Molecular players in neutrophil chemotaxis—focus on PI3K and small GTPases
Review of cross‐talk between signaling intermediates during neutrophil chemotaxis, focusing on PI3K and small GTPase signaling. Neutrophil chemotaxis is a process by which individual cells sense a gradient of chemoattractant, polarize, and then migrate toward the chemoattractant. Many features of ch...
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| Published in | Journal of leukocyte biology Vol. 94; no. 4; pp. 603 - 612 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
Society for Leukocyte Biology
01.10.2013
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0741-5400 1938-3673 1938-3673 |
| DOI | 10.1189/jlb.1112564 |
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| Abstract | Review of cross‐talk between signaling intermediates during neutrophil chemotaxis, focusing on PI3K and small GTPase signaling.
Neutrophil chemotaxis is a process by which individual cells sense a gradient of chemoattractant, polarize, and then migrate toward the chemoattractant. Many features of chemotaxis are shared with other forms of cell migration. We continue to expand our understanding of the mechanisms governing these features. The rapid process through which neutrophils polarize when placed into a gradient of chemoattractant remains least well‐understood. Several key molecular players involved in the regulation of polarization have been identified. However, crosstalk among the different molecular players is required to polarize the cell and to maintain cell polarity during directional migration. The mechanism(s) by which this occurs are the subject of current investigations using experimental and computational approaches. Here, we review progress in the field, putting recent observations into context with established findings. We concentrate on the signaling processes regulated by PI3Ks, their lipid products, the role of Rho‐family small GTPases, and crosstalk between these important families of regulators. |
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| AbstractList | Neutrophil chemotaxis is a process by which individual cells sense a gradient of chemoattractant, polarize, and then migrate toward the chemoattractant. Many features of chemotaxis are shared with other forms of cell migration. We continue to expand our understanding of the mechanisms governing these features. The rapid process through which neutrophils polarize when placed into a gradient of chemoattractant remains least well-understood. Several key molecular players involved in the regulation of polarization have been identified. However, crosstalk among the different molecular players is required to polarize the cell and to maintain cell polarity during directional migration. The mechanism(s) by which this occurs are the subject of current investigations using experimental and computational approaches. Here, we review progress in the field, putting recent observations into context with established findings. We concentrate on the signaling processes regulated by PI3Ks, their lipid products, the role of Rho-family small GTPases, and crosstalk between these important families of regulators. Review of cross‐talk between signaling intermediates during neutrophil chemotaxis, focusing on PI3K and small GTPase signaling. Neutrophil chemotaxis is a process by which individual cells sense a gradient of chemoattractant, polarize, and then migrate toward the chemoattractant. Many features of chemotaxis are shared with other forms of cell migration. We continue to expand our understanding of the mechanisms governing these features. The rapid process through which neutrophils polarize when placed into a gradient of chemoattractant remains least well‐understood. Several key molecular players involved in the regulation of polarization have been identified. However, crosstalk among the different molecular players is required to polarize the cell and to maintain cell polarity during directional migration. The mechanism(s) by which this occurs are the subject of current investigations using experimental and computational approaches. Here, we review progress in the field, putting recent observations into context with established findings. We concentrate on the signaling processes regulated by PI3Ks, their lipid products, the role of Rho‐family small GTPases, and crosstalk between these important families of regulators. Review of cross-talk between signaling intermediates during neutrophil chemotaxis, focusing on PI3K and small GTPase signaling. Neutrophil chemotaxis is a process by which individual cells sense a gradient of chemoattractant, polarize, and then migrate toward the chemoattractant. Many features of chemotaxis are shared with other forms of cell migration. We continue to expand our understanding of the mechanisms governing these features. The rapid process through which neutrophils polarize when placed into a gradient of chemoattractant remains least well-understood. Several key molecular players involved in the regulation of polarization have been identified. However, crosstalk among the different molecular players is required to polarize the cell and to maintain cell polarity during directional migration. The mechanism(s) by which this occurs are the subject of current investigations using experimental and computational approaches. Here, we review progress in the field, putting recent observations into context with established findings. We concentrate on the signaling processes regulated by PI3Ks, their lipid products, the role of Rho-family small GTPases, and crosstalk between these important families of regulators.Neutrophil chemotaxis is a process by which individual cells sense a gradient of chemoattractant, polarize, and then migrate toward the chemoattractant. Many features of chemotaxis are shared with other forms of cell migration. We continue to expand our understanding of the mechanisms governing these features. The rapid process through which neutrophils polarize when placed into a gradient of chemoattractant remains least well-understood. Several key molecular players involved in the regulation of polarization have been identified. However, crosstalk among the different molecular players is required to polarize the cell and to maintain cell polarity during directional migration. The mechanism(s) by which this occurs are the subject of current investigations using experimental and computational approaches. Here, we review progress in the field, putting recent observations into context with established findings. We concentrate on the signaling processes regulated by PI3Ks, their lipid products, the role of Rho-family small GTPases, and crosstalk between these important families of regulators. |
| Author | Sonja Vermeren Laure Gambardella |
| Author_xml | – sequence: 1 givenname: Laure surname: Gambardella fullname: Gambardella, Laure – sequence: 2 givenname: Sonja surname: Vermeren fullname: Vermeren, Sonja email: sonja.vermeren@ed.ac.uk |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23667166$$D View this record in MEDLINE/PubMed |
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Cell Biol. doi: 10.1038/ncb1517 |
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| Snippet | Review of cross‐talk between signaling intermediates during neutrophil chemotaxis, focusing on PI3K and small GTPase signaling.
Neutrophil chemotaxis is a... Neutrophil chemotaxis is a process by which individual cells sense a gradient of chemoattractant, polarize, and then migrate toward the chemoattractant. Many... Review of cross-talk between signaling intermediates during neutrophil chemotaxis, focusing on PI3K and small GTPase signaling. |
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| SubjectTerms | Animals Cell Polarity Chemotaxis, Leukocyte directionality Humans integrin migration Models, Biological Monomeric GTP-Binding Proteins - metabolism Neutrophils - cytology Neutrophils - enzymology Phosphatidylinositol 3-Kinases - metabolism polarization |
| Title | Molecular players in neutrophil chemotaxis—focus on PI3K and small GTPases |
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