Serum level of transforming growth factor-beta1 in major idiopathic interstitial pneumonia

• Published in: Egyptian Journal of Bronchology Vol. 14; no. 1; pp. 1 - 6
• Main Authors: Zakaria, Mohamed W., El-Korashy, Reem I., Selim, Samah, Badawy, Ingy, Amum, Kwashi J.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2020; Springer; Springer Nature B.V; SpringerOpen
• Subjects: Age; Antibodies; Bacterial pneumonia; Collaboration; Comparative analysis; Cytokines; Dyspnea; Enzymes; Growth factors; Idiopathic interstitial pneumonia; Lung fibrosis; Medical research; Medicine; Medicine & Public Health; Oxygen saturation; Patients; Pneumonia; Pulmonary fibrosis; Six-minute walk test; Transforming growth factor-beta1; Transforming growth factors; Variables; Six-minute walk test; Idiopathic interstitial pneumonia; Lung fibrosis; Transforming growth factor-beta1
• ISSN: 1687-8426; 2314-8551
• DOI: 10.1186/s43168-020-00023-0

Background Different inflammatory cytokines play a role in the mechanism and pathogenesis of fibrosis in idiopathic interstitial pneumonia (IIP). Transforming growth factor-beta1 (TGF-β1) has become a subject of interest. The aim of the work is to measure the serum level of TGF-β1 in different forms of major IIP and to find out its relation to the patients ’ clinical and arterial blood gases’ parameters. Results The patients’ group showed significant elevation of serum level of TGF-β1 in comparison with the control group ( P value < 0.001). In patients with IPF, the serum level of TGF-β1 was not significantly increased compared to patients with other forms of major IIP (mean ± SD = 300 ± 84.52 versus 340 ± 131.20 pg/ml, P value = 0.32). There was an inverse negative correlation between the age and serum level of TGF-β1 ( r  = − 0.39; P  = 0.03). An inverse non-significant correlation was found between the serum level of TGF-β1 and the dyspnoea score ( r  = − 0.30, P  = 0.11). However, there was a significant positive correlation between the serum level of TGF-β1 and the distance of 6-MWT ( r  = 0.44; P  = 0.02). It was also found that there was a positive correlation between the serum level of TGF-β1 and both arterial oxygen pressure (PaO 2 ) ( r  = 0.39, P  = 0.03) and arterial oxygen saturation ( r  = 0.33, P  = 0.07). Conclusion Serum level of TGF-β1 is elevated in patients with IIP and it positively correlated to both 6-MWD and PaO 2 . Further larger studies are needed to evaluate its prognostic value.