Leveraging self-assembled nanobiomaterials for improved cancer immunotherapy

Nanomaterials and targeted drug delivery vehicles improve the therapeutic index of drugs and permit greater control over their pharmacokinetics, biodistribution, and bioavailability. Here, nanotechnologies applied to cancer immunotherapy are discussed with a focus on current and next generation self...

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Published inCancer cell Vol. 40; no. 3; pp. 255 - 276
Main Authors Vincent, Michael P., Navidzadeh, Justin O., Bobbala, Sharan, Scott, Evan A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 14.03.2022
Subjects
cancer
drug delivery
Drug Delivery Systems
Humans
Immunotherapy
nanomaterial
Nanoparticles - chemistry
Nanostructures - chemistry
Neoplasms - therapy
targeting
Tissue Distribution
Tumor Microenvironment
vaccine
nanomaterial
targeting
vaccine
cancer
drug delivery
tumor microenvironment
Online AccessGet full text
ISSN1535-6108
1878-3686
1878-3686
DOI10.1016/j.ccell.2022.01.006

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Abstract Nanomaterials and targeted drug delivery vehicles improve the therapeutic index of drugs and permit greater control over their pharmacokinetics, biodistribution, and bioavailability. Here, nanotechnologies applied to cancer immunotherapy are discussed with a focus on current and next generation self-assembling drug delivery systems composed of lipids and/or polymers. Topics covered include the fundamental design, suitability, and inherent properties of nanomaterials that induce anti-tumor immune responses and support anti-cancer vaccination. Established active and passive targeting strategies as well as newer “indirect” methods are presented together with insights into how nanocarrier structure and surface chemistry can be leveraged for controlled delivery to the tumor microenvironment while minimizing off-target effects.
AbstractList Nanomaterials and targeted drug delivery vehicles improve the therapeutic index of drugs and permit greater control over their pharmacokinetics, biodistribution, and bioavailability. Here, nanotechnologies applied to cancer immunotherapy are discussed with a focus on current and next generation self-assembling drug delivery systems composed of lipids and/or polymers. Topics covered include the fundamental design, suitability, and inherent properties of nanomaterials that induce anti-tumor immune responses and support anti-cancer vaccination. Established active and passive targeting strategies as well as newer "indirect" methods are presented together with insights into how nanocarrier structure and surface chemistry can be leveraged for controlled delivery to the tumor microenvironment while minimizing off-target effects.Nanomaterials and targeted drug delivery vehicles improve the therapeutic index of drugs and permit greater control over their pharmacokinetics, biodistribution, and bioavailability. Here, nanotechnologies applied to cancer immunotherapy are discussed with a focus on current and next generation self-assembling drug delivery systems composed of lipids and/or polymers. Topics covered include the fundamental design, suitability, and inherent properties of nanomaterials that induce anti-tumor immune responses and support anti-cancer vaccination. Established active and passive targeting strategies as well as newer "indirect" methods are presented together with insights into how nanocarrier structure and surface chemistry can be leveraged for controlled delivery to the tumor microenvironment while minimizing off-target effects.
Nanomaterials and targeted drug delivery vehicles improve the therapeutic index of drugs and permit greater control over their pharmacokinetics, biodistribution, and bioavailability. Here, nanotechnologies applied to cancer immunotherapy are discussed with a focus on current and next generation self-assembling drug delivery systems composed of lipids and/or polymers. Topics covered include the fundamental design, suitability, and inherent properties of nanomaterials that induce anti-tumor immune responses and support anti-cancer vaccination. Established active and passive targeting strategies as well as newer "indirect" methods are presented together with insights into how nanocarrier structure and surface chemistry can be leveraged for controlled delivery to the tumor microenvironment while minimizing off-target effects.
Author Vincent, Michael P.
Scott, Evan A.
Bobbala, Sharan
Navidzadeh, Justin O.
AuthorAffiliation 3 Interdisciplinary Biological Sciences, Northwestern University, Evanston, IL 60208, USA
4 Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA
5 Simpson Querrey Institute, Northwestern University, Chicago, IL 60611, USA
6 Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA
2 Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV, USA
1 Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA
AuthorAffiliation_xml – name: 1 Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA
– name: 2 Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV, USA
– name: 6 Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA
– name: 5 Simpson Querrey Institute, Northwestern University, Chicago, IL 60611, USA
– name: 4 Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA
– name: 3 Interdisciplinary Biological Sciences, Northwestern University, Evanston, IL 60208, USA
Author_xml – sequence: 1
  givenname: Michael P.
  orcidid: 0000-0001-9669-4921
  surname: Vincent
  fullname: Vincent, Michael P.
  organization: Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA
– sequence: 2
  givenname: Justin O.
  orcidid: 0000-0001-8218-9131
  surname: Navidzadeh
  fullname: Navidzadeh, Justin O.
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  orcidid: 0000-0002-0740-330X
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  givenname: Evan A.
  orcidid: 0000-0002-8945-2892
  surname: Scott
  fullname: Scott, Evan A.
  email: evan.scott@northwestern.edu
  organization: Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35148814$$D View this record in MEDLINE/PubMed
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Keywords nanomaterial
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cancer
drug delivery
tumor microenvironment
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PublicationCentury 2000
PublicationDate 2022-03-14
PublicationDateYYYYMMDD 2022-03-14
PublicationDate_xml – month: 03
  year: 2022
  text: 2022-03-14
  day: 14
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Cancer cell
PublicationTitleAlternate Cancer Cell
PublicationYear 2022
Publisher Elsevier Inc
Publisher_xml – name: Elsevier Inc
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Snippet Nanomaterials and targeted drug delivery vehicles improve the therapeutic index of drugs and permit greater control over their pharmacokinetics,...
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SubjectTerms cancer
drug delivery
Drug Delivery Systems
Humans
Immunotherapy
nanomaterial
Nanoparticles - chemistry
Nanostructures - chemistry
Neoplasms - therapy
targeting
Tissue Distribution
Tumor Microenvironment
vaccine
Title Leveraging self-assembled nanobiomaterials for improved cancer immunotherapy
URI https://dx.doi.org/10.1016/j.ccell.2022.01.006
https://www.ncbi.nlm.nih.gov/pubmed/35148814
https://www.proquest.com/docview/2628298534
https://pubmed.ncbi.nlm.nih.gov/PMC8930620
Volume 40
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