Vagotomy and the risk of mental disorders: A nationwide population‐based study
Objective To investigate vagotomy, the severance of the vagus nerve, and its association with mental disorders, as gut‐brain communication partly mediated by the vagus nerve have been suggested as a risk factor. Methods Nationwide population‐based Danish register study of all individuals alive and l...
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| Published in | Acta psychiatrica Scandinavica Vol. 145; no. 1; pp. 67 - 78 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Blackwell Publishing Ltd
01.01.2022
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0001-690X 1600-0447 1600-0447 |
| DOI | 10.1111/acps.13343 |
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| Abstract | Objective
To investigate vagotomy, the severance of the vagus nerve, and its association with mental disorders, as gut‐brain communication partly mediated by the vagus nerve have been suggested as a risk factor.
Methods
Nationwide population‐based Danish register study of all individuals alive and living in Denmark during the study period 1977–2016 and who had a hospital contact for ulcer with or without vagotomy. Follow‐up was until any diagnosis of mental disorders requiring hospital contact, emigration, death, or end of follow‐up on December 31, 2016, whichever came first. Data were analyzed using survival analysis and adjusted for sex, age, calendar year, ulcer type, and Charlson comorbidity index score.
Results
During the study period, 113,086 individuals had a hospital contact for ulcer. Of these, 5,408 were exposed to vagotomy where 375 (6.9%) subsequently developed a mental disorder. Vagotomy overall was not associated with mental disorders (HR: 1.10; 95%CI: 0.99–1.23), compared to individuals with ulcer not exposed to vagotomy. However, truncal vagotomy was associated with an increased HR of 1.22 (95%CI: 1.06–1.41) for mental disorders, whereas highly selective vagotomy was not associated with mental disorders (HR: 0.98; 95%CI: 0.84–1.15). Truncal vagotomy was also associated with higher risk of mental disorders when compared to highly selective vagotomy (p = 0.034).
Conclusions
Overall, vagotomy did not increase the risk of mental disorders; however, truncal vagotomy specifically was associated with a small risk increase in mental disorders, whereas no association was found for highly selective vagotomy. Thus, the vagus nerve does not seem to have a major impact on the development of mental disorders. |
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| AbstractList | Objective
To investigate vagotomy, the severance of the vagus nerve, and its association with mental disorders, as gut‐brain communication partly mediated by the vagus nerve have been suggested as a risk factor.
Methods
Nationwide population‐based Danish register study of all individuals alive and living in Denmark during the study period 1977–2016 and who had a hospital contact for ulcer with or without vagotomy. Follow‐up was until any diagnosis of mental disorders requiring hospital contact, emigration, death, or end of follow‐up on December 31, 2016, whichever came first. Data were analyzed using survival analysis and adjusted for sex, age, calendar year, ulcer type, and Charlson comorbidity index score.
Results
During the study period, 113,086 individuals had a hospital contact for ulcer. Of these, 5,408 were exposed to vagotomy where 375 (6.9%) subsequently developed a mental disorder. Vagotomy overall was not associated with mental disorders (HR: 1.10; 95%CI: 0.99–1.23), compared to individuals with ulcer not exposed to vagotomy. However, truncal vagotomy was associated with an increased HR of 1.22 (95%CI: 1.06–1.41) for mental disorders, whereas highly selective vagotomy was not associated with mental disorders (HR: 0.98; 95%CI: 0.84–1.15). Truncal vagotomy was also associated with higher risk of mental disorders when compared to highly selective vagotomy (p = 0.034).
Conclusions
Overall, vagotomy did not increase the risk of mental disorders; however, truncal vagotomy specifically was associated with a small risk increase in mental disorders, whereas no association was found for highly selective vagotomy. Thus, the vagus nerve does not seem to have a major impact on the development of mental disorders. ObjectiveTo investigate vagotomy, the severance of the vagus nerve, and its association with mental disorders, as gut‐brain communication partly mediated by the vagus nerve have been suggested as a risk factor.MethodsNationwide population‐based Danish register study of all individuals alive and living in Denmark during the study period 1977–2016 and who had a hospital contact for ulcer with or without vagotomy. Follow‐up was until any diagnosis of mental disorders requiring hospital contact, emigration, death, or end of follow‐up on December 31, 2016, whichever came first. Data were analyzed using survival analysis and adjusted for sex, age, calendar year, ulcer type, and Charlson comorbidity index score.ResultsDuring the study period, 113,086 individuals had a hospital contact for ulcer. Of these, 5,408 were exposed to vagotomy where 375 (6.9%) subsequently developed a mental disorder. Vagotomy overall was not associated with mental disorders (HR: 1.10; 95%CI: 0.99–1.23), compared to individuals with ulcer not exposed to vagotomy. However, truncal vagotomy was associated with an increased HR of 1.22 (95%CI: 1.06–1.41) for mental disorders, whereas highly selective vagotomy was not associated with mental disorders (HR: 0.98; 95%CI: 0.84–1.15). Truncal vagotomy was also associated with higher risk of mental disorders when compared to highly selective vagotomy (p = 0.034).ConclusionsOverall, vagotomy did not increase the risk of mental disorders; however, truncal vagotomy specifically was associated with a small risk increase in mental disorders, whereas no association was found for highly selective vagotomy. Thus, the vagus nerve does not seem to have a major impact on the development of mental disorders. To investigate vagotomy, the severance of the vagus nerve, and its association with mental disorders, as gut-brain communication partly mediated by the vagus nerve have been suggested as a risk factor. Nationwide population-based Danish register study of all individuals alive and living in Denmark during the study period 1977-2016 and who had a hospital contact for ulcer with or without vagotomy. Follow-up was until any diagnosis of mental disorders requiring hospital contact, emigration, death, or end of follow-up on December 31, 2016, whichever came first. Data were analyzed using survival analysis and adjusted for sex, age, calendar year, ulcer type, and Charlson comorbidity index score. During the study period, 113,086 individuals had a hospital contact for ulcer. Of these, 5,408 were exposed to vagotomy where 375 (6.9%) subsequently developed a mental disorder. Vagotomy overall was not associated with mental disorders (HR: 1.10; 95%CI: 0.99-1.23), compared to individuals with ulcer not exposed to vagotomy. However, truncal vagotomy was associated with an increased HR of 1.22 (95%CI: 1.06-1.41) for mental disorders, whereas highly selective vagotomy was not associated with mental disorders (HR: 0.98; 95%CI: 0.84-1.15). Truncal vagotomy was also associated with higher risk of mental disorders when compared to highly selective vagotomy (p = 0.034). Overall, vagotomy did not increase the risk of mental disorders; however, truncal vagotomy specifically was associated with a small risk increase in mental disorders, whereas no association was found for highly selective vagotomy. Thus, the vagus nerve does not seem to have a major impact on the development of mental disorders. To investigate vagotomy, the severance of the vagus nerve, and its association with mental disorders, as gut-brain communication partly mediated by the vagus nerve have been suggested as a risk factor.OBJECTIVETo investigate vagotomy, the severance of the vagus nerve, and its association with mental disorders, as gut-brain communication partly mediated by the vagus nerve have been suggested as a risk factor.Nationwide population-based Danish register study of all individuals alive and living in Denmark during the study period 1977-2016 and who had a hospital contact for ulcer with or without vagotomy. Follow-up was until any diagnosis of mental disorders requiring hospital contact, emigration, death, or end of follow-up on December 31, 2016, whichever came first. Data were analyzed using survival analysis and adjusted for sex, age, calendar year, ulcer type, and Charlson comorbidity index score.METHODSNationwide population-based Danish register study of all individuals alive and living in Denmark during the study period 1977-2016 and who had a hospital contact for ulcer with or without vagotomy. Follow-up was until any diagnosis of mental disorders requiring hospital contact, emigration, death, or end of follow-up on December 31, 2016, whichever came first. Data were analyzed using survival analysis and adjusted for sex, age, calendar year, ulcer type, and Charlson comorbidity index score.During the study period, 113,086 individuals had a hospital contact for ulcer. Of these, 5,408 were exposed to vagotomy where 375 (6.9%) subsequently developed a mental disorder. Vagotomy overall was not associated with mental disorders (HR: 1.10; 95%CI: 0.99-1.23), compared to individuals with ulcer not exposed to vagotomy. However, truncal vagotomy was associated with an increased HR of 1.22 (95%CI: 1.06-1.41) for mental disorders, whereas highly selective vagotomy was not associated with mental disorders (HR: 0.98; 95%CI: 0.84-1.15). Truncal vagotomy was also associated with higher risk of mental disorders when compared to highly selective vagotomy (p = 0.034).RESULTSDuring the study period, 113,086 individuals had a hospital contact for ulcer. Of these, 5,408 were exposed to vagotomy where 375 (6.9%) subsequently developed a mental disorder. Vagotomy overall was not associated with mental disorders (HR: 1.10; 95%CI: 0.99-1.23), compared to individuals with ulcer not exposed to vagotomy. However, truncal vagotomy was associated with an increased HR of 1.22 (95%CI: 1.06-1.41) for mental disorders, whereas highly selective vagotomy was not associated with mental disorders (HR: 0.98; 95%CI: 0.84-1.15). Truncal vagotomy was also associated with higher risk of mental disorders when compared to highly selective vagotomy (p = 0.034).Overall, vagotomy did not increase the risk of mental disorders; however, truncal vagotomy specifically was associated with a small risk increase in mental disorders, whereas no association was found for highly selective vagotomy. Thus, the vagus nerve does not seem to have a major impact on the development of mental disorders.CONCLUSIONSOverall, vagotomy did not increase the risk of mental disorders; however, truncal vagotomy specifically was associated with a small risk increase in mental disorders, whereas no association was found for highly selective vagotomy. Thus, the vagus nerve does not seem to have a major impact on the development of mental disorders. |
| Author | Mortensen, Preben B. Christensen, Rune H. B. Nordentoft, Merete Benros, Michael E. Orlovska‐Waast, Sonja Bunyoz, Artemis H. Petersen, Liselotte V. |
| Author_xml | – sequence: 1 givenname: Artemis H. orcidid: 0000-0003-1154-4022 surname: Bunyoz fullname: Bunyoz, Artemis H. organization: Copenhagen University Hospital – sequence: 2 givenname: Rune H. B. surname: Christensen fullname: Christensen, Rune H. B. organization: Copenhagen University Hospital – sequence: 3 givenname: Sonja surname: Orlovska‐Waast fullname: Orlovska‐Waast, Sonja organization: Copenhagen University Hospital – sequence: 4 givenname: Merete surname: Nordentoft fullname: Nordentoft, Merete organization: iPSYCH The Lundbeck Foundation Initiative for Integrative Psychiatric Research – sequence: 5 givenname: Preben B. surname: Mortensen fullname: Mortensen, Preben B. organization: CIRRAU – Centre for Integrated Register‐based Research – sequence: 6 givenname: Liselotte V. surname: Petersen fullname: Petersen, Liselotte V. organization: CIRRAU – Centre for Integrated Register‐based Research – sequence: 7 givenname: Michael E. surname: Benros fullname: Benros, Michael E. email: michael.eriksen.benros@regionh.dk organization: University of Copenhagen |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34195992$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_bbi_2024_11_023 crossref_primary_10_1016_j_ajp_2023_103861 crossref_primary_10_3902_jnns_30_142 |
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| Keywords | vagus nerve inflammation immunology vagotomy mental disorders |
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To investigate vagotomy, the severance of the vagus nerve, and its association with mental disorders, as gut‐brain communication partly mediated by... To investigate vagotomy, the severance of the vagus nerve, and its association with mental disorders, as gut-brain communication partly mediated by the vagus... ObjectiveTo investigate vagotomy, the severance of the vagus nerve, and its association with mental disorders, as gut‐brain communication partly mediated by... |
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| SubjectTerms | Emigration Hospitals Humans immunology inflammation Mental disorders Mental Disorders - epidemiology Population studies Population-based studies Risk Factors Survival analysis Ulcers Vagotomy Vagus Nerve |
| Title | Vagotomy and the risk of mental disorders: A nationwide population‐based study |
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