematic Coronary Risk Evaluation (SCORE) and Framingham Risk Score (FRS).The gene expression of LncRNA-HIX003209 was elevated significantly in newly-diagnosed compared to under-treatment and control groups (p < 0.05). The miR-6089 gene expression was elevated significantly in under-treatment RA patients group compared to control group (p < 0.001). There was a significant positive correlation between LncRNA-HIX003209 with CXCR3 gene expression (p < 0.01, r = 0.341). There was a significantly negative correlation between the gene expression of miR-6089 with DAS-28 (p < 0.05, r = -0.309), NT-proBNP plasma level (p = 0.039, r = -0.268), and CXCL9 plasma level (p < 0.001, r = -0.421).ResultsThe gene expression of LncRNA-HIX003209 was elevated significantly in newly-diagnosed compared to under-treatment and control groups (p < 0.05). The miR-6089 gene expression was elevated significantly in under-treatment RA patients group compared to control group (p < 0.001). There was a significant positive correlation between LncRNA-HIX003209 with CXCR3 gene expression (p < 0.01, r = 0.341). There was a significantly negative correlation between the gene expression of miR-6089 with DAS-28 (p < 0.05, r = -0.309), NT-proBNP plasma level (p = 0.039, r = -0.268), and CXCL9 plasma level (p < 0.001, r = -0.421).Regarding its anti-inflammatory effects, miR-6089 may play an important role in preventing the pathological events of cardiovascular disorders in RA patients, through its inhibitory effects on inflammatory chemokines, such as CXCL9, and NT-ProBNP. Higher expression of LncRNA-HIX003209 may disrupt the anti-inflammatory effect of miR-6089 in RA patients.ConclusionRegarding its anti-inflammatory effects, miR-6089 may play an important role in preventing the pathological events of cardiovascular disorders in RA patients, through its inhibitory effects on inflammatory chemokines, such as CXCL9, and NT-ProBNP. Higher expression of LncRNA-HIX003209 may disrupt the anti-inflammatory effect of miR-6089 in RA patients. |
| ArticleNumber | e36763 |
| Author | Shamsi, Mohammad Roghani, Seyed Askar Shamsi, Afsaneh Soufivand, Parviz Taghadosi, Mahdi Jalili, Cyrus |
| Author_xml | – sequence: 1 givenname: Afsaneh surname: Shamsi fullname: Shamsi, Afsaneh organization: Immunology Department, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran – sequence: 2 givenname: Seyed Askar surname: Roghani fullname: Roghani, Seyed Askar organization: Immunology Department, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran – sequence: 3 givenname: Mohammad surname: Shamsi fullname: Shamsi, Mohammad organization: School of Dentistry, AJA University of Medical Sciences, Tehran, Iran – sequence: 4 givenname: Cyrus surname: Jalili fullname: Jalili, Cyrus organization: Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran – sequence: 5 givenname: Mahdi orcidid: 0000-0002-3516-0130 surname: Taghadosi fullname: Taghadosi, Mahdi email: mtaghad@gmail.com organization: Immunology Department, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran – sequence: 6 givenname: Parviz surname: Soufivand fullname: Soufivand, Parviz organization: Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39281435$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkUtr3DAUhUVJadI0P6FFy25mKlkve1VC6CMQKIR2La6k60SDbU0lz8D8-2jiaeiuXUm6fOdwdc5bcjalCQl5z9maM64_bdaPOMRDmtYNa-QahTZavCIXjWRq1UrJzv66n5OrUjaMMa5a3RnxhpyLrmm5FOqC2DHerzRrOzrCgW4z7nGa6fyINE79AOMIc8oH-jwudEAIcXqgc6IecohpD8XvBsg0xJJywFyqjt5f0y3M8Sh5R173MBS8Op2X5NfXLz9vvq_ufny7vbm-W3mpunnl0Lmec963vAWPDRPgW9bKvpO8AeNdh9q0ThnosHFaHH_TmK6-0fQQjLgkt4tvSLCx2xxHyAebINrnQcoPFvIc_YC26QGF0z64zsmgG_CsFSoobzB4YWT1-rh4bXP6vcMy15CKx2GACdOuWMGV5FpJrf4DZZqJ2gKv6IcTunMjhpcd_3RRAbUAPqdSMvYvCGf2WLvd2FPt9li7XWqvus-LDmu--4jZFl-z9xhiRj_XAOI_HJ4ApPq34w |
| Cites_doi | 10.3390/ijms20081820 10.1016/S0140-6736(13)61752-3 10.1016/0021-9681(67)90082-3 10.3389/fimmu.2020.588776 10.1016/j.biopha.2023.114672 10.1016/j.trac.2021.116477 10.1016/j.phrs.2022.106549 10.1186/s43044-022-00317-2 10.1038/s41584-019-0256-0 10.1038/s41392-022-01055-2 10.3389/fimmu.2019.02218 10.1016/j.ejim.2022.07.001 10.1038/s41580-020-00315-9 10.1093/rheumatology/kead493 10.1007/s10067-023-06826-y 10.1056/NEJMra2103726 10.1007/s10753-023-01884-5 10.18632/aging.103079 10.1111/jcmm.15880 10.1016/S0195-668X(03)00114-3 10.1080/08916934.2022.2126460 10.1016/j.jtauto.2020.100044 10.1371/journal.pone.0023539 10.1080/15384101.2020.1867788 10.1002/jcp.27014 10.1016/j.autrev.2021.102776 10.3390/cells11223642 10.1093/cvr/cvr097 10.1371/journal.pone.0141394 10.18632/oncotarget.20036 10.3389/fphar.2021.652751 10.3389/fendo.2018.00402 10.1038/nrrheum.2015.40 10.1016/j.autrev.2020.102735 10.1093/nar/29.9.e45 10.3389/fimmu.2021.807738 10.1038/s43587-021-00082-y 10.1038/s41584-020-0428-y 10.1097/HCO.0000000000001041 10.3390/ijms241813723 |
| ContentType | Journal Article |
| Copyright | 2024 The Authors 2024 The Authors. |
| Copyright_xml | – notice: 2024 The Authors – notice: 2024 The Authors. |
| DBID | 6I. AAFTH AAYXX CITATION NPM 7X8 7S9 L.6 DOA |
| DOI | 10.1016/j.heliyon.2024.e36763 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | AGRICOLA PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2405-8440 |
| ExternalDocumentID | oai_doaj_org_article_2fae3b6cdb9b4d62ac0835d5c7edc374 39281435 10_1016_j_heliyon_2024_e36763 S2405844024127946 |
| Genre | Journal Article |
| GroupedDBID | 0R~ 457 53G 5VS 6I. AAEDW AAFTH AAFWJ AALRI AAYWO ABMAC ACGFS ACLIJ ACVFH ADBBV ADCNI ADEZE ADVLN AEUPX AEXQZ AFJKZ AFPKN AFPUW AFTJW AGHFR AIGII AITUG AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS APXCP BAWUL BCNDV DIK EBS FDB GROUPED_DOAJ HYE KQ8 M~E O9- OK1 ROL RPM SSZ AAYXX CITATION EJD IPNFZ RIG 0SF AACTN NCXOZ NPM 7X8 7S9 L.6 |
| ID | FETCH-LOGICAL-c459t-bebbf111f818ace203ac8084f9412a7cb9e678b57a9e2b63000127957ae7fad73 |
| IEDL.DBID | DOA |
| ISSN | 2405-8440 |
| IngestDate | Wed Aug 27 01:20:57 EDT 2025 Fri Aug 22 20:40:14 EDT 2025 Fri Jul 11 09:19:08 EDT 2025 Thu Jan 02 22:33:32 EST 2025 Thu Sep 11 00:13:14 EDT 2025 Sat Sep 27 17:13:40 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 17 |
| Keywords | VSMCs CXCL9 SCORE BPS FRS LncRNA Cardiovascular disease RA CVD NT-proBNP Cardiovascular risk factors Rheumatoid arthritis CXCR3 BPD miRNA HS-CRP LncRNA-HIX003209 miR-6089 |
| Language | English |
| License | This is an open access article under the CC BY license. 2024 The Authors. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c459t-bebbf111f818ace203ac8084f9412a7cb9e678b57a9e2b63000127957ae7fad73 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0002-3516-0130 |
| OpenAccessLink | https://doaj.org/article/2fae3b6cdb9b4d62ac0835d5c7edc374 |
| PMID | 39281435 |
| PQID | 3106038441 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_2fae3b6cdb9b4d62ac0835d5c7edc374 proquest_miscellaneous_3154165465 proquest_miscellaneous_3106038441 pubmed_primary_39281435 crossref_primary_10_1016_j_heliyon_2024_e36763 elsevier_sciencedirect_doi_10_1016_j_heliyon_2024_e36763 |
| PublicationCentury | 2000 |
| PublicationDate | 2024-09-15 |
| PublicationDateYYYYMMDD | 2024-09-15 |
| PublicationDate_xml | – month: 09 year: 2024 text: 2024-09-15 day: 15 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Heliyon |
| PublicationTitleAlternate | Heliyon |
| PublicationYear | 2024 |
| Publisher | Elsevier Ltd Elsevier |
| Publisher_xml | – name: Elsevier Ltd – name: Elsevier |
| References | Conforti (bib2) 2021; 20 Shamsi (bib36) 2023; 46 Yan (bib48) 2019; 10 Cao, Jia, Zhu (bib31) 2019; 20 Miao (bib22) 2021; 12 Feng (bib47) 2022; 11 Fang (bib45) 2020; 24 Shamsi (bib35) 2024; 43 Pfaffl (bib39) 2001; 29 Yan (bib25) 2019; 10 Lee, Lee (bib32) 2023; 13 Erre (bib33) 2022; 104 Statello (bib13) 2021; 22 Ma (bib15) 2023; 162 Fang (bib18) 2020; 24 England (bib4) 2018; 361 Schwartz (bib9) 2020; 11 Skeoch, Bruce (bib7) 2015; 11 Yang (bib12) 2022; 186 Shi (bib28) 2020; 12 Wołowiec (bib10) 2023; 24 Ferguson (bib5) 2019; 15 O'Brien (bib16) 2018; 9 Gravallese, Firestein (bib1) 2023; 388 Wang (bib23) 2021; 20 Kış, Şenöz, Güzel (bib51) 2022; 10 Goff Jr (bib43) 2014; 129 Qiu (bib19) 2022; 55 Szadkowska (bib50) 2009; 67 Bedeković (bib8) 2023; 59 Shamsi (bib37) 2024; 43 Truett, Cornfield, Kannel (bib41) 1967; 20 Xu (bib49) 2019; 234 Xu (bib24) 2017; 8 Huang (bib44) 2022; 12 Conroy (bib42) 2003; 24 Thupakula (bib29) 2022; 74 Altara (bib52) 2015; 10 Goryacheva (bib30) 2022; 146 Bartels (bib26) 2023; 63 Mahmood (bib40) 2014; 383 Semb (bib6) 2020; 16 Pierer (bib27) 2011; 6 Xu (bib46) 2017; 8 Medhat (bib20) 2022; 10 Sayed (bib38) 2021; 1 Figus (bib3) 2021; 20 Zou, Xu (bib17) 2020; 3 Pope, Choy (bib34) 2021 Kaikkonen, Lam, Glass (bib14) 2011; 90 Kohlmaier, Holdt, Teupser (bib21) 2023; 38 Shi (bib11) 2022; 7 Figus (10.1016/j.heliyon.2024.e36763_bib3) 2021; 20 Bedeković (10.1016/j.heliyon.2024.e36763_bib8) 2023; 59 Ferguson (10.1016/j.heliyon.2024.e36763_bib5) 2019; 15 Shamsi (10.1016/j.heliyon.2024.e36763_bib35) 2024; 43 Wang (10.1016/j.heliyon.2024.e36763_bib23) 2021; 20 Altara (10.1016/j.heliyon.2024.e36763_bib52) 2015; 10 Truett (10.1016/j.heliyon.2024.e36763_bib41) 1967; 20 Qiu (10.1016/j.heliyon.2024.e36763_bib19) 2022; 55 Erre (10.1016/j.heliyon.2024.e36763_bib33) 2022; 104 Thupakula (10.1016/j.heliyon.2024.e36763_bib29) 2022; 74 Kaikkonen (10.1016/j.heliyon.2024.e36763_bib14) 2011; 90 O'Brien (10.1016/j.heliyon.2024.e36763_bib16) 2018; 9 Xu (10.1016/j.heliyon.2024.e36763_bib24) 2017; 8 Shamsi (10.1016/j.heliyon.2024.e36763_bib36) 2023; 46 Huang (10.1016/j.heliyon.2024.e36763_bib44) 2022; 12 Feng (10.1016/j.heliyon.2024.e36763_bib47) 2022; 11 Miao (10.1016/j.heliyon.2024.e36763_bib22) 2021; 12 Sayed (10.1016/j.heliyon.2024.e36763_bib38) 2021; 1 Cao (10.1016/j.heliyon.2024.e36763_bib31) 2019; 20 Xu (10.1016/j.heliyon.2024.e36763_bib49) 2019; 234 Kohlmaier (10.1016/j.heliyon.2024.e36763_bib21) 2023; 38 Mahmood (10.1016/j.heliyon.2024.e36763_bib40) 2014; 383 Semb (10.1016/j.heliyon.2024.e36763_bib6) 2020; 16 Medhat (10.1016/j.heliyon.2024.e36763_bib20) 2022; 10 Yan (10.1016/j.heliyon.2024.e36763_bib48) 2019; 10 England (10.1016/j.heliyon.2024.e36763_bib4) 2018; 361 Pierer (10.1016/j.heliyon.2024.e36763_bib27) 2011; 6 Yang (10.1016/j.heliyon.2024.e36763_bib12) 2022; 186 Shi (10.1016/j.heliyon.2024.e36763_bib28) 2020; 12 Fang (10.1016/j.heliyon.2024.e36763_bib45) 2020; 24 Ma (10.1016/j.heliyon.2024.e36763_bib15) 2023; 162 Conroy (10.1016/j.heliyon.2024.e36763_bib42) 2003; 24 Pope (10.1016/j.heliyon.2024.e36763_bib34) 2021 Yan (10.1016/j.heliyon.2024.e36763_bib25) 2019; 10 Goff Jr (10.1016/j.heliyon.2024.e36763_bib43) 2014; 129 Goryacheva (10.1016/j.heliyon.2024.e36763_bib30) 2022; 146 Lee (10.1016/j.heliyon.2024.e36763_bib32) 2023; 13 Bartels (10.1016/j.heliyon.2024.e36763_bib26) 2023; 63 Shamsi (10.1016/j.heliyon.2024.e36763_bib37) 2024; 43 Zou (10.1016/j.heliyon.2024.e36763_bib17) 2020; 3 Wołowiec (10.1016/j.heliyon.2024.e36763_bib10) 2023; 24 Statello (10.1016/j.heliyon.2024.e36763_bib13) 2021; 22 Schwartz (10.1016/j.heliyon.2024.e36763_bib9) 2020; 11 Pfaffl (10.1016/j.heliyon.2024.e36763_bib39) 2001; 29 Kış (10.1016/j.heliyon.2024.e36763_bib51) 2022; 10 Shi (10.1016/j.heliyon.2024.e36763_bib11) 2022; 7 Gravallese (10.1016/j.heliyon.2024.e36763_bib1) 2023; 388 Xu (10.1016/j.heliyon.2024.e36763_bib46) 2017; 8 Skeoch (10.1016/j.heliyon.2024.e36763_bib7) 2015; 11 Conforti (10.1016/j.heliyon.2024.e36763_bib2) 2021; 20 Szadkowska (10.1016/j.heliyon.2024.e36763_bib50) 2009; 67 Fang (10.1016/j.heliyon.2024.e36763_bib18) 2020; 24 |
| References_xml | – volume: 22 start-page: 96 year: 2021 end-page: 118 ident: bib13 article-title: Gene regulation by long non-coding RNAs and its biological functions publication-title: Nat. Rev. Mol. Cell Biol. – volume: 10 start-page: 2218 year: 2019 ident: bib25 article-title: Long non-coding RNA HIX003209 promotes inflammation by sponging miR-6089 via TLR4/NF-κB signaling pathway in rheumatoid arthritis publication-title: Front. Immunol. – volume: 43 start-page: 137 year: 2024 end-page: 145 ident: bib35 article-title: CXCL9 and NT-proBNP, a notable link between inflammatory mediator and cardiovascular disease biomarker in rheumatoid arthritis publication-title: Clin. Rheumatol. – volume: 8 start-page: 95280 year: 2017 end-page: 95292 ident: bib24 article-title: Long noncoding RNAs expression profile and functional networks in rheumatoid arthritis publication-title: Oncotarget – volume: 162 year: 2023 ident: bib15 article-title: Mechanisms of circRNA/lncRNA-miRNA interactions and applications in disease and drug research publication-title: Biomed. Pharmacother. – volume: 13 year: 2023 ident: bib32 article-title: Early elevation of high-sensitivity C-reactive protein as a predictor for cardiovascular disease incidence and all-cause mortality: a landmark analysis publication-title: Sci. Rep. – volume: 24 start-page: 987 year: 2003 end-page: 1003 ident: bib42 article-title: Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project publication-title: Eur. Heart J. – volume: 20 start-page: 1820 year: 2019 ident: bib31 article-title: BNP and NT-proBNP as diagnostic biomarkers for cardiac dysfunction in both clinical and forensic medicine publication-title: Int. J. Mol. Sci. – volume: 361 year: 2018 ident: bib4 article-title: Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications publication-title: Bmj – volume: 8 year: 2017 ident: bib46 article-title: Long noncoding RNAs expression profile and functional networks in rheumatoid arthritis publication-title: Oncotarget – volume: 11 start-page: 3642 year: 2022 ident: bib47 article-title: Role of long noncoding RNAs in the regulation of cellular immune response and inflammatory diseases publication-title: Cells – volume: 7 start-page: 200 year: 2022 ident: bib11 article-title: Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials publication-title: Signal Transduct Target Ther – volume: 146 year: 2022 ident: bib30 article-title: Heart failure biomarkers BNP and NT-proBNP detection using optical labels publication-title: TrAC, Trends Anal. Chem. – volume: 24 start-page: 12246 year: 2020 end-page: 12257 ident: bib18 article-title: Recent advances on the roles of LncRNAs in cardiovascular disease publication-title: J. Cell Mol. Med. – volume: 67 start-page: 1201 year: 2009 end-page: 1206 ident: bib50 article-title: Original article Left ventricular dysfunction and NT-proBNP levels in patients with one-vessel disease after first ST-elevation myocardial infarction treated with primary coronary angioplasty publication-title: Kardiol. Pol. – volume: 20 year: 2021 ident: bib2 article-title: Beyond the joints, the extra-articular manifestations in rheumatoid arthritis publication-title: Autoimmun. Rev. – volume: 20 year: 2021 ident: bib3 article-title: Rheumatoid arthritis: extra-articular manifestations and comorbidities publication-title: Autoimmun. Rev. – volume: 46 start-page: 2374 year: 2023 end-page: 2385 ident: bib36 article-title: CXCL9 and its receptor CXCR3, an important link between inflammation and cardiovascular risks in RA patients publication-title: Inflammation – volume: 12 year: 2021 ident: bib22 article-title: Dysregulation of lncRNAs in rheumatoid arthritis: biomarkers, pathogenesis and potential therapeutic targets publication-title: Front. Pharmacol. – volume: 10 year: 2015 ident: bib52 article-title: Left ventricular dysfunction and CXCR3 ligands in hypertension: from animal experiments to a population-based pilot study publication-title: PLoS One – volume: 15 start-page: 461 year: 2019 end-page: 474 ident: bib5 article-title: Cardiometabolic comorbidities in RA and PsA: lessons learned and future directions publication-title: Nat. Rev. Rheumatol. – volume: 12 start-page: 8913 year: 2020 ident: bib28 article-title: HIX003209 promotes vascular smooth muscle cell migration and proliferation through modulating miR-6089 publication-title: Aging (Albany NY) – volume: 129 start-page: S49 year: 2014 end-page: S73 ident: bib43 article-title: 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of cardiology/American heart association task force on practice guidelines publication-title: Circulation – volume: 10 start-page: 2218 year: 2019 ident: bib48 article-title: Long non-coding RNA HIX003209 promotes inflammation by sponging miR-6089 via TLR4/NF-κB signaling pathway in rheumatoid arthritis publication-title: Front. Immunol. – volume: 20 start-page: 194 year: 2021 end-page: 203 ident: bib23 article-title: LncRNA MIAT downregulates IL-1β, TNF-ɑ to suppress macrophage inflammation but is suppressed by ATP-induced NLRP3 inflammasome activation publication-title: Cell Cycle – volume: 11 start-page: 390 year: 2015 end-page: 400 ident: bib7 article-title: Atherosclerosis in rheumatoid arthritis: is it all about inflammation? publication-title: Nat. Rev. Rheumatol. – volume: 59 year: 2023 ident: bib8 article-title: Role of inflammatory cytokines in rheumatoid arthritis and development of atherosclerosis: a review publication-title: Medicina (Kaunas) – volume: 11 year: 2020 ident: bib9 article-title: T cells in autoimmunity-associated cardiovascular diseases publication-title: Front. Immunol. – volume: 16 start-page: 361 year: 2020 end-page: 379 ident: bib6 article-title: Atherosclerotic cardiovascular disease prevention in rheumatoid arthritis publication-title: Nat. Rev. Rheumatol. – volume: 63 start-page: 608 year: 2023 end-page: 618 ident: bib26 article-title: Inhibition of TLR4 signalling to dampen joint inflammation in osteoarthritis publication-title: Rheumatology – volume: 234 start-page: 1502 year: 2019 end-page: 1511 ident: bib49 article-title: Exosome‐encapsulated miR‐6089 regulates inflammatory response via targeting TLR4 publication-title: J. Cell. Physiol. – volume: 29 start-page: e45 year: 2001 ident: bib39 article-title: A new mathematical model for relative quantification in real-time RT–PCR publication-title: Nucleic acids research – volume: 10 start-page: 614 year: 2022 end-page: 621 ident: bib20 article-title: HOTAIR and THRIL long non coding RNAs and their target genes in rheumatoid arthritis patients publication-title: Rep Biochem Mol Biol – volume: 186 year: 2022 ident: bib12 article-title: The role of non-coding RNAs (miRNA and lncRNA) in the clinical management of rheumatoid arthritis publication-title: Pharmacol. Res. – volume: 24 year: 2023 ident: bib10 article-title: The role of selected epigenetic pathways in cardiovascular diseases as a potential therapeutic target publication-title: Int. J. Mol. Sci. – volume: 74 start-page: 77 year: 2022 ident: bib29 article-title: Emerging biomarkers for the detection of cardiovascular diseases publication-title: Egypt Heart J – volume: 55 start-page: 567 year: 2022 end-page: 576 ident: bib19 article-title: LncRNA HOTAIR inhibits the progression of fibroblast-like synoviocytes by sponging miRNA-106b-5p in rheumatoid arthritis publication-title: Autoimmunity – volume: 43 start-page: 137 year: 2024 end-page: 145 ident: bib37 article-title: CXCL9 and NT-proBNP, a notable link between inflammatory mediator and cardiovascular disease biomarker in rheumatoid arthritis publication-title: Clin. Rheumatol. – volume: 10 year: 2022 ident: bib51 article-title: The relationship between N-terminal pro-brain natriuretic peptide level and left ventricular metabolic Index in patients with heart failure with mildly reduced ejection fraction publication-title: J. Cardiovasc. Med. – volume: 3 year: 2020 ident: bib17 article-title: Involvement of long noncoding RNAs in the pathogenesis of autoimmune diseases publication-title: Journal of Translational Autoimmunity – volume: 104 start-page: 49 year: 2022 end-page: 54 ident: bib33 article-title: C-reactive protein and 10-year cardiovascular risk in rheumatoid arthritis publication-title: Eur. J. Intern. Med. – volume: 12 year: 2022 ident: bib44 article-title: LncRNAs and rheumatoid arthritis: from identifying mechanisms to clinical investigation publication-title: Front. Immunol. – volume: 383 start-page: 999 year: 2014 end-page: 1008 ident: bib40 article-title: The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective publication-title: The lancet – volume: 90 start-page: 430 year: 2011 end-page: 440 ident: bib14 article-title: Non-coding RNAs as regulators of gene expression and epigenetics publication-title: Cardiovasc. Res. – volume: 6 year: 2011 ident: bib27 article-title: Toll-like receptor 4 is involved in inflammatory and joint destructive pathways in collagen-induced arthritis in DBA1J mice publication-title: PLoS One – volume: 9 year: 2018 ident: bib16 article-title: Overview of MicroRNA biogenesis, mechanisms of actions, and circulation publication-title: Front. Endocrinol. – volume: 1 start-page: 598 year: 2021 end-page: 615 ident: bib38 article-title: An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging publication-title: Nature aging – volume: 24 start-page: 12246 year: 2020 end-page: 12257 ident: bib45 article-title: Recent advances on the roles of LncRNAs in cardiovascular disease publication-title: J. Cell Mol. Med. – volume: 388 start-page: 529 year: 2023 end-page: 542 ident: bib1 article-title: Rheumatoid arthritis—common origins, divergent mechanisms publication-title: N. Engl. J. Med. – volume: 38 start-page: 179 year: 2023 end-page: 192 ident: bib21 article-title: Long noncoding RNAs in cardiovascular disease publication-title: Curr. Opin. Cardiol. – year: 2021 ident: bib34 article-title: C-reactive protein and implications in rheumatoid arthritis and associated comorbidities publication-title: Seminars in Arthritis and Rheumatism – volume: 20 start-page: 511 year: 1967 end-page: 524 ident: bib41 article-title: A multivariate analysis of the risk of coronary heart disease in Framingham publication-title: J. Chron. Dis. – volume: 20 start-page: 1820 issue: 8 year: 2019 ident: 10.1016/j.heliyon.2024.e36763_bib31 article-title: BNP and NT-proBNP as diagnostic biomarkers for cardiac dysfunction in both clinical and forensic medicine publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms20081820 – volume: 383 start-page: 999 issue: 9921 year: 2014 ident: 10.1016/j.heliyon.2024.e36763_bib40 article-title: The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective publication-title: The lancet doi: 10.1016/S0140-6736(13)61752-3 – volume: 20 start-page: 511 issue: 7 year: 1967 ident: 10.1016/j.heliyon.2024.e36763_bib41 article-title: A multivariate analysis of the risk of coronary heart disease in Framingham publication-title: J. Chron. Dis. doi: 10.1016/0021-9681(67)90082-3 – volume: 11 year: 2020 ident: 10.1016/j.heliyon.2024.e36763_bib9 article-title: T cells in autoimmunity-associated cardiovascular diseases publication-title: Front. Immunol. doi: 10.3389/fimmu.2020.588776 – volume: 162 year: 2023 ident: 10.1016/j.heliyon.2024.e36763_bib15 article-title: Mechanisms of circRNA/lncRNA-miRNA interactions and applications in disease and drug research publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2023.114672 – year: 2021 ident: 10.1016/j.heliyon.2024.e36763_bib34 article-title: C-reactive protein and implications in rheumatoid arthritis and associated comorbidities – volume: 67 start-page: 1201 issue: 11 year: 2009 ident: 10.1016/j.heliyon.2024.e36763_bib50 article-title: Original article Left ventricular dysfunction and NT-proBNP levels in patients with one-vessel disease after first ST-elevation myocardial infarction treated with primary coronary angioplasty publication-title: Kardiol. Pol. – volume: 146 year: 2022 ident: 10.1016/j.heliyon.2024.e36763_bib30 article-title: Heart failure biomarkers BNP and NT-proBNP detection using optical labels publication-title: TrAC, Trends Anal. Chem. doi: 10.1016/j.trac.2021.116477 – volume: 186 year: 2022 ident: 10.1016/j.heliyon.2024.e36763_bib12 article-title: The role of non-coding RNAs (miRNA and lncRNA) in the clinical management of rheumatoid arthritis publication-title: Pharmacol. Res. doi: 10.1016/j.phrs.2022.106549 – volume: 74 start-page: 77 issue: 1 year: 2022 ident: 10.1016/j.heliyon.2024.e36763_bib29 article-title: Emerging biomarkers for the detection of cardiovascular diseases publication-title: Egypt Heart J doi: 10.1186/s43044-022-00317-2 – volume: 15 start-page: 461 issue: 8 year: 2019 ident: 10.1016/j.heliyon.2024.e36763_bib5 article-title: Cardiometabolic comorbidities in RA and PsA: lessons learned and future directions publication-title: Nat. Rev. Rheumatol. doi: 10.1038/s41584-019-0256-0 – volume: 7 start-page: 200 issue: 1 year: 2022 ident: 10.1016/j.heliyon.2024.e36763_bib11 article-title: Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials publication-title: Signal Transduct Target Ther doi: 10.1038/s41392-022-01055-2 – volume: 10 start-page: 2218 year: 2019 ident: 10.1016/j.heliyon.2024.e36763_bib48 article-title: Long non-coding RNA HIX003209 promotes inflammation by sponging miR-6089 via TLR4/NF-κB signaling pathway in rheumatoid arthritis publication-title: Front. Immunol. doi: 10.3389/fimmu.2019.02218 – volume: 104 start-page: 49 year: 2022 ident: 10.1016/j.heliyon.2024.e36763_bib33 article-title: C-reactive protein and 10-year cardiovascular risk in rheumatoid arthritis publication-title: Eur. J. Intern. Med. doi: 10.1016/j.ejim.2022.07.001 – volume: 22 start-page: 96 issue: 2 year: 2021 ident: 10.1016/j.heliyon.2024.e36763_bib13 article-title: Gene regulation by long non-coding RNAs and its biological functions publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/s41580-020-00315-9 – volume: 10 start-page: 614 issue: 4 year: 2022 ident: 10.1016/j.heliyon.2024.e36763_bib20 article-title: HOTAIR and THRIL long non coding RNAs and their target genes in rheumatoid arthritis patients publication-title: Rep Biochem Mol Biol – volume: 63 start-page: 608 issue: 3 year: 2023 ident: 10.1016/j.heliyon.2024.e36763_bib26 article-title: Inhibition of TLR4 signalling to dampen joint inflammation in osteoarthritis publication-title: Rheumatology doi: 10.1093/rheumatology/kead493 – volume: 43 start-page: 137 year: 2024 ident: 10.1016/j.heliyon.2024.e36763_bib37 article-title: CXCL9 and NT-proBNP, a notable link between inflammatory mediator and cardiovascular disease biomarker in rheumatoid arthritis publication-title: Clin. Rheumatol. doi: 10.1007/s10067-023-06826-y – volume: 388 start-page: 529 issue: 6 year: 2023 ident: 10.1016/j.heliyon.2024.e36763_bib1 article-title: Rheumatoid arthritis—common origins, divergent mechanisms publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra2103726 – volume: 10 issue: 1 year: 2022 ident: 10.1016/j.heliyon.2024.e36763_bib51 article-title: The relationship between N-terminal pro-brain natriuretic peptide level and left ventricular metabolic Index in patients with heart failure with mildly reduced ejection fraction publication-title: J. Cardiovasc. Med. – volume: 46 start-page: 2374 issue: 6 year: 2023 ident: 10.1016/j.heliyon.2024.e36763_bib36 article-title: CXCL9 and its receptor CXCR3, an important link between inflammation and cardiovascular risks in RA patients publication-title: Inflammation doi: 10.1007/s10753-023-01884-5 – volume: 12 start-page: 8913 issue: 10 year: 2020 ident: 10.1016/j.heliyon.2024.e36763_bib28 article-title: HIX003209 promotes vascular smooth muscle cell migration and proliferation through modulating miR-6089 publication-title: Aging (Albany NY) doi: 10.18632/aging.103079 – volume: 24 start-page: 12246 issue: 21 year: 2020 ident: 10.1016/j.heliyon.2024.e36763_bib45 article-title: Recent advances on the roles of LncRNAs in cardiovascular disease publication-title: J. Cell Mol. Med. doi: 10.1111/jcmm.15880 – volume: 361 year: 2018 ident: 10.1016/j.heliyon.2024.e36763_bib4 article-title: Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications publication-title: Bmj – volume: 24 start-page: 987 issue: 11 year: 2003 ident: 10.1016/j.heliyon.2024.e36763_bib42 article-title: Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project publication-title: Eur. Heart J. doi: 10.1016/S0195-668X(03)00114-3 – volume: 55 start-page: 567 issue: 8 year: 2022 ident: 10.1016/j.heliyon.2024.e36763_bib19 article-title: LncRNA HOTAIR inhibits the progression of fibroblast-like synoviocytes by sponging miRNA-106b-5p in rheumatoid arthritis publication-title: Autoimmunity doi: 10.1080/08916934.2022.2126460 – volume: 3 year: 2020 ident: 10.1016/j.heliyon.2024.e36763_bib17 article-title: Involvement of long noncoding RNAs in the pathogenesis of autoimmune diseases publication-title: Journal of Translational Autoimmunity doi: 10.1016/j.jtauto.2020.100044 – volume: 6 issue: 8 year: 2011 ident: 10.1016/j.heliyon.2024.e36763_bib27 article-title: Toll-like receptor 4 is involved in inflammatory and joint destructive pathways in collagen-induced arthritis in DBA1J mice publication-title: PLoS One doi: 10.1371/journal.pone.0023539 – volume: 20 start-page: 194 issue: 2 year: 2021 ident: 10.1016/j.heliyon.2024.e36763_bib23 article-title: LncRNA MIAT downregulates IL-1β, TNF-ɑ to suppress macrophage inflammation but is suppressed by ATP-induced NLRP3 inflammasome activation publication-title: Cell Cycle doi: 10.1080/15384101.2020.1867788 – volume: 43 start-page: 137 issue: 1 year: 2024 ident: 10.1016/j.heliyon.2024.e36763_bib35 article-title: CXCL9 and NT-proBNP, a notable link between inflammatory mediator and cardiovascular disease biomarker in rheumatoid arthritis publication-title: Clin. Rheumatol. doi: 10.1007/s10067-023-06826-y – volume: 234 start-page: 1502 issue: 2 year: 2019 ident: 10.1016/j.heliyon.2024.e36763_bib49 article-title: Exosome‐encapsulated miR‐6089 regulates inflammatory response via targeting TLR4 publication-title: J. Cell. Physiol. doi: 10.1002/jcp.27014 – volume: 20 issue: 4 year: 2021 ident: 10.1016/j.heliyon.2024.e36763_bib3 article-title: Rheumatoid arthritis: extra-articular manifestations and comorbidities publication-title: Autoimmun. Rev. doi: 10.1016/j.autrev.2021.102776 – volume: 11 start-page: 3642 issue: 22 year: 2022 ident: 10.1016/j.heliyon.2024.e36763_bib47 article-title: Role of long noncoding RNAs in the regulation of cellular immune response and inflammatory diseases publication-title: Cells doi: 10.3390/cells11223642 – volume: 90 start-page: 430 issue: 3 year: 2011 ident: 10.1016/j.heliyon.2024.e36763_bib14 article-title: Non-coding RNAs as regulators of gene expression and epigenetics publication-title: Cardiovasc. Res. doi: 10.1093/cvr/cvr097 – volume: 10 issue: 10 year: 2015 ident: 10.1016/j.heliyon.2024.e36763_bib52 article-title: Left ventricular dysfunction and CXCR3 ligands in hypertension: from animal experiments to a population-based pilot study publication-title: PLoS One doi: 10.1371/journal.pone.0141394 – volume: 8 start-page: 95280 issue: 56 year: 2017 ident: 10.1016/j.heliyon.2024.e36763_bib24 article-title: Long noncoding RNAs expression profile and functional networks in rheumatoid arthritis publication-title: Oncotarget doi: 10.18632/oncotarget.20036 – volume: 12 year: 2021 ident: 10.1016/j.heliyon.2024.e36763_bib22 article-title: Dysregulation of lncRNAs in rheumatoid arthritis: biomarkers, pathogenesis and potential therapeutic targets publication-title: Front. Pharmacol. doi: 10.3389/fphar.2021.652751 – volume: 129 start-page: S49 issue: 25_suppl_2 year: 2014 ident: 10.1016/j.heliyon.2024.e36763_bib43 article-title: 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of cardiology/American heart association task force on practice guidelines publication-title: Circulation – volume: 59 issue: 9 year: 2023 ident: 10.1016/j.heliyon.2024.e36763_bib8 article-title: Role of inflammatory cytokines in rheumatoid arthritis and development of atherosclerosis: a review publication-title: Medicina (Kaunas) – volume: 9 year: 2018 ident: 10.1016/j.heliyon.2024.e36763_bib16 article-title: Overview of MicroRNA biogenesis, mechanisms of actions, and circulation publication-title: Front. Endocrinol. doi: 10.3389/fendo.2018.00402 – volume: 11 start-page: 390 issue: 7 year: 2015 ident: 10.1016/j.heliyon.2024.e36763_bib7 article-title: Atherosclerosis in rheumatoid arthritis: is it all about inflammation? publication-title: Nat. Rev. Rheumatol. doi: 10.1038/nrrheum.2015.40 – volume: 24 start-page: 12246 issue: 21 year: 2020 ident: 10.1016/j.heliyon.2024.e36763_bib18 article-title: Recent advances on the roles of LncRNAs in cardiovascular disease publication-title: J. Cell Mol. Med. doi: 10.1111/jcmm.15880 – volume: 20 issue: 2 year: 2021 ident: 10.1016/j.heliyon.2024.e36763_bib2 article-title: Beyond the joints, the extra-articular manifestations in rheumatoid arthritis publication-title: Autoimmun. Rev. doi: 10.1016/j.autrev.2020.102735 – volume: 29 start-page: e45 issue: 9 year: 2001 ident: 10.1016/j.heliyon.2024.e36763_bib39 article-title: A new mathematical model for relative quantification in real-time RT–PCR publication-title: Nucleic acids research doi: 10.1093/nar/29.9.e45 – volume: 12 year: 2022 ident: 10.1016/j.heliyon.2024.e36763_bib44 article-title: LncRNAs and rheumatoid arthritis: from identifying mechanisms to clinical investigation publication-title: Front. Immunol. doi: 10.3389/fimmu.2021.807738 – volume: 1 start-page: 598 issue: 7 year: 2021 ident: 10.1016/j.heliyon.2024.e36763_bib38 article-title: An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging publication-title: Nature aging doi: 10.1038/s43587-021-00082-y – volume: 16 start-page: 361 issue: 7 year: 2020 ident: 10.1016/j.heliyon.2024.e36763_bib6 article-title: Atherosclerotic cardiovascular disease prevention in rheumatoid arthritis publication-title: Nat. Rev. Rheumatol. doi: 10.1038/s41584-020-0428-y – volume: 13 issue: 1 year: 2023 ident: 10.1016/j.heliyon.2024.e36763_bib32 article-title: Early elevation of high-sensitivity C-reactive protein as a predictor for cardiovascular disease incidence and all-cause mortality: a landmark analysis publication-title: Sci. Rep. – volume: 38 start-page: 179 issue: 3 year: 2023 ident: 10.1016/j.heliyon.2024.e36763_bib21 article-title: Long noncoding RNAs in cardiovascular disease publication-title: Curr. Opin. Cardiol. doi: 10.1097/HCO.0000000000001041 – volume: 8 issue: 56 year: 2017 ident: 10.1016/j.heliyon.2024.e36763_bib46 article-title: Long noncoding RNAs expression profile and functional networks in rheumatoid arthritis publication-title: Oncotarget doi: 10.18632/oncotarget.20036 – volume: 24 issue: 18 year: 2023 ident: 10.1016/j.heliyon.2024.e36763_bib10 article-title: The role of selected epigenetic pathways in cardiovascular diseases as a potential therapeutic target publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms241813723 – volume: 10 start-page: 2218 year: 2019 ident: 10.1016/j.heliyon.2024.e36763_bib25 article-title: Long non-coding RNA HIX003209 promotes inflammation by sponging miR-6089 via TLR4/NF-κB signaling pathway in rheumatoid arthritis publication-title: Front. Immunol. doi: 10.3389/fimmu.2019.02218 |
| SSID | ssj0001586973 |
| Score | 2.2789137 |
| Snippet | Cardiovascular disease (CVD) is the most important comorbid condition in rheumatoid arthritis (RA) patients. Dysregulated expression of non-coding RNA families... Background: Cardiovascular disease (CVD) is the most important comorbid condition in rheumatoid arthritis (RA) patients. Dysregulated expression of non-coding... |
| SourceID | doaj proquest pubmed crossref elsevier |
| SourceType | Open Website Aggregation Database Index Database Publisher |
| StartPage | e36763 |
| SubjectTerms | anti-inflammatory activity biomarkers Cardiovascular disease cardiovascular diseases Cardiovascular risk factors chemokines gene expression inflammation LncRNA-HIX003209 microRNA miR-6089 non-coding RNA people quantitative polymerase chain reaction Rheumatoid arthritis risk risk assessment |
| Title | miR-6089 may prevent the inflammatory events leading to cardiovascular disorders in RA patients |
| URI | https://dx.doi.org/10.1016/j.heliyon.2024.e36763 https://www.ncbi.nlm.nih.gov/pubmed/39281435 https://www.proquest.com/docview/3106038441 https://www.proquest.com/docview/3154165465 https://doaj.org/article/2fae3b6cdb9b4d62ac0835d5c7edc374 |
| Volume | 10 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 2405-8440 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001586973 issn: 2405-8440 databaseCode: KQ8 dateStart: 20150901 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2405-8440 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001586973 issn: 2405-8440 databaseCode: DOA dateStart: 20150101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 2405-8440 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001586973 issn: 2405-8440 databaseCode: DIK dateStart: 20150101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2405-8440 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001586973 issn: 2405-8440 databaseCode: M~E dateStart: 20150101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 2405-8440 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001586973 issn: 2405-8440 databaseCode: AKRWK dateStart: 20150901 isFulltext: true providerName: Library Specific Holdings – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 2405-8440 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001586973 issn: 2405-8440 databaseCode: RPM dateStart: 20150101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV09T8MwELUQSIgF8U35kpFYU9LYjp2xIBCigqECwWbZzkUU0RaRMvDvOcduoQOwMMZyEvud5XvW3T0TciK8hpThLmEVg4SLAnAftHhKYSY3PKt4zLa4za_u-fWjePx21ZfPCQvywAG406wywGzuSltYXuaZcZ40lMJJKB2TjRIourFvh6lQH6zyQrKvkp3T5_YTvAw-xl7zNONt8EplbM4ZNZr9cz7pJ87Z-J7LNbIaSSPthsGukwUYbZDlmxgW3yR6OOgneaoKOjQf9DWoMlGkdhTXD5p82ITSadNc05eQN08nY-rmslFpGaU4a3yP9rs0iq7WW-T-8uLu_CqJNyckDuGeJBasrXAXq9AdGwdZyoxTqeJVwTuZkc4WgE7KCmkKyKxX3fIR6AKfQVamlGybLI7GI9gltJLISVKhlHAZdwqQr5SgvKZOhxkjyxZpTyHUr0EgQ08zx551xFx7zHXAvEXOPNCzzl7fumlAq-todf2X1VtETc2kI1UIFAA_Nfjr_8dTs6J1ah8fMSMYv9camW6eMoUE8bc-gjcFYKJFdsKamM0Eqaby9HPvP2a4T1b8oH1qSkcckMXJ2zscIv-Z2COy1O31H3pHzZL_BCAuBiw |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=miR-6089+may+prevent+the+inflammatory+events+leading+to+cardiovascular+disorders+in+RA+patients&rft.jtitle=Heliyon&rft.au=Shamsi%2C+Afsaneh&rft.au=Roghani%2C+Seyed+Askar&rft.au=Shamsi%2C+Mohammad&rft.au=Jalili%2C+Cyrus&rft.date=2024-09-15&rft.issn=2405-8440&rft.eissn=2405-8440&rft.volume=10&rft.issue=17+p.e36763-&rft_id=info:doi/10.1016%2Fj.heliyon.2024.e36763&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2405-8440&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2405-8440&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2405-8440&client=summon |