Human sensitivity to 1,3-butadiene: role of microsomal epoxide hydrolase polymorphisms - Abdel-Rahman, Sherif Z.; Ammenheuser, Marinel M.; Ward, Jonathan B. (Carcinogenesis (New York), 2001)
Keywords: 1,3-butadiene; 2-butanediol; 3-butadiene; 4-diepoxybutane; 4-epoxy-1; 4-epoxy-1-butene; 6-thioguanine; Alleles; Biological and medical sciences; Butadienes - adverse effects; Chemical and industrial products toxicology. Toxic occupational diseases; Chemical mutagenesis; DEB; EBD; Epoxide Hydrolases - genetics; Epoxide Hydrolases - metabolism; glutahione S-transferases; Glutathione Transferase - genetics; growth medium; GSTM1 gene; GSTs; GSTT1 gene; hprt gene; Humans; Hypoxanthine Phosphoribosyltransferase - genetics; IARC; International Agency for Reseach on Cancer; labeling index; Medical sciences; mEH; mEH gene; microsomal epoxide hydrolase; Microsomes - enzymology; Occupational Exposure; Occupational Safety and Health Administration; OSHA; PEL; permissible exposure limit; Polymorphism, Genetic; SBR; SCE; SEM; sister chromatid exchanges; standard error of the mean; styrene-butadiene rubber; tame-weighted average; Toxicology; TWA; University of Texas Medical Branch; UTMB; Various organic compounds; Metabolite; Toxicity; Genotoxicity; Biological marker; Occupational exposure; Microsome; Mutagen; Epoxide hydrolase; Blood; Genetics; Human; Enzyme; Genetic variant; Detoxication; Genotype; 1,3-Butadiene; In vitro; Hydrolysis; Carcinogen; Allele; Sensitivity resistance; DNA; Ether hydrolases; Hydrolases; Drug-metabolizing enzyme; Lesion; Mutation; Lymphocyte; Occupational medicine; Polymorphism